Drug-coated balloon in patients with in-stent restenosis: A prospective observational study by Shuvanan Ray, Siddhartha Bandyopadhyay, Prithwiraj Bhattacharjee, Priyam Mukherjee, Suman Karmakar, Pallab Bose, Basabendra Choudhury, Deepankar Paul, Avik Karak

“…Aim: The aim of this study was to compare the safety and efficacy of paclitaxel-coated balloons (PCB) and sirolimus-coated balloons (SCB) in patients with in-stent restenosis (ISR). Methods: This prospective, observational, single-centre pilot study enrolled 85 patients diagnosed with drug-eluting stent ISR. …”
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Mapping the complexity and diversity of tertiary lymphoid structures in primary and peritoneal metastatic gastric cancer by Carolina Martinez-Ciarpaglini, Tanja D de Gruijl, Daniela S Thommen, Nicole C T van Grieken, Joep Grootjans, Sarah Derks, Tessa S Groen-van Schooten, Rosalia Franco Fernandez, Emma N Bos, Jens Seidel, Job Saris, Tania C Fleitas

“…Tumor location (primary vs metastatic site) accounted for the majority of differences in TLS maturity, as TLS in peritoneal metastases were predominantly immature. …”
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Multi-split nitrogen application via drip irrigation improved dry matter accumulation, nitrogen uptake and utilization efficiency in flue-cured tobacco by Abdullah Khan, Chuanxi Peng, Keling Chen, Xinghua Ma

“…The treatments differed in terms of N application timing and proportions. …”
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Measuring readiness for nurse-led shared decision making in clinical practice: development and first testing of the RSDM-N scale by Meiqi Meng, Sihan Chen, Dan Yang, Xiaoyan Zhang, Yajuan Yang, Ziyan Wang, Jingyuan Zhang, Xuejing Li, Yufang Hao

“…Two rounds of Delphi consultations were conducted to optimize items, developed an initial scale. Cognitive interviews were then conducted to understand the target population’s comprehension of each item, addressing differences during the development process, resulting in the first scale version. …”
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SURGICAL TREATMENT OF ABDOMINAL INJURIES WITH COMBINED TRAUMA AND POLYTRAUMA: A COMPARATIVE ANALYSIS OF THE STRUCTURE AND COMPONENTS OF THE ABDOMINAL INTERVENTION PHASE (MESSAGE TW... by Serhii I. Panasenko, Serhii O. Guriev, Volodymyr V. Nehoduiko, Nizar R. Kerbazh

“…The optimization of surgical management for abdominal injuries in combined thoracoabdominal trauma hinges on avoiding exploratory laparotomies and incorporating surgical strategies outlined in the concepts of nonoperative management of solid organ injuries and damage control surgery.…”
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Association Between Cardiometabolic Index and Mortality Among Patients with Atherosclerotic Cardiovascular Disease: Evidence from NHANES 1999–2018 by Duo Yang, Wei Li, Wei Luo, Yunxiao Yang, Jiayi Yi, Chen Li, Hai Gao, Xuedong Zhao

“…Subgroup analyses were used to investigate potential differences among specific ASCVD patients. <i>Results:</i> A total of 2157 patients with ASCVD were included. …”
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Decatecholaminization of Septic Shock Patients in Intensive Care Unit: an Economic Assessment in the Italian Setting by Alfredo Del Gaudio, Assunta Caiazza, Luana Bortone, Sonia Tomasso, Ilaria Bozzari, Laura Vincenzi, Gianluca Furneri, Luigi Tritapepe

“…This study presents an economic analysis evaluating the economic implications of the decatecholaminization use in patients with septic shock treated in intensive care unit (ICU) from the Italian National Health Service (NHS) perspective. METHODS: Two analyses were conducted: (1) a patient-level comparison of costs between two real-world cases, one treated with decatecholaminization and one without this approach, and (2) a cohort-level analysis using a pharmacoeconomic model to project cost differences for the Italian National Health Service (NHS) before and after implementing decatecholaminization. …”
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Diagnostic Accuracy of Contrast-enhanced Flair Magnetic Resonance Imaging in Detecting Meningeal Abnormalities in Suspected Cases of Infectious Meningitis by Ashapurna Bhagawati, Lipee Nath Dhanowar, Rajesh Kr Dhanowar, Gargi Choudhury, Pronami Borah, Venkatesh Dharavath

“…Adding this sequence to the conventional sequence can optimize the early detection of abnormal meningeal enhancement.…”
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Influence of anti-Spike protein antibody levels on tocilizumab efficacy in hospitalized patients with severe COVID-19 pneumonia: a post-hoc analysis of the COVACTA trial by José Aguareles, Carles Forné, Ana García-Casas, Guillermo Santamaría-Corral, Daniel Carnevali-Ruiz, Gabriel Sotres-Fernández, Javier T Solera, Pablo Guisado-Vasco

“…Abstract Background Our aim in this work is to find biomarkers to optimize therapy with IL-6 inhibitors, as not all clinical trials have shown clear benefits on mortality or mechanical ventilation progression. …”
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A Novel Temozolomide-Myricetin Drug-Drug Cocrystal: Preparation, Characterization, Property Evaluations by Hai-Xin Qin, Jie Wang, Jia-Hui Peng, Xia-Lin Dai, Cai-Wen Li, Tong-Bu Lu, Jia-Mei Chen

