Investigating the dynamics of intracranial pressure and cerebral autoregulation during extracorporeal cardiopulmonary resuscitation using a porcine model by Tito Porras, Mingfeng Cao, Jessica Briscoe, Jin Kook Kang, Ifeanyi David Chinedozi, Zachary Darby, Shivalika Khanduja, Anastasios Bezerianos, Nitish Thakor, Glenn Whitman, Debraj Mukherjee, Steve Keller, Sung-Min Cho

“…However, the impact of ECPR’s rapid, non-pulsatile restoration of cerebral blood flow on intracranial physiology and autoregulation remains poorly understood. Methods: Using a porcine model, this study investigated the dynamics of intracranial pressure (ICP), cerebral autoregulation, and pulsatility during key experimental phases: Baseline, Fibrillation, ECMO, and ROSC. …”
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Impact of tumor size and peritumoral edema on outcomes and complications in anterior midline skull base meningiomas by Lina-Elisabeth Qasem, Dilara Soydas, Ali Al-Hilou, Jan Oros, Katharina J. Weber, Fee Keil, Daniel Jussen, Vincent Prinz, Volker Seifert, Peter Baumgarten, Gerhard Marquardt, Marcus Czabanka

“…Research question: This study evaluates the impact of tumor size and peritumoral edema on clinical outcome. Material and methods: A retrospective analysis of 109 patients who underwent resection between 2012 and 2022 was conducted. …”
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Superior electron transport in the single-crystalline TiCoSb-based half-Heuslers by Sheng Ye, Shizhen Zhi, Xiaojing Ma, Xin Bao, Peng Zhao, Jinxuan Cheng, Sichen Duan, Chenhao Lin, Zuoxu Wu, Shanquan Chen, Jiamin Qiu, Li Yin, Xuanhe Zhang, Yifan Zhou, Feng Jiang, Zuhuang Chen, Feng Cao, Yuhao Fu, Qian Zhang, Jun Mao

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Blood loss, complications, and the role of suction drains in shoulder arthroplasty: a systematic review and meta-analysis by Luiz Henrique Oliveira Almeida, MD, Vitor La Banca, MD, Octavio Matsumoto, MD, Arthur Steven de Sá, MD, Ana Victória Palagi Viganó, MD, Gabriel Kalman, MedStud, Felipe Fernandes Gonzalez, MD, MSc, Guilherme Henrique Vieira Lima, MD, Joel Murachovsky, MD, PhD, Roberto Yukio Ikemoto, MD, PhD

“…Given the conflicting evidence in the literature about suction drains in shoulder arthroplasty, this study aims to evaluate their efficacy in reducing complications and in consequence the need for hospital stay and reoperations. Methods: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. …”
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Electron microscopic findings predict clinical outcomes in patients with non‐ischaemic cardiomyopathy by Rie Higuchi, Shozo Konishi, Tomohito Ohtani, Fusako Sera, Misato Chimura, Machiko Kanzaki, Themistoklis Katsimichas, Masahiro Seo, Tetsuya Watanabe, Takahiro Okumura, Toyoaki Murohara, Hiroyuki Takahama, Atsushi Okada, Chisato Izumi, Masaru Hatano, Issei Komuro, Yoshihiko Ikeda, Yoshihiro Asano, Hatsue Ishibashi‐Ueda, Yasushi Sakata

“…This study aimed to examine the association between electron microscopic findings and outcomes in patients with NICM. Methods In this multicentre, prospective, observational study, 170 patients with NICM with reduced ejection fraction (EF) < 40%, scheduled for diagnostic endomyocardial biopsy and optimization of medical therapies, were enrolled. …”
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MRI guided online adaptive radiotherapy and the dosimetric impact of inter- and intrafractional motion in patients with cervical cancer by Shouliang Ding, Zun Piao, Meining Chen, Fanghua Li, Yongbao Li, Biaoshui Liu, Hongdong Liu, Xiaoyan Huang, Junyun Li

