Assessing the role of genotype by environment interaction of winter wheat cultivars using envirotyping techniques in North China by Haiwang Yue, Yanbing Wang, Zhaoyang Chen, Jiashuai Zhu, Partha Pratim Behera, Pengcheng Liu, Haoxiang Yang, Jianwei Wei, Junzhou Bu, Xuwen Jiang, Xuwen Jiang, Wujun Ma

“…Accurate yield estimation depends on understanding the patterns of GEI in multi-environment trials (METs).MethodsFrom 2014 to 2018, continuous experiments were conducted in the Heilonggang region of the North China Plain (NCP), evaluating 71 winter wheat genotypes across 16 locations over five years. …”
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Whether exercises and testosterone replacement therapy support a treatment for cardiovascular and atherosclerotic patients with iliac artery stenosis and low total testosterone and... by Sid Solaković, Nina Solaković, Anes Jogunčić, Hajrudin Spahović, Fedja Hajrulahović, Mensur Vrcić, Emir Solaković, Amina Godinjak, Iryna Skrypchenko, Olena Dorofieieva, Kseniia Yarymbash

“…It also attempts to remodel a patient behavioral pattern, optimize ST levels and link them to outcomes and patency of vascular procedures on the iliac segment. …”
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Conception and development of a neurological registry of patients with persistent health impairments following work-related COVID-19 disease in Germany by Schwenkreis, Peter, Kozak, Agnessa, Gonschorek, Andreas, Schmehl, Ingo, Seddigh, Susann, Fürst, Andrea, Wohlfahrt, Kai, Rademacher, Corinna, Engel, Lynn, Wefers, Jacob, Kobes, Kerrin, Kleinmüller, Olaf, Wischnat, Jana, Nienhaus, Albert, Tegenthoff, Martin

“…The design of the post-COVID registry, along with a description of the study population, is detailed in this paper.Methods: The registry includes patients with an occupational disease or accident. …”
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Microbiological aspects and clinical impact of lower lung field tuberculosis: An observational cohort study in Peru by Qi Tan, Chuan-Chin Huang, Roger Calderon, Leonid Lecca, Milagros Mendoza, Gabriela Reyes Rocha, Karen Tintaya, Ximena Tovar, Jia-Yih Feng, Sheng-Wei Pan, Yen-Han Tseng, Jhong-Ru Huang, Zibiao Zhang, Megan B. Murray

“…We aimed to identify microbiological determinants of LLF TB and evaluate treatment responses to optimize care. Methods: We conducted an observational cohort study in Lima, Peru, enrolling adults with microbiologically confirmed pulmonary TB (PTB) diagnosed by GeneXpert MTB/RIF assay or sputum culture. …”
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Path and Practice of Gap Management in National Parks: A Comparison Between China and the US and Inspirations Therefrom by Yun MA, Siyuan HE

“…The research highlights key similarities and differences between the two countries in the aforesaid aspects, and proposes policy recommendations for optimizing gap management in China’s national parks.ResultsIn China, the concept of “gap” in land planning generally refers to small areas within designated zones that do not align with the intended function, such as plots scattering in ecological protection, agricultural, and urban development zones. …”
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Admission systolic blood pressure and short-term outcomes after dual antiplatelet therapy in patients with minor ischemic stroke or transient ischemic attack by Federico De Santis, Eleonora De Matteis, Lucio D’Anna, Michele Romoli, Tiziana Tassinari, Valentina Saia, Silvia Cenciarelli, Chiara Bedetti, Chiara Padiglioni, Bruno Censori, Valentina Puglisi, Luisa Vinciguerra, Maria Guarino, Valentina Barone, Marialuisa Zedde, Ilaria Grisendi, Marina Diomedi, Maria Rosaria Bagnato, Marco Petruzzellis, Domenico Maria Mezzapesa, Vincenzo Inchingolo, Manuel Cappellari, Cecilia Zivelonghi, Paolo Candelaresi, Vincenzo Andreone, Giuseppe Rinaldi, Alessandra Bavaro, Anna Cavallini, Stefan Moraru, Maria Grazia Piscaglia, Valeria Terruso, Marina Mannino, Alessandro Pezzini, Giovanni Frisullo, Francesco Muscia, Maurizio Paciaroni, Maria Giulia Mosconi, Andrea Zini, Ruggiero Leone, Carmela Palmieri, Letizia Maria Cupini, Michela Marcon, Rossana Tassi, Enzo Sanzaro, Giulio Papiri, Giovanna Viticchi, Daniele Orsucci, Anne Falcou, Simone Beretta, Roberto Tarletti, Patrizia Nencini, Eugenia Rota, Federica Nicoletta Sepe, Delfina Ferrandi, Luigi Caputi, Gino Volpi, Salvatore La Spada, Mario Beccia, Claudia Rinaldi, Vincenzo Mastrangelo, Francesco Di Blasio, Paolo Invernizzi, Giuseppe Pelliccioni, Maria Vittoria De Angelis, Laura Bonanni, Giampietro Ruzza, Emanuele Alessandro Caggia, Monia Russo, Agnese Tonon, Maria Cristina Acciarri, Chiara Di Fino, Cinzia Roberti, Giovanni Manobianca, Gaspare Scaglione, Francesca Pistoia, Alberto Fortini, Antonella De Boni, Alessandra Sanna, Alberto Chiti, Marcella Caggiula, Maela Masato, Massimo Del Sette, Francesco Passarelli, Maria Roberta Bongioanni, Manuela De Michele, Stefano Ricci, Raffaele Ornello, Simona Sacco, Matteo Foschi

