Fecal microbiota transplantation for chronic constipation: a systematic review and meta-analysis of clinical efficacy, safety, and microbial dynamics by Ke Wang, Chun Gao, Li Zhu, Min Chen, Yi Xin Tong, Sheng Zhang

“…This systematic review and meta-analysis evaluate the efficacy, safety, and gut microbial dynamics of FMT in adults with chronic constipation.MethodsWe systematically searched PubMed, Embase, Web of Science, and Cochrane Library up to January 2025, identifying 1,072 records. …”
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Effects of Antibiotic De-Escalation on Outcomes in Severe Community-Acquired Pneumonia: An Inverse Propensity Score-Weighted Analysis by Diego Viasus, Gabriela Abelenda-Alonso, Juan Bolivar-Areiza, Carlota Gudiol, Jordi Carratalà

“…<b>Objective</b>: This study aimed to assess the effect of antibiotic de-escalation on 30-day mortality, duration of intravenous (IV) antibiotic therapy and length of hospital stay (LOS) in severe community-acquired pneumonia (sCAP). <b>Methods</b>: We performed a retrospective analysis of prospectively collected data from a cohort of adults diagnosed with sCAP and microbiologically confirmed etiology between 1995 to 2022. …”
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Real-world insights into safety, tolerability, and predictive factors of adverse drug reactions in treating idiopathic pulmonary fibrosis with pirfenidone and nintedanib by Alessio Provenzani, Daniele Leonardi Vinci, Miriam Alaimo, Salvatore Di Maria, Fabio Tuzzolino, Gaetano Floridia, Roberta Di Stefano, Anna Carollo, Adriana Callari, Piera Polidori, Patrizio Vitulo

“…Both pirfenidone and nintedanib are crucial in managing IPF, highlighting the need for further research to optimize personalized therapies and patient outcomes.…”
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A Comparison of the Safety and Efficacy of Remimazolam and Dexmedetomidine for Sedation in Surgical Patients Under Regional Anesthesia: A Meta-Analysis of Randomized Controlled Tri... by Hyo-Seok Na, Sang-Hi Park, Bon-Wook Koo, Seunguk Bang, Hyun-Jung Shin

“…Effect sizes were calculated as relative risks (RRs) or mean differences (MDs) using random-effects models. <i>Results</i>: Five RCTs involving 439 participants were included. …”
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Reducing fluoroscopy time during cardioverter-defibrillator implantation, performed with considering of myocardium perfusion scintigraphy results in patients with coronary artery d... by T. A. Atabekov, R. E. Batalov, S. N. Krivolapov, M. S. Khlynin, S. I. Sazonova, A. D. Shvarzman, G. Zh. Suranova, S. V. Popov

“…Implantable cardioverter­defibrillator (ICD) implantation technique optimization in patients with coronary artery disease (CAD) in order to reduce fluoroscopy time and total radiation dose to staff.Material and methods. …”
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6-mercaptopurine Metabolites as Predictors of Neutropenia and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia by Ebrahim Salehifar, Omid Abed Khojasteh, Seyed Jalal Hosseinimehr, Hossein Karami, Mohammad Naderi Sorki, Hadi Darvish-Khezri, Kimia Karami

“…Objectives: This study aimed to assess the metabolites of 6-MP and their relationships with hepatotoxicity and neutropenia in the erythrocytes of children with ALL. Methods: A total of 32 children with ALL treated with 6-MP were included in this study. …”
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Abdominoplasty in gastric bypass patients: anthropometric profile, comorbidities, and complications by Simone Corrêa Rosa, Jefferson Lessa Soares de Macedo, Flávio Gondim Freitas, João Luiz Darques Ferreira, Lucas Ribeiro Canedo, Luiz Augusto Casulari

“…Furthermore, AP is fundamental for the comprehensive care of obese patients and has optimized the results achieved with VBG-RYGB.…”
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Current status of vocational delay of gratification among practicing nursing students and its influencing factors: a cross-sectional study by Tianyu Chu, Xian Chen, Qian Zhang, Juanjuan Yang, Hui Zhou, Yibo Wu, Jie Jiao

“…The study conducted in three hospitals in Anhui Province may limit the generalizability of the results due to regional differences in education and practice. Nonetheless, this study provides important insights for optimizing the career development and retention of nursing interns. …”
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Combined Effects of Postactivation Performance Enhancement and Caffeine Intake on Explosive and Anaerobic Power in Recreationally Active Males by Nazila Heydari, Mahsa Shojaee, Javad Nemati, Ahmad Reza Dehghani, Alireza Niknam, Fereshte Eftekhari, Mohammad Hemmatinafar

“…Conclusion: These findings highlight a synergistic effect between PAPE and CAF in enhancing short-term explosive performance, offering practical strategies for optimizing high-intensity activities in recreationally active individuals.…”
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Biceps and Triceps Muscle Activation Under Progressive Loads: A Study on Functional Symmetry of the Upper Limbs by Haider Hashim, Saif Ali Mohammed, Bashar Mohammed Ali, Safaa A. Ismaeel, Mohammed Nasir

“…Specifically, it investigated how incremental load variations affect the recruitment of agonist and antagonist muscles and examined the biomechanical relationship between load intensity and muscle coordination. Methods A total of 22 healthy male participants (aged 23–26 years) with resistance training experience were included. …”
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Effects of a Cooling Vest on Core and Skin Temperatures Following a Soccer-Specific Exercise Protocol by Carlos Lorente-González, Jose Vicente Beltran-Garrido, Abraham Batalla-Gavaldà, Francisco Corbi

