The VALTIVE1 study protocol: a study for the validation of Tie2 as the first tumour vascular response biomarker for VEGF inhibitors by Margherita Carucci, Andrew Clamp, Cong Zhou, Chris Hurt, Rosalind Glasspool, Phillip J. Monaghan, Sally Thirkettle, Michael Wheatley, Madia Mahmood, Monica Narasimham, Tracy Cox, Hilary Morrison, Susan Campbell, Annmarie Nelson, Daniella Holland-Hart, Noreen Hopewell-Kelly, Abin Thomas, Catharine Porter, Magdalena Slusarczyk, Alys Irving, Caroline Dive, Richard Adams, Gordon C. Jayson

“…The aim of the VALTIVE1 study is to validate the utility of plasma Tie2 as a vascular response biomarker and to optimise the Tie2-definition of vascular response so that the subsequent randomised discontinuation VALTIVE2 study can be powered optimally. Methods VALTIVE1 is a multi-centre, single arm, non-interventional biomarker study, with a sample size of 205 participants (176 bevacizumab-treated participants + 29 participants receiving bevacizumab and olaparib/PARPi), who are 16 years or older, have FIGO stage IIIc/IV ovarian cancer on treatment with first-line platinum-based chemotherapy and bevacizumab. …”
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Erector spinae plane block versus transversus abdominis plane block with rectus sheath block for postoperative analgesia in laparoscopic hepatectomy: a randomized clinical trial by Mengke Liu, Xuan Mo, Ruonan Zhan, Han Wang, Yangxi Zhao, Yi Zhang

“…Methods Sixty patients scheduled for laparoscopic hepatectomy were randomly divided into two groups: E group received ultrasound-guided ESPB, while the TR group received subcostal TAPB with RSB. …”
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Effect of triple therapy on mortality and cardiovascular risk in patients with moderate to severe COPD: a meta-analysis of randomized controlled trials by Yubing Li, Jun Li, Hongxia Yang, Yong Zhang

“…However, its long-term effects on mortality and cardiovascular safety remain controversial, highlighting the critical need for systematic evidence to inform clinical decision-making. Methods A systematic search of PubMed, Embase, and the Cochrane Library (up to July 2024) identified 13 randomized controlled trials (RCTs) comparing triple therapy with dual therapies (LAMA/LABA or ICS/LABA) in patients with moderate-to-severe COPD. …”
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How Information Exposure Shapes Risk Perceptions and Vaccination Intentions Among Gay, Bisexual, and Other Men Who Have Sex With Men: Cross-Sectional Survey Study by Doug Cheung, Luyao Xie, Lijuan Wang, Siyu Chen, Xinge Li, Zheng Zhang, Xinyue Chen, Shen Ge, Fuk-yuen Yu, Yuan Fang, Zihuang Chen, Zhennan Li, Fenghua Sun, Phoenix Mo, Yingjie Liu, Zixin Wang

“…MethodsWe conducted a cross-sectional survey of mpox-unvaccinated GBMSM in Hong Kong (n=470) and Beijing (n=519) between November 2023 and March 2024. …”
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Predictors of high-acuity outcomes among 10–17-year-olds utilizing pediatric emergency services in Taiwan: a sex-based comparison of male and female adolescents by Mei-Wen Wang, Jiun-Hau Huang

“…Methods We analyzed data from 16,910 non-traumatic pediatric ED visits by adolescents aged 10–17 years at a major tertiary-care hospital in northern Taiwan (2009–2014). …”
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Dietary micronized hemp fiber enhances in vitro nutrient digestibility and cecal fermentation, antioxidant enzyme, lysosomal activity, and productivity in finisher broilers reared... by Tossaporn Incharoen, Tossaporn Incharoen, Manatsanun Nopparatmaitree, Adisak Kongkeaw, Keatisak Soisuwan, Wirot Likittrakulwong, Atichat Thongnum, Nima Norbu, Jigme Tenzin, Natphapat Supatsaraphokin, Juan J. Loor

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The contribution of personalized video feedback to robotic partial nephrectomy training in realistic 3D tumor kidney models: design, production and implementation by Ahmet Furkan Sarıkaya, Kayhan Tarım, Ersin Köseoğlu, Arif Özkan, İbrahim Can Aykanat, Baris Esen, Umut Can Karaarslan, Mustafa Müdüroğlu, Şevval Kanlı, Murat Can Kiremit, Yakup Kordan, Mevlana Derya Balbay, Tarık Esen, Serdar Aydın, Serdar Aydın, Abdullah Erdem Canda, Abdullah Erdem Canda

