Comparative outcomes of revision total knee arthroplasty: a systematic review and meta-Analysis of high tibial osteotomy vs. unicompartmental knee arthroplasty by Peijie Li, Yongjie Qiao, Yingjia Zhou, Jiahuan Li, Zhiqiang Lin, Yafei Cao, Fei Tan, Jiankang Zeng, Xiaoyang Song, Peng Liu, Shuo Ye, Kaipeng Zhuang, Qiuming Gao, Shenghu Zhou

“…Although the HTO-TKA group showed statistically higher knee function scores, the mean difference (MD = 3.35) did not reach the established MCID threshold for KSS (6–10 points), indicating that the clinical significance of this difference remains uncertain. …”
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Admission systolic blood pressure and short-term outcomes after dual antiplatelet therapy in patients with minor ischemic stroke or transient ischemic attack by Federico De Santis, Eleonora De Matteis, Lucio D’Anna, Michele Romoli, Tiziana Tassinari, Valentina Saia, Silvia Cenciarelli, Chiara Bedetti, Chiara Padiglioni, Bruno Censori, Valentina Puglisi, Luisa Vinciguerra, Maria Guarino, Valentina Barone, Marialuisa Zedde, Ilaria Grisendi, Marina Diomedi, Maria Rosaria Bagnato, Marco Petruzzellis, Domenico Maria Mezzapesa, Vincenzo Inchingolo, Manuel Cappellari, Cecilia Zivelonghi, Paolo Candelaresi, Vincenzo Andreone, Giuseppe Rinaldi, Alessandra Bavaro, Anna Cavallini, Stefan Moraru, Maria Grazia Piscaglia, Valeria Terruso, Marina Mannino, Alessandro Pezzini, Giovanni Frisullo, Francesco Muscia, Maurizio Paciaroni, Maria Giulia Mosconi, Andrea Zini, Ruggiero Leone, Carmela Palmieri, Letizia Maria Cupini, Michela Marcon, Rossana Tassi, Enzo Sanzaro, Giulio Papiri, Giovanna Viticchi, Daniele Orsucci, Anne Falcou, Simone Beretta, Roberto Tarletti, Patrizia Nencini, Eugenia Rota, Federica Nicoletta Sepe, Delfina Ferrandi, Luigi Caputi, Gino Volpi, Salvatore La Spada, Mario Beccia, Claudia Rinaldi, Vincenzo Mastrangelo, Francesco Di Blasio, Paolo Invernizzi, Giuseppe Pelliccioni, Maria Vittoria De Angelis, Laura Bonanni, Giampietro Ruzza, Emanuele Alessandro Caggia, Monia Russo, Agnese Tonon, Maria Cristina Acciarri, Chiara Di Fino, Cinzia Roberti, Giovanni Manobianca, Gaspare Scaglione, Francesca Pistoia, Alberto Fortini, Antonella De Boni, Alessandra Sanna, Alberto Chiti, Marcella Caggiula, Maela Masato, Massimo Del Sette, Francesco Passarelli, Maria Roberta Bongioanni, Manuela De Michele, Stefano Ricci, Raffaele Ornello, Simona Sacco, Matteo Foschi

“…Future studies should further investigate if optimizing blood pressure management may further improve prognosis.…”
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Vitamin D Deficiency Is Common in Ghana despite Abundance of Sunlight: A Multicentre Comparative Cross-Sectional Study by Samuel Asamoah Sakyi, Maxwell Hubert Antwi, Linda Ahenkorah Fondjo, Edwin Ferguson Laing, Richard K. Dadzie Ephraim, Alexander Kwarteng, Benjamin Amoani, Seth Christopher Appiah, Bright Oppong Afranie, Stephen Opoku, Tonnies Abeku Buckman

“…Methods and Results. In a cross-sectional study, a total of five hundred (500) healthy blood donors from three geographical areas in Ghana were enrolled. …”
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Exploring the ability of plasma pTau217, pTau181 and beta-amyloid in mirroring cerebrospinal fluid biomarker profile of Mild Cognitive Impairment by the fully automated Lumipulse®... by Marcella Catania, Claudia Battipaglia, Alberto Perego, Erika Salvi, Emanuela Maderna, Federico Angelo Cazzaniga, Paolo M. Rossini, Camillo Marra, Nicola Vanacore, Alberto Redolfi, Daniela Perani, Patrizia Spadin, Maria Cotelli, Stefano Cappa, Naike Caraglia, Pietro Tiraboschi, Fabrizio Tagliavini, Giuseppe Di Fede

“…All the biomarkers, except Aβ40, showed differences in A+ vs. A-, A+T+ vs. A-T- and A+T- vs. …”
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Construction of a risk prediction model for pulmonary infection in patients with spontaneous intracerebral hemorrhage during the recovery phase based on machine learning by Jixiang Xu, Yuan Li, Fumin Zhu, Fumin Zhu, Xiaoxiao Han, Liang Chen, Yinliang Qi, Yinliang Qi, Xiaomei Zhou, Xiaomei Zhou

