Performance and comparison of FLCCheck: a novel serum free light chain assay for the Auxiliary Diagnosis of Multiple Myeloma by Jinghao Cao, Xi Chen, Yu Zhou, Yajuan Lu, Aoli Deng, Sainan Li, Yuhan Chen, Jing Du, Jun Xia

“…Results The FLCCheck assay demonstrated a validated linear range, high precision, and strong resistance to interference for both κ and λ light chain detection. …”
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Establishment and epidemiological investigation of a dual fluorescent qPCR assay for Pasteurella multocida and Salmonella in yaks in the Tibetan Autonomous Prefecture of Garzê, Chi... by Yao Pan, Qingting Yu, Qi Wang, Qiang Li, Wei Tian, Lingxiang Xin, Xing Hu, Haiyue Xiao, Yuanjie Liu, Luo Rong Deng Zhu, Lan Lan, Liangquan Zhu, Jianping Wu

“…Following rigorous optimization, a duplex assay was established. Recombinant plasmids were constructed to serve as standards for generating standard curves. …”
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Evaluation of Nematocidal Action against Caenorhabditis elegans of Essential Oil of Flesh Fingered Citron and Its Mechanism by Xixi Piao, Min Sun, Fengping Yi

“…Essential oils from flesh fingered citrons were obtained by mechanical pressing extraction under optimal conditions. Thirty-three components, representing 78.25% of the total oil, were identified by gas chromatography-mass spectrometry (GC-MS). …”
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Combining inhibition of galectin-3 with and before a therapeutic vaccination is critical for the prostate-tumor-free outcome by Carolina Tiraboschi, Lucas Gentilini, Carla Velazquez, Enrique Corapi, Felipe Martín Jaworski, José Daniel Garcia Garcia, Yorfer Rondón, Anne Chauchereau, Diego José Laderach, Daniel Compagno

“…Our results show that low and non-cytotoxic doses of docetaxel lead to the inhibition of Gal-3 expression in PCa cells as well as in clinical samples of patients with metastatic and castration-resistant PCa promoting a Th1 response. We thus optimized a prostate cancer animal model that undergoes surgical resection of the tumor to mimic prostatectomy usually performed in patients. …”
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SMART DShot: Secure Machine-Learning-Based Adaptive Real-Time Timing Correction by Hyunmin Kim, Zahid Basha Shaik Kadu, Kyusuk Han

“…Our approach addresses critical vulnerabilities in Electronic Speed Controller (ESC) interfaces by deploying four synergistic algorithms—Kalman Filter Timing Correction (KFTC), Recursive Least Squares Timing Correction (RLSTC), Fuzzy Logic Timing Correction (FLTC), and Hybrid Adaptive Timing Correction (HATC)—each optimized for specific error characteristics and attack scenarios. …”
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Comparison of TAP block and epidural analgesia for postoperative analgesia after robotic-assisted radical prostatectomy by O.O. Volkov, Lutsenko V.V., M.O. Plis, M.V. Pavlenko, Krishtafor D.A.

“…To alleviate pain and optimize improved recovery after laparoscopic prostatectomy, regional anesthesia techniques have been used to avoid or reduce the need for opioids. …”
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Paper strip sensor based on γ-fe2O3@prussian blue nanozyme for H2O2 detection by Zoha Babaei Afrapoli, Sharmin Kharrazi, Fardin Amidi, Ramin Rahimnia, Reza Faridi-Majidi

“…The concentrations of γ-Fe2O3@PB NPs and TMB, immobilized on paper strips, were optimized. The detection limit of the constructed lateral flow assays (LFA) for H2O2 in acetate buffer was 50.0 µM. …”
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Deep Reinforcement Learning for Efficient Scheduling of Ground-based Astronomical Observations by Hai Cao, Shaoming Hu, Junju Du, Xu Chen, Shuqi Liu, Shuai Feng, Bo Zhang, Yuchen Jiang

“…In this study, we formalize observation scheduling as a time-dependent combinatorial optimization problem. To achieve this, we implement a pointer network with temporal attention that is capable of planning observations while accounting for time-varying factors such as moonlight interference, target altitude, and air mass, which impact the exposure time and image quality. …”
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Understanding university students' experiences of sitting while studying at home: A qualitative study. by Hannah Clare Wood, Sanjana Prabhakar, Rebecca Upsher, Myanna Duncan, Eleanor J Dommett, Benjamin Gardner

“…These findings suggest that intervention designers should more explicitly consider the home environment when aiming to reduce student sedentary behaviour and should seek to reduce sitting in a way that promotes, or at least does not interfere with, productivity.…”
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Sesquiterpene Lactones from Artemisia Genus: Biological Activities and Methods of Analysis by Bianca Ivanescu, Anca Miron, Andreia Corciova