“…This study investigates the impact of 3D-printed renal models and video-based feedback on skill acquisition in robotic partial nephrectomy training.MethodsForty urology residents without prior robotic surgery experience participated in this study. …”
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Abstract 014: Beveled‐Tip Aspiration Catheters Reduce Stoke Procedure Time And Cost For Large And Medium Vessel Occlusions by Mohamad M. Ezzeldin, Riichi Ota, Eric Riha, Adam Delora, Bader Alenzi, Victoria Gordon, Himanshu Gupta, Rime Ezzeldin, Saif Bushnaq

“…In this study, we aimed to determine whether the utilization of angled‐tip catheters could lead to reduced procedural expenses and shorter time to reperfusion in our patient population. Methods We conducted a retrospective single‐center cohort study involving consecutive patients with acute ischemic stroke due to large and medium vessel occlusions. …”
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A Web-Based Lifestyle-Related Course for People Living With Multiple Sclerosis: Quantitative Evaluation of Course Completion, Satisfaction, and Lifestyle Changes Among Participants... by Maggie Yu, Sandra Neate, Steve Simpson-Yap, Rebekah Davenport, William Bevens, George Jelinek, Jeanette Reece

“…Noncompleters were queried on barriers to course completion. Differences between the 2 study arms were examined using chi-square and 2-tailed t tests. …”
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Research on the association of breast cancer patients’ prognosis with internal mammary sentinel lymph node biopsy by JIA Ruijie, SHI Zhiqiang, ZHANG Qi, LU Yongjin, ZHENG Junsheng, SUN Jing, BI Zhao, SUN Xiao, WANG Yongsheng, QIU Pengfei

“…The purpose of this study was to investigate the prognosis of IMSLNB in early breast cancer. Methods: In this study, a retrospective cohort of 7 949 patients with breast cancer from January 1, 2016 to December 31, 2021 was analyzed. …”
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The influence of the interfacing angle between the pedicle screw and support rods on the clinical outcomes after posterior lumbar-sacral topping-off surgery: A retrospective clinic... by Mingzheng Zhao, Honghao Yang, Shixuan Guo, Fengqi Cheng, Yaoshen Zhang, Yong Hai, Yuzeng Liu

“…Purpose This study aims to assess the incidence of postoperative screw/rod mismatch and its effect on clinical outcomes, including (1) Adjacent segment degeneration (ASD); (2) Screw loosening and rod breakage; (3) Visual analogue scale (VAS) scores; and (4) Oswestry disability index (ODI) scores. Methods This study is a monocentric retrospective observational study that included patients diagnosed with lumbosacral degenerative disease and underwent topping-off surgery. …”
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Psychopathological Comorbidities in Children and Adolescents with Feeding and Eating Disorders: An Italian Clinical Study by Maria Califano, Jacopo Pruccoli, Oliviero Cavallino, Alessandra Lenzi, Antonia Parmeggiani

“…This study explores the psychiatric comorbidities associated with FED, focusing on common etiopathogenetic factors and their clinical implications. Methods: Data were retrospectively collected from the Italian Regional Center for FED in the Emilia-Romagna Region between June 2023 and April 2024. …”
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Analyzing Insights of Super-Response in Cardiac Resynchronization Therapy with Fusion Pacing by Alexandra-Iulia Lazăr-Höcher, Simina Crișan, Cristina Văcărescu, Samuel Nistor, Adelina Andreea Faur-Grigori, Andreea Cozgarea, Petru Baneu, Liviu Cirin, Laurențiu Brăescu, Larissa Dăniluc, Dan Gaiță, Constantin-Tudor Luca, Dragoș Constantin Cozma

“…Fusion pacing may be particularly beneficial in selected patients and understanding the structural and functional differences between responders could guide future optimization strategies. …”
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Multigenetic pharmacogenomics–guided treatment shows greater improvements on motor symptoms compared to usual therapy in Parkinson’s disease: a small real-word prospective cohort s... by Yifan Li, Mao Li, Miao Wang, Jiarui Yao, Fengzhu Li, Siyu Chen, Xi Yin, Zhongbao Gao

