From colorless to pink: Structural insights into vitamin B12-induced color change in monoclonal antibodies by Kai-feng He, Hao-dong Cui, Wen-hui Deng, Na Xing, Guo-jian Liu, Abdallah Iddy Chaurembo, Li-dan Fu, Yuan Li, Xin-yue Tong, Han-bin Lin, Chun-he Wang

“…This study elucidates the structural basis of antibody-VB12 interactions, offering critical insights for optimizing mAb quality control.…”
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Bimodal onset and pan-cancer uniformity of immune-mediated liver injury: a retrospective cohort study by Jiaojiao Song, Jiaojiao Song, Biying Xu, Biying Xu, Lan Yu, Haiwei Fu, Binliang Wang, Mo Zhou, Yumin Hu, Yang Xia

“…The study aims to characterize the clinical heterogeneity, temporal dynamics, and immunological drivers of PD-1/PD-L1 inhibitor-associated IMLI and optimize surveillance and management strategies.MethodsWe retrospectively recruited 373 IMLI patients. …”
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Human studies of the efficacy and safety of stem cells in the treatment of diabetic peripheral neuropathy: a systematic review and meta-analysis by Seyed Danial Alizadeh, Shima Jahani, Mohammad Rezaei Zadeh Rukerd, Reza Tabrizi, Rasoul Masoomi, Seyedeh Zahra Banihashemian, Mahgol Sadat Hassan Zadeh Tabatabaei, Zahra Ghodsi, Ahmad Pour-Rashidi, James Harrop, Vafa Rahimi-Movaghar

“…Further research is needed to consolidate these findings and optimize therapeutic protocols.…”
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Assessing HIV-1 subtype C infection dynamics, therapeutic responses and reservoir distribution using a humanized mouse model by Snehal Kaginkar, Leila Remling-Mulder, Ashashree Sahoo, Tejaswini Pandey, Pranay Gurav, Jyoti Sutar, Amit Kumar Singh, Ella Barnett, Sivasankar Panickan, Ramesh Akkina, Vainav Patel

“…Thus, treatment approaches developed for HIV-1B need to be suitably optimized for HIV-1C. A suitable animal model will help delineate comparative aspects of HIV-1C and HIV-1B infections.MethodsHere, we used a humanized mouse model to evaluate HIV-1C infection, disease progression, response to anti-retroviral therapy (ART) and viral rebound following therapy interruption. …”
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Hepatocellular carcinoma in Korea: an analysis of the 2016-2018 Korean Nationwide Cancer Registry by Jihyun An, Young Chang, Gwang Hyeon Choi, Won Sohn, Jeong Eun Song, Hyunjae Shin, Jae Hyun Yoon, Jun Sik Yoon, Hye Young Jang, Eun Ju Cho, Ji Won Han, Suk Kyun Hong, Ju-Yeon Cho, Kyu-Won Jung, Eun Hye Park, Eunyang Kim, Bo Hyun Kim

“…This study evaluated the characteristics of Korean patients newly diagnosed with HCC in 2016-2018. Methods Data from the Korean Primary Liver Cancer Registry (KPLCR), a representative database of patients newly diagnosed with HCC in South Korea, were analyzed. …”
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RAC2 inhibition enhances tumor sensitivity to NK cell-mediated cytotoxicity by Lin Li, Hui Guo, Jie Hu, Lei Cui, Zining Wang, Feifei Xu, Xiaojuan Wang, Huanling Zhang, Chunyuan Xie, Yongxiang Liu, Xiaojun Xia, Zixuan Guo, Heping Li, Tiantian Wang, Ruhui Yao, Huan Jin, Yanxun Lin

“…Identification of molecular mechanisms by which tumor cells evade from NK cell-mediated killing may offer novel therapeutic strategies for potentiating NK-based cancer immunotherapy.Methods An in vitro tumor-NK cell co-culture system was employed to identify the most significantly altered genes in tumor cells following NK cell interaction. …”
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iTBS on RDLPFC improves performance of motor imagery: a brain-computer interface study combining EEG and fNIRS by Jialin Chen, Quan Liu, Gengbin Chen, Guiyuan Cai, Junbo Jiang, Xueru Yang, Chunqiu Tan, Cailin Zhang, Guangqing Xu, Yue Lan