“…Purpose: The aim of this study was to evaluate the inter- and intrafractional organs motions and dosimetric advantages of MRI guided online adaptive radiotherapy for cervical cancer. Methods: A total of 150 fractions treated on the 1.5 T Unity MR-Linac were included in this study. …”
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Prevalence of chronic kidney disease among Chinese adults with diabetes: a nationwide population-based cross-sectional studyResearch in context by Weiping Jia, Rong Yu, Limin Wang, Dalong Zhu, Lixin Guo, Jianping Weng, Hong Li, Mei Zhang, Xiaoqi Ye, Zhiguang Zhou, Dajin Zou, Qiuhe Ji, Xiaohui Guo, Yinan Zhang, Dong Lang, Jiarui Wu, Jing Wu, Xuhong Hou, Xiaohui Guo, Kai Wu, Liming Chen, Demin Liu, Guangyao Song, Linyi Shu, Jing Yang, Yan Wang, Dongmei Li, Qiansha Guo, Ling Li, Na Wu, Yadong Sun, Huifang Cheng, Hongyu Kuang, Huijuan Zhang, Weiping Jia, Xuhong Hou, Dalong Zhu, Jian Zhu, Hong Li, Fenping Zheng, Qiu Zhang, Honglin Hu, Gang Chen, Xingquan Yang, Xiaoyang Lai, Jianping Liu, Li Chen, Ming Dong, Zhigang Zhao, Jian Liu, Guangda Xiang, Junxia Zhang, Zhiguang Zhou, Jian Peng, Jianping Weng, Longyi Zeng, Yuzhen Liang, Guoqiao Li, Kaining Chen, Leweihua Lin, Qifu Li, Qingfeng Cheng, Xingwu Ran, Dawei Chen, Hong Li, Xin Nian, Lihui Yang, Shuyou Meng, Jing Xu, Junhong Long, Jing Liu, Qi Zhang, Qingxiang Dai, Xiaomin Xie, Guirong Bai, Jun Li, Tao Li, Zhong Dong, Tao Zhang, Sijia Liu, Yong Yang, Kun Geng, Wenlong Zheng, Zhihong Li, Hui Wang, Zuojun Wu, Miao Wang, Jixin Sun, Jianwei Zhou, Jun An, Huaqing Shen, Yanfang Li, Zeping Ren, Xiuli Xue, Shaohui Jia, Yongping Zheng, Jiaoxia Li, Yonggang Qian, Ping Ma, Yan Su, Liang Cao, Xuyi Yang, Guowei Pan, Guangzhi Pan, Ling Jin, Quanfu Yu, Yunfei Liu, Yingli Zhu, Zhifang Cheng, Jun Yang, Chundi Jia, Qing Wang, Shichun Yan, Jingyang Huang, Yumei Chi, Li Zhang, Ruifa Pang, Yan Shi, Yan Lu, Yiling Wu, Jie Yu, Chunxiang Wu, Jinyi Zhou, Yunxia Wu, Ning Zhang, Jing Sun, Xiumei Tian, Jieming Zhong, Jingying Chen, Kaixu Xie, Lingjuan Fu, Xiaohua Wang, Yeji Chen, Ling Zeng, Zhenqian Cao, Maomin Yang, Biao Hu, Wenling Zhong, Qingyan Liu, Zhiding Huang, Qingbin Lai, Yuyu Zhang, Liping Zhu, Yujing Zhao, Wuming Tao, Yonghai Tu, Lin Zhou, Xiaolei Guo, Benzheng Chai, Liping Ding, Yuewei Zou, Dongzhi Li, Li Hua, Shixian Feng, Jianli Guo, Wanguang Liu, Qingxiang Li, Yunzhi Zheng, Minli Xu, Lan Zhang, Chunbo Li, Yingchao Wan, Chi Hu, Shengping Xu, Biyun Chen, Huilin Liu, Xiaojia Bian, Wenwei Chen, Honghua Li, Yanjun Xu, Fan Weng, Hong Wu, Weijin Zhang, Liankai Zhu, Jun Meng, Jin Yang, Yongsong Zeng, Gaoke Zhai, Lingfeng Qin, Yi Lu, Zhenwang Fu, Shukuan Wu, Caigang Li, Na Wang, Lianfen Chen, Xianbin Ding, Qi Zhou, Yiling Xie, Rui Chen, Dongsheng Yang, Ying Deng, Youping Hu, Bo Huang, Ping Wang, Peng Cai, Changyan Peng, Xiaofang Chen, Ling Li, Liang Xiao, Chenglin Wang, Chaogang Tan, Daobin Chen, Min Chen, Mingfang Qin, Zhaomin Lei, Jianzhi Qiu, Wei Yu, Yunfei Li, Guoxia Bai, Ying Wang, Lin Qiu, Ning Wang, Xudong Zhao, Ani Yan, Jianfei Liu, Tingcai Wang, Kaihua Hao, Zaihong Zhang, Zhanqi Xian, Tenghuan Ma, Zhihua Xu, Yi Yang, Hongli Wang, Rong Li, Zhonggang Zhao, Caixia Fan, Purhati, Hongjun Xu, Liping Gao