“…Future studies should further investigate if optimizing blood pressure management may further improve prognosis.…”
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Multifactorial Risk Stratification in Patients with Heart Failure, Chronic Kidney Disease, and Atrial Fibrillation: A Comprehensive Analysis by Mihai Sorin Iacob, Nilima Rajpal Kundnani, Abhinav Sharma, Vlad Meche, Paul Ciobotaru, Ovidiu Bedreag, Dorel Sandesc, Simona Ruxanda Dragan, Marius Papurica, Livia Claudia Stanga

“…This study aims to explore the influence of comorbidities, hypertension severity, anticoagulation strategy, and risk scores on hospitalization outcomes in patients with coexisting HF, CKD, and AF. <b>Materials and Methods:</b> A retrospective case study was conducted on 174 hospitalized patients with HF, CKD, and AF. …”
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Effects of transitional care model on postpartum depression of primiparas (产后延续护理对初产妇产后抑郁的影响) by ZHANG Yongqiang (张勇强), YANG Jingying (杨晶莹), LIU Huiling (刘会玲), XU Yuanle (许远乐), ZHU Kunkun (朱坤坤)

“…Compared with those in the control group, A lower incidence of postpartum depression and higher satisfaction degree were reported in the observation, with a significant difference(P＜0. 01). Conclusion The transitional care model, as a proved way of optimizing quality of postpartum nursing, is effective to relieve the primipara’s negative emotion, improve the sleep quality and reduce the incidence of postpartum depression. …”
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Early hemodynamic impact of SGLT2 inhibitors in overweight cardiometabolic heart failure: beyond fluid offloading to vascular adaptation– a preliminary report by Nadia Salerno, Jessica Ielapi, Angelica Cersosimo, Isabella Leo, Assunta Di Costanzo, Giuseppe Armentaro, Salvatore De Rosa, Angela Sciacqua, Sabato Sorrentino, Daniele Torella

“…Sodium-glucose cotransporter-2 inhibitors (SGLT2i) reduce HF hospitalizations and cardiovascular mortality across ejection fraction (EF) categories, yet their early hemodynamic effects in cardiometabolic HF, and with preserved ejection fraction (HFpEF) in particular, remain underexplored. Methods A prospective, single-center study included 20 consecutive HF patients receiving SGLT2i alongside optimized therapy. …”
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The Combined Effect of Multisensory Stimulation and Therapist Support on Physical and Mental Health of Older Adults Living in Nursing Homes: Pilot Randomized Controlled Trial by Sewar Khatib, Yuval Palgi, Yoni K Ashar, Natalya Polyvyannaya, Pavel Goldstein

“…ObjectiveThis randomized controlled trial examines the specific and combined effects of brief SS and TS interventions on older adults’ physical and mental health and pain intensity levels, among individuals living in nursing homes. MethodsA total of 96 patients aged 65-99 years from a nursing home were randomly assigned to 3 groups: SS, TS, and combined SS+TS interventions, each delivered as four 20-minute sessions. …”
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National and subnational burden of brain and central nervous system cancers in China and global from 1990 to 2021: results from the global burden of disease study 2021 by Shifan Tu, Xiaolu Huang, Xiaoxuan Fan, Yi Zhang, Lan Huang, Kai Li, Xinyue Wang, Yunpeng Gao, Xiaoping Zhao, Zhaoqun Feng

“…Methods Using open data from the GBD 2021 database, we analyzed characteristics of CNS cancer burden in China and globally from 1990 to 2021, including changes in incidence, prevalence, mortality, and DALYs.We employed Joinpoint regression analysis to calculate the average annual percentage change (AAPC) with 95% confidence intervals (95%CI), evaluating temporal trends in CNS cancer burden.A comparative analysis was conducted across multiple dimensions (age, sex, and time periods) to examine differences in CNS cancer burden between China and other world regions. …”
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Trends in Antihypertensive Drug Use and Irrational Prescriptions Among Elderly Patients in China (2016&amp;ndash;2023): A Nationwide Multi-Center Cross-Sectional Survey Study by Hong D, Chen W, Du S, Ren J, Lv D, Shan W, Lu X, Zhao Q

“…While the overall use of first-line antihypertensive drugs remained high, there were differences across subgroups. The increasing rate of contraindicated medications and the identification of high-risk groups and clinical settings provide important insights for optimizing antihypertensive treatment in elderly populations.Keywords: elderly hypertension, antihypertensive medication, irrational prescription, trend analysis, contraindicated medication…”
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Impact of differentiated service delivery models on quality of life among people living with HIV in Uganda– a quasi-experimental study by Benson Nasasira, Grace Banturaki, Nelson Kalema, Joseph Musaazi, Aidah Nanvuma, Stephen Okoboi, Nancy Gathoni Kiarie, Joash Ntenga Moitui, Damazo Kadengye, Jonathan Izudi, Barbara Castelnuovo