“…This study aimed to enhance motor imagery ability and MI-BCI performance by modulating the excitability of the right dorsolateral prefrontal cortex (RDLPFC) through intermittent theta-burst stimulation (iTBS), inducing neuroplastic changes. Methods Fifty-two healthy right-handed participants were randomly assigned to either the iTBS or sham group. …”
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Are protein substitutes available in Italy for infants with inherited metabolic diseases all the same? by Margherita Di Costanzo, Margherita Di Costanzo, Martina Tosi, Martina Tosi, Martina Muzi, Enrico Vito Buono, Valentina D’Onghia, Anna Munerati, Gabriele Tarditi, Simone Bruni, Elvira Verduci, Elvira Verduci, Giacomo Biasucci, Giacomo Biasucci

“…In Italy, a variety of PSs is available for infants with IMDs requiring a controlled protein and/or amino acid intake; however, differences in their nutritional composition may impact clinical outcomes. …”
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Regional patterns of genetic variants in expanded carrier screening: a next-generation sequencing pilot study in Fujian Province, China by Danhua Guo, Danhua Guo, Nani Zhou, Qianqian He, Qianqian He, Na Lin, Na Lin, Shuqiong He, Shuqiong He, Deqin He, Deqin He, Yifang Dai, Yifang Dai, Ying Li, Ying Li, Xuemei Chen, Xuemei Chen, Hailong Huang, Hailong Huang, Jia Jia, Hua Cao, Liangpu Xu, Liangpu Xu

“…BackgroundThis pilot study aimed to characterize the regional distribution of genetic variants associated with autosomal recessive and X-linked recessive (AR/XLR) conditions in Fujian Province, Southeast China, to inform the development of targeted carrier screening programs.MethodsAn expanded carrier screening (ECS) panel utilizing next-generation sequencing (NGS) technology was designed to analyze 332 genes associated with 343 AR/XLR conditions. …”
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How sustainable are hypocaloric and balanced diets for weight loss? by Ramona De Amicis, Andrea Foppiani, Alessandro Leone, Federica Sileo, Francesca Menichetti, Sara Paola Mambrini, Marta Pellizzari, Massimiliano Tucci, Daniela Martini, Cristian Del Bo, Patrizia Riso, Simona Bertoli, Alberto Battezzati

“…Objective To compare conventional hypocaloric and balanced weight-loss diets with the sustainable EAT-IT diet, investigating their alignment, the influence of BMI and sex on EAT-IT adherence, to optimize the EAT-IT diet for weight management. Methods 4032 patients (72% female, median age 49y, BMI 29 kg/m2) received hypocaloric diets based on Mediterranean principles (51% carbohydrates, 31% lipids, 0.9 g/kg body weight protein, 17 g/1000 kcal fiber), following Italian dietary guidelines. …”
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Possibilities of PRECISE-DAPT Score for Risk Prediction of Ischemic and Hemorrhagic Events in ST-Elevated Myocardial Infarction (According to the Data of the Registry Study in Keme... by D. Yu. Sedykh, V. V. Kashtalap, R. M. Velieva, O. L. Barbarash

“…We aimed to study in real clinical practice the clinical and anamnestic characteristics, the peculiarities of double antiplatelet therapy (DAPT) prescription as well the incidence of ischemic and hemorrhagic events in patients with ST-elevated myocardial infarction (MI) during a year of follow-up, taking into account the baseline PRECISE-DAPT scores.Material and methods. The study included 680 patients with MI from the database of Kemerovo observational registry for acute coronary syndrome (ACS). …”
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Preliminary impact of an mHealth education and social support intervention on maternal health knowledge and outcomes among postpartum mothers in Punjab, India by Alison M. El Ayadi, Nadia G. Diamond-Smith, Mona Duggal, Pushpendra Singh, Preetika Sharma, Jasmeet Kaur, Lakshmi Gopalakrishnan, Navneet Gill, Garima Singh Verma, Alka Ahuja, Vijay Kumar, Laura Weil, Rashmi Bagga