“…Interpretation: Chinese adults with diabetes are heavily burdened by CKD. Optimized CVH is central to reducing CKD risk across different subpopulations. …”
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SMART accelerates rate of cognitive gains in service members with mTBI and PTSD by Erin Venza, Jeffrey S. Spence, Jennifer Zientz, Cole Devlin, Jason Bailie, Jason Bailie, Jason Bailie, Andrew Darr, Andrew Darr, Andrew Darr, Ida Babakhanyan, Ida Babakhanyan, Ida Babakhanyan, Sandra Bond Chapman

“…The study also examined the relationship between PTSD symptom severity and cognitive outcomes.MethodsA total of 148 ADSMs with mTBI and persistent cognitive complaints were randomized to receive either SMART (20 h over 4 weeks) or SCORE (60 h over 6 weeks). …”
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Global, regional and national burdens of alcoholic cardiomyopathy among the working-age population, 1990–2021: a systematic analysis by Zhongkai Wang, Changyong Wu, Bingqing Zhang, Huang Sun, Wenjie Liu, Yuan Yang, Ying Gu, Lifei Pu, Lihui Zheng, Suli Bao, Yihua Luo, Ruijie Li, Yunzhu Peng

“…The aim of this study was to inform strategies to combat this preventable yet escalating health issue. Methods We calculated estimated annual percentage changes (EAPCs) to quantify the dynamics of prevalence, deaths, and disability-adjusted life years (DALYs) for ACM. …”
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Assessment of health-related quality of life of children with idiopathic nephrotic syndrome and their caregivers in China by Xia Wang, Danny Junyi Tan, Lejing Guan, Yifei Shao, Jingjing Wang, Chunyue Feng, Haidong Fu, Huijun Shen, Xiujuan Zhu, Abdul Rafay, Jianhua Mao, Guannan Bai

“…Additionally, the study aimed to evaluate the HRQoL and caregiving burden of their caregivers and investigate the correlation between the HRQoL of the children and that of their caregivers. Methods This study recruited 181 children diagnosed with INS from Children’s Hospital, Zhejiang University School of Medicine in China. …”
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Vitamin D Deficiency Is Common in Ghana despite Abundance of Sunlight: A Multicentre Comparative Cross-Sectional Study by Samuel Asamoah Sakyi, Maxwell Hubert Antwi, Linda Ahenkorah Fondjo, Edwin Ferguson Laing, Richard K. Dadzie Ephraim, Alexander Kwarteng, Benjamin Amoani, Seth Christopher Appiah, Bright Oppong Afranie, Stephen Opoku, Tonnies Abeku Buckman

