Thalassemia and assisted reproduction: non-transfusion-dependent thalassemia shows no significant effect on live birth rates after embryo transfer by Li Fan, Li Fan, Liuyan Wei, Liuyan Wei, Ni Tang, Ni Tang, Zhetao Li, Zhetao Li, Wugao Li, Wugao Li, Liuying Nong, Liuying Nong, Jingjing Li, Jingjing Li, Jingjing Li, Jingjing Li, Wenjie Huang, Wenjie Huang

“…However, NTDT patients exhibited higher oocyte maturation rates and a greater number of fertilized oocytes. Despite these differences in embryo development metrics, there were no statistically significant differences in clinical pregnancy rates and live birth rates between NTDT and TC patients in both fresh embryo transfer (IVF-ET) and FET cycles (p > 0.05). …”
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Elevated mepolizumab levels in patients with severe asthma responsive to 1 year’s mepolizumab treatment by Takayasu Nishimaki, MD, Hitoshi Sasano, MD, PhD, Sonoko Harada, PhD, Tomohito Takeshige, MD, PhD, Yuuki Sandhu, MD, PhD, Yuki Tanabe, MD, Kei Matsuno, MD, PhD, Tetsutaro Nagaoka, MD, PhD, Jun Ito, MD, PhD, Ryo Atsuta, MD, PhD, Mayu Ohuchi, PhD, Shigehiro Yagishita, MD, PhD, Akinobu Hamada, PhD, Kazuhisa Takahashi, MD, PhD, Norihiro Harada, MD, PhD

“…Further research is needed to validate these findings and optimize treatment strategies for patients with severe asthma.…”
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Leveraging automated time-lapse microscopy coupled with deep learning to automate colony forming assay by Anusha Klett, Anusha Klett, Dennis Raith, Dennis Raith, Paula Silvestrini, Paula Silvestrini, Paula Silvestrini, Matías Stingl, Jonas Bermeitinger, Avani Sapre, Avani Sapre, Avani Sapre, Martin Condor, Roman Melachrinos, Mira Kusterer, Alexandra Brand, Guido Pisani, Guido Pisani, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Marie Follo, Marie Follo, Jesús Duque-Afonso, Roland Mertelsmann, Roland Mertelsmann

“…The detection model accurately identified the majority of objects in the dataset.ResultsThis AI-assisted CFA was successfully applied for density optimization, enabling the determination of seeding densities that maximize plating efficiency (PE), and for IC50 determination, offering an efficient, less labor-intensive method for testing drug concentrations. …”
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Acceptability of the live biotherapeutic LACTIN-V (Lactobacillus crispatus CTV-05) among young women at high risk of HIV acquisition in South Africa: data from the phase 2 placebo-... by A. Hemmerling, V. Govender, K. Dong, K. Dong, K. Dong, K. Dong, M. Dong, M. Dong, Sooseela Pillay, T. Ndung’u, T. Ndung’u, T. Ndung’u, T. Ndung’u, A. Bhoola, J. Moodley, G. Casillas, L. Lagenaur, C. M. Mitchell, C. M. Mitchell, D. S. Kwon, D. S. Kwon, D. S. Kwon, C. R. Cohen

“…IntroductionLive biotherapeutic products (LBPs) containing Lactobacillus crispatus may optimize the vaginal microbiota, reduce genital inflammation, and protect against HIV acquisition. …”
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Single Anastomosis Duodenoileostomy with Sleeve Gastrectomy Versus Sleeve Gastrectomy Alone: A Systematic Review and Meta-Analysis on Behalf of TROGSS—The Robotic Global Surgical S... by Yeisson Rivero-Moreno, Alba Zevallos, Samantha Redden-Chirinos, Víctor Bolivar-Marín, Dayanna Silva-Martinez, Aman Goyal, Arturo Estrada, Rebeca Domínguez-Profeta, Diego Camacho, Sjaak Pouwels, Wah Yang, Luigi Marano, Adel Abou-Mrad, Rodolfo J. Oviedo