“…The goal of the present study is to obtain novel drug-drug cocrystals involving two anti-glioma agents, temozolomide (TMZ) and myricetin (MYR). <b>Methods</b>: The novel TMZ-MYR cocrystal was prepared via slurry and solvent evaporation techniques and characterized by X-ray diffraction, thermal analysis, infrared spectroscopy, and dynamic vapor sorption measurements. …”
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A systematic review of alterations in brain activation and intensity following stroke: implications for integration and functional outcomes by Amirul Azri, Noorazrul Yahya, Umi Nabilah Ismail, Muhammad Aminuddin Ashari, Hanani Abdul Manan, Hanani Abdul Manan

“…Further research is needed to deepen our understanding of these associations and optimize patient outcomes in stroke rehabilitation.…”
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Spatio-Temporal Evolution, Factors, and Enhancement Paths of Ecological Civilization Construction Effectiveness: Empirical Evidence Based on 48 Cities in the Yellow River Basin of... by Haifa Jia, Pengyu Liang, Xiang Chen, Jianxun Zhang, Wanmei Zhao, Shaowen Ma

“…The lower reaches face intense anthropogenic pressures, necessitating greater economic–ecological coordination. (3) Among the dimensions considered, Territorial Space and Eco-environmental Protection emerged as the two most influential dimensions contributing to performance differences. According to the ecological civilization construction performance and changing characteristics of the 48 cities, this study proposes differentiated optimization measures and coordinated development pathways to advance the implementation of the national strategy for ecological protection and high-quality development in the Yellow River Basin.…”
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Comparison of length of stay in community-acquired pneumonia patients who fit protocol for pharmacy driven de-escalation of ceftriaxone to standard of care by Brady Raab, Faith Furst, Katelyn Zumpf, Tina Samson, Timothy F. Murrey

“…Conclusion: These findings underscore the potential benefits of pharmacist driven IV to oral de-escalation protocols in optimizing antibiotic and resource utilization in CAP management. …”
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Microbial and clinical disparities in pneumonia: insights from metagenomic next-generation sequencing in patients with community-acquired and severe pneumonia by Wang Luo, Shuhua Zhang, Jinhuan Sun, Jinhuan Sun, Jianhui Xu, Weihua Huang, Ruiqing Hao, Zhao Ou, Zhao Ou, Ziyang Wen, Ziyang Wen, Daiwei Wang, Daiwei Wang, Guanhua Xiao, Hangming Dong

“…Beta diversity analysis demonstrated significant differences in microbial community composition between CAP and SP groups (p = 0.001), though alpha diversity metrics showed no significant differences. …”
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Polymorphism of TNF gene in acute coronary syndrome patients: data from the registries ORACLE I and ORACLE II by V. A. Brazhnik, L. О. Minushkina, A. О. Averkova, Е. A. Zubova, A. A. Rogozhina, М. A. Evdokimova, A. S. Galyavich, S. N. Tereshchenko, N. A. Koziolova, М. G. Glezer, А. V. Jagoda, О. I. Boeva, Е. V. Khoroletz, Е. А. Karmanchikova, V. O. Konstantinov, G. I. Speshilov, Е. N. Dankovtseva, D. А. Zateishchikov

“…To analyze possible association of the risk of adverse outcomes development in patients post acute coronary episode (ACS), with the polymorphism of gene TNF. Material and methods. To the study, patients included, that were under observation in 2 registry studies ORACLE I and II (Exacerbation of coronary heart disease: logic-probability ways of course prediction and treatment optimization). …”
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Patterns of Engagement With the mHealth Component of a Sexual and Reproductive Health Risk Reduction Intervention for Young People With Depression: Latent Trajectory Analysis by Lydia A Shrier, Carly E Milliren, Brittany Ciriello, Madison M O'Connell, Sion Kim Harris

“…ConclusionsYoung people with depressive symptoms showed initial high engagement with the intervention’s mHealth app to reduce adverse SRH outcomes. Methods to increase and sustain mHealth engagement and differences in engagement by sociodemographic characteristics warrant further studies to optimize the reach of mHealth interventions.…”
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Dengue Severity Prediction in a Hyperendemic Region in Colombia by Jorge Emilio Salazar Flórez, Katerine Marín Velasquez, Luz Stella Giraldo Cardona, Ángela María Segura Cardona, Berta Nelly Restrepo Jaramillo, Margarita Arboleda

“…This study aimed to identify predictors of SD in a hyperendemic region of Colombia. Methods: A cross-sectional analysis was conducted using data from 2018 to 2022, encompassing 233 patients. …”
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Nursing students’ perceptions about the use of clinical simulation to teach safe medication administration: a focus group study by Cristina Alfonso-Arias, Mireia Llaurado-Serra, Encarna Rodríguez-Higueras, Blanca Goni-Fuste, Laura Brichs-Masnou, Laia Wennberg-Capellades, Maria Angeles de Juan-Pardo

“…The purpose of this study was to explore nursing students’ perceptions about the use of clinical simulation to teach safe medication administration. Methods Descriptive qualitative study through focus groups with nursing students who had participated in simulation-based training on safe medication administration where they had been split into two groups that differed only on the degree of fidelity (low fidelity mannequin or standardized patient). …”
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Subgroups of suicidal ideation and simulated intervention responses among left-behind children with depression risk: an Ising computational network model by Xiaofan Yu, Ling Li, Chang Liu, Lei Ren, Xiewan Chen, Kuiliang Li

“…Targeted interventions prioritizing positive ideation in high-risk groups are recommended to optimize prevention and treatment strategies.…”
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Duration of onset, body temperature and C-reactive protein can be used to predict the results of pus culture in children with acute osteomyelitis of long bones by Haiting Jia, Yanan Liu, Tao Liu

“…The aim of our study is to identify some indicators that could be used to distinguish the culture results to optimize the use of PCR and mNGS. Methods In this study, a total of 117 cases of acute osteomyelitis of long bones in children who underwent pus culture were included. …”
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