Plasma microRNAs to Select Optimal Patients for Antibody Production from Anti-Addiction Vaccines by Thomas R. Kosten, Amrit Koirala, David A. Nielsen, Coreen B. Domingo, Ynhi T. Thomas, Preethi H. Gunaratne, Cristian Coarfa

“…<b>Results</b>: Using a DE-FDR < 0.05 and a >3-fold difference between high- and low-AB responders yielded 12 miRs down and 3 miRs up compared to low-AB patients. …”
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Optimal duration of antimicrobial prophylaxis in patients undergoing distal pancreatectomy: A multicenter cohort study by Kenjiro Okada, Kenichiro Uemura, Sohei Satoi, Tsutomu Fujii, Manabu Kawai, So Yamaki, Toru Watanabe, Hideki Motobayashi, Shinya Takahashi

“…However, there is limited evidence regarding optimal duration of antimicrobial prophylaxis. This study aimed to evaluate the optimal duration of antimicrobial prophylaxis in distal pancreatectomy. …”
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Serum Thyroglobulin: Preoperative Levels and Factors Affecting Postoperative Optimal Timing following Total Thyroidectomy by Anery Patel, Valerie Shostrom, Kelly Treude, William Lydiatt, Russell Smith, Whitney Goldner

“…We evaluated if preoperative TG levels affected postoperative levels and if other factors may influence the optimal time to check postoperative TG. Methods. This is a prospective, observational pilot study. …”
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Development of a Population Pharmacokinetic Model of Levofloxacin in Healthy Adults and Identification of Optimal Dosing Regimens by Yun-Jung Lee, Gaeun Kang, Dae-Young Zang, Dong-Hwan Lee

“…This study aimed to develop a population pharmacokinetic (PK) model of levofloxacin in healthy adults and identify optimal dosing regimens. <b>Methods</b>: In this prospective, open-label study, 12 healthy adults received a single dose of levofloxacin. …”
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Study on the Train Operation Optimization of Passenger Dedicated Lines Based on Satisfaction by Zhipeng Huang, Huimin Niu

“…This paper considers an optimization problem for train operations at the junction station in passenger dedicated lines. …”
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The Optimization of Stand Structure Can Significantly Alleviate the Flammability of Forest Ecosystems by Yan Zhang, Xiangwen Deng, Xiaoyong He, Xiaolong Zhang, Zhihong Huang, Liang Chen, Shuai Ouyang, Wenhua Xiang

“…ABSTRACT The accurate classification of forest fuels and the evaluation of the flammability of different forest types are crucial for effective forest fire control and classification management. …”
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Adverse childhood experiences: terms, concepts, and study methods by Diana S. Shumskaia, Anna V. Trusova, Alexander O. Kibitov

“…However, to date, there is no unique and universally accepted approach to assessment of ACE, which may lead to controversy and low reproducibility of results.The purpose of this review is to examine and compare various methods of assessing and interpreting of ACE in order to identify optimal research algorithms within the current interpretation of the biopsychosocial model in psychiatry.This article reviews current terms, concepts, and methods of studying ACE. …”
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Automatic Optimization of a Parallel-Plate Avalanche Counter with Optical Readout by María Pereira Martínez, Xabier Cid Vidal, Pietro Vischia

“…Exploiting differentiable programming and automatic differentiation, we model the reconstruction of the position of impinging 5.5 MeV alpha particles for different detector configurations and build an optimization cycle that minimizes an objective function. …”
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Optimized DenseNet Architectures for Precise Classification of Edible and Poisonous Mushrooms by Jay Prakash Singh, Debolina Ghosh, Jagannath Singh, Anurag Bhattacharjee, Mahendra Kumar Gourisaria

“…Traditional methods often result in errors which led to misclassifications and conventional machine learning models often struggle in feature extraction due to subtle differences in mushroom species. …”
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Optimizing wind-PV-battery microgrids for sustainable and resilient residential communities by Jyotismita Mishra, Ajay Shankar

“…The method aims to minimize renewable energy costs by determining the optimal sizing of components based on a given microgrid load profile. …”
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PORTFOLIO OPTIMIZATION WITH SEMI-VARIANCE MODEL: AN APPLICATION ON BIST-100 INDEX by Serdar Ramazan Kahraman, Kartal Somuncu

“…Aim: The aim of the study is to compare the performance of portfolios constructed based on variance and semi-variance using data obtained from the BIST-100 Index. Method: In the study, using the return data obtained from the adjusted weighted average price data of securities in the BIST-100, variance and covariance matrices were constracted to generate optimal portfolios, and the returns of two different portfolios were calculated and compared. …”
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Evaluation of Emulsification Techniques to Optimize the Properties of Chalcone Nanoemulsions for Antifungal Applications by Joice Farias do Nascimento, Flavia Oliveira Monteiro da Silva Abreu, Taysse Holanda, Raquel Oliveira dos Santos Fontenelle, Júlio César Sousa Prado, Emmanuel Silva Marinho, Matheus Nunes da Rocha, Jesyka Macêdo Guedes, Bruno Coelho Cavalcanti, Wesley Lyeverton Correia Ribeiro, Márcia Machado Marinho, Helcio Silva dos Santos

