From colorless to pink: Structural insights into vitamin B12-induced color change in monoclonal antibodies by Kai-feng He, Hao-dong Cui, Wen-hui Deng, Na Xing, Guo-jian Liu, Abdallah Iddy Chaurembo, Li-dan Fu, Yuan Li, Xin-yue Tong, Han-bin Lin, Chun-he Wang

“…This study elucidates the structural basis of antibody-VB12 interactions, offering critical insights for optimizing mAb quality control.…”
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RAC2 inhibition enhances tumor sensitivity to NK cell-mediated cytotoxicity by Lin Li, Hui Guo, Jie Hu, Lei Cui, Zining Wang, Feifei Xu, Xiaojuan Wang, Huanling Zhang, Chunyuan Xie, Yongxiang Liu, Xiaojun Xia, Zixuan Guo, Heping Li, Tiantian Wang, Ruhui Yao, Huan Jin, Yanxun Lin

“…Identification of molecular mechanisms by which tumor cells evade from NK cell-mediated killing may offer novel therapeutic strategies for potentiating NK-based cancer immunotherapy.Methods An in vitro tumor-NK cell co-culture system was employed to identify the most significantly altered genes in tumor cells following NK cell interaction. …”
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How sustainable are hypocaloric and balanced diets for weight loss? by Ramona De Amicis, Andrea Foppiani, Alessandro Leone, Federica Sileo, Francesca Menichetti, Sara Paola Mambrini, Marta Pellizzari, Massimiliano Tucci, Daniela Martini, Cristian Del Bo, Patrizia Riso, Simona Bertoli, Alberto Battezzati

“…Objective To compare conventional hypocaloric and balanced weight-loss diets with the sustainable EAT-IT diet, investigating their alignment, the influence of BMI and sex on EAT-IT adherence, to optimize the EAT-IT diet for weight management. Methods 4032 patients (72% female, median age 49y, BMI 29 kg/m2) received hypocaloric diets based on Mediterranean principles (51% carbohydrates, 31% lipids, 0.9 g/kg body weight protein, 17 g/1000 kcal fiber), following Italian dietary guidelines. …”
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Multigenetic pharmacogenomics–guided treatment shows greater improvements on motor symptoms compared to usual therapy in Parkinson’s disease: a small real-word prospective cohort s... by Yifan Li, Mao Li, Miao Wang, Jiarui Yao, Fengzhu Li, Siyu Chen, Xi Yin, Zhongbao Gao

“…However, the application of multigenetic pharmacogenomics-guided treatment (MPGT) to optimize therapeutic outcomes in Parkinson’s disease (PD) remains under-explored. …”
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Gantry-based pencil beam scanning proton therapy for uveal melanoma: IMPT versus proton arc therapy by Hang Qi, Lei Hu, Sheng Huang, Yen-Po Lee, Francis Yu, Qing Chen, Yunjie Yang, Minglei Kang, Huifang Zhai, Milo Vermeulen, Andy Shim, Peter Park, Xuanfeng Ding, Jun Zhou, David H. Abramson, Jasmine H. Francis, Charles B. Simone, Christopher A. Barker, Haibo Lin

“…IMPT plans were robustly optimized with perturbations of 3 mm setup and 3.5% range uncertainties using 3–4 fields without apertures. …”
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Independent and combined relationships between nighttime light exposure, air pollution, PM2.5 constituents, greenness and diabetes or high blood sugar: a national prospective cohor... by Siyu Qing, Ziyue Liang, Yifang Liang, Renfang Zhang, Xiaojie Chen, Wenqing Wang, Chunejie Xu, Fei Lin, Yongbin Wang

“…Methods Using data from the China Health and Retirement Longitudinal Study (CHARLS, 2011–2015), we included 11,865 participants aged ≥ 45 years without baseline D/HBS. …”
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Efficacy and safety of traditional Chinese medicine for post-COVID-19 syndrome: a systematic review and meta-analysis by Yiting Wang, Xiao Li, Huaizheng Hui, Dianxing Yang

“…Further large-scale, high-quality trials are needed to validate these outcomes and optimize treatment strategies. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/home , CRD420251016442.…”
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Construction and practice of information platform for blood collection in outpatient clinics in the public health emergencies (突发卫生公共事件下门诊采血中心信息化平台的构建及应用)... by ZHAO Lu (赵路), LI Qianqian (李倩倩), CUI Hailing (崔海伶)

“…Results there was no significant difference in the total number of blood collection cases and the maximum number of blood collection cases in the blood collection clinics between the study group( Hospital A and the control group (Hospital B) (P>0. 05). …”
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Improving pain, function and quality of life in end-stage knee osteoarthritis: a patient-preference cohort study on whole-body vibration and exercise as bridging therapies for tota... by Kendrew Yu-Hei Choi, Wai-Wang Chau, Linda Man-Kuen Li, Sammie Yuk-Lam Ng, Boie Po-Yee Lo, Michael Tim-Yun Ong, Patrick Shu-Hang Yung

“…Minimal Clinically Important Difference (MCID) and Minimal Detectable Change (MDC) were calculated to assess the clinical significance of the results. …”
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Chronic Khat Chewing Induced High-Grade Hemorrhoidal Disease and Post-Operative Bleeding in Yemen by Al-Kubati WR

“…Post-operative complications, including bleeding and severe pain, were significantly higher in male khat chewers (p < 0.05), while no significant differences were observed in females.Conclusion: Chronic khat chewing is strongly associated with high-grade hemorrhoidal disease and increased post-operative complications. …”
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Reflections and implementation strategies for constructing a standard system for deep coalbed methane exploration and exploitation by Xinjun CHEN, Zengqin LIU, Baojian SHEN, Shihu ZHAO, Jiaqi ZHANG, Jincheng YE

“…This leads to insufficient technical adaptability and pronounced risks of safety and environmental protection in the exploration and exploitation of deep CBM. MethodsThrough a systematic analysis of differences in geological and engineering characteristics between shallow and deep CBM, this study proposed a standard system framework following three dimensions (i.e., geological complexity, technical adaptability, and industrial and ecological collaboration) and four principles (scientific, systematic, practical, and dynamic natures). …”
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Muscular and Renal Safety of Ticagrelor with High-Intensity Statins: Retrospective Cohort Findings by Alshammari AS, Shalwala AA, Alnuhait MA, Alhazmi AY, Fagieha RE, Hallabi NB, Alandijani EA, Aloufi MA, Alharbi MS, Alzahrani RS, Elkholy EM, Elrggal ME, Alotaibi AS

“…This study aimed to evaluate these risks in a real-world clinical setting in Saudi Arabia.Methods: This retrospective observational cohort study was conducted at the Makkah Cardiology Center, Saudi Arabia. …”
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Smartphone-Based Telemonitoring for Better Oral Health With Toothbrushes: 6-Month Randomized Controlled Trial by Jaeyeon Kim, Yiseul Choi, Yoolbin Song, Wonse Park

“…However, further studies are needed to optimize feedback intervals and improve long-term adherence. …”
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O IMPACTO DAS EXPERIÊNCIAS ESTIGMATIZADORAS E AUTOESTIGMA NA SAÚDE MENTAL E NO COMPORTAMENTO SUICIDA: UM ESTUDO EM PAÍSES DE LÍNGUA PORTUGUESA by Henrique Marques Pereira, Mariana Quelhas Marques Coelho

“…Conclusions: Self-stigmatization has a negative impact on mental health and suicidal behavior, and countries should initiate mental health promotion campaigns and suicide prevention campaigns whose central goal should be to optimize people's quality of life…”
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Effectiveness of Topic-Based Chatbots on Mental Health Self-Care and Mental Well-Being: Randomized Controlled Trial by Alan C Y Tong, Kent T Y Wong, Wing W T Chung, Winnie W S Mak

“…However, these improvements did not differ significantly at 1 month when compared to the waitlist control group. …”
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Phosphate Peritoneal Equilibration Test, Hypothesizing New Parameters to Classify Peritoneal Phosphate Handling Through the Peritoneal Membrane by Francesca K. Martino, Chiara Ciotti, Anna Basso, Ruggero Zanella, Lucia F. Stefanelli, Dorella Del Prete, Federico Nalesso

“…Methods: We hypothesized a simple two-compartment model to describe phosphate removal driven by diffusion. …”
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Examining the Effects of the Protection Motivation Theory–Based Online Intervention on Improving the Cognitive Behavioral Outcomes of Caregivers of Children With Atopic Diseases: Q... by Dequan Shen, Qinzhun Zhang, Jiayu Tang, Jiahui Wu, Hui Huang, Yuchang Xu, Yinan He, Jialu He, Chengyin Ye

“…In the intervention group, caregivers exhibited stronger intentions and partial behavioral optimization (eg, environmental allergen control, with Z=–3.025; P=.002) and children showed improved medication adherence (Z=–4.457; P<.001) and alleviated eczema (Z=–3.112; P=.002) and allergic rhinitis symptoms (Z=–3.277; P<.001), although no significant differences emerged in asthma control (Z=–.830; P=.41) or food allergy–related caregiver burden (Z=–1.693; P=.09). …”
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Application of Six Sigma in the management of caregivers of inpatients in Department of Neurology during the COVID-19 outbreak (六西格玛管理法在新型冠状病毒肺炎疫情防控期间神经内科住院患者陪护人员管理中的应用)... by PAN Xi (潘习), XU Lan (徐岚), WANG Zhi (王稚)

“…The potential factors influencing the management quality were analyzed, and targeted improvement strategies were carried out from the aspect of cross-sector cooperation, process optimization, establishment of special position, tool utilization, standard training. …”
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Multi-omics analysis identifies a liquid-liquid phase separation-related subtypes in head and neck squamous cell carcinoma by Peng-Lei Zhai, Peng-Lei Zhai, Meng-Min Chen, Meng-Min Chen, Meng-Min Chen, Qi Wang, Jing-Jun Zhao, Xiao-Mei Tang, Cui-Ni Lu, Jia Liu, Qin-Xin Yang, Ming-Liang Xiang, Qing-Hai Tang, Biao Gu, Shu-Ping Zhang, Si-Ping Tang, Da Fu, Da Fu

“…Subsequently, we explored the differences among the three LLPS subtypes using multi-omics analysis. …”
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Exploring the Impact of the Multimodal CAPABLE eHealth Intervention on Health-Related Quality of Life in Patients With Melanoma Undergoing Immune-Checkpoint Inhibition: Prospective... by Itske Fraterman, Lucia Sacchi, Henk Mallo, Valentina Tibollo, Savannah Lucia Catherina Glaser, Stephanie Medlock, Ronald Cornet, Matteo Gabetta, Vitali Hisko, Vadzim Khadakou, Ella Barkan, Laura Del Campo, David Glasspool, Alexandra Kogan, Giordano Lanzola, Roy Leizer, Manuel Ottaviano, Mor Peleg, Konrad Śniatała, Aneta Lisowska, Szymon Wilk, Enea Parimbelli, Silvana Quaglini, Mimma Rizzo, Laura Deborah Locati, Annelies Boekhout, Lonneke V van de Poll-Franse, Sofie Wilgenhof

“…When aiming at personalized patient and survivorship care, further optimization and prospective investigation of eHealth tools is warranted.…”
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