Real-world impact of COVID-19 vaccination, household exposure, and circulating SARS-CoV-2 variants on infection risk and symptom presentation in a U.S./Mexico border community by Ariel Cohen, Breanna Reyes, Maria Linda Burola, Angel Lomeli, Arleth A. Escoto, Linda Salgin, Borsika A. Rabin, Borsika A. Rabin, Nicole A. Stadnick, Nicole A. Stadnick, Nicole A. Stadnick, Ilya Zaslavsky, Robert Tukey, Louise C. Laurent, Marva Seifert

“…In this increased infection risk environment, we explored the impact of COVID-19 vaccine status, household exposure, and primary circulating SARS-CoV-2 variant on the probability of infection and symptom presentation while controlling for temporal and sociodemographic factors.MethodsData were collected as part of CO-CREATE (Community-Driven Optimization of COVID-19 Testing to Reach and Engage underserved Areas for Testing Equity), a collaborative implementation study between University of California San Diego, a local Federally Qualified Health Center, and the Global Action Research Center. …”
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Regional variations and trends in liver transplantation practices across Europe by Tommaso Di Maira, Valérie Cailliez, Beatriz Domínguez-Gil, Beatriz Mahíllo, Marina Álvarez, Luca Saverio Belli, René Adam, Constantino Fondevila, Giacomo Germani, Hermien Hartog, Marina Berenguer

“…This study reviews LT practices and trends in Europe to identify potential policies for improving outcomes. Methods: Data were extracted from the European Liver Transplant Registry and the Global Observatory on Donation and Transplantation. …”
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Assessment of antibiotic utilization patterns in an Indian Level-1 Trauma Center: a pilot study exploring days of antibiotic spectrum coverage and defined daily doses using WHO AWa... by M Nizam Ahmed, Arpan Kumar Thakur, Smriti Srivastava, Aparna Ningombam, Madhavi Kirti, Sushma Sagar, Keshav Goyal, Subodh Kumar, Ashish Bindra, Gyaninder Pal Singh, Navdeep Sokhal, Richa Aggarwal, Vijay Sharma, Samarth Mittal, Kamran Farooque, Purva Mathur

“…BackgroundRising antimicrobial resistance (AMR) necessitates innovative metrics, such as days of antibiotic spectrum coverage (DASC), to optimize antibiotic stewardship. This study evaluated antibiotic use in an Indian trauma center using DASC, defined daily doses (DDD), and the World Health Organization (WHO) Access, Watch, Reserve (AWaRe) classification.MethodsThis retrospective cohort study analyzed data from 1,812 adult inpatients (mean age: 35 years; 70% male; 80% with polytrauma) admitted to a 250-bed Level-1 Trauma Center at the All India Institute of Medical Sciences (AIIMS), India, from August to October 2022. …”
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Role of Genetic Testing and Complex Endoscopic Examination in Differential Diagnosis of Hereditary Polyposes in Pediatric and Adolescent Patients: 10 Years Clinical Experience by Tatiana S. Belysheva, Tatiana V. Nasedkina, Timur T. Valiev, Elena V. Sharapova, Vera V. Semenova, Valentina M. Kozlova, Svetlana N. Mikhaylova, Irina S. Kletskaya, Alexey V. Butuzov, Yana V. Vishnevskaja, Valeria V. Lozovaya, Olga A. Gusarova, Armen O. Tumanyan, Olga A. Malichova, Svetlana R. Varfolomeeva

“…The aim of the study is to determine the role of molecular genetic testing and endoscopic examination in the diagnosis and management of children with HPS. Materials and methods. The retrospective observational study included 17 patients with clinical signs of hereditary polyposes who applied to the L.A. …”
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The Spatial Proximity of CD8⁺ FoxP3⁺PD-1⁺ Cells to Tumor Cells: A More Accurate Predictor of Immunotherapy Outcomes in Advanced Non-Small-Cell Lung... by Zijuan Hu, Zhihuang Hu, Keji Chen, Huixia Huang, Xinyang Zhong, Yaxian Wang, Jiayu Chen, Xuefeng He, Di Shi, Yupeng Zeng, Jiwei Li, Xiaoyan Zhou, Ping Wei

