Collagenase injection versus limited fasciectomy surgery to treat Dupuytren’s contracture in adult patients in the UK: DISC, a non-inferiority RCT and economic evaluation by Joseph Dias, Puvan Tharmanathan, Catherine Arundel, Charlie Welch, Qi Wu, Paul Leighton, Maria Armaou, Belen Corbacho, Nick Johnson, Sophie James, John Cooke, Christopher Bainbridge, Michael Craigen, David Warwick, Samantha Brady, Lydia Flett, Judy Jones, Catherine Knowlson, Michelle Watson, Ada Keding, Catherine Hewitt, David Torgerson

“…The photography substudy found poor agreement between goniometry and both participant and clinician taken photographs, even after accounting for systematic differences from each method. Limitations Impacts of the COVID-19 pandemic resulted in longer waits for Dupuytren’s contracture treatment, meaning some participants could not be followed up for 2 years. …”
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Profiling the full-length transcriptome of plasma cell mastitis via nanopore sequencing by Su Li, Hongyue Chen, Yan Fan, Can Wang, Lijing An, Qifeng Xu, Wenming Cai, Suzhen Zhao, Tian Tian, Baoyong Zhang, Mengmeng Yang, Lulu Zhang

“…Abstract Introduction In this study, we aimed to determine the transcriptomic profile of plasma cell mastitis (PCM) and elucidate its underlying mechanisms using nanopore sequencing technology (ONT). Methods and results Through comparisons and analyses of redundantly removed transcripts with known reference genome annotations, we identified 39,408 novel transcripts and 20,980 genes. …”
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Single spike mutation differentiating XBB.1 and XBB.1.5 enhances SARS-CoV-2 cell-to-cell transmission and facilitates serum-mediated enhancement by Elena Criscuolo, Benedetta Giuliani, Matteo Castelli, Mattia Cavallaro, Sofia Sisti, Roberto Burioni, Davide Ferrari, Nicasio Mancini, Massimo Locatelli, Nicola Clementi, Nicola Clementi

“…The mechanisms underlying this resistance, particularly in relation to spike-mediated fusion, remain poorly understood.MethodsWe analyzed two clinical SARS-CoV-2 isolates differing by a single amino acid substitution in the S protein. …”
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Outer Membrane Proteins as Vaccine Targets Against <i>Lawsonia intracellularis</i> in Piglets by Kara L. Aves, Ana H. Fresno, Sajid Nisar, Mauro M. Saraiva, Nicole B. Goecke, Adam F. Sander, Morten A. Nielsen, John E. Olsen, Priscila R. Guerra

“…Aim: To evaluate the effectiveness of two novel subunit vaccines targeting outer membrane proteins on LI. Methods: The two vaccines included OMP2c.cVLP, where the OMP2c antigen was anchored on the surface of capsid virus-like particles (cVLP); and MBP.INVASc, where antigens were anchored to an MBP fusion protein. …”
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Study on evaluation of the sensitivity and specificity of the electrophysiological parameters LD and AR in carpal tunnel syndrome by Lenuța Bîrsanu, Roxana Covali, Andrei Ionuț Cucu, Amelian Mădălin Bobu, Ioana Păvăleanu, Robert-Constantin Anicăi, Alin Ciubotaru, Mihaela-Dana Turliuc

“…The 2LIO test demonstrated high diagnostic accuracy, with sensitivity and specificity of 93.3% and 97.7%, respectively, surpassing traditional methods like distal latency (AUC 0.600). Notably, the AR parameter achieved an exceptional area under the curve (AUC) of 0.971, signifying its robust sensitivity and specificity as a marker for CTS progression. …”
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Discrepancies between human and murine model cerebral aneurysms at single-cell resolution by Hang Ji, Hang Ji, Guicheng Kuang, Hailan Yang, Haitao Liu, Yue Li, Shaoshan Hu, Anqi Xiao, Chao You, Haogeng Sun, Chaofeng Fan, Guozhang Sun

