Real-world impact of COVID-19 vaccination, household exposure, and circulating SARS-CoV-2 variants on infection risk and symptom presentation in a U.S./Mexico border community by Ariel Cohen, Breanna Reyes, Maria Linda Burola, Angel Lomeli, Arleth A. Escoto, Linda Salgin, Borsika A. Rabin, Borsika A. Rabin, Nicole A. Stadnick, Nicole A. Stadnick, Nicole A. Stadnick, Ilya Zaslavsky, Robert Tukey, Louise C. Laurent, Marva Seifert

“…In this increased infection risk environment, we explored the impact of COVID-19 vaccine status, household exposure, and primary circulating SARS-CoV-2 variant on the probability of infection and symptom presentation while controlling for temporal and sociodemographic factors.MethodsData were collected as part of CO-CREATE (Community-Driven Optimization of COVID-19 Testing to Reach and Engage underserved Areas for Testing Equity), a collaborative implementation study between University of California San Diego, a local Federally Qualified Health Center, and the Global Action Research Center. …”
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Regional variations and trends in liver transplantation practices across Europe by Tommaso Di Maira, Valérie Cailliez, Beatriz Domínguez-Gil, Beatriz Mahíllo, Marina Álvarez, Luca Saverio Belli, René Adam, Constantino Fondevila, Giacomo Germani, Hermien Hartog, Marina Berenguer

“…This study reviews LT practices and trends in Europe to identify potential policies for improving outcomes. Methods: Data were extracted from the European Liver Transplant Registry and the Global Observatory on Donation and Transplantation. …”
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Assessment of antibiotic utilization patterns in an Indian Level-1 Trauma Center: a pilot study exploring days of antibiotic spectrum coverage and defined daily doses using WHO AWa... by M Nizam Ahmed, Arpan Kumar Thakur, Smriti Srivastava, Aparna Ningombam, Madhavi Kirti, Sushma Sagar, Keshav Goyal, Subodh Kumar, Ashish Bindra, Gyaninder Pal Singh, Navdeep Sokhal, Richa Aggarwal, Vijay Sharma, Samarth Mittal, Kamran Farooque, Purva Mathur

“…BackgroundRising antimicrobial resistance (AMR) necessitates innovative metrics, such as days of antibiotic spectrum coverage (DASC), to optimize antibiotic stewardship. This study evaluated antibiotic use in an Indian trauma center using DASC, defined daily doses (DDD), and the World Health Organization (WHO) Access, Watch, Reserve (AWaRe) classification.MethodsThis retrospective cohort study analyzed data from 1,812 adult inpatients (mean age: 35 years; 70% male; 80% with polytrauma) admitted to a 250-bed Level-1 Trauma Center at the All India Institute of Medical Sciences (AIIMS), India, from August to October 2022. …”
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Multifactorial Risk Stratification in Patients with Heart Failure, Chronic Kidney Disease, and Atrial Fibrillation: A Comprehensive Analysis by Mihai Sorin Iacob, Nilima Rajpal Kundnani, Abhinav Sharma, Vlad Meche, Paul Ciobotaru, Ovidiu Bedreag, Dorel Sandesc, Simona Ruxanda Dragan, Marius Papurica, Livia Claudia Stanga

“…Personalized, integrated approaches are essential to optimize anticoagulation, reduce hospitalization, and improve prognosis.…”
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Effects of transitional care model on postpartum depression of primiparas (产后延续护理对初产妇产后抑郁的影响) by ZHANG Yongqiang (张勇强), YANG Jingying (杨晶莹), LIU Huiling (刘会玲), XU Yuanle (许远乐), ZHU Kunkun (朱坤坤)

“…Compared with those in the control group, A lower incidence of postpartum depression and higher satisfaction degree were reported in the observation, with a significant difference(P＜0. 01). Conclusion The transitional care model, as a proved way of optimizing quality of postpartum nursing, is effective to relieve the primipara’s negative emotion, improve the sleep quality and reduce the incidence of postpartum depression. …”
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Early hemodynamic impact of SGLT2 inhibitors in overweight cardiometabolic heart failure: beyond fluid offloading to vascular adaptation– a preliminary report by Nadia Salerno, Jessica Ielapi, Angelica Cersosimo, Isabella Leo, Assunta Di Costanzo, Giuseppe Armentaro, Salvatore De Rosa, Angela Sciacqua, Sabato Sorrentino, Daniele Torella