“…Accurate prediction of PI risk is crucial for early intervention and optimized clinical management. The aim of this study was to develop a machine learning (ML) model for predicting PI risk in patients during the recovery phase of deep SICH and to investigate the contributions of individual risk factors through explainable artificial intelligence techniques.MethodsWe conducted a retrospective study involving 649 patients diagnosed with PI during the recovery phase of deep SICH between 2021 and 2023. …”
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The impact of obesity and weight loss treatment on metabolic parameters, cardiovascular autonomic and sensory nerve function and in vitro fertilization outcomes in infertile women:... by Anna Vágvölgyi, Viktor Vedelek, Nóra Keller, Dalma Szöllősi, Szilvia Lada, Attila Nemes, Péter Kempler, Adrienn Menyhárt, István Baczkó, Tamás Várkonyi, Csaba Lengyel, János Zádori

“…Our study aimed to analyze the effects of preconceptional weight loss in infertile women with obesity on peripheral sensory and cardiovascular autonomic nerve function, metabolic parameters, and the success of in vitro fertilization (IVF).MethodsA retrospective cohort study included women with obesity and infertility undergoing weight optimization before IVF, alongside age-matched controls. …”
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Vitamin D Deficiency and Mastalgia: A Prospective Controlled Study on Prevalence and the Therapeutic Impact of Supplementation by Goranta Navya Sree, Sanjay Kumar Yadav, Deepti Bala Sharma, Dhananjaya Sharma, Saket Shekhar

“…Objective: To investigate the relationship between vitamin D deficiency and mastalgia and assess the effectiveness of vitamin D supplementation in alleviating mastalgia symptoms. Materials and Methods: A prospective investigational study conducted in an Indian tertiary teaching centre. …”
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Experts' consensus over key components of online learning environments in medical education: a modified e-Delphi study by Noor-i-Kiran Naeem, Siti Nurma Hanim Hadie, Irwan Mahazir Ismail, Zil-e-Fatima Naeem, Ahmad Hassan Khan, Muhamad Saiful Bahri Yusoff

“…Friedman test showed no significant differences in rankings (p >0.05), confirming consensus. …”
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National needs assessment of emergency medicine faculty regarding scholarly activity practices and support by Nidhi Garg, Jennifer Johnson, Sumedha Garg, Bernard Chang, Christopher Zabbo, Pridha Kumar, Lance Becker, Phillip Levy, Gabor D. Kelen, Joshua J. Davis, Manish Shah

“…This study examined the belief and need for modern‐day SA, potential barriers, and department resources provided. Methods We conducted a descriptive cross‐sectional survey study of EM physicians across the United States identified from the American College of Emergency Physicians and American College of Osteopathic Physicians directories. …”
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EV‐Elute: A universal platform for the enrichment of functional surface marker‐defined extracellular vesicle subpopulations by Willemijn S. deVoogt, Rowan Frunt, Raul M. Leandro, Casper S. Triesscheijn, Bella Monica, Ioanna Paspali, Mark Tielemans, Jerney J. J. M. François, Cor W. Seinen, Olivier G. deJong, Sander A. A. Kooijmans

“…However, it has been technically challenging to examine such functional heterogeneity due to a lack of non‐destructive methods to separate EV subpopulations based on their surface markers. …”
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Trends in Heart Transplantation and Outcome Analysis: Nationwide Study Using the National Inpatient Sample and Readmission Database by Vivek Joseph Varughese, Aditya Sunil Bhaskaran, Hadrian Hoang-Vu Tran, Nikita Wadhwani, Vignesh Krishnan Nagesh, Izage Kianifar Aguilar, Damien Islek, Simcha Weissman, Adam Atoot

“…Future efforts should focus on optimizing post-transplant care and addressing disparities to improve long-term outcomes.…”
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The Role of Ferritin and Folate in Determining Stem Cell Collection for Autologous Stem Cell Transplant in Multiple Myeloma by Charles J. Weeks, Mohammad Mian, Michael Stokes, Matthew Gold, Anvay Shah, Rohan Vuppala, Katherine J. Kim, Abigayle B. Simon, Jorge Cortes, Anand Jillela, Vamsi Kota

“…Abnormal hemoglobin (Hgb), ferritin, and folate statuses did not exhibit significant differences in survival analysis. Conclusions: The findings reveal that folate, ferritin, and Hgb levels are significantly associated with apheresis outcomes, offering guidance for optimizing stem cell mobilization in patients with MM.…”
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Comparative Analysis of SARS-CoV-2 Antibodies in Diabetic and Non-Diabetic Healthcare Workers Post-Infection and Vaccination by Mariya Rouf Tramboo1*, Anjum Farhana1, Danish Zahoor1, Ilhaam Iqbal1, Zahoor Mohuiddin1

“…Diabetic individuals had lower antibody titers, while age and gender differences also affected antibody responses. These findings suggest the need for personalized vaccination strategies, especially for diabetic healthcare workers, to optimize COVID-19 prevention and ensure effective immunity.…”
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Comparative Effects of Two Acupuncture Protocols in the Management of Chronic Insomnia: A Randomized Controlled Trial by Li L, Xia M, Chen X, Wang F, Li J, Zhao N, Liu Z, Chen Y

