The Spatial Proximity of CD8⁺ FoxP3⁺PD-1⁺ Cells to Tumor Cells: A More Accurate Predictor of Immunotherapy Outcomes in Advanced Non-Small-Cell Lung... by Zijuan Hu, Zhihuang Hu, Keji Chen, Huixia Huang, Xinyang Zhong, Yaxian Wang, Jiayu Chen, Xuefeng He, Di Shi, Yupeng Zeng, Jiwei Li, Xiaoyan Zhou, Ping Wei

“…Background: To optimize precision immunotherapy for advanced NSCLC, comprehensive tumor immune microenvironment (TIME) characterization is crucial for efficacy prediction. …”
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Preparation of Hollow Nanocarbon Spheres Supported Bismuth and Electrocatalytic Reduction of CO₂ to Formic Acid by REN Mingye, Han Shihao, HU Jingbing, ZHAO Kun, GAO Pan, YANG Shaoxia

“…The effects of the reaction operating conditions (cathode potential, KHCO₃ electrolyte concentration and pH) on the formation of formic acid were optimized in the CO₂RR over the Bi₂O₃@HCS-2 catalyst. …”
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Dosimetric evaluation of a novel automated noncoplanar volumetric modulated arc therapy technique for treating optic nerve sheath meningiomas by Zhenyu Xiong, Zhenyu Xiong, Zhenyu Xiong, Chingyun Cheng, Lili Zhou, Brett Eckroate, Brett Eckroate, Brett Eckroate, Loren Bell, Fredrick Warburton, David Huang, Sabin B. Motwani, Sabin B. Motwani, Charles S. Cathcart, Ke Nie, Ke Nie, Ke Nie, Ning Yue, Ning Yue, Ning Yue, Yin Zhang, Yin Zhang, Yin Zhang

“…Furthermore, HA plans achieved the lowest maximum dose values for the following OARs: lenses, hippocampi, contralateral optic nerve, and contralateral retina (p < 0.05), thereby optimally sparing these critical structures. No significant differences were observed across techniques regarding Dmean, Dmin, PCI, or maximum dose to the ipsilateral optic nerve, ipsilateral retina, and optic chiasm.ConclusionsHA plans demonstrated superior dosimetric performance, ensuring adequate target coverage, reduced PTV hotspots, and better OAR protection compared to coplanar VMAT plans on the Varian TrueBeam and Halcyon. …”
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Age-related changes in upper limb motion during typical development. by Cristina Simon-Martinez, Gabriela Lopes Dos Santos, Ellen Jaspers, Ruth Vanderschueren, Lisa Mailleux, Katrijn Klingels, Els Ortibus, Kaat Desloovere, Hilde Feys

“…Here, we investigated age-related differences in UL movement characteristics over the entire movement cycle in TD children.…”
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Analysis on omission of checking laparoscopic instruments for hepatological surgery and application evaluation of modified handing-over checking list (肝胆外科手术腹腔镜器械交接过程中漏清点事件分析与改良清点单... by ZHANG Tianqiang (张天强), HUANG Xuanxuan (黄玄玄), YANG Caihui (杨彩慧), FU Li (付立)

“…Objective To analyze the omission events of checking laparoscopic instruments for hepatological surgery, and reduce the incidence of omission events by using modified handing-over checking list. Methods The records of handing over laparoscopic instruments for hepatological surgery from January and December 2022 were retrospectively analyzed, and a quality control team was established to optimize the handing-over checking list according to the analysis on the omission of checking laparoscopic instruments. …”
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Properties and sensory acceptability of creatine-fortified foods using ultra-micronized creatine monohydrate – the KREAFOOD Project by Julián Quintero-Quiroz, Sebastian Botero-Ramirez, Simon Jaramillo-Caro, Natalia Zuluaga, Diego A. Bonilla

“…In the mocaccino, sensory analysis revealed significant differences in granularity (P = 0.049), with lower granularity observed in the KreaFood product. …”
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Haemodynamic effects of intra‐aortic balloon pumps stratified by baseline pulmonary artery pulsatility index by George Kalapurakal, Vinh Q. Chau, Teruhiko Imamura, Sanika Tolia, Chris Sciamanna, Gregory P. Macaluso, Anjali Joshi, Jessica Pillarella, Sunil Pauwaa, Muhyaldeen Dia, Tarek Kabbany, James Monaco, Mark Dela Cruz, William G. Cotts, Patroklos Pappas, Antone J. Tatooles, Nikhil Narang