“…Sodium-glucose cotransporter-2 inhibitors (SGLT2i) reduce HF hospitalizations and cardiovascular mortality across ejection fraction (EF) categories, yet their early hemodynamic effects in cardiometabolic HF, and with preserved ejection fraction (HFpEF) in particular, remain underexplored. Methods A prospective, single-center study included 20 consecutive HF patients receiving SGLT2i alongside optimized therapy. …”
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The Combined Effect of Multisensory Stimulation and Therapist Support on Physical and Mental Health of Older Adults Living in Nursing Homes: Pilot Randomized Controlled Trial by Sewar Khatib, Yuval Palgi, Yoni K Ashar, Natalya Polyvyannaya, Pavel Goldstein

“…This brief intervention can be readily implemented to improve well-being and optimize therapeutic resources in nursing home settings. …”
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National and subnational burden of brain and central nervous system cancers in China and global from 1990 to 2021: results from the global burden of disease study 2021 by Shifan Tu, Xiaolu Huang, Xiaoxuan Fan, Yi Zhang, Lan Huang, Kai Li, Xinyue Wang, Yunpeng Gao, Xiaoping Zhao, Zhaoqun Feng

“…Methods Using open data from the GBD 2021 database, we analyzed characteristics of CNS cancer burden in China and globally from 1990 to 2021, including changes in incidence, prevalence, mortality, and DALYs.We employed Joinpoint regression analysis to calculate the average annual percentage change (AAPC) with 95% confidence intervals (95%CI), evaluating temporal trends in CNS cancer burden.A comparative analysis was conducted across multiple dimensions (age, sex, and time periods) to examine differences in CNS cancer burden between China and other world regions. …”
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Trends in Antihypertensive Drug Use and Irrational Prescriptions Among Elderly Patients in China (2016–2023): A Nationwide Multi-Center Cross-Sectional Survey Study by Hong D, Chen W, Du S, Ren J, Lv D, Shan W, Lu X, Zhao Q

“…While the overall use of first-line antihypertensive drugs remained high, there were differences across subgroups. The increasing rate of contraindicated medications and the identification of high-risk groups and clinical settings provide important insights for optimizing antihypertensive treatment in elderly populations.Keywords: elderly hypertension, antihypertensive medication, irrational prescription, trend analysis, contraindicated medication…”
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Impact of differentiated service delivery models on quality of life among people living with HIV in Uganda– a quasi-experimental study by Benson Nasasira, Grace Banturaki, Nelson Kalema, Joseph Musaazi, Aidah Nanvuma, Stephen Okoboi, Nancy Gathoni Kiarie, Joash Ntenga Moitui, Damazo Kadengye, Jonathan Izudi, Barbara Castelnuovo

“…Methods Records of 1,000 PLHIV enrolled in a 10-year cohort at the Infectious Diseases Institute (IDI) clinic in Kampala, Uganda were retrospectively analyzed. …”
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Efficacy and safety of oxaliplatin-based chemotherapy as first-line treatment in elderly patients with metastatic colorectal cancer: a meta-analysis by Shaoqing Fan, Zeming Zhao, Haiqian Wang, Handong Wang, Wenbo Niu

“…Future trials must integrate biomarker-driven approaches (e.g., ctDNA monitoring, RAS/RAF stratification) to optimize therapeutic precision in aging populations.…”
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Uncovering abnormal gray and white matter connectivity patterns in Alzheimer’s disease spectrum: a dynamic graph theory analysis for early detection by Juanjuan Jiang, Tao Kang, Ronghua Ling, Yingqian Liu, Jiuai Sun, Yiming Li, Xiaoou Li, Hui Yang, Bingcang Huang, the Alzheimer’s Disease Neuroimaging Initiative