“…Methods: Pretreatment tumor samples from 46 advanced NSCLC patients treated with PD-1/PD-L1 inhibitors were analyzed. …”
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Dosimetric evaluation of a novel automated noncoplanar volumetric modulated arc therapy technique for treating optic nerve sheath meningiomas by Zhenyu Xiong, Zhenyu Xiong, Zhenyu Xiong, Chingyun Cheng, Lili Zhou, Brett Eckroate, Brett Eckroate, Brett Eckroate, Loren Bell, Fredrick Warburton, David Huang, Sabin B. Motwani, Sabin B. Motwani, Charles S. Cathcart, Ke Nie, Ke Nie, Ke Nie, Ning Yue, Ning Yue, Ning Yue, Yin Zhang, Yin Zhang, Yin Zhang

“…Furthermore, HA plans achieved the lowest maximum dose values for the following OARs: lenses, hippocampi, contralateral optic nerve, and contralateral retina (p < 0.05), thereby optimally sparing these critical structures. No significant differences were observed across techniques regarding Dmean, Dmin, PCI, or maximum dose to the ipsilateral optic nerve, ipsilateral retina, and optic chiasm.ConclusionsHA plans demonstrated superior dosimetric performance, ensuring adequate target coverage, reduced PTV hotspots, and better OAR protection compared to coplanar VMAT plans on the Varian TrueBeam and Halcyon. …”
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Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparibResearch in context by Xiaonan Zhang, Natallia Rameika, Lei Zhong, Verónica Rendo, Margus Veanes, Snehangshu Kundu, Sandro Nuciforo, Jordan Dupuis, Muhammad Al Azhar, Ioanna Tsiara, Pauline Seeburger, Shahed Al Nassralla, Viktor Ljungström, Richard Svensson, Ivaylo Stoimenov, Per Artursson, Markus H. Heim, Daniel Globisch, Tobias Sjöblom

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Age-related changes in upper limb motion during typical development. by Cristina Simon-Martinez, Gabriela Lopes Dos Santos, Ellen Jaspers, Ruth Vanderschueren, Lisa Mailleux, Katrijn Klingels, Els Ortibus, Kaat Desloovere, Hilde Feys

“…Here, we investigated age-related differences in UL movement characteristics over the entire movement cycle in TD children.…”
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Clinical and economic impact of the availability of innovative therapies for advanced lung cancer in men in Latin America: a population-based secondary data studyResearch in contex... by Andrés F. Cardona, Natalia Sánchez, Liliana Gutiérrez-Babativa, Leonardo Rojas, Jairo Zuluaga, Stella Martínez, Lucia Viola, Carlos Carvajal, Juliana Bogoya, Laura Prieto-Pinto, Daniel Samacá-Samacá, Antonio Robles, Joshua Kock, Claudio Martín, Luis Corrales, Luis E. Raez, Vladmir Cordeiro de Lima, Suraj Samtani, Oscar Arrieta

“…This study estimated the clinical and economic impact of delays in the approval of innovative therapies for the treatment of advanced lung cancer in men in five Latin American countries. Methods: Using public data, we estimated the relationship between available innovative therapies (AIT) and age-specific mortality rate (ASMR) for Argentina, Brazil, Chile, Colombia, and Mexico through a regression model. …”
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Analysis on omission of checking laparoscopic instruments for hepatological surgery and application evaluation of modified handing-over checking list (肝胆外科手术腹腔镜器械交接过程中漏清点事件分析与改良清点单... by ZHANG Tianqiang (张天强), HUANG Xuanxuan (黄玄玄), YANG Caihui (杨彩慧), FU Li (付立)

