Opioid Use Following Primary Unilateral Total Knee Arthroplasty Varies With Age by Shah Fahad, MD, Jason A. Bryman, MD, Michael A. Behun, MD, Maryam Salimi, MD, Olivia Vyge, MS, Nina Rosen, BS, Todd Miner, MD, Jason M. Jennings, MD, DPT

“…We hypothesize that older patients consume fewer narcotic medications than younger patients following primary unilateral total knee arthroplasty (TKA). Methods: We retrospectively reviewed 506 primary unilateral TKA patients for perioperative opioid utilization. …”
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Effectiveness, Utility, and Economic Analysis of Three-drug Treatment vs Two-drug Treatment in Chronic Obstructive Pulmonary Disease Patients by Aamir A Syed, Subhranshu Panda, Aleemuddin NM

“…This study aimed to evaluate the effectiveness, utility, and economic analysis of a three-drug treatment vs a two-drug treatment in COPD patients. Materials and methods: An observation was conducted at a superspecialty hospital in Hyderabad. …”
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Learning Curve of Third-generation Minimally Invasive Chevron-Akin Osteotomy for Hallux Valgus Correction in Asian Population: A Retrospective Cohort Study by Ramesh Radhakrishnan, Adriel YW Tay, Kae Sian Tay, Nicholas EM Yeo

“…Objective: This study aims to evaluate the learning curve of third-generation MICA osteotomy for HV correction in an Asian population and to determine the number of cases required to achieve surgical expertise. Methods: A retrospective cohort study was conducted on 49 patients who underwent MICA by a single surgeon at a tertiary institution between January 2018 and April 2020. …”
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The Value of Combining Carbon Dioxide Gap and Oxygen-Derived Variables with Lactate Clearance in Predicting Mortality after Resuscitation of Septic Shock Patients by Walid Ahmed, Mohamed Laimoud

“…Methods. A prospective observational study was conducted to evaluate and validate combining CO2 gap and oxygen-derived variables with lactate clearance during early hours of resuscitation of adults presenting with septic shock. …”
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Regional aspects of fetal morphometry depending on climatic factors in a temperate continental climate by E. M. Iutinskiy, L. M. Zheleznov, S. A. Dvoryanskiy

“…To identify the relationship between climatic conditions, morphometric parameters of the fetus and the weight of the newborn in the temperate continental climate of the Kirov region.Object and methods. The study included 1,200 pregnant women without pronounced obstetric and extragenital pathology who underwent at least two ultrasound examinations during pregnancy. …”
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NUTRIENT SUPPORT OF PREGNANT WOMEN'S DIET AND ITS ROLE IN THE PREVENTION OF GESTATIONAL COMPLICATIONS AND REDUCTION OF ADVERSE PERINATAL OUTCOMES by Ирина Борисовна Фаткуллина, Наталья Алексеевна Стеценко, Евгений Мусинович Гареев

“…Based on the data obtained, reliable significant differences were revealed between the group receiving nutritional support and the control group. …”
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Is Topical Tranexamic Acid Effective in Reducing Hematoma and Seroma in Breast Surgery? A Systematic Review and Meta-analysis by Ammar S.A. Hashemi, MD, Sara M. Hussein, MD, Zainab H. Alshehab, Abdullah A. Al Qurashi, MD, Lucas Kreutz-Rodrigues, MD, Basel A. Sharaf, MD, DDS, FACS

“…However, evidence on the efficacy of topical TXA in breast surgery remains sparse. Methods:. This systematic review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. …”
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Effect of breed, sex, and age on the body and internal organ weight of chickens for food security in resource-poor communities of KwaZulu-Natal, South Africa by Thando Tenza, Thando Tenza, Lindokuhle Christopher Mhlongo, Cyprial Ndumiso Ncobela, Zikhona Rani

“…Understanding these factors is important for optimizing poultry production and enhancing food security in such environments.MethodsA total of 120 chickens were used, comprising three breeds: broilers (n=40), Potchefstroom Koekoek (n=40), and a non-descriptive breed (n=40). …”
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Fecal microbiota transplantation for chronic constipation: a systematic review and meta-analysis of clinical efficacy, safety, and microbial dynamics by Ke Wang, Chun Gao, Li Zhu, Min Chen, Yi Xin Tong, Sheng Zhang

“…This systematic review and meta-analysis evaluate the efficacy, safety, and gut microbial dynamics of FMT in adults with chronic constipation.MethodsWe systematically searched PubMed, Embase, Web of Science, and Cochrane Library up to January 2025, identifying 1,072 records. …”
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Effects of Antibiotic De-Escalation on Outcomes in Severe Community-Acquired Pneumonia: An Inverse Propensity Score-Weighted Analysis by Diego Viasus, Gabriela Abelenda-Alonso, Juan Bolivar-Areiza, Carlota Gudiol, Jordi Carratalà

“…<b>Objective</b>: This study aimed to assess the effect of antibiotic de-escalation on 30-day mortality, duration of intravenous (IV) antibiotic therapy and length of hospital stay (LOS) in severe community-acquired pneumonia (sCAP). <b>Methods</b>: We performed a retrospective analysis of prospectively collected data from a cohort of adults diagnosed with sCAP and microbiologically confirmed etiology between 1995 to 2022. …”
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Real-world insights into safety, tolerability, and predictive factors of adverse drug reactions in treating idiopathic pulmonary fibrosis with pirfenidone and nintedanib by Alessio Provenzani, Daniele Leonardi Vinci, Miriam Alaimo, Salvatore Di Maria, Fabio Tuzzolino, Gaetano Floridia, Roberta Di Stefano, Anna Carollo, Adriana Callari, Piera Polidori, Patrizio Vitulo