“…In this study, we conducted a prospective cohort investigation to evaluate the potential benefits of MPGT on motor symptoms in PD patients.MethodsA total of 28 patients with PD were followed for 4 weeks. …”
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Gantry-based pencil beam scanning proton therapy for uveal melanoma: IMPT versus proton arc therapy by Hang Qi, Lei Hu, Sheng Huang, Yen-Po Lee, Francis Yu, Qing Chen, Yunjie Yang, Minglei Kang, Huifang Zhai, Milo Vermeulen, Andy Shim, Peter Park, Xuanfeng Ding, Jun Zhou, David H. Abramson, Jasmine H. Francis, Charles B. Simone, Christopher A. Barker, Haibo Lin

“…Abstract Background This study reports the single-institution clinical experience of multifield pencil beam scanning (PBS) intensity-modulated proton therapy (IMPT) and dosimetric comparison to proton arc for uveal melanoma (UM) in a regular PBS gantry room. Methods Eleven consecutive UM patients were treated with IMPT to 50 Gy in 5 fractions. …”
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Independent and combined relationships between nighttime light exposure, air pollution, PM2.5 constituents, greenness and diabetes or high blood sugar: a national prospective cohor... by Siyu Qing, Ziyue Liang, Yifang Liang, Renfang Zhang, Xiaojie Chen, Wenqing Wang, Chunejie Xu, Fei Lin, Yongbin Wang

“…Methods Using data from the China Health and Retirement Longitudinal Study (CHARLS, 2011–2015), we included 11,865 participants aged ≥ 45 years without baseline D/HBS. …”
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Multi-omics analysis identifies a liquid-liquid phase separation-related subtypes in head and neck squamous cell carcinoma by Peng-Lei Zhai, Peng-Lei Zhai, Meng-Min Chen, Meng-Min Chen, Meng-Min Chen, Qi Wang, Jing-Jun Zhao, Xiao-Mei Tang, Cui-Ni Lu, Jia Liu, Qin-Xin Yang, Ming-Liang Xiang, Qing-Hai Tang, Biao Gu, Shu-Ping Zhang, Si-Ping Tang, Da Fu, Da Fu

“…Therefore, we aimed to categorize patients with HNSCC based on LLPS-related genes and explored their multidimensional heterogeneity.MethodsWe integrated the transcriptomic data of 3,541 LLPS-related genes to assess the LLPS patterns in 501 patients with HNSCC within The Cancer Genome Atlas cohort. …”
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Efficacy and safety of traditional Chinese medicine for post-COVID-19 syndrome: a systematic review and meta-analysis by Yiting Wang, Xiao Li, Huaizheng Hui, Dianxing Yang

“…This study aimed to evaluate the clinical efficacy and safety of Chinese herbal medicine (CHM) in treating post-COVID-19 syndrome through a systematic review and meta-analysis of randomized controlled trials (RCTs). Methods Five electronic databases (PubMed, Embase, Web of Science, Cochrane Library and CNKI) were systematically searched up to March 15, 2025. …”
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Construction and practice of information platform for blood collection in outpatient clinics in the public health emergencies (突发卫生公共事件下门诊采血中心信息化平台的构建及应用)... by ZHAO Lu (赵路), LI Qianqian (李倩倩), CUI Hailing (崔海伶)

“…Objective To investigate the construction and practice of information platform for blood collection in outpatient clinics in the public health emergencies. Methods The comprehensive informatization construction had been launched since December 2019 in Hospital A(study group), and an information platform was constructed to regulate the blood collection in outpatient clinics. …”
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Improving pain, function and quality of life in end-stage knee osteoarthritis: a patient-preference cohort study on whole-body vibration and exercise as bridging therapies for tota... by Kendrew Yu-Hei Choi, Wai-Wang Chau, Linda Man-Kuen Li, Sammie Yuk-Lam Ng, Boie Po-Yee Lo, Michael Tim-Yun Ong, Patrick Shu-Hang Yung

“…This study compared the efficacy of supervised exercise therapy alone and combined with WBV in reducing pain and improving function in this population. Methods In this prospective cohort study, 555 patients with end-stage knee OA awaiting TKR were allocated to three groups: Exercise (n = 227), Exercise + WBV (n = 127), and Control (n = 201). …”
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