“…Objective To analyze the omission events of checking laparoscopic instruments for hepatological surgery, and reduce the incidence of omission events by using modified handing-over checking list. Methods The records of handing over laparoscopic instruments for hepatological surgery from January and December 2022 were retrospectively analyzed, and a quality control team was established to optimize the handing-over checking list according to the analysis on the omission of checking laparoscopic instruments. …”
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Properties and sensory acceptability of creatine-fortified foods using ultra-micronized creatine monohydrate – the KREAFOOD Project by Julián Quintero-Quiroz, Sebastian Botero-Ramirez, Simon Jaramillo-Caro, Natalia Zuluaga, Diego A. Bonilla

“…Here, we present preliminary data as part of The KreaFood Project, a research and innovation project conceptualized by the DBSS Research Division and co-developed with the Center for Advanced Studies in Nutrition and Food – CESNUTRAL at Universidad CES.Methods We assessed the potential of KreaFood products using Creavitalis®, an ultra-micronized creatine monohydrate powder, for developing creatine-fortified beverages and solid foods. …”
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Haemodynamic effects of intra‐aortic balloon pumps stratified by baseline pulmonary artery pulsatility index by George Kalapurakal, Vinh Q. Chau, Teruhiko Imamura, Sanika Tolia, Chris Sciamanna, Gregory P. Macaluso, Anjali Joshi, Jessica Pillarella, Sunil Pauwaa, Muhyaldeen Dia, Tarek Kabbany, James Monaco, Mark Dela Cruz, William G. Cotts, Patroklos Pappas, Antone J. Tatooles, Nikhil Narang

“…We aimed to assess short‐term haemodynamic changes in patients with HF‐CS following IABP support stratified by baseline PAPi. Methods and results This is a single‐centre study of 67 consecutive patients with HF‐CS who underwent IABP placement between 2020 and 2022. …”
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Integration of clinical and serological biomarkers in a nomogram for predicting interstitial lung disease in idiopathic inflammatory myopathies by Zhixia Wang, Jingyun Zhang, Jin Li, Xiaona Mao, Yangyang Li, Dekun Wang, Wenpeng Ge, Jingzhan Li, Changhua Liang, Zhiqiang Zhang

“…Early identification of IIM patients at risk for developing ILD is crucial for timely intervention and personalized treatment, yet the factors contributing to this risk remain inadequately defined. Methods This retrospective study analyzed medical records of 130 patients with IIM from the First Affiliated Hospital of Xinxiang Medical University, China, between August 2018 and July 2023. …”
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Analysis of the impact of rotation error on PTV margins in multiple brain metastases fractionated stereotactic radiotherapy based on single-isocenter multi-target technique by Yuhong Li, Rui Hua, Liling Dai, Wei Chen, Junyuan Zhang, Qian Wang, Yufeng Xu, Tingting Wang

“…We explored the impact of rotational error on planning target volume (PTV) margins, providing clinical evidence for the selection of appropriate PTV margin values.MethodsA total of 161 patients with multiple brain metastases (733 treatments; actual clinical PTV margins ranged from 1~2 mm) were included. …”
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The efficacy and safety of ceftazidime/avibactam or polymyxin B based regimens for carbapenem-resistant Pseudomonas aeruginosa infection: a multicenter real-world and propensity sc... by Wen-Ming Long, Wen-Ming Long, Wei-Xin Xu, Qin Hu, Qiang Qu, Xiao-Li Wu, Ying Chen, Qing Wan, Tian-Tian Xu, Yue Luo, Jian Qu, Jian Qu

“…To address this knowledge gap, a multicenter real-world study was conducted.MethodsCRPA-infected patients treated with PMB or CAZ/AVI-based regimens were enrolled from five hospitals between January 1, 2021, to July 31, 2023. …”
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Recognition and management of community-acquired acute kidney injury in low-resource settings in the ISN 0by25 trial: A multi-country feasibility study. by Etienne Macedo, Ulla Hemmila, Sanjib Kumar Sharma, Rolando Claure-Del Granado, Henry Mzinganjira, Emmanuel A Burdmann, Jorge Cerdá, John Feehally, Fredric Finkelstein, Guillermo García-García, Vivekanand Jha, Norbert H Lameire, Euyhyun Lee, Nathan W Levin, Andrew Lewington, Raúl Lombardi, Michael V Rocco, Eliah Aronoff-Spencer, Marcello Tonelli, Karen Yeates, Giuseppe Remuzzi, Ravindra L Mehta, ISN 0by25 Trial Study Group