“…Methods Records of 1,000 PLHIV enrolled in a 10-year cohort at the Infectious Diseases Institute (IDI) clinic in Kampala, Uganda were retrospectively analyzed. …”
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Efficacy and safety of oxaliplatin-based chemotherapy as first-line treatment in elderly patients with metastatic colorectal cancer: a meta-analysis by Shaoqing Fan, Zeming Zhao, Haiqian Wang, Handong Wang, Wenbo Niu

“…This meta-analysis evaluates the therapeutic benefits and risks of oxaliplatin-based regimens in elderly patients with mCRC, with emphasis on tumor response, survival endpoints, and treatment-related toxicities.MethodsWe systematically reviewed PubMed, Web of Science, Cochrane Library, and Chinese databases (CNKI, Wan Fang) through November 2024 for randomized controlled trials (RCTs) comparing oxaliplatin-based chemotherapy to non-oxaliplatin regimens in patients aged ≥65 with mCRC. …”
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Uncovering abnormal gray and white matter connectivity patterns in Alzheimer’s disease spectrum: a dynamic graph theory analysis for early detection by Juanjuan Jiang, Tao Kang, Ronghua Ling, Yingqian Liu, Jiuai Sun, Yiming Li, Xiaoou Li, Hui Yang, Bingcang Huang, the Alzheimer’s Disease Neuroimaging Initiative

“…This study aimed to improve preclinical AD stratification by integrating dynamic gray-white matter functional connectivity (DFC) and machine learning.MethodsUsing multi-cohort ADNI data [N = 1,415 participants across cognitive normal[CN], SMC, and cognitive impairment [CI]groups],dynamic functional networks were constructed via sliding-window analysis (20–50 TR windows, 98% overlap) of 200 gray matter (Schaefer atlas) and 128 data-driven white matter nodes. …”
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Prognostic Value of Non-Traditional Lipid Indices for In-Hospital Mortality in Patients with Acute Coronary Syndromes by Rustem Yilmaz, Kenan Toprak, Ahmet Karagoz, Osman Can Yontar, Melisa Ucar, Halil Ibrahim Kokcu, Berkant Ozturk, Enes Kaya, Mustafa Yilmaz, Ersoy Öz

“…This study aimed to assess the prognostic value of these non-traditional lipid indices, along with traditional lipid and biochemical markers, for in-hospital mortality in ACS patients. <i>Materials and Methods</i>: This retrospective observational study analyzed data from ACS patients admitted to the coronary care unit (CCU) between January 2019 and September 2024. …”
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Two-Dimensional Mammography Imaging Techniques for Screening Women with Silicone Breast Implants: A Pilot Phantom Study by Isabelle Fitton, Virginia Tsapaki, Jonathan Zerbib, Antoine Decoux, Amit Kumar, Aude Stembert, Françoise Malchair, Claire Van Ngoc Ty, Laure Fournier

“…The mammography of the left breast of a single clinical case was included. Three methods of image acquisition were identified. They were based on misused, recommended, and reference settings. …”
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Predictive Significance of the Monocyte-to-High-Density Lipoprotein Cholesterol Ratio in Post-Percutaneous Coronary Intervention Contrast-Induced Nephropathy Among Patients with Co... by Lin A, Peng Y, Shao J, Chen L, Lin Y

“…Survival analysis showed significant differences in long-term mortality among the three groups (Log rank test, P = 0.032). …”
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Clinical characteristics and prognosis of amyopathic dermatomyositis patients with interstitial lung disease: insights from a retrospective cohort by Yanan Ying, Tingting Wu, Long Wang, Yun Zhang, Yiming Yu, Zaichun Deng, Qunli Ding

“…We aimed to determine the characteristics and prognosis of patients with ADM-ILD to further guide their clinical management. Methods A retrospective cohort study comprising 190 Chinese patients diagnosed with interstitial lung disease (ILD) was conducted. …”
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Evaluation of ctDNA-guided adjuvant therapy de-escalation in head and neck squamous cell carcinoma: a comparative cohort study by Xu Zhang, Qigen Fang, Junhui Yuan, Liyuan Dai, Ruihua Luo, Tao Huang, Tao Huang, Yinfei Wu

“…We evaluated whether ctDNA-directed stratification could optimize locoregional control in HNSCC patients following neoadjuvant chemoimmunotherapy.MethodsIn this comparative cohort study, consecutive HNSCC patients treated with neoadjuvant chemoimmunotherapy were stratified into two management groups: a ctDNA-guided cohort where tumor-informed ctDNA testing determined POCRT administration given only for detectable ctDNA, and a traditional cohort where all patients received PORT, with postoperative chemotherapy decisions made by multidisciplinary team review based on pathologic response status and pretreatment imaging findings. …”
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