“…Another problematic aspect is represented by the complexity of vegetal samples, which may contain compounds that can interfere with the analysis. Therefore, this paper proposes an overview of the methods used for the identification and quantification of sesquiterpene lactones found in Artemisia genus, as well as the optimal conditions for their extraction and separation.…”
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Exploring Sample Storage Conditions for the Mass Spectrometric Analysis of Extracted Lipids from Latent Fingerprints by Aleesa E. Chua, Eden P. Go, Heather Desaire

“…In large-scale studies, uncontrolled systematic variability introduced during sample preparation, processing, and storage can interfere with the detection of subtle biological signals. …”
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A condition diagnosis method for subway track structures employing distributed optical fiber sensing by Hong Han, Xiaopei Cai, Liang Gao

“…First, a method for constructing a correlation model for strain monitoring data based on the optimal space window is proposed to realize the division of measuring points to reduce the computational complexity, and then, the deep generative adversarial network model with residual learning is constructed. …”
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The prevalence of exercise-induced asthma among school children by Bhekiwe F. Mtshali, Kebogile E. Mokwena

“…Exercise-induced asthma (EIA) is one of the major factors that affect optimal performance in sport. The prevalence of EIA is reported to be on the increase among school children worldwide. …”
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Management options in the sudden hearing loss of a diabetic patient by Andreea Rusescu, Viorel Zainea, Oana Ruxandra Iana, Irina Ioniță, George Traian Alexandru Burcea-Dragomiroiu, Dragos Cristian Ștefănescu, Dumitru Cristinel Badiu, Florentina Gherghiceanu, Cătălina Pietroșanu, Corina Silvia Pop, Razvan Hainarosie, Mura Hainarosie

“…Adequate control of the progression, treatment and complications of diabetes mellitus ensures optimal treatment management in case of a sudden hearing loss and therefore interferes with the favorable functional hearing outcomes. …”
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Chip-to-chip photonic quantum teleportation over optical fibers of 12.3 km by Dongning Liu, Zhanping Jin, Jingyuan Liu, Xiaotong Zou, Xiaosong Ren, Hao Li, Lixing You, Xue Feng, Fang Liu, Kaiyu Cui, Yidong Huang, Wei Zhang

“…The unbalanced Mach–Zehnder interferometers (UMZI) for time-bin encoding in these quantum photonic circuits are optimized to reduce insertion losses and suppress noise photons generated on the chip. …”
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Comprehensive search for assessment indicators that influence the level of handwriting difficulties among children in educational settings by Shuhei Takahata, Hiromichi Hagihara, Hiroyuki Ishihara, Daiki Enomoto, Naoto Ienaga, Haruka Noda, Shoichi Ishida, Kei Terayama

“…Abstract Handwriting difficulties are a major public health problem among school-aged children worldwide, as they seriously interfere with their academic performance and well-being. …”
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Amperometric Biosensor Based on Glutamate Oxidase to Determine Ast Activity by Daryna Mruga, Kseniia Berketa, Andrii Sverstiuk, Vasyl Martsenyuk, Aleksandra Klos-Witkowska, Yurii Palianytsia, Sergei Dzyadevych, Oleksandr Soldatkin

“…This work presents the development of an amperometric biosensor for detecting aspartate aminotransferase (AST) activity in biological fluids using a platinum disk electrode as the working transducer. Optimal concentrations of substrates (aspartate, α-ketoglutarate) and the coenzyme (pyridoxal phosphate) were determined to ensure efficient biosensor operation. …”
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High-throughput screening for the identification of dual inhibitors of BRD4 and RIPK3 toward the development of small-molecule medical countermeasure agents against arsenicals by Marina Fosso Yatchang, Ling Zhai, Omar Moukha-Chafiq, Bini Mathew, Fuad Al Abir, Sixue Zhang, Pedro Ruiz, Sara McKellip, Miranda Nebane, Jake Y. Chen, Anupam Agarwal, James R. Bostwick, Mark J. Suto, Mohammad Athar, Corinne E. Augelli-Szafran

“…These compounds could serve as good candidates for further chemical optimization for the development of small-molecule medical counter measure agents against arsenicals.…”
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A naked-eye biosensing system based on one-pot RPA-CRISPR/Cas12a driver G4-hemin self-assembly for Mycobacterium tuberculosis by Ting Yuan, Ting Yuan, Jianbo Yuan, Jianbo Yuan, Jian Huang, Jian Huang, Nana Li, Nana Li, Huan Cai, Yan Yang, Juan Li, Rui Chen, Xun Min, Xun Min

“…Glycerol was employed as a phase-separation barrier to prevent interference between RPA amplification and CRISPR/Cas12a trans-cleavage. …”
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Sequential Antibiotic Therapy: Effective Cost Management and Patient Care by Lionel A Mandell, Michel G Bergeron, Marie J Gribble, Peter J Jewesson, Donald E Low, Thomas J Marrie, Lindsay E Nicolle

“…However, it is also clear that further studies are necessary to determine the optimal time for intravenous to oral changeover and to identify the variables that may interfere with the use of oral drugs. …”
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