“…Background/Objectives: Cooling strategies are critical for optimizing athlete recovery and performance in team sports, yet practical, accessible solutions remain underexplored. …”
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Cryoablation-induced modulation of Treg cells and the TGF-β pathway in lung adenocarcinoma: implications for increased antitumor immunity by Shicheng Lin, Dianna Liu, Tianyu Liang, Yaoxue Zhuang, Xiaofan Wang, Shengmao Ma, Quanwang Li, Kaiwen Hu

“…This study aimed to explore the impact of cryoablation on the local immune microenvironment, focusing on regulatory T cells (Tregs) and the TGF-β pathway. Methods Single-cell sequencing was employed to identify differences in immune cell populations and related pathway expression between lung adenocarcinoma tissues and adjacent noncancerous tissues. …”
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Analysis of Carbon Stock Evolution and Its Vulnerability Characteristics Based on Land Use Change in Guizhou Province by Chen Darong, Zhou Xu, Yang Shengtian, Pei Yu, Hu Yuxue, Hu Feng

“…In the future, land use structure should be optimized, and planning and management should be strengthened.…”
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Surgeons Knowledge, Attitude, and Practice Toward Preoperative Inflammatory Bowel Disease Medications and Post-Operative Complications by Alhassan N, Alnwdel AN, Beyari MB, Aldeligan SH, Alhassan R, Abdulla MH, Bin Traiki T

“…Unnecessary cessation may increase disease flare risk, highlighting the need for targeted education and multidisciplinary collaboration to optimize surgical outcomes.Keywords: inflammatory bowel disease, biologics, corticosteroids, immunomodulators, surgical outcomes…”
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Automated process assessment of primary healthcare for hyperlipidemia: preliminary findings and implications form Anhui, China by Ningjing Yang, Yuning Wang, Ying Li, Dongying Xiao, Ruirui Cui, Nana Li, Rong Liu, Jing Chai, Xingrong Shen, Debin Wang

“…This study aims at identifying pragmatic measures out from routinely collected electronic records to enable automatic monitoring and inform continuous optimization of HL-management at PHC settings. Methods The study used randomly selected electronic records of PHC (from the province-wide data center of Anhui-province, China) as the main data source and generated both procedure-based and encounter-based measures for assessing HL-management. …”
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The Acute Effects of Varying Frequency and Pulse Width of Transcutaneous Auricular Vagus Nerve Stimulation on Heart Rate Variability in Healthy Adults: A Randomized Crossover Contr... by Peter Atanackov, Jakob Peterlin, Maja Derlink, Uroš Kovačič, Nataša Kejžar, Fajko F. Bajrović

“…Future studies should optimize taVNS parameters to maximize physiological and clinical outcomes.…”
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Trajectories of α-fetoprotein and unresectable hepatocellular carcinoma outcomes receiving lenvatinib: a retrospective, multicenter cohort study by Yitao Zheng, Jingna Hu, Yingna Mei, Yanjun Xiang, Haofeng Lu, Jiuting Zhu, Kaile Pan, Shuqun Cheng, Yang Liu

“…AFP trajectories provide valuable biomarkers for assessing treatment efficacy and optimizing therapeutic strategies.…”
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Heart rate variability in soccer players and the application of unsupervised machine learning by Wollner Materko, Sávio Andrei Medeiros Miranda, Thiago Henrique Lobato Bezerra, Carlos Alberto Machado de Oliveira Figueira

“…Aim: This study aimed to investigate the relationship between heart rate variability (HRV) parameters and performance in soccer players. Methods: This study used a cross-sectional design to assess HRV parameters in a cohort of twenty-nine male athletes, aged 18 to 20 years, randomly selected from the Macapá Sports Club team in the Amazon region. …”
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Gas Exchange and Mechanical Properties of the Lung in Miners with Severe Concomitant Injury by V. V. Moroz, Yu. A. Churlyaev, V. N Kiselev, P. G Sitnikov, L. Yu. Redkokasha

“…Objective: to study the specific features of pulmonary gas exchange and mechanical properties in various manifestations of respiratory failure in miners with severe concomitant injury, who have a service length of 10 years or more, in order to optimize respiratory support.Subjects and methods. …”
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Early Recurrence of Hepatocellular Carcinoma in Patients without Microscopic Vascular Invasion: Clinicopathological Characteristics and Risk Factors by Ngo HTT, Nguyen DD, Dang MX, Doan TTP, Thai TT

“…Independent factors for early tumor recurrence included preoperative treatment with Transarterial Chemoembolization (TACE) or Radiofrequency Ablation (RFA) (HR = 8.63, 95% CI = 1.45– 51.38), tumor size &gt; 5 cm (HR = 3.82, 95% CI = 1.17– 12.42), and HCV infection (HR = 4.61, 95% CI = 1.41– 15.1).Conclusion: The pathogenesis and pattern of early tumor recurrence in MVI-negative HCC differ from that in MVI-positive cases. Identifying risk factors, such as HCV infection, tumor size, and preoperative locoregional therapy, may aid in optimizing treatment strategies and postoperative surveillance.Keywords: hepatocellular carcinoma, microvascular invasion, early recurrence, risk factor, clinical characteristics, pathological characteristics…”
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