“…Window function type (e.g., Gau20 for early changes, Ham50 for late stability) and data sampling points influenced sensitivity, with short windows optimizing early detection and long windows capturing late-stage network degeneration. …”
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Prognostic Value of Non-Traditional Lipid Indices for In-Hospital Mortality in Patients with Acute Coronary Syndromes by Rustem Yilmaz, Kenan Toprak, Ahmet Karagoz, Osman Can Yontar, Melisa Ucar, Halil Ibrahim Kokcu, Berkant Ozturk, Enes Kaya, Mustafa Yilmaz, Ersoy Öz

“…<i>Results</i>: Significant differences were observed between survivor and non-survivor groups in terms of age, c-reactive protein (CRP), white blood cell count (WBC), hemoglobin (HGB), and creatinine levels (all <i>p</i>-values < 0.05). …”
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Two-Dimensional Mammography Imaging Techniques for Screening Women with Silicone Breast Implants: A Pilot Phantom Study by Isabelle Fitton, Virginia Tsapaki, Jonathan Zerbib, Antoine Decoux, Amit Kumar, Aude Stembert, Françoise Malchair, Claire Van Ngoc Ty, Laure Fournier

“…It could also be used to evaluate and optimize the manufacturer’s recommended settings.…”
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Predictive Significance of the Monocyte-to-High-Density Lipoprotein Cholesterol Ratio in Post-Percutaneous Coronary Intervention Contrast-Induced Nephropathy Among Patients with Co... by Lin A, Peng Y, Shao J, Chen L, Lin Y

“…Survival analysis showed significant differences in long-term mortality among the three groups (Log rank test, P = 0.032). …”
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Clinical characteristics and prognosis of amyopathic dermatomyositis patients with interstitial lung disease: insights from a retrospective cohort by Yanan Ying, Tingting Wu, Long Wang, Yun Zhang, Yiming Yu, Zaichun Deng, Qunli Ding

“…We aimed to determine the characteristics and prognosis of patients with ADM-ILD to further guide their clinical management. Methods A retrospective cohort study comprising 190 Chinese patients diagnosed with interstitial lung disease (ILD) was conducted. …”
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Evaluation of ctDNA-guided adjuvant therapy de-escalation in head and neck squamous cell carcinoma: a comparative cohort study by Xu Zhang, Qigen Fang, Junhui Yuan, Liyuan Dai, Ruihua Luo, Tao Huang, Tao Huang, Yinfei Wu

“…We evaluated whether ctDNA-directed stratification could optimize locoregional control in HNSCC patients following neoadjuvant chemoimmunotherapy.MethodsIn this comparative cohort study, consecutive HNSCC patients treated with neoadjuvant chemoimmunotherapy were stratified into two management groups: a ctDNA-guided cohort where tumor-informed ctDNA testing determined POCRT administration given only for detectable ctDNA, and a traditional cohort where all patients received PORT, with postoperative chemotherapy decisions made by multidisciplinary team review based on pathologic response status and pretreatment imaging findings. …”
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Thirst Modulates Parasympathetic Recovery: Comparing Oral and Intravenous Rehydration by Alan T. Ky, Ryan A. Dunn, Marcos S. Keefe, Yasuki Sekiguchi

“…These findings have implications for optimizing rehydration strategies in sports and occupational settings.…”
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Development of a model for mathematical prediction of the course of the disease in patients with nasal furunculosis by D.S. Samusenko, M.M. Popov, O.V. Martynenko

“…Purpose – The aim of the study is to evaluate the factors and develop a linear prediction model for the severity and duration of hospitalization in patients with nasal furunculosis, based on retrospective data analysis. Materials and Methods. This study was conducted at the clinical base of the Medical Faculty of V.N. …”
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Dynamic association of serum albumin changes with inflammation, nutritional status and clinical outcomes: a secondary analysis of a large prospective observational cohort study by Yonghao Li, Liru Chen, Xin Yang, Hongyuan Cui, Zijian Li, Wei Chen, Hanping Shi, Mingwei Zhu

“…This study aimed to investigate the comprehensive associations of ALB dynamics with inflammation, nutritional status, and clinical outcomes in hospitalized patients, providing evidence to optimize clinical management. Methods This secondary analysis utilized data from a prospective observational cohort study conducted in 34 tertiary hospitals across China between June and September 2014. …”
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