“…This highlights the urgent need for effective and safe therapeutic approaches that can target both nocturnal and daytime symptoms.Objective: To evaluate the clinical efficacy and safety of acupuncture in improving sleep quality and daytime functioning in patients with chronic insomnia, and to optimize its treatment protocol.Methods: This study was a single-blind, randomised, controlled trial. …”
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Thalassemia and assisted reproduction: non-transfusion-dependent thalassemia shows no significant effect on live birth rates after embryo transfer by Li Fan, Li Fan, Liuyan Wei, Liuyan Wei, Ni Tang, Ni Tang, Zhetao Li, Zhetao Li, Wugao Li, Wugao Li, Liuying Nong, Liuying Nong, Jingjing Li, Jingjing Li, Jingjing Li, Jingjing Li, Wenjie Huang, Wenjie Huang

“…However, NTDT patients exhibited higher oocyte maturation rates and a greater number of fertilized oocytes. Despite these differences in embryo development metrics, there were no statistically significant differences in clinical pregnancy rates and live birth rates between NTDT and TC patients in both fresh embryo transfer (IVF-ET) and FET cycles (p > 0.05). …”
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Chest trauma clinical practice guideline protects against delirium in patients with rib fractures by Valérie Courval, Raymond Tang, Peter Rose, Naisan Garraway, Robin Som, Jenna Kroeker, Anas Wess, Yuwei Yang, Bader Al-Zeer, Harjot Uppal, Patricia Balmes, Nasira Lakha, Angie Brisson, Jennifer Sakai, Emilie Joos

“…Vancouver General Hospital, a level 1 trauma center in British Columbia, Canada, developed a comprehensive multidisciplinary chest trauma clinical practice guideline (CTCPG) to optimize the management of patients with rib fractures. …”
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U-Pb age characteristics of detrital zircon and provenance analysis of a Middle Miocene submarine fan in the Qiongdongnan Basin by Shengli GONG, Zhuoyu YAN, Baiqiang LI, Tongyao ZHANG, Turong WU, Junfeng PENG, Lei ZHENG, Dongfeng ZHANG, Xiangsheng HUANG, Chengfei LUO, Ren WANG

“…Provenance analysis will be important for the optimization of natural gas exploration in this area. …”
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Clinical Characteristics of EGPA Patients in Comparison to GPA Subgroup with Increased Blood Eosinophilia from POLVAS Registry by Anna Drynda, Agnieszka Padjas, Krzysztof Wójcik, Radosław Dziedzic, Grzegorz Biedroń, Katarzyna Wawrzycka-Adamczyk, Anna Włudarczyk, Joanna Wilańska, Jacek Musiał, Zbigniew Zdrojewski, Zenobia Czuszyńska, Anna Masiak, Maria Majdan, Radosław Jeleniewicz, Hanna Augustyniak-Bartosik, Katarzyna Jakuszko, Magdalena Krajewska, Alicja Dębska-Ślizień, Hanna Storoniak, Barbara Bułło-Piontecka, Witold Tłustochowicz, Joanna Kur-Zalewska, Małgorzata Wisłowska, Piotr Głuszko, Marta Madej, Ewa Jassem, Iwona Damps-Konstańska, Eugeniusz Kucharz, Marek Brzosko, Marcin Milchert, Anna Hawrot-Kawecka, Joanna Miłkowska-Dymanowska, Paweł Górski, Anna Lewandowska-Polak, Joanna Makowska, Joanna Zalewska, Lech Zaręba, Stanisława Bazan-Socha

“…Further studies are needed to optimize their differentiation and tailored therapy, including biologics.…”
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Construction and evaluation of a height prediction model for children with growth disorders treated with recombinant human growth hormone by Feng Zhu, Anle Wu, Lingling Chen, Ya Xia, Xiaoju Luo, Jieqian Zhu, Lina Huang, Yu Zhang

“…Methods A total of 786 children were included, randomly split into a derivation cohort (N = 551) and a test cohort (N = 235). …”
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Long-Term Outcomes of Patients Undergoing Conversion Surgery After Induction Chemotherapy: Turkish Oncology Group Study by Furkan Ceylan, Selin Aktürk Esen, Olçun Ümit Ünal, Ferit Aslan, İlknur Deliktaş Onur, Öztürk Ateş, Erkut Demirciler, İlkay Tuğba Ünek, Ahmet Gülmez, Esra Özen Engin, Semra Taş, Gamze Gököz Doğu, Melih Şimşek, Hacı Mehmet Türk, Ali İnal, Gökhan Şahin, Haydar Çağatay Yüksel, Ateş Kutay Tenekeci, Mutlu Hızal, Mehmet Ali Nahit Şendur, Doğan Uncu

“…The median progression-free survival (PFS) and overall survival (OS) were 21.1 and 53.7 months, respectively. No significant differences in PFS or OS were observed based on biological therapy use or tumor localization. …”
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