“…Abstract Background Significant disruptions in the perinatal continuum of care occur postpartum in India, despite it being a critical time to optimize maternal health and wellbeing. Group-oriented mHealth approaches may help mitigate the impact of limited access to care and the lack of social support that characterize this period. …”
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The effect of audit and feedback and implementation support on guideline adherence and patient outcomes in cardiac rehabilitation: a study protocol for an open-label cluster-random... by Halldóra Ögmundsdóttir Michelsen, Matthias Lidin, Maria Bäck, Therese Scott Duncan, Björn Ekman, Emil Hagström, Maria Hägglund, Bertil Lindahl, Mona Schlyter, Margrét Leósdóttir

“…While treatment target attainment rates at Swedish cardiac rehabilitation centres is among the highest in Europe, there are considerable differences in service delivery and variations in patient-level outcomes between centres. …”
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Can virtual reality replace conventional vestibular rehabilitation tools in multisensory balance exercises for vestibular disorders? A non-inferiority study by Gaël Le Perf, Guillaume Thebault, Claire Duflos, Fanchon Herman, Sylvie Cauquil-Gleizes, Isabelle Laffont

“…Abstract Background Vestibular rehabilitation uses multisensory balance exercises to optimize the integration and weighting of sensory inputs, including visual, vestibular, and proprioceptive signals. …”
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Development and validation of a nomogram prediction model for factors influencing 131I-refractory Graves’ hyperthyroidism by Kehua Liao, Xiaojuan Wei, Yan Chen, Dongyun Meng, Shaozhou Mo, Zeyong Sun, Fengyang Song, Lu Lu, Wentan Huang

“…ObjectiveTo examine the factors influencing 131I-refractory Graves’ disease (GD) hyperthyroidism in patients, develop a nomogram prediction model, and conduct its validation.MethodsA total of 272 hyperthyroidism patients who received initial 131I treatment at our hospital from January 2021 to January 2022 were randomly selected. …”
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Depression and Its Effect on Geriatric Rehabilitation Outcomes in Switzerland’s Aging Population by Bojan Miletic, Antonia Plisic, Lejla Jelovica, Jan Saner, Marcus Hesse, Silvije Segulja, Udo Courteney, Gordana Starcevic-Klasan

“…Considering mental health during admission and planning is critical in optimizing rehabilitation outcomes.…”
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Enhanced Recovery After Surgery (ERAS) Rehabilitation Protocols Significantly Improve Postoperative Pain and Recovery in Ankle Fracture Surgery by Yang Q, Yang H, Zhao J, Ren L

“…This study investigated the effectiveness of rehabilitation therapies rooted in ERAS protocols in alleviating postoperative wound pain and improving recovery for patients undergoing ankle fracture surgery.Methods: A total of 376 patients who underwent ankle fracture surgery between December 2022 and December 2023 were included in this retrospective analysis. …”
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Public Involvement in Cancer Research: Collaborative Evaluation Using Photovoice by Piotr Teodorowski, Melanie McInnes, Glen Dale, Linda Galbraith, Esme Radin, Karen Gold, Erica Gadsby

“…ObjectiveThis study aims to evaluate the public involvement process in 2 cancer research projects. MethodsThis was a collaborative evaluation with the research team and public contributors jointly evaluating the process. …”
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Is Salvage Autologous Stem Cell Transplantation Still a Viable Treatment Option in Relapsed Myeloma Patients? by Luka Čemažar, Matevž Škerget, Barbara Skopec

“…In this study, no statistically significant factors were identified to predict the benefit, underscoring the need for further research to optimize patient selection.…”
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The prevalence of dyslipidemia and its correlation with anti-retroviral therapy among people living with HIV in China: a systematic review and meta-analysis by Zhai Wenjing, Ouyang Fei, Zhan Shenao, Huang Yu, Fu Gengfeng, Yang Haitao, Yang Haitao

“…The prevalence of dyslipidemia and mean difference of serum lipids were estimated using random-effects models. …”
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