“…Methods and Results. In a cross-sectional study, a total of five hundred (500) healthy blood donors from three geographical areas in Ghana were enrolled. …”
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Exploring the ability of plasma pTau217, pTau181 and beta-amyloid in mirroring cerebrospinal fluid biomarker profile of Mild Cognitive Impairment by the fully automated Lumipulse®... by Marcella Catania, Claudia Battipaglia, Alberto Perego, Erika Salvi, Emanuela Maderna, Federico Angelo Cazzaniga, Paolo M. Rossini, Camillo Marra, Nicola Vanacore, Alberto Redolfi, Daniela Perani, Patrizia Spadin, Maria Cotelli, Stefano Cappa, Naike Caraglia, Pietro Tiraboschi, Fabrizio Tagliavini, Giuseppe Di Fede

“…All the biomarkers, except Aβ40, showed differences in A+ vs. A-, A+T+ vs. A-T- and A+T- vs. …”
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Construction of a risk prediction model for pulmonary infection in patients with spontaneous intracerebral hemorrhage during the recovery phase based on machine learning by Jixiang Xu, Yuan Li, Fumin Zhu, Fumin Zhu, Xiaoxiao Han, Liang Chen, Yinliang Qi, Yinliang Qi, Xiaomei Zhou, Xiaomei Zhou

“…Accurate prediction of PI risk is crucial for early intervention and optimized clinical management. The aim of this study was to develop a machine learning (ML) model for predicting PI risk in patients during the recovery phase of deep SICH and to investigate the contributions of individual risk factors through explainable artificial intelligence techniques.MethodsWe conducted a retrospective study involving 649 patients diagnosed with PI during the recovery phase of deep SICH between 2021 and 2023. …”
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The impact of obesity and weight loss treatment on metabolic parameters, cardiovascular autonomic and sensory nerve function and in vitro fertilization outcomes in infertile women:... by Anna Vágvölgyi, Viktor Vedelek, Nóra Keller, Dalma Szöllősi, Szilvia Lada, Attila Nemes, Péter Kempler, Adrienn Menyhárt, István Baczkó, Tamás Várkonyi, Csaba Lengyel, János Zádori

“…Our study aimed to analyze the effects of preconceptional weight loss in infertile women with obesity on peripheral sensory and cardiovascular autonomic nerve function, metabolic parameters, and the success of in vitro fertilization (IVF).MethodsA retrospective cohort study included women with obesity and infertility undergoing weight optimization before IVF, alongside age-matched controls. …”
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Clinical Characteristics of EGPA Patients in Comparison to GPA Subgroup with Increased Blood Eosinophilia from POLVAS Registry by Anna Drynda, Agnieszka Padjas, Krzysztof Wójcik, Radosław Dziedzic, Grzegorz Biedroń, Katarzyna Wawrzycka-Adamczyk, Anna Włudarczyk, Joanna Wilańska, Jacek Musiał, Zbigniew Zdrojewski, Zenobia Czuszyńska, Anna Masiak, Maria Majdan, Radosław Jeleniewicz, Hanna Augustyniak-Bartosik, Katarzyna Jakuszko, Magdalena Krajewska, Alicja Dębska-Ślizień, Hanna Storoniak, Barbara Bułło-Piontecka, Witold Tłustochowicz, Joanna Kur-Zalewska, Małgorzata Wisłowska, Piotr Głuszko, Marta Madej, Ewa Jassem, Iwona Damps-Konstańska, Eugeniusz Kucharz, Marek Brzosko, Marcin Milchert, Anna Hawrot-Kawecka, Joanna Miłkowska-Dymanowska, Paweł Górski, Anna Lewandowska-Polak, Joanna Makowska, Joanna Zalewska, Lech Zaręba, Stanisława Bazan-Socha

