FtsZ as a novel target for antibiotics development: Promises and challenges by Ming-Wei Wang, Kaini Hang, Wei Han, Xin Li, Qingtong Zhou, Dehua Yang

“…To address these challenges, future efforts should be directed to resolve transient assembly intermediates, leveraging machine learning with high-throughput screening, and integrating structural biology with pharmacokinetic optimization. Multidisciplinary strategies combining these approaches hold promise for translating FtsZ-focused research into clinically viable therapies, addressing the critical unmet need posed by antibiotics resistance.…”
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Physics-Informed Decoupled Calibration for Fourier Ptychographic Microscopy by Mingdi Liu, Junzhao Liang, Yanxiong Wu, Zicong Luo, Rui Xie, Jiaxiong Luo, Lisong Yan

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Image analysis optimization for nanowire-based optical detection of molecules by Davtyan Rubina, Anttu Nicklas, Valderas-Gutiérrez Julia, Höök Fredrik, Linke Heiner

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Nutritional optimization for bioprocess production of staphyloxanthin from Staphylococcus aureus with response surface methodology: promising anticancer scaffold targeting EGFR inh... by Ahmed M. Nosair, Ahmed A. Abdelaziz, Amal M. Abo-Kamer, Lamiaa A. Al-Madboly, Mahmoud H. Farghali

“…It plays a crucial role in combating reactive oxygen species (ROS), positioning it as a promising and effective alternative in cancer treatment. …”
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Optimizing hybrid fiber concrete: an experimental analysis of steel and polypropylene fiber composites using RSM by Muhammad Aftab Khan, Qaiser uz Zaman Khan

“…Hybrid fiber-reinforced concrete (HYFRC), incorporating both steel and polypropylene fibers, has emerged as a promising solution to enhance crack resistance of concrete, its durability, and overall mechanical properties. …”
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Comparison of MEMS-based photoacoustic microscopy in biomedical imaging by Pasin Suttikittipong, Parawee Tangkiatphaibun, Nicholas Piyawattanametha, Wibool Piyawattanametha

“…Photoacoustic microscopy (PAM) has emerged as a promising biomedical imaging technique, renowned for its capability to visualize the microvasculature and measure oxygen saturation levels in biological tissues, both non-invasively and in real-time. …”
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Deep‐Learning‐Enhanced Electron Microscopy for Earth Material Characterization by Hans vanMelick, Richard Taylor, Oliver Plümper

“…To address this challenge, this research introduces a novel image enhancement process for scanning electron microscopy data sets, demonstrating significant resolution improvement through Deep‐Learning‐Enhanced Electron Microscopy (DLE‐EM). …”
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Radiation dosimetry performance appraisal of the optimal concentration of nitro blue tetrazolium dye in PVA composite film at low X-ray doses by Reham Albejadi, Saleh Alashrah, Yassine El-Ghoul, Zabih Ullah, Saleh A. Almatroodi

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Nonequilibrium heat dissipation as a probe for detecting wavefront distortion in microscopy by Taro Ando, Tomoko Otsu-Hyodo

“…We propose an adaptive wavefront-optimization concept, where minor wavefront distortion in microscopy can be probed by the additional heat dissipation itself. …”
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Quantum Diamond Microscopy of Individual Vaterite Microspheres Containing Magnetite Nanoparticles by Mona Jani, Hani Barhum, Janis Alnis, Mohammad Attrash, Tamara Amro, Nir Bar-Gill, Toms Salgals, Pavel Ginzburg, Ilja Fescenko

“…Biocompatible vaterite microspheres, renowned for their porous structure, are promising carriers for magnetic nanoparticles (MNPs) in biomedical applications such as targeted drug delivery and diagnostic imaging. …”
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Monolithic dual-wedge prism-based spectroscopic single-molecule localization microscopy by Song Ki-Hee, Brenner Benjamin, Yeo Wei-Hong, Kweon Junghun, Cai Zhen, Zhang Yang, Lee Youngseop, Yang Xusan, Sun Cheng, Zhang Hao F.

“…By manipulating the spectral dispersion of detected photons, spectroscopic single-molecule localization microscopy (sSMLM) permits concurrent high-throughput single-molecular spectroscopic analysis and imaging. …”
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Application of Luminescent Microscopy in Analysis of Anatomic-diagnostic Signs of Fruits of Sea Buckthorn by O. V. Trineeva, A. A. Gudkova, M. A. Rudaya

“…Sea buckthorn (Hippophae rhamnoides), the family Eleagnaceae – a promising source of biologically active substances, the traditional raw materials of which are fruits. …”
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Uncovering multiscale structure-property correlations via active learning in scanning tunneling microscopy by Ganesh Narasimha, Dejia Kong, Paras Regmi, Rongying Jin, Zheng Gai, Rama Vasudevan, Maxim Ziatdinov

“…Here we demonstrate a multi-scale Bayesian deep-learning based framework that automatically correlates material structure with its electronic properties using scanning tunneling microscopy (STM) measurements in real-time. Its predictions are used to autonomously direct exploration toward regions of the sample that optimize a given material property. …”
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Supervised Machine Learning Thyroid Carcinoma Diagnosis Using Wide-Field SHG Microscopy by Yaraslau Padrez, Radu Hristu, Igor Timoshchenko, Lucian G. Eftimie, Danielis Rutkauskas, Lena Golubewa

“…Since the structure of the collagen capsule surrounding thyroid nodules provides diagnostically valuable information, label-free imaging with second harmonic generation (SHG) microscopy combined with machine learning (ML)-based analysis offers a promising approach for automated classification. …”
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Leveraging automated time-lapse microscopy coupled with deep learning to automate colony forming assay by Anusha Klett, Anusha Klett, Dennis Raith, Dennis Raith, Paula Silvestrini, Paula Silvestrini, Paula Silvestrini, Matías Stingl, Jonas Bermeitinger, Avani Sapre, Avani Sapre, Avani Sapre, Martin Condor, Roman Melachrinos, Mira Kusterer, Alexandra Brand, Guido Pisani, Guido Pisani, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Marie Follo, Marie Follo, Jesús Duque-Afonso, Roland Mertelsmann, Roland Mertelsmann

“…DiscussionFuture integration with a perfusion-based drug screening system promises to enhance personalized cancer therapy by optimizing broad drug screening approaches and enabling real-time evaluation of therapeutic efficacy.…”
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Promising reagents for the extraction of strategic metals from difficult-to-enrich mineral raw materials by Tamara N. Matveeva, Nadezhda K. Gromova, Lyudmila B. Lantsova

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Advancement in scanning magnetic microscopy utilizing high-sensitivity room-temperature TMR sensors for geological applications by Hirokuni Oda, Seiji Kumagai, Kosuke Fujiwara, Hitoshi Matsuzaki, Hiroshi Wagatsuma, Mikihiko Oogane, Hitoshi Kubota, Naoto Fukuyo, Akihiro Tanimoto

“…Overall, the high-sensitivity TMR sensors exhibited promising performance. Further improvements can be made by optimizing the sensors, preamplifiers, and measurement systems for magnetic microscopy to achieve an optimum target resolution. …”
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Pushing Optical Resolution to the Few-Nanometer Scale via dSTORM Imaging of Expanded Specimen–Gel Composites by Jimmy Ching-Cheng Hsu, T. Tony Yang

“…Yet achieving ultrastructural resolution using dSTORM alone remains challenging, despite its advantage of requiring only minimal modifications to the imaging setup and sample preparation compared to conventional fluorescence microscopy. A recent advancement that integrates expansion microscopy (ExM), which embeds specimens in a swellable polymer gel, with dSTORM holds promise for attaining imaging resolutions below 10 nm. …”
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Cerium doped superparamagnetic Mn–Zn ferrite particles as a promising material for self-regulated magnetic hyperthermia by Mattheus Torquato, Eliel Gomes da Silva Neto, Magno de Assis Verly Heringer, Elisa Maria Baggio-Saitovich, Emilson Ribeiro Viana, Ronaldo Sergio de Biasi

“…These results suggest that Ce3+ is a promising doping ion to optimize the heating rate behavior of Mn–Zn ferrite for cancer treatment by hyperthermia.…”
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Optimization of Wear Behavior of DLC Coatings Through Optimization of Deposition Conditions by Ming-Der JEAN, Cheng-Wu LIU, Pao-Hua YANG, Wen-Hsien HO

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