“…Design: A retrospective observational study was conducted on 531 IPF patients treated at IRCCS ISMETT with either pirfenidone or nintedanib. Methods: Eligible patients were selected based on the logged monthly dispensations provided by the pharmacy service for both therapies. …”
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A Comparison of the Safety and Efficacy of Remimazolam and Dexmedetomidine for Sedation in Surgical Patients Under Regional Anesthesia: A Meta-Analysis of Randomized Controlled Tri... by Hyo-Seok Na, Sang-Hi Park, Bon-Wook Koo, Seunguk Bang, Hyun-Jung Shin

“…<i>Background and Objectives</i>: This meta-analysis compares the safety and efficacy of remimazolam and dexmedetomidine for sedation during regional anesthesia, focusing on respiratory and hemodynamic outcomes. <i>Materials and Methods</i>: A systematic search of CENTRAL, Embase, PubMed, Scopus, and Web of Science up to November 2024 identified randomized controlled trials (RCTs) comparing remimazolam with dexmedetomidine. …”
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Reducing fluoroscopy time during cardioverter-defibrillator implantation, performed with considering of myocardium perfusion scintigraphy results in patients with coronary artery d... by T. A. Atabekov, R. E. Batalov, S. N. Krivolapov, M. S. Khlynin, S. I. Sazonova, A. D. Shvarzman, G. Zh. Suranova, S. V. Popov

“…Implantable cardioverter­defibrillator (ICD) implantation technique optimization in patients with coronary artery disease (CAD) in order to reduce fluoroscopy time and total radiation dose to staff.Material and methods. …”
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6-mercaptopurine Metabolites as Predictors of Neutropenia and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia by Ebrahim Salehifar, Omid Abed Khojasteh, Seyed Jalal Hosseinimehr, Hossein Karami, Mohammad Naderi Sorki, Hadi Darvish-Khezri, Kimia Karami

“…Objectives: This study aimed to assess the metabolites of 6-MP and their relationships with hepatotoxicity and neutropenia in the erythrocytes of children with ALL. Methods: A total of 32 children with ALL treated with 6-MP were included in this study. …”
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Abdominoplasty in gastric bypass patients: anthropometric profile, comorbidities, and complications by Simone Corrêa Rosa, Jefferson Lessa Soares de Macedo, Flávio Gondim Freitas, João Luiz Darques Ferreira, Lucas Ribeiro Canedo, Luiz Augusto Casulari

“…Introduction: Patients who undergo vertical-banded gastroplasty- Roux-en-Y gastric bypass (VBG-RYGB) have significant weight loss, and abdominoplasty (AP) is an effective corrective surgery for removing excess skin. Methods: A prospective study conducted from January 2011 to December 2016 in a public hospital evaluated patients who underwent AP after VBG-RYGB. …”
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Current status of vocational delay of gratification among practicing nursing students and its influencing factors: a cross-sectional study by Tianyu Chu, Xian Chen, Qian Zhang, Juanjuan Yang, Hui Zhou, Yibo Wu, Jie Jiao

“…The study conducted in three hospitals in Anhui Province may limit the generalizability of the results due to regional differences in education and practice. Nonetheless, this study provides important insights for optimizing the career development and retention of nursing interns. …”
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Combined Effects of Postactivation Performance Enhancement and Caffeine Intake on Explosive and Anaerobic Power in Recreationally Active Males by Nazila Heydari, Mahsa Shojaee, Javad Nemati, Ahmad Reza Dehghani, Alireza Niknam, Fereshte Eftekhari, Mohammad Hemmatinafar

“…Objective: This study explores the combined effects of PAPE and caffeine CAF supplementation on explosive power, sprint performance, and anaerobic capacity in recreationally active men. Methods: In a double-blind, crossover design, 20 participants completed 4 sessions with distinct interventions: placebo (PLA) with usual warm-up (No-PAPE + PLA), PAPE + PLA, CAF without PAPE (No-PAPE + CAF), and PAPE + CAF. …”
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Biceps and Triceps Muscle Activation Under Progressive Loads: A Study on Functional Symmetry of the Upper Limbs by Haider Hashim, Saif Ali Mohammed, Bashar Mohammed Ali, Safaa A. Ismaeel, Mohammed Nasir

“…Specifically, it investigated how incremental load variations affect the recruitment of agonist and antagonist muscles and examined the biomechanical relationship between load intensity and muscle coordination. Methods A total of 22 healthy male participants (aged 23–26 years) with resistance training experience were included. …”
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Effects of a Cooling Vest on Core and Skin Temperatures Following a Soccer-Specific Exercise Protocol by Carlos Lorente-González, Jose Vicente Beltran-Garrido, Abraham Batalla-Gavaldà, Francisco Corbi

“…This study evaluated the efficacy of a cool vest during a 15 min recovery period following 45 min of simulated soccer match play on core and skin temperature regulation. Methods: Forty-seven physically active males completed an exercise protocol replicating the physiological demands of a soccer half-match. …”
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Cryoablation-induced modulation of Treg cells and the TGF-β pathway in lung adenocarcinoma: implications for increased antitumor immunity by Shicheng Lin, Dianna Liu, Tianyu Liang, Yaoxue Zhuang, Xiaofan Wang, Shengmao Ma, Quanwang Li, Kaiwen Hu

“…This study aimed to explore the impact of cryoablation on the local immune microenvironment, focusing on regulatory T cells (Tregs) and the TGF-β pathway. Methods Single-cell sequencing was employed to identify differences in immune cell populations and related pathway expression between lung adenocarcinoma tissues and adjacent noncancerous tissues. …”
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