“…Moreover, the inflammatory status of the CA tissue differs between humans and mouse models, with the former exhibiting a more acute and intense inflammation.ConclusionThese findings demonstrate subtle but important disparities between human and murine model CAs, and may shed light upon an optimization of murine CA model.…”
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Estimating the Effects of Natural and Anthropogenic Activities on Vegetation Cover: Analysis of Zhejiang Province, China, from 2000 to 2022 by Lv Chen, Chong Li, Chunyu Pan, Yancun Yan, Jiejie Jiao, Yufeng Zhou, Xiaoxian Wang, Guomo Zhou

“…Zhejiang Province, a pivotal economically developed region within China’s Yangtze River Delta, requires systematic investigation of spatiotemporal vegetation dynamics and their drivers to formulate targeted ecological protection policies and optimize vegetation restoration strategies. Utilizing the Google Earth Engine (GEE) platform, this study applied the Kernel Normalized Difference Vegetation Index (kNDVI) to assess vegetation responses to climate variability and human activities in Zhejiang Province from 2000 to 2022. …”
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Prophylactic internal Iliac artery balloon occlusion in placenta accreta spectrum: evaluating efficacy, risks, and clinical implications by Rui Wang, Jiayi Li, Bing Peng, Yidan Cao, Chuan Liu, Pengfei Ye, Kaiming Li, Fumin Zhao, Haibo Qu, Lingjun Liu

“…Abstract Introduction This study aimed to assess the efficacy and risks of prophylactic internal iliac artery balloon occlusion (IIABO) in managing placenta accreta spectrum (PAS) disorders and to discuss the clinical implications of this technique. Methods We retrospectively analyzed 616 confirmed patients with PAS, including placenta accreta, increta, and percreta, between December 2013 and December 2022. …”
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Effect of Relative Isometric Strength on Countermovement Jump Performance in Professional and Semi-Professional Soccer Players by Nicholas Joel Ripley, Jack Fahey, Nabil Hassim, Paul Comfort

“…As such, it was hypothesized that stronger players would have a greater jump performance than weaker players. Methods: An observational cross-sectional research design was used to assess ballistic and isometric force production of the lower limbs across players from four professional and semi-professional soccer clubs during the pre-season period. …”
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Comparative analysis of ground reaction forces and spatiotemporal gait parameters in older adults with sway-back posture and chronic low back pain: a cross-sectional study by Fatemeh Esmaeilpour, Amir Letafatkar, Mohammad Taghi Karimi, Mehdi Khaleghi, Giacomo Rossettini, Jorge Hugo Villafañe

“…The ASI was calculated for all participants. Between-group differences were examined using one-way ANOVA and ANCOVA. …”
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Economic Burden, Length of Hospital Stay and Complication of Simultaneous versus Staged Bilateral Hip Arthroplasty: A Hospital Prospective Study by Shen M, Jiang W, Qian P, Cai G, Wu X, Wang J, Ning X, Song L

“…No significant difference was found in prosthesis costs between the groups. …”
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Impact of Narrow Anvil Stapler on Graft Vein Length in Right-sided Living-donor Nephrectomy by Hiroshi Noguchi, MD, PhD, Yu Sato, MD, PhD, Yu Hisadome, MD, PhD, Shinsuke Kubo, MD, Keizo Kaku, MD, PhD, Yuki Nakafusa, MD, PhD, Yoshifumi Miura, MD, PhD, Masafumi Nakamura, MD, PhD

“…We hypothesized that the use of a narrow anvil stapler could optimize vein preservation by allowing safer and more effective transection closer to the inferior vena cava. …”
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“I’m a paper and pencil person”: a qualitative descriptive study of potential barriers and facilitators to engagement with pre-operative total knee replacement education and prehab... by Anna M. Anderson, Anthony C. Redmond, Judith Joseph, Gretl A. McHugh

