Significantly Increased Aqueous Solubility of Piperine via Nanoparticle Formulation Serves as the Most Critical Factor for Its Brain Uptake Enhancement by Li J, Leung SSY, Chan EHY, Jiang C, Ho ETY, Zuo Z

“…In the current study, formulation strategies and routes of administration were assessed to enhance systemic and brain uptake of piperine.Methods: Formulation of piperine nanoparticles (PIP NPs) was developed to enhance its solubility. …”
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How repeatable is PAPE effect: the impact of in-season isometric squat activation on countermovement jump performance enhancement in national level soccer players by Jakub Jarosz, Dawid Gawel, Pawel Grycmann, Piotr Aschenbrenner, Michal Spieszny, Michal Wilk, Michal Krzysztofik

“…However, pairwise McNemar tests did not reveal significant differences (p = 0.549–1.000), suggesting that while response distribution fluctuated, no specific session-to-session differences were detected. …”
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Prognostic Value of the Goutallier Scale for Paravertebral Muscle Atrophy in Predicting Disability and Pain Outcomes in Degenerative Lumbar Spinal Stenosis: A Longitudinal Cohort S... by Giuseppe Corazzelli, Sergio Corvino, Chiara Di Domenico, Federico Russo, Vincenzo Meglio, Settimio Leonetti, Valentina Pizzuti, Marco Santilli, Alessandro D’Elia, Francesco Ricciardi, Sergio Paolini, Raffaele de Falco, Oreste de Divitiis, Vincenzo Esposito, Gualtiero Innocenzi

“…No significant differences in comorbidities or complication rates were identified across GS subgroups. …”
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Fournier gangrene is associated with increased length of stay and higher healthcare costs compared to non-perineal necrotizing soft tissue infections: a retrospective analysis of t... by Hayato Mitaka, Kristen McQuerry, Kelsey Karnik, Alexandre R. Marra, Toshio Naito, Patrick Ten Eyck, Paul G. Auwaerter, Yuji Yamada, Takaaki Kobayashi

“…After adjustment, no significant difference in mortality was observed (adjusted odds ratio [aOR]: 1.04; 95% CI: 0.90–1.20). …”
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Combined Positive Score and Cisplatin Sensitivity Are Prognostic Factors for Response to Nivolumab Therapy for Recurrent Metastatic Squamous Cell Carcinoma of the Head and Neck by Hiroaki Iijima, Akihiro Sakai, Koji Ebisumoto, Go Ogura, Mayu Yamauchi, Takanobu Teramura, Aritomo Yamazaki, Takane Watanabe, Toshihide Inagi, Ryoko Yanagiya, Ai Yamamoto, Hiroshi Ashida, Yoshiyuki Ota, Yurina Sato, Naoya Kobayashi, Daisuke Maki, Naoya Nakamura, Kenji Okami

“…This finding may help to optimize ICI therapy strategies.…”
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Longitudinal Analysis of Tetanus- and Influenza-Specific IgG Antibodies in Myeloma Patients by Sebastian Kobold, Tim Luetkens, Britta Marlen Bartels, Yanran Cao, York Hildebrandt, Orhan Sezer, Henrike Reinhard, Julia Templin, Katrin Bartels, Nesrine Lajmi, Friedrich Haag, Carsten Bokemeyer, Nicolaus Kröger, Djordje Atanackovic

“…We found that MM is associated with a profound disease- and therapy-related immunosuppression, which is compensated for a few months after alloSCT, most likely by application of IVIG. This and the differences regarding the recovery of anti-FLU and anti-TT antibody titers during the following years need to be taken into account for optimizing IVIG application and immunization after alloSCT.…”
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The influence of physical activity on emotional management ability in college students: a chain mediating role of psychological resilience and health literacy by Qi Liu, Wei-dong Zhu, Hu Lou, Ding-you Zhang, Fan-zheng Mu, Xin-yu Zhang, Yu-han Li, Wen-hao Zhang, Mo-han He, Jia-qi ang Wang, Chen-xi Li, Hao-yu Li, Ning Zhou, Yao Zhang, Wei Wang, Xiao-yu Wang, Bo-chun Lu, Shan-shan Han, Ya-xing Li, Yang-sheng Zhang, Ling-li Xu, Yu-yan Qian, Lei Ding, Chuan-yi Xu, Han Li, Shuo Feng, Bao-wei Zhou, Jian-gang Sun, Lan-lan Yang, Yong Wei, Bo Li

