Polymorphic positions 349 and 725 of the autoimmunity-protective allotype 10 of ER aminopeptidase 1 are key in determining its unique enzymatic properties by Galateia Georgaki, Galateia Georgaki, Anastasia Mpakali, Anastasia Mpakali, Myrto Trakada, Athanasios Papakyriakou, Efstratios Stratikos, Efstratios Stratikos

“…ERAP1 allotype 10 is highly protective toward developing some forms of autoimmunity and displays unusual functional properties, including very low activity versus some substrates.MethodsTo understand the molecular mechanisms that underlie the biology of allotype 10, we studied its enzymatic and biophysical properties focusing on its unique polymorphisms V349M and Q725R.ResultsCompared to ancestral allotype 1, allotype 10 is much less effective in trimming small substrates but presents allosteric kinetics that ameliorate activity differences at high substrate concentrations. …”
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Impact of Immersive Virtual Reality During Outpatient Sedation‐Free Colonoscopy: A Randomized Prospective Controlled Study by Myriam Ayari, Sameh Riahi, Mohamed Hedi Douggui, Taieb Jomni

“…The aim of this study was to evaluate the impact of immersive virtual reality (VR) during sedation‐free colonoscopy. Methods We conducted a prospective controlled study including outpatients presenting for unsedated colonoscopy. …”
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The winding road to health: A systematic scoping review on the effect of geographical accessibility to health care on infectious diseases in low- and middle-income countries. by Fleur Hierink, Emelda A Okiro, Antoine Flahault, Nicolas Ray

“…Therefore, we aimed at evaluating the current state of knowledge on the effect of geographical accessibility to health care on infectious diseases in low- and middle-income countries.<h4>Methods and findings</h4>A search strategy was developed and conducted on Web of Science and PubMed on 4 March 2019. …”
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Intracortical inhibiton assessment using threshold tracking technique in amyotrophic lateral sclerosis by I. S. Bakulin, A. Kh. Zabirova, A. G. Poydasheva, D. O. Sinitsyn, D. Yu. Lagoda, A. R. Nagieva, M. N. Zakharova, N. A. Suponeva, M. A. Piradov

“…The replication of data showing impairment of SICI assessed by threshold tracking technique in patients with ALS.Materials and methods. 18 patients with ALS and 13 healthy volunteers were included into the study. …”
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The Impact of Rest Intervals on the Force–Velocity Relationship Obtained During the Keiser’s 10-Repetition Leg Press Test by John Magne Kalhovde, Christian M. M. Johannessen, Sigmund B. Aasen, Espen Tønnessen

“…<b>Background:</b> The Keiser 10-rep leg press test protocol employs short inter-repetition rest intervals (2–38 s), raising concerns as to whether athletes perform optimally. <b>Objectives:</b> The aim of this study was to compare the results of the standard Keiser protocol with an identical protocol modified to include a significantly longer inter-repetition rest intervals and to evaluate whether these effects differed between men and women. …”
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The influence of FADS1 and ELOVL2 genetic polymorphisms on polyunsaturated fatty acid composition in response to fish oil supplementation by Alessandro Medoro, Francesca Graziