Design and Optimization of Sustained-Release Dental Implants for Targeted Periodontal Drug Delivery by Silpi Chatterjee, Daya Shankar, Yagyesh Mehta, Swamini Ajay Shete, Asim Mustafa Khan, Ankita Kumari

“…Implants were prepared using solvent evaporation techniques and optimized for drug release by altering polymer-to-drug ratios. …”
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Tool geometry optimization for enhanced mechanical properties in friction stir welding of carbon steel by Anmol Bhatia, Reeta Wattal, Rajeev Kumar, Anant Prakash Agrawal, Saurabh Dewangan

“…A tungsten carbide tool containing 7 wt.% cobalt with a tapered pin profile—identified as the optimal configuration—was employed for the welding process. …”
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Antibacterial potential and chromatographic profiling of bioactive compounds from endophytic Streptomyces sp. strain MIRK71 isolated from Mirabilis jalapa (L.) by Lalrokimi, Purbajyoti Deka, William Carrie, Lallawmsangi, Christine Vanlalbiakdiki Sailo, Lalrosangpuii, Felicia Lalremruati, Awmpuizeli Fanai, Yasangam Umbon, Esther Lalnunmawii, Zothanpuia

“…Gas chromatography-mass spectrometry (GC-MS) analysis detected 20 volatile compounds. Further profiling was conducted using high-performance thin-layer chromatography (HPTLC) with three optimized solvent systems: ethyl acetate:methanol:water (20:3:2) for glycosides (SS1), cyclohexane:ethyl acetate:formic acid (4:6:1) for phenols (SS2), and toluene:ethyl acetate:methanol:acetic acid (3:5:1:0.5) for anthracenes (SS3). …”
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Multiresponse optimization applied to friction-stir processing to enhance wear and corrosion performance in Al–Si alloys by Denner Traiano, Silvia do Nascimento Rosa, Luciano Augusto Lourençato, Angel Sánchez Roca, Mario César Sánchez Orozco, Hipólito Domingo Carvajal Fals

“…The multiresponse optimization identified the optimal FSP parameters for Al12Si alloys at a tool rotation speed of 1100 rpm and a travel speed of 16 mm/min. …”
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Extraction of fermentable sugars and phenolic compounds from Colombian cashew (Anacardium occidentale) nut shells using subcritical water technology: Response surface methodology a... by Luis J. Cruz-Reina, Jader Rodríguez-Cortina, Fabrice Vaillant, Israel Herrera-Orozco, Chiara Carazzone, Rocío Sierra

“…This study aimed to evaluate SCWE applied to CNS from Vichada, Colombia, using a surface response methodology and to perform a comprehensive chemical profiling of the recovered extracts and the remaining solids. …”
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Enhancing the nutritional profile of purple sweet potato flour through fermentation with Lactiplantibacillus plantarum InaCC B157: A functional food perspective by Tiurma Pasaribu, Yati Sudaryati Soeka, Novik Nurhidayat, Suciatmih Suciatmih, Titin Yulinery, Evi Triana, Tri Ratna Sulistiyani, Ninik Setyowati, Desty Dwi Sulistyowati, Dwi Ningsih Susilowati

“…Future studies should investigate sensory profiling, shelf-life extension, and optimization of fermentation parameters to further enhance the application of this functional ingredient.…”
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Green synthesis of ultrafine zinc oxide nanoparticles for photocatalytic degradation of methylene blue dye: Optimization and kinetic studies by Muthusamy Kandasamy, Santhanakrishnan Suresh, Perumal Rameshkumar, Rajendran Jayasree, Panneerselvam Sathishkumar, Prem Gunnasegaran, Niraj S Topare, Sekar Thambidurai, Jemini Arumugam, Rajendran Jothilakshmi, Nalandhiran Pugazhenthiran

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Optimization and Characterization Studies of Dissimilar Friction Stir Welding Parameters of Brass and Aluminum Alloy 6063 Using Taguchi by Vimal Agarwal, Deepam Goyal, B. S. Pabla, S. C. Vettivel, A. Haiter Lenin

“…This paper focuses on optimizing process parameters such as tool rotating speed, preheat-treated workpiece temperature, traverse speed, and tool pin profile for dissimilar friction stir welding (FSW) of brass and AA 6063. …”
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MALDI-TOF mass spectrometry combined with machine learning algorithms to identify protein profiles related to malaria infection in human sera from Côte d’Ivoire by Fateneba Kone, Lucie Conrad, Jean T. Coulibaly, Kigbafori D. Silué, Sören L. Becker, Brama Kone, Issa Sy

“…In endemic areas, malaria is mainly diagnosed using microscopy or rapid diagnostic tests (RDTs), which have limited sensitivity, and microscopic expertise is waning in non-endemic regions. …”
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Optimizing Antitumor Effect of Triple-Negative Breast Cancer via Rosmarinic Acid–β-Cyclodextrin Inclusion Complex by Yuan Li, Muhammad Inam, Muhammad Waqqas Hasan, Kaixin Chen, Zhongqian Zhang, Yongcheng Zhu, Jiayu Huang, Zhuowen Wu, Wenjie Chen, Min Li

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Optimized methods for scRNA-seq and snRNA-seq of skeletal muscle stored in nucleic acid stabilizing preservative by Elisabeth F. Heuston, Ayo P. Doumatey, Faiza Naz, Shamima Islam, Stacie Anderson, Martha R. Kirby, Stephen Wincovitch, Stefania Dell’Orso, Charles N. Rotimi, Adebowale A. Adeyemo

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Secretome enriched with small extracellular vesicles derived from human gingiva-derived mesenchymal stem cells enhances rat tongue muscle regeneration by Qunzhou Zhang, Puhan He, Shihong Shi, Qilin Xu, Eric J. Granquist, Beth A. Winkelstein, Rabie M. Shanti, Anh D. Le

“…Conclusion Secretome derived from GMSCs cultured under optimized xeno-free induction displayed enrichment of EVs and SPs and enhanced pro-myogenic potentials and anti-inflammatory effect on macrophages. …”
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Optimization of In-Situ Exosome Enrichment Methodology On-a-Chip to Mimic Tumor Microenvironment Induces Cancer Stemness in Glioblastoma Tumor Model by Saleheh Saffar, Ali Ghiaseddin, Shiva Irani, Amir Ali Hamidieh

“…To address this, a microfluidic bioreactor (µBR) with an expanded culture surface was designed to optimize exosome enrichment and glioblastoma cell behavior. …”
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Nutritional optimization for bioprocess production of staphyloxanthin from Staphylococcus aureus with response surface methodology: promising anticancer scaffold targeting EGFR inh... by Ahmed M. Nosair, Ahmed A. Abdelaziz, Amal M. Abo-Kamer, Lamiaa A. Al-Madboly, Mahmoud H. Farghali

“…Conclusion The bioprocess for optimized production, combined with the biological profiling and low cytotoxicity, substantiates the potential application of STX pigment in combating lung cancer.…”
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HSPiP and QbD oriented optimized stearylamine-elastic liposomes for topical delivery of ketoconazole to treat deep seated fungal infections: In vitro and ex vivo evaluations by Afzal Hussain, Mohammad A. Altamimi, Yaser Saleh Alneef

“…Using quality by design (QbD) method, we optimized the formulations and evaluated for vesicle size, polydispersity index, zeta potential, morphology (scanning electron microscopy), in vitro drug release (%), and ex vivo permeation profiles. …”
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Viscosity reduction and stability study of Indian heavy crude oil/water emulsion using hydrogenated castor oil ethoxylate with 40 moles of ethylene oxide as surfactant by Shreyas Desai, Mousumi Chakraborty, Arun Kumar Jana, Himanshu P. Kohli

“…An interaction plot and Box-Behnken Design (BBD) approach were used to optimize oil: water ratio, pH, and surfactant concentration to minimize the consumption of chemicals. …”
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Effесt of Chеmiсаl Cоmposition оn thе Miсrоstruсture, Hаrdnеss, аnd Elесtrical Conductivity Profiles of the Bi-Gе-X (Gа, Cu, Zn) Allоys by A. Djordjević, M. Zečević, D. Minić, M. Kolarević, D. Manasijević, V. Ristić

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Stabilized diverse HIV-1 envelope trimers for vaccine design by Qian Wang, Bingting Ma, Qingtai Liang, Angqi Zhu, Hua Wang, Lili Fu, Xiaoxu Han, Xuanling Shi, Ye Xiang, Hong Shang, Linqi Zhang

“…Here, we design and characterize uncleaved prefusion-optimized (UFO) trimers for 12 Envs currently circulating in China. …”
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Fabrication and electrocatalytic performance of CoW11CpFe@Cu-BTC/MWCNTs-COOH modified glassy carbon electrode for simultaneous detection of dopamine and uric acid by Somayeh Kochebaghi, Somayeh Dianat

“…Electrochemical profiling was conducted using cyclic voltammetry (CV), differential pulse voltammetry (DPV), and amperometry. …”
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Green Synthesis of Silver Nanoparticles Using Aidia densiflora Leaf Extract: Characterisation and Bioactivities by Ainul Hayati Zeheri, Muhammad Taher, Muhammad Taufiq Mohd Jailani, Juliana Md Jaffri, Deny Susanti Darnis, Junaidi Khotib

“…Liquid chromatography-mass spectrometry quadrupole time-of-flight was utilised for phytochemical profiling. The synthesised AgNPs were characterised using a zetasizer and zeta potential analyser, scanning electron microscopy-energy dispersive X-ray, Fourier Transform Infrared, X-ray diffraction (XRD), and thermogravimetric analysis. …”
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