“…Abstract Objective This study aimed to investigate the impact of physical activity (PA) on emotional management ability (EMA) in college students and to analyze the chain mediating roles of psychological resilience (PR) and health literacy (HL) in the relationship between PA and EMA. Methods Demographic information was collected using a stratified, cluster, and multi-stage sampling method. …”
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Chest trauma clinical practice guideline protects against delirium in patients with rib fractures by Valérie Courval, Raymond Tang, Peter Rose, Naisan Garraway, Robin Som, Jenna Kroeker, Anas Wess, Yuwei Yang, Bader Al-Zeer, Harjot Uppal, Patricia Balmes, Nasira Lakha, Angie Brisson, Jennifer Sakai, Emilie Joos

“…Vancouver General Hospital, a level 1 trauma center in British Columbia, Canada, developed a comprehensive multidisciplinary chest trauma clinical practice guideline (CTCPG) to optimize the management of patients with rib fractures. …”
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Hepatocellular carcinoma in Korea: an analysis of the 2016-2018 Korean Nationwide Cancer Registry by Jihyun An, Young Chang, Gwang Hyeon Choi, Won Sohn, Jeong Eun Song, Hyunjae Shin, Jae Hyun Yoon, Jun Sik Yoon, Hye Young Jang, Eun Ju Cho, Ji Won Han, Suk Kyun Hong, Ju-Yeon Cho, Kyu-Won Jung, Eun Hye Park, Eunyang Kim, Bo Hyun Kim

“…However, since approximately half of the patients remained diagnosed at an advanced stage, more rigorous and optimized HCC screening strategies should be implemented.…”
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Genetic and transcriptomic analyses of early-onset colon cancer (EOCC): a post hoc analysis of 2973 patients from two adjuvant randomized trials by A. Gandini, C. Gallois, H. Blons, C. Mulot, N. Agueeff, C. Lepage, R. Guimbaud, L. Mineur, J. Desramé, B. Chibaudel, A. de Reyniès, T. André, P. Laurent-Puig, J. Taieb

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The state of combined thoracoabdominal triple-organ transplantation in the United States by Emily G. Dunbar, BS, Ye In Christopher Kwon, BA, Matthew Ambrosio, MS, Inna F. Tchoukina, MD, Keyur B. Shah, MD, David A. Bruno, MD, Walker A. Julliard, MD, Josue Chery, MD, Vigneshwar Kasirajan, MD, Zubair A. Hashmi, MD

“…There were no statistically significant differences in long-term survival between TOTs (p = 0.13). …”
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From virtual to reality: application of a novel 3D printing hollow model for early-stage lung cancer in the clinical teaching of thoracoscopic sublobar resection by Di Yang, Di Yang, Yafei Miao, Yafei Miao, Linqian Li, Linqian Li, Linqian Li, Qing Yu, Qing Yu, Qiang Guo, Hefei Li, Xuguang Zhang, Shujie Cheng, Shujie Cheng, Jinghua Li, Jinghua Li, Ke Zhang, Ke Zhang, Ke Zhang, Ke Zhang

“…This study evaluates the educational efficacy of a 3DP lung cancer model optimized for surgery in teaching thoracoscopic sublobar resection.MethodsA total of 62 clinical interns were randomly assigned into two groups: a 3D visualization (3DV) model group and a 3DP model group. …”
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The Effectiveness of Teaching Spiritual Concepts Based on Mention and Prayer on Moral Intelligence and Quality of Attachment in Students by سارا آقابابایی, Fateme Hekmatzade

“…The sampling was done by available method that 30 people were randomly assigned to two groups of 15 people tested and controlled. …”
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Aging, HIV infection, and alcohol exert synergist effects on regional thalamic volumes resulting in functional impairment by Adolf Pfefferbaum, Natalie M. Zahr, Stephanie A. Sassoon, Rosemary Fama, Manojkumar Saranathan, Kilian M. Pohl, Edith V. Sullivan

“…Although compared with controls HIV + AUD declined faster than HIV alone, the two HIV groups did not differ significantly from each other in aging rates. …”
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Re-sperm collection with a short abstinence time: a strategy for successful cryopreservation in cryptozoospermia by Wen-Rui Zhao, Bo Liu, Xue-Feng Luo, Jin-Yan Xu, Chen Luo, Yuan Liu, Yang Xian, Fu-Ping Li

“…However, no significant difference was observed in post-thaw sperm survival rates between the first and second samples (45.59% ± 21.16% vs. 40.83% ± 19.82%, p = 0.626). …”
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Neuropsychological outcome of indoor rehabilitation in post-COVID-19 condition—results of the PoCoRe study by Michael Jöbges, Melanie Tempfli, Melanie Tempfli, Christoph Kohl, Christoph Herrmann, Stefan Kelm, Alexa Kupferschmitt, Alexa Kupferschmitt, Alexa Kupferschmitt, Ida Montanari, Nike Walter, Gerhard Suetfels, Thomas Loew, Volker Köllner, Volker Köllner, Thilo Hinterberger

“…Sustained attention was abnormal in 55% of patients on admission, decreasing to 43% on discharge. These differences were significant with mild effect sizes. …”
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Impact of carbohydrate timing on glucose metabolism and substrate oxidation following high-intensity evening aerobic exercise in athletes: a randomized controlled study by Stig Mattsson, Fredrik Edin, Jonny Trinh, Peter Adolfsson, Johan Jendle, Stefan Pettersson

“…No difference was observed in nocturnal glucose regulation (00:00–06:00) regardless of whether CHO was consumed before or after exercise. …”
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Stress state calculation and potential failure risk identification of LNG storage tank inlet pipeline by Yanbing WANG, Hong ZHANG, Mengying XIA, Hongyu ZHOU, Baisong LI, Qiyu HUANG, Xiaoben LIU

“…Future efforts should focus on optimizing operational processes to reduce this temperature difference, assess safety risks, and ensure stable and reliable pipeline operation.…”
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Effectiveness of an Innovative Mobile-Based Perioperative Care Program for Women Undergoing Breast Cancer Surgery (iCareBreast): Randomized Controlled Trial by Yan Pang, Honggu He, Ruey-Pyng Ng, Nicole Kim Luan Lee, Me Me Win Htein, Xiao-Xin Zhao, Ying-Hong Li, Elizabeth Jiahui Chan, Lixia Zhu, Guang Yu Liu, Minna Pikkarainen, Swee-Ho Lim

“…Baseline scores were similar (P=.80), and while the iCareBreast group showed slightly lower scores at T1 (mean difference [MD] –1.63, 95% CI –3.43 to 0.18; P=.08) and T2 (MD –1.90, 95% CI –4.06 to 0.26; P=.09), the differences were not statistically significant. …”
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Multi-peak light sources can improve the physical and mechanical properties of a zirconia- and diatomite-based dental resin: an in vitro study by Jucivaldo Martins Gonçalves, Thalles Arievo Mota Sales, Cauã Santiago Figueiredo, Rafael Pinto de Mendonça, Jefferson Pires da Silva Júnior, Tânia Mara da Silva, Sérgio Eduardo de Paiva Gonçalves, Hércules Bezerra Dias

“…Material and Methods: A total of 270 specimens were prepared to evaluate the degree of conversion (DC), flexural strength (FS), elastic modulus (ME), water sorption (SOR), and solubility (SOL). …”
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