“…Given the higher risk of postoperative complications associated with SADI-S, careful evaluation and personalized decision-making for patient selection and education are essential to optimize clinical and safety outcomes.…”
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CPAP modulation of sleep microstructure (N2-SSD and REM-AHI) as predictors of neurological recovery in ischemic stroke patients with moderate-to-severe OSA by Tianyu Jing, Tianyu Jing, Tianyu Jing, Liwen Xu, Liwen Xu, Shutong Sun, Wenyi Yu, Wenyi Yu, Yixi Zheng, Yixi Zheng, Gang Xu, Xinhao Shen, Tieyu Tang, Cheng Chu, Cheng Chu

“…The findings are expected to optimize treatment strategies and improve overall patient outcomes.MethodsA total of 141 patients with IS combined with moderate-to-severe OSA admitted to the Affiliated Hospital of Yangzhou University from October 2022 to August 2024 were enrolled. …”
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Effects of vagus nerve stimulation on daily function and quality of life in markedly treatment-resistant major depression: Findings from a one-year, randomized, sham-controlled tri... by A. John Rush, Charles R. Conway, Scott T. Aaronson, Mark S. George, Patricio Riva-Posse, David L. Dunner, John Zajecka, Mark T. Bunker, João Quevedo, Rebecca M. Allen, Gustavo Alva, Heather Luing, Ziad Nahas, Lucian Manu, Jeffrey I. Bennett, Brian J. Mickey, Jonathan Becker, Yvette Sheline, Cristina Cusin, James W. Murrough, Kevin Reeves, Peter B. Rosenquist, Ying-Chieh (Lisa) Lee, Shannon Majewski, Jeffrey Way, Bryan Olin, Harold A. Sackeim

“…Background: Depression treatments aim to minimize symptom burden and optimize quality of life (QoL) and psychosocial function. …”
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Comparative outcomes of revision total knee arthroplasty: a systematic review and meta-Analysis of high tibial osteotomy vs. unicompartmental knee arthroplasty by Peijie Li, Yongjie Qiao, Yingjia Zhou, Jiahuan Li, Zhiqiang Lin, Yafei Cao, Fei Tan, Jiankang Zeng, Xiaoyang Song, Peng Liu, Shuo Ye, Kaipeng Zhuang, Qiuming Gao, Shenghu Zhou

“…Although the HTO-TKA group showed statistically higher knee function scores, the mean difference (MD = 3.35) did not reach the established MCID threshold for KSS (6–10 points), indicating that the clinical significance of this difference remains uncertain. …”
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Performance of popular large language models in glaucoma patient education: A randomized controlled study by Yuyu Cao, Wei Lu, Runhan Shi, Fuying Liu, Steven Liu, Xinwei Xu, Jin Yang, Guangyu Rong, Changchang Xin, Xujiao Zhou, Xinghuai Sun, Jiaxu Hong

“…The Chinese Readability Platform was employed to assess the recommended reading age and reading difficulty score of the four LLMs. Subsequently, optimized models were filtered, and 29 glaucoma patients participated in posing questions to the chatbots and scoring the answers within a real-world clinical setting. …”
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The triglyceride-glucose index and risk of cognitive impairment: a systematic review and meta-analysis with inclusion of two national databases by Ying Yang, Ying Yang, Pai Peng, Pai Peng, Huadong Huang, Huadong Huang, Yanan Zhao, Yanan Zhao, Yating Li, Yating Li, Xiao Xu, Shixie Jiang, Yanrong Yang, Gaofeng Pan, Yanting Wen, Dan Wu, Shanping Chen, Lei Feng, Tangming Peng, Jiang Wang, Jiang Wang, Zheng Li

“…Furthermore, the risk of developing distinct types of CI differed significantly [CI: OR = 1.64, 95% CI: 1.29; 2.07, p < 0.001; Vascular Cognitive Impairment (VCI): OR = 5.39, 95% CI: 3.33; 8.70, p < 0.001].ConclusionA positive correlation exists between the TyG index and risk of CI, which has potential value in optimizing CI risk stratification among elderly people, especially those hospitalized.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023450336.…”
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Standard Dose Versus Reduced Dose Single Fraction Preoperative Radiosurgery for Resected Brain Metastases (PROPS-BM) International Multicenter Cohort Study by Roshan S. Prabhu, MD, MS, Rachel Russek, MPH, Zachary K. Vaslow, MD, Jennifer K. Matsui, PhD, Neda Haghighi, MD, Tu Dan, MD, Mark V. Mishra, MD, Erin S. Murphy, MD, Susan Boyles, RTT, Haley K. Perlow, MD, Joshua D. Palmer, MD, Cristian Udovicich, MD, Toral R. Patel, MD, Zabi Wardak, MD, Graeme F. Woodworth, MD, Alexander Ksendzovsky, MD, PhD, Kailin Yang, MD, PhD, Samuel T. Chao, MD, Anthony L. Asher, MD, Stuart H. Burri, MD

“…Additional studies are warranted to optimize preoperative SRS dose and fractionation.…”
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Enhancing the nutritional profile of purple sweet potato flour through fermentation with Lactiplantibacillus plantarum InaCC B157: A functional food perspective by Tiurma Pasaribu, Yati Sudaryati Soeka, Novik Nurhidayat, Suciatmih Suciatmih, Titin Yulinery, Evi Triana, Tri Ratna Sulistiyani, Ninik Setyowati, Desty Dwi Sulistyowati, Dwi Ningsih Susilowati

“…Future studies should investigate sensory profiling, shelf-life extension, and optimization of fermentation parameters to further enhance the application of this functional ingredient.…”
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Influence of agroclimatic factors on the efficiency of multi-ovulation in cattle in the Peruvian tropics by Gleni Tatiana Segura Portocarrero, Gleni Tatiana Segura Portocarrero, Gleni Tatiana Segura Portocarrero, Nilton Luis Murga Valderrama, Rainer Marco Lopez Lapa, José Américo Saucedo Uriarte, Deiner Jhonel Gongora Bardales, Hugo Frias Torres, Annie Yoselin Poclín Rojas, Benjamin Depaz Hizo, Ronald Will Vasquez Tarrillo, Lizeth Amparo Heredia Vilchez, Gustavo Ampuero Trigoso

“…IntroductionAgroclimatic conditions are key determinants in the development of animal production and reproduction, with specific breed differences in vulnerability to environmental stress. …”
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Evaluation of Patient Benefits from the Superficial Circumflex Iliac Artery Perforator Flap in Elderly Patients by Hongmin Luo, Huining Bian, Zuan Liu, Chuanwei Sun, Hanhua Li, Lianghua Ma, Xiaoyan Wang, Zhifeng Huang, Xu Mu, Shenghua Chen, Yuyang Han, Lin Zhang, Shaoyi Zheng, Zeyang Yao, Wen Lai

“…However, no significant differences were found between the groups in terms of flap area, recipient sites, or arterial sources. …”
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Clinical performance evaluation of the SiJoy GS1 continuous glucose monitor during oral glucose tolerance testing in healthy adults by Wanyi Zhao, Wanyi Zhao, Wanyi Zhao, Wanyi Zhao, Wanyi Zhao, Dongmei Zheng, Dongmei Zheng, Dongmei Zheng, Dongmei Zheng, Dongmei Zheng, Xianbao Shi, Feng Xu, Feng Xu, Lin Chen, Lin Chen, Xingmei Liu, Xingmei Liu, Xingmei Liu, Xingmei Liu, Xiaolong Jin, Xiaolong Jin, Qingbo Guan, Qingbo Guan, Qingbo Guan, Qingbo Guan, Qingbo Guan, Chao Xu, Chao Xu, Chao Xu, Chao Xu, Chao Xu

“…This investigation would elucidate the implications of physiological delay time and optimize technical delays in populations.Research design and methodsA total of 129 participants wore SiJoy GS1 sensors on their posterior upper arms for at least 48 hours before undergoing an OGTT.ResultsTo minimize the Mean Absolute Relative Difference (MARD), two approaches were tested: MARD minimization and minimum deviation match. …”
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Long COVID-19 alters muscle architecture and muscle-tendon force transmission: a one-year longitudinal study by Leandro Gomes de Jesus Ferreira, Leandro Gomes de Jesus Ferreira, Isabella da Silva Almeida, Isabella da Silva Almeida, Rochelle Rocha Costa, Gabrielle Vieira Roriz, Gabrielle Vieira Roriz, Jeam Marcel Geremia, João Luiz Quagliotti Durigan, João Luiz Quagliotti Durigan, Rita de Cássia Marqueti, Rita de Cássia Marqueti