“…To characterize the eosinophilic granulomatosis with polyangiitis (EGPA) population from the POLVAS registry depending on ANCA status and diagnosis onset, including their comparison with the granulomatosis with polyangiitis (GPA) subset with elevated blood eosinophilia (min. 400/μl) (GPA HE) to develop a differentiating strategy. Methods. A retrospective analysis of the POLVAS registry. …”
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Long-Term Outcomes of Patients Undergoing Conversion Surgery After Induction Chemotherapy: Turkish Oncology Group Study by Furkan Ceylan, Selin Aktürk Esen, Olçun Ümit Ünal, Ferit Aslan, İlknur Deliktaş Onur, Öztürk Ateş, Erkut Demirciler, İlkay Tuğba Ünek, Ahmet Gülmez, Esra Özen Engin, Semra Taş, Gamze Gököz Doğu, Melih Şimşek, Hacı Mehmet Türk, Ali İnal, Gökhan Şahin, Haydar Çağatay Yüksel, Ateş Kutay Tenekeci, Mutlu Hızal, Mehmet Ali Nahit Şendur, Doğan Uncu

“…This study aimed to evaluate the efficacy and safety of integrating biological therapies with fluorouracil-based induction chemotherapy in patients with isolated liver mCRC who subsequently underwent curative resection of both the primary tumor and liver metastases. <i>Materials and Methods:</i> This multicenter, retrospective study, conducted by the Turkish Oncology Group (TOG), included 116 patients from 11 tertiary centers who underwent conversion surgery following induction chemotherapy between 2009 and 2024. …”
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From colorless to pink: Structural insights into vitamin B12-induced color change in monoclonal antibodies by Kai-feng He, Hao-dong Cui, Wen-hui Deng, Na Xing, Guo-jian Liu, Abdallah Iddy Chaurembo, Li-dan Fu, Yuan Li, Xin-yue Tong, Han-bin Lin, Chun-he Wang

“…This study investigated the mechanism linking this color change to Vitamin B12 (VB12), which converts to hydroxycobalamin (OH-Cbl) under light and binds covalently to cysteine residues in antibodies via cobalt-sulfur bonds. Methods: Three batches of IgG1 antibodies (SP1, SP2, and NL)—were expressed in CHO cells, exposed to light, and purified. …”
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RAC2 inhibition enhances tumor sensitivity to NK cell-mediated cytotoxicity by Lin Li, Hui Guo, Jie Hu, Lei Cui, Zining Wang, Feifei Xu, Xiaojuan Wang, Huanling Zhang, Chunyuan Xie, Yongxiang Liu, Xiaojun Xia, Zixuan Guo, Heping Li, Tiantian Wang, Ruhui Yao, Huan Jin, Yanxun Lin

“…Identification of molecular mechanisms by which tumor cells evade from NK cell-mediated killing may offer novel therapeutic strategies for potentiating NK-based cancer immunotherapy.Methods An in vitro tumor-NK cell co-culture system was employed to identify the most significantly altered genes in tumor cells following NK cell interaction. …”
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How sustainable are hypocaloric and balanced diets for weight loss? by Ramona De Amicis, Andrea Foppiani, Alessandro Leone, Federica Sileo, Francesca Menichetti, Sara Paola Mambrini, Marta Pellizzari, Massimiliano Tucci, Daniela Martini, Cristian Del Bo, Patrizia Riso, Simona Bertoli, Alberto Battezzati

“…Objective To compare conventional hypocaloric and balanced weight-loss diets with the sustainable EAT-IT diet, investigating their alignment, the influence of BMI and sex on EAT-IT adherence, to optimize the EAT-IT diet for weight management. Methods 4032 patients (72% female, median age 49y, BMI 29 kg/m2) received hypocaloric diets based on Mediterranean principles (51% carbohydrates, 31% lipids, 0.9 g/kg body weight protein, 17 g/1000 kcal fiber), following Italian dietary guidelines. …”
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Intravenous immunoglobulin therapy: usage patterns and response to treatment in Qatar over ten years by Salma A. Taha, Sherin Thalappil, Ramzy M. Ali, Haajra Fatima, Asaad Omer A. Imameldin, Sami Aqel, Ahmed M. Abdelaal, Timo Siepmann, Timo Siepmann, Jessica Barlinn, Jessica Barlinn, Maryam A. Al-Nesf

“…Further research is warranted to inform local guidelines and optimize IVIg therapy outcomes.…”
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