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Selection of an Optimal Metabolic Model for Accurately Predicting the Hepatic Clearance of Albumin-Binding-Sensitive Drugs by Ren-Jong Liang, Shu-Hao Hsu, Hsueh-Tien Chen, Wan-Han Chen, Han-Yu Fu, Hsin-Ying Chen, Hong-Jaan Wang, Sung-Ling Tang

“…To address this limitation, an in silico-based model selection approach for optimizing hepatic clearance predictions was introduced in a previous study. …”
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Optimizing smart city planning: A deep reinforcement learning framework by Junyoung Park, Jiwoo Baek, Yujae Song

“…We introduce a deep reinforcement learning-based approach for smart city planning, designed to determine the optimal timing for constructing various smart city components such as apartments, base stations, and hospitals over a specified development period. …”
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DETERMINING THE SIZE OF THE POPULATION OF THE GENETIC ALGORITHM FOR THE PROBLEMS OF DISCRETE OPTIMIZATION IN CAD by V. V. Frolov

“…The main area of use of this method is discrete optimization problems with objective functions of several variables, where the ranges of admissible values are finite and have a small dimension.…”
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MULTI-OBJECTIVE OPTIMIZATION DESIGN OF ROADHEADER’S CUTTING HEAD BASED ON THE GA by ZHAO LiJuan, FAN JiaYi

“…In order to improve the dynamic reliability of the roadheader,the roadheader’s rigid-flexible coupled model was established based on virtual prototyp,dynamic reliability analysis was done on the rotary table of different structural parameters,evaluation function was established based on mechanical optimization design theory,the function’s design variables was half cone angle,helix Angle and cutting line spacing, the function’s objective function was the minimization of maximum equivalent stress as the objective function.The cutting head’s optimal structural parameters was obtained by genetic algorithm.Based on the cutting productivity and rotary table equivalent stress, the optimal yawing speed was obtained by optimized multi-objective.The results shows that after two optimizations,rotary table maximum stress is decreased 18.495 MPa,the fatigue life is improved from 3.067 E4 to 3.326 E6,productivity is improved 18.6 t/h,prediction error is less than 1.3%,meet the design requirement.This method provides data support for the structure and kinematic parameters of cutting head,provides a new method for the optimization design of heavy complicated mechanical equipment.…”
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A Randomized Controlled Trial for the Optimal Implementation of Psoriasis Treatment by Integrating Chinese and Western Medicine by Yu Y, Sun X, Hu R, Xia P, Wei Y, Yang W, Huang N, Ding Y, Guo S, Yang C, Weng H, Zhang Y, Ding X, Huang Q, Zhou X, Li X, Li B

“…Currently, the prevalent guideline-recommended regimen is based on psoriasis severity; however, no corresponding studies have been conducted on the hierarchical selection of integrated Chinese and Western medicine treatments.Objective: To explore the optimal implementation of psoriasis treatment by integrating Chinese and Western medicine.Methods: We conducted a 16-week multicenter single-blind randomized controlled trial in China between December 2019 and July 2022. …”
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Subthalamic nucleus deep brain stimulation for cranial-cervical dystonia: optimal stimulation sites and networks by Hutao Xie, Jiansong Huang, Ningfei Li, Houyou Fan, Shihang Yang, Zixiao Yin, Zhaoting Zheng, Zehua Zhao, Yin Jiang, Lin Shi, Anchao Yang, Fangang Meng, Guanyu Zhu, Quan Zhang, Jianguo Zhang

“…Methods: We retrospectively analyzed 51 patients with CCD treated with STN-DBS at a single center. …”
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Study on Cold End Temperature Optimization of Supercritical CO2 Cycle by Kaiyun ZHENG

“…In order to obtain the best annual average efficiency, it is necessary to introduce artificial refrigeration to make the supercritical CO2 cycle run at a more optimized cold end temperature. For the supercritical CO2 recompression cycle with parameters of 550℃/20MPa, the annual average cycle efficiency under different cold end temperature of 5 to 35℃, with the combination of natural cooling and artificial refrigeration was analyzed by thermodynamic method, and the feasibility and economic analysis of the cold end temperature optimization method were studied as well. …”
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Balance Optimization of Energy Consumption and Running Time for Urban Metro Trains by WU Xiao-gang, CHEN Yu, GUO Hao-qi, DU Jiu-yu

“…The results show that under different auxiliary device power conditions, the optimized cruise speed of the MT can effectively reduce the energy consumption of the whole MT, and the maximum energy saving potential can reach 19.13%.…”
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