“…<h4>Methods and findings</h4>Patients presenting to healthcare centers (HCCs) from 1 October 2016 to 29 September 2017 in the cities Cochabamba, Bolivia; Dharan, Nepal; and Blantyre, Malawi, were assessed utilizing a symptom-based risk score to identify patients at moderate to high AKI risk. …”
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Residential greenness, genetic susceptibility, and asthma risk: Mediating roles of air pollution in UK and Chinese populations by Mingkai Huang, Junjie Wen, Chenyang Lu, Xuliang Cai, Changxing Ou, Zhenan Deng, Xinyi Huang, Enli Zhang, Kian Fan Chung, Jie Yan, Nanshan Zhong, Qingling Zhang

“…This study aimed to explore the association between residential greenness and asthma incidence, while also examining potential mediating pathways and the role of genetic susceptibility. Methods: Data were analyzed from two independent cohorts: the UK Biobank and the Chinese Biomarkers for the Prediction of Respiratory Disease Outcomes (C-BIOPRED) study. …”
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高中生知覺教師支持對其投入學習歷程檔案的影響：以焦慮及自我效能為中介變項 Effect of Perceived Teacher Support on Senior High School Students’ Engagement in the Academic Portfolio: Mediating Roles of Anxiety and Self-e... by 湯家偉 Chia-Wei Tang, 王俐淳 Li-Chun Wang

“…The convenience sampling method was selected for its practical advantages, allowing efficient data collection within the study’s constraints. …”
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Circulating miR-28-5p is overexpressed in patients with sarcopenia despite long-term remission of Cushing’s syndrome: a pilot study by Marta Seco-Cervera, Marta Seco-Cervera, Marta Seco-Cervera, José Santiago Ibáñez-Cabellos, Federico V. Pallardo, Federico V. Pallardo, Federico V. Pallardo, José-Luis García-Giménez, José-Luis García-Giménez, José-Luis García-Giménez, Anna Aulinas, Anna Aulinas, Anna Aulinas, Luciana Martel-Duguech, Susan M. Webb, Susan M. Webb, Susan M. Webb, Elena Valassi, Elena Valassi, Elena Valassi

“…We aimed to identify circulating microRNAs (miRNAs) with differential expression that could be potential biomarkers for the diagnosis and/or prognosis in CS.Patients and methodsThirty-six women in sustained remission for 13 ± 7 years (mean ± SD) from CS, with a median age (IQ range) of 51 (45.2–60) years and mean ± SD BMI of 27 ± 4 Kg/m2, and 36 matched healthy controls were investigated. …”
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Antibiotic stewardship in hematological patients with Escherichia coli and Klebsiella pneumoniae bloodstream infections: evaluating short-course and carbapenem-sparing strategies by Yuqing Cui, Xiaomeng Feng, Ling Pan, Qingsong Lin, Jieru Wang, Sisi Zhen, Yuping Fan, Xin Chen, Yizhou Zheng, Yingchang Mi, Fengkui Zhang, Xiaofan Zhu, Zhijian Xiao, Erlie Jiang, Mingzhe Han, Jianxiang Wang, Sizhou Feng

“…Abstract Background To address the overuse of antibiotics, this study examined the clinical characteristics and outcomes associated with antibiotic duration and carbapenem-sparing regimens in hematological patients with Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) bloodstream infections (BSI). Methods We conducted a retrospective analysis of hematological patients with E. coli or K. pneumoniae BSI from 2017 to 2023. …”
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