“…We aimed to assess short‐term haemodynamic changes in patients with HF‐CS following IABP support stratified by baseline PAPi. Methods and results This is a single‐centre study of 67 consecutive patients with HF‐CS who underwent IABP placement between 2020 and 2022. …”
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Integration of clinical and serological biomarkers in a nomogram for predicting interstitial lung disease in idiopathic inflammatory myopathies by Zhixia Wang, Jingyun Zhang, Jin Li, Xiaona Mao, Yangyang Li, Dekun Wang, Wenpeng Ge, Jingzhan Li, Changhua Liang, Zhiqiang Zhang

“…However, further validation in larger, multicenter cohorts is warranted to corroborate the model’s predictive accuracy and to optimize its clinical utility.…”
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Analysis of the impact of rotation error on PTV margins in multiple brain metastases fractionated stereotactic radiotherapy based on single-isocenter multi-target technique by Yuhong Li, Rui Hua, Liling Dai, Wei Chen, Junyuan Zhang, Qian Wang, Yufeng Xu, Tingting Wang

“…Rotational errors reduce dose coverage, and a minimum safety margin of 1.79 mm is recommended to ensure tumor coverage and reduce local failure, providing a basis for future treatment optimization.…”
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The efficacy and safety of ceftazidime/avibactam or polymyxin B based regimens for carbapenem-resistant Pseudomonas aeruginosa infection: a multicenter real-world and propensity sc... by Wen-Ming Long, Wen-Ming Long, Wei-Xin Xu, Qin Hu, Qiang Qu, Xiao-Li Wu, Ying Chen, Qing Wan, Tian-Tian Xu, Yue Luo, Jian Qu, Jian Qu

“…To address this knowledge gap, a multicenter real-world study was conducted.MethodsCRPA-infected patients treated with PMB or CAZ/AVI-based regimens were enrolled from five hospitals between January 1, 2021, to July 31, 2023. …”
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Recognition and management of community-acquired acute kidney injury in low-resource settings in the ISN 0by25 trial: A multi-country feasibility study. by Etienne Macedo, Ulla Hemmila, Sanjib Kumar Sharma, Rolando Claure-Del Granado, Henry Mzinganjira, Emmanuel A Burdmann, Jorge Cerdá, John Feehally, Fredric Finkelstein, Guillermo García-García, Vivekanand Jha, Norbert H Lameire, Euyhyun Lee, Nathan W Levin, Andrew Lewington, Raúl Lombardi, Michael V Rocco, Eliah Aronoff-Spencer, Marcello Tonelli, Karen Yeates, Giuseppe Remuzzi, Ravindra L Mehta, ISN 0by25 Trial Study Group

“…We evaluated the feasibility of the use of point-of-care (POC) serum creatinine and urine dipstick testing with an education and training program to optimize the identification and management of AKI in the community in 3 low-resource countries.…”
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Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparibResearch in context by Xiaonan Zhang, Natallia Rameika, Lei Zhong, Verónica Rendo, Margus Veanes, Snehangshu Kundu, Sandro Nuciforo, Jordan Dupuis, Muhammad Al Azhar, Ioanna Tsiara, Pauline Seeburger, Shahed Al Nassralla, Viktor Ljungström, Richard Svensson, Ivaylo Stoimenov, Per Artursson, Markus H. Heim, Daniel Globisch, Tobias Sjöblom

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Clinical and economic impact of the availability of innovative therapies for advanced lung cancer in men in Latin America: a population-based secondary data studyResearch in contex... by Andrés F. Cardona, Natalia Sánchez, Liliana Gutiérrez-Babativa, Leonardo Rojas, Jairo Zuluaga, Stella Martínez, Lucia Viola, Carlos Carvajal, Juliana Bogoya, Laura Prieto-Pinto, Daniel Samacá-Samacá, Antonio Robles, Joshua Kock, Claudio Martín, Luis Corrales, Luis E. Raez, Vladmir Cordeiro de Lima, Suraj Samtani, Oscar Arrieta

“…Based on the difference between the number of FDA-approved therapies and the number approved by each local agency, we calculated the avoidable deaths (ADs) if innovation had been available. …”
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The clinical characteristics of Hirayama disease in females by Hongwei Wang, Wei Lei, Ye Tian, Jianwei Wu, Xiaosheng Ma, Feizhou Lyu, Xinlei Xia, Jingjuan Liang, Jianyuan Jiang, Hongli Wang

