Reactive Behaviour of Platinum(II) Salts with Ethylenediamine in Sustainable Water/Choline Chloride-Based Deep Eutectic Solvents Mixtures by Nicola Garofalo, Francesco Messa, Alessandra Barbanente, Francesco Paolo Fanizzi, Antonio Salomone, Nicola Margiotta, Paride Papadia

“…This study investigates the simple model reaction between K₂PtCl₄ and ethylenediamine (<i>en</i>), exploring the behaviour in DES environment, to optimize the synthesis of simple cisplatin-like platinum compounds with the potential objective of improving the traditional methods, decreasing the number of steps required for obtaining target compounds and reducing chemical waste. …”
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P-103 AN ELEVATED BASELINE LEVEL OF ALKALINE PHOSPHATASE, ALANINE AMINOTRANSFERASE, AND ASPARTATE AMINOTRANSFERASE PREDICT A LACK OF BIOCHEMICAL RESPONSE TO UDCA THERAPY AMONG HISP... by LUIS ALEJANDRO ROSALES RENTERIA, José David Prieto Nava, Giovanni Francisco Pérez Roa, César Salcido Yáñez, Adrián Sandez Araiza, María Saraí González Huezo

“…Identifying predictors of non-response is crucial for optimizing treatment strategies and improving patient outcomes. …”
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Exploiting the power of stepwise intraoperative irrigant activation to maximize oval canal disinfection: an ex-vivo investigation by Mohammed Turky, Shaimaa Hamdy, Soha Elhady

“…Abstract Objectives To evaluate the antibacterial effectiveness of stepwise intraoperative activation of the root canal irrigant, both alone and when combined with conventional ultrasonic activation, compared to the traditional syringe irrigation method in oval root canals. Methods Sixty single-rooted maxillary second premolars were selected according to specific criteria. …”
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Impact of an emotion management course on emotion regulation， coping strategies， and mental health among first-year university students by NIU Yating, QIAN Ming, ZHOU Jinping, YUAN Qin, XING Xiaoping

“…ObjectiveTo develop an emotion management course and evaluate its effectiveness in improving emotion regulation, coping strategies, and anxiety and depression among first-year university students, so as to provide a basis for colleges to optimize mental health education courses.MethodsUsing a multi-stage cluster random sampling method, five classes of first-year students (n=169) from a university were randomly selected as participants, with three classes assigned to the experimental group (n=102) and two classes to the control group (n=67). …”
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US-individualized infusion therapy in geriatric patients after emergency abdominal surgery: effect on the development of acute kidney injury by N. V. Momot, N. V. Tumanska, S. I. Vorotyntsev

“…It is considered that ultrasound examination of the inferior vena cava (IVC) can be an effective additional method of assessing volemia in this category of patients. …”
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Risk Factors of Aseptic Loosening After Total Hip Arthroplasty With Collum Femoris Preserving Stem: A Long‐Term Follow‐Up Study by Yongbo Ma, Yansong Liu, Zeming Liu, Jiangqi Chang, Mengnan Li, Tao Wu

“…Comparative analyses were conducted, and variables with significant differences were subjected to Cox regression to identify independent risk factors of aseptic loosening. …”
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Performance of PCA3 and TMPRSS2:ERG Within the Prostate Cancer Prevention Trial Risk Calculator Version 2 in a Lithuanian Cohort by Kemesiene J, Nicolau C, Cholstauskas G, Zviniene K, Lopeta M, Veneviciute S, Asmenaviciute I, Tamosauskaite K, Pikuniene I, Jievaltas M

“…However, no significant differences were noted in distinguishing csPCa from non-csPCa.Conclusion: Incorporating PCA3 and T:E into PCPTRC2 substantially enhances diagnostic accuracy for detecting PCa in biopsy-naïve patients. …”
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Prognostic value of the combination of serial APACHE II with serum lactate for predicting post-operative mortality in gastrointestinal perforation peritonitis: a prospective cohort... by Ram Prasad Subedi, Navin Kumar, Summi Karn, V. Arunkumar, Nirmal Raj, Parth Maheshwari, Dipendra Singh, Sanketh Edem, Asish Das, Farhanul Huda, Somprakas Basu

“…Methods In this prospective cohort study, 120 adult patients diagnosed with gastrointestinal perforation peritonitis and undergoing emergency laparotomy were enrolled after obtaining ethical approval and informed consent. …”
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Plasma cholinergic markers are associated with post-stroke walking recovery—revisiting the STROKEWALK study by Sumonto Mitra, Taher Darreh-Shori, Erik Lundström, Staffan Eriksson, Staffan Eriksson, Staffan Eriksson, Tommy Cederholm, Maria Eriksdotter, Maria Eriksdotter, Birgit Vahlberg

“…IntroductionOptimizing post-stroke rehabilitation strategies remains imperative for improving patient outcomes. …”
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Prevalence and perinatal risk factors of growth retardation in congenital diaphragmatic hernia survivors by Soo Hyun Kim, Sung Hyeon Park, Ha Na Lee, Jungbok Lee, Jiyoon Jeong, Hyunhee Kwon, Euiseok Jung, Jung-Man Namgung, Byong Sop Lee

“…This study aimed to investigate the prevalence and perinatal risk factors of growth failure in CDH survivors. Methods We retrospectively reviewed the medical records of isolated CDH patients with gestational age ≥ 35 weeks who survived to 3 years of age. …”
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Impact of COVID-19 control measures on influenza positivity among patients with acute respiratory infections, 2018–2023: an interrupted time series analysis by Wei Chen, Huabin Wang, Xianlin Ten, Miao Fu, Meili Lin, Xiaoping Xu, Yongjun Ma