“…TAC stiffness did not differ between groups (p = 0.517), but torque production demonstrated an effect on this variable (p = 0.001). …”
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Real-world impact of COVID-19 vaccination, household exposure, and circulating SARS-CoV-2 variants on infection risk and symptom presentation in a U.S./Mexico border community by Ariel Cohen, Breanna Reyes, Maria Linda Burola, Angel Lomeli, Arleth A. Escoto, Linda Salgin, Borsika A. Rabin, Borsika A. Rabin, Nicole A. Stadnick, Nicole A. Stadnick, Nicole A. Stadnick, Ilya Zaslavsky, Robert Tukey, Louise C. Laurent, Marva Seifert

“…In this increased infection risk environment, we explored the impact of COVID-19 vaccine status, household exposure, and primary circulating SARS-CoV-2 variant on the probability of infection and symptom presentation while controlling for temporal and sociodemographic factors.MethodsData were collected as part of CO-CREATE (Community-Driven Optimization of COVID-19 Testing to Reach and Engage underserved Areas for Testing Equity), a collaborative implementation study between University of California San Diego, a local Federally Qualified Health Center, and the Global Action Research Center. …”
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Regional variations and trends in liver transplantation practices across Europe by Tommaso Di Maira, Valérie Cailliez, Beatriz Domínguez-Gil, Beatriz Mahíllo, Marina Álvarez, Luca Saverio Belli, René Adam, Constantino Fondevila, Giacomo Germani, Hermien Hartog, Marina Berenguer

“…Results: Etiology of LT differed across regions: HBV cirrhosis predominated in EEC (37.3%), whereas alcohol-related liver disease was more frequent in NEC (41.8%) and MEC (49.1%). …”
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Assessment of antibiotic utilization patterns in an Indian Level-1 Trauma Center: a pilot study exploring days of antibiotic spectrum coverage and defined daily doses using WHO AWa... by M Nizam Ahmed, Arpan Kumar Thakur, Smriti Srivastava, Aparna Ningombam, Madhavi Kirti, Sushma Sagar, Keshav Goyal, Subodh Kumar, Ashish Bindra, Gyaninder Pal Singh, Navdeep Sokhal, Richa Aggarwal, Vijay Sharma, Samarth Mittal, Kamran Farooque, Purva Mathur

“…BackgroundRising antimicrobial resistance (AMR) necessitates innovative metrics, such as days of antibiotic spectrum coverage (DASC), to optimize antibiotic stewardship. This study evaluated antibiotic use in an Indian trauma center using DASC, defined daily doses (DDD), and the World Health Organization (WHO) Access, Watch, Reserve (AWaRe) classification.MethodsThis retrospective cohort study analyzed data from 1,812 adult inpatients (mean age: 35 years; 70% male; 80% with polytrauma) admitted to a 250-bed Level-1 Trauma Center at the All India Institute of Medical Sciences (AIIMS), India, from August to October 2022. …”
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Role of Genetic Testing and Complex Endoscopic Examination in Differential Diagnosis of Hereditary Polyposes in Pediatric and Adolescent Patients: 10 Years Clinical Experience by Tatiana S. Belysheva, Tatiana V. Nasedkina, Timur T. Valiev, Elena V. Sharapova, Vera V. Semenova, Valentina M. Kozlova, Svetlana N. Mikhaylova, Irina S. Kletskaya, Alexey V. Butuzov, Yana V. Vishnevskaja, Valeria V. Lozovaya, Olga A. Gusarova, Armen O. Tumanyan, Olga A. Malichova, Svetlana R. Varfolomeeva

“…The case follow-up tactics in hereditary polyposes have significant differences, and differential diagnosis can be complicated due to the phenotype variability and the clinical manifestations similarity. …”
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