“…Theme 1, ‘Accounting for individual differences’, suggests pre-operative TKR digital interventions should account for the impact of individual differences on engagement with digital technologies, pre-operative education and prehabilitation. …”
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Effects of an e-Learning Program (Physiotherapy Exercise and Physical Activity for Knee Osteoarthritis [PEAK]) on Chinese Physical Therapists’ Confidence and Knowledge: Randomized... by Zi-Ru Wang, Yunqi Wang, Shuning Duan, Xier Chen, Guoxin Ni

“…The intervention group demonstrated significant improvements in confidence compared to the control group, including managing OA with exercise-based programs (adjusted mean difference=3.27, 95% CI 2.72-3.81), prescribing exercise (adjusted mean difference=3.13, 95% CI 2.55-3.72), and delivering telehealth (adjusted mean difference=4.41, 95% CI 3.77-5.05). …”
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Construction and Completion of the Knowledge Graph for Cow Estrus with the Association Rule Mining by Zhiwei Cheng, Luyu Ding, Cheng Peng, Helong Yu, Baozhu Yang, Ligen Yu, Qifeng Li

“…<b>Methods:</b> This study gathered cow estrus data from 812 literature sources using Python 3.9 crawler technology. …”
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Machine learning in prediction of epidermal growth factor receptor status in non-small cell lung cancer brain metastases: a systematic review and meta-analysis by Bardia Hajikarimloo, Ibrahim Mohammadzadeh, Salem M. Tos, Mohammad Amin Habibi, Rana Hashemi, Ehsan Bahrami Hezaveh, Dorsa Najari, Arman Hasanzade, Mehdi Hooshmand, Sara bana

“…This systematic review and meta-analysis evaluated the predictive performance of machine learning (ML)-based models in EGFR status in NSCLC patients with brain metastasis. Methods On December 20, 2024, the four electronic databases, Pubmed, Embase, Scopus, and Web of Science, were systematically searched. …”
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Importance of Spectral Information, Seasonality, and Topography on Land Cover Classification of Tropical Land Cover Mapping by Chansopheaktra Sovann, Stefan Olin, Ali Mansourian, Sakada Sakhoeun, Sovann Prey, Sothea Kok, Torbern Tagesson

“…Combining these variable selection methods with hyperparameter tuning optimized the classification, providing a more reliable LC product that outperforms existing LC products and proves valuable for deforestation monitoring, forest management, biodiversity conservation, and land use studies.…”
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Evaluating the immunogenicity and safety of ID93 + GLA-SE in BCG-vaccinated healthy adults: a systematic review and meta-analysis of randomized controlled trials by Erum Siddiqui, Mohammad Saad Khan, Maliha Khalid, Harshika Khaim Chandani, Umaimah Naeem, Muhammad Mohsin Khan, Syed Owais Wasti

“…Dose optimization remains crucial due to the higher side effect risks of increased doses. …”
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The utility of preoperative computed tomography-guided screw marking in thoracic spine surgery by Christopher Marvin Jesse, Aatharshan Kannathasan, Ralph T. Schär, Johannes Goldberg, Andreas Raabe, Jan Gralla, Johannes Kaesmacher, Tomas Dobrocky, Eike Immo Piechowiak

“…Research question: Evaluate the impact of preoperative, computed tomography (CT)-guided screw marking on avoiding WLS and optimizing intraoperative workflows. Material and methods: We conducted a retrospective case-control study at Bern University Hospital, enrolling all patients treated with thoracic spinal surgery between February 2017 and August 2022. …”
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Impact of early vs. delayed physical therapy on functional recovery, proprioception, and return to sport after anterior cruciate ligament (ACL) reconstruction: a cross-sectional st... by Turki Ahmed Alqahtani, Saleh M. Kardm, Hani Hassan Alnakhli, Faisal M Alyazedi, Praveen Kumar Kandakurti, Ravi Shankar Reddy

“…No significant differences were observed in graft integrity (p = 0.715) or knee stability tests (p > 0.05). …”
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