“…Discussion: Although females presented with Hirayama disease two years earlier than males, no other clinical differences were observed. Hirayama disease is likely associated with growth and development in puberty, and early identification, regardless of whether patients are male or female, is critical to optimizing prognosis. …”
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Circulating miR-28-5p is overexpressed in patients with sarcopenia despite long-term remission of Cushing’s syndrome: a pilot study by Marta Seco-Cervera, Marta Seco-Cervera, Marta Seco-Cervera, José Santiago Ibáñez-Cabellos, Federico V. Pallardo, Federico V. Pallardo, Federico V. Pallardo, José-Luis García-Giménez, José-Luis García-Giménez, José-Luis García-Giménez, Anna Aulinas, Anna Aulinas, Anna Aulinas, Luciana Martel-Duguech, Susan M. Webb, Susan M. Webb, Susan M. Webb, Elena Valassi, Elena Valassi, Elena Valassi

“…In a validation study of the 3 upregulated miRNAs in 36 patients and 26 controls, no differences were observed by RT-qPCR; however, the expression of circulating miR-28-5p was upregulated in CS patients with sarcopenia as compared with those without (AUC for fold-change in the ROC analysis, 0.798; p=0.0156). …”
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Residential greenness, genetic susceptibility, and asthma risk: Mediating roles of air pollution in UK and Chinese populations by Mingkai Huang, Junjie Wen, Chenyang Lu, Xuliang Cai, Changxing Ou, Zhenan Deng, Xinyi Huang, Enli Zhang, Kian Fan Chung, Jie Yan, Nanshan Zhong, Qingling Zhang

“…Our findings advocate for integrating green space optimization into urban planning as a precision public health strategy.…”
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Safety assessment of symptomatic intracranial atherosclerotic stenosis: a comparison between sole balloon angioplasty and medical treatment by Wen-feng Cao, Wen-feng Cao, An Wen, An Wen, Xian-min Cao, Ling-feng Wu, Ling-feng Wu, Yong-liang Zhou, Yong-liang Zhou, Zheng-bing Xiang, Zheng-bing Xiang, Wei Rao, Wei Rao, Quan-hong Chu, Quan-hong Chu, Wang-Wang Hong, Wang-Wang Hong, Shi-min Liu, Shi-min Liu

“…No deaths occurred in either group. The difference in the event rates was not statistically significant (p > 0.05). …”
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Antibiotic stewardship in hematological patients with Escherichia coli and Klebsiella pneumoniae bloodstream infections: evaluating short-course and carbapenem-sparing strategies by Yuqing Cui, Xiaomeng Feng, Ling Pan, Qingsong Lin, Jieru Wang, Sisi Zhen, Yuping Fan, Xin Chen, Yizhou Zheng, Yingchang Mi, Fengkui Zhang, Xiaofan Zhu, Zhijian Xiao, Erlie Jiang, Mingzhe Han, Jianxiang Wang, Sizhou Feng

“…These findings highlight the potential for optimizing antibiotic use, but further validation through randomized controlled trials is warranted.…”
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Robust computation of subcortical functional connectivity guided by quantitative susceptibility mapping: An application in Parkinson’s disease diagnosis by Jianmei Qin, Haoting Wu, Chenqing Wu, Tao Guo, Cheng Zhou, Xiaojie Duanmu, Sijia Tan, Jiaqi Wen, Qianshi Zheng, Weijin Yuan, Zihao Zhu, Jingwen Chen, Jingjing Wu, Chenyu He, Yiran Ma, Chunlei Liu, Xiaojun Xu, Xiaojun Guan, Minming Zhang

“…However, subcortical structures are characterized by subtle contrast differences, making their accurate delineation challenging on T1WI. …”
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Regional patterns of genetic variants in expanded carrier screening: a next-generation sequencing pilot study in Fujian Province, China by Danhua Guo, Danhua Guo, Nani Zhou, Qianqian He, Qianqian He, Na Lin, Na Lin, Shuqiong He, Shuqiong He, Deqin He, Deqin He, Yifang Dai, Yifang Dai, Ying Li, Ying Li, Xuemei Chen, Xuemei Chen, Hailong Huang, Hailong Huang, Jia Jia, Hua Cao, Liangpu Xu, Liangpu Xu

“…However, before integrating ECS into regional public health initiatives, the development of a region-specific, curated disease panel is necessary to optimize screening efficacy and clinical utility.…”
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