“…Strengthened surveillance and optimized strategies remain necessary to mitigate the threat of influenza in the post-pandemic era.…”
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Psychological and didactic problems of introducing a digital textbook into the educational process of a university by Lyudmila Valerievna Shelekhova, Sultanovna Fatimet Brantova

“…The results of the research are the difference between a digital textbook and an electronic textbook and an electronic form of a textbook has been revealed. …”
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Development of Aeromonas salmonicida Vaccine Carrier Expressing G Protein of Infectious Hematopoietic Necrosis Virus by Yatong GAO, Zhipeng WANG, Ye GAO, Ming ZHU, Jie LI

“…The expression of G protein was optimized by adjusting the induction time, IPTG concentration, and culture temperature. …”
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Exploring research trends in cancer immunotherapy via single-cell technologies: a scientometric perspective by Zhongxun Li, Zhongxun Li, Qi Han, Qi Han, Zimu Huang, Sen Zhang, Huina Guo, Huina Guo, Hongliang Liu, Hongliang Liu, Hongliang Liu, Xiaoya Guan, Xiaoya Guan, Hairong Li, Chunming Zhang, Chunming Zhang, Chunming Zhang

“…IntroductionCancer immunotherapy has brought new therapeutic hopes for cancer patients, but it is complex in its mechanism of action, and there are significant individual differences, which restricts its wide use. As single-cell analysis technology develops rapidly, it provides an innovative research approach to investigate immunotherapy mechanisms, to identify potential biomarkers, and to optimize individualized treatment strategies.MethodsThe Core Collection of Web of Science (WOSCC) was used to retrieve and obtain relevant literature related to “application of single cell sequencing in cancer immunotherapy” since the establishment of the WOSCC. …”
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Amphotericin B tissue penetration and pharmacokinetics in healthy and Candida albicans-infected rats: insights from microdialysis and population modeling by Valdeene Vieira Santos, Valdeene Vieira Santos, Laiz Campos Pereira, Laiz Campos Pereira, Jackeline Marley Santos de Araújo, Jackeline Marley Santos de Araújo, Matheus Antônio da Hora Borges, Matheus Antônio da Hora Borges, Carolina Magalhães Brandão, Luisa Oliveira Santos, Luisa Oliveira Santos, Cristiane Flora Villarreal, Francine Johansson Azeredo

“…The findings of this study, which show that plasma levels are a good predictor for AmB kidney concentrations and can be used to optimize its dosing regimen, underscore the importance of this research.MethodsMicrodialysis probe recovery rates were determined by dialysis and retrodialysis in vitro, as well as by retrodialysis in vivo. …”
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Investigating cardiovascular diseases related to endocrine therapy in hormone receptor-positive early breast cancer: insights from a nationwide real-world study by Cheng Zeng, Hong Li, Wenna Wang, Lixi Li, Binliang Liu, Bo Lan, Qing Li, Wenjing Yang, Jiani Wang, Fei Ma

“…These findings highlight the relevance of enhanced lipid monitoring and cardiovascular risk management to support optimized treatment outcomes in the Chinese population.…”
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Hypothermic machine perfusion in uterus transplantation in a porcine model: A proof of concept and the first results in graft preservation by Carla Héléna Sousa, Marion Mercier, Nathalie Rioux‐Leclercq, Erwan Flecher, Claude Bendavid, David Val‐Laillet, Juliette Ferrant, Sylvie Jaillard, Emma Loiseau, Julien Branchereau, Yanis Berkane, Krystel Nyangoh Timoh, Isis Carton, Maëla Le Lous, Vincent Lavoue, Ludivine Dion

“…Abstract Introduction Graft optimization is a necessity in order to develop uterus transplantation from brain‐dead donors, as a complement to living donors, as these grafts are rare and the last organs retrieved in multiple organ donation. …”
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Antiphospholipid Antibodies and COVID‐19: A Systematic Review of Clinical Implications by Tahereh Sabaghian, Amir Behnam Kharazmi, Fatemeh Omidi, Bahareh Hajikhani, Shabnam Tehrani, Sayna Mardani, Amir Hashem Shahidi Bonjar, Rosella Centis, Lia D'Ambrosio, Giovanni Sotgiu, Fabio Angeli, Mohammad Javad Nasiri, Giovanni Battista Migliori

“…The review reveals some limitations, such as variability in study designs and demographics and inherent differences in methodologies among included studies. …”
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Comparative Analysis of Biochemical Parameters, Thermal Behavior, Rheological Features, and Gelling Characteristics of Thai Ligor Hybrid Chicken and Broiler Meats by Ngassa Julius Mussa, Chantira Wongnen, Warangkana Kitpipit, Worawan Panpipat, Mingyu Yin, Siriporn Riebroy Kim, Manat Chaijan

“…Understanding these variations in biochemical properties and functional behavior can help optimize processing methods and produce meat products of superior quality that meet consumer preferences.…”
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Evaluating pediatric tuberculosis dosing guidelines: A model-based individual data pooled analysis. by Lufina Tsirizani Galileya, Roeland E Wasmann, Chishala Chabala, Helena Rabie, Janice Lee, Irene Njahira Mukui, Anneke Hesseling, Heather Zar, Rob Aarnoutse, Anna Turkova, Diana Gibb, Mark F Cotton, Helen McIlleron, Paolo Denti

“…We pooled data from large pharmacokinetic studies to identify key covariates influencing drug exposure to optimize tuberculosis dosing in children.<h4>Methods and findings</h4>We used nonlinear mixed-effects modeling to characterize the pharmacokinetics of rifampicin, isoniazid, and pyrazinamide, and investigated the association of human immunodeficiency virus (HIV), antiretroviral therapy (ART), drug formulation, age, and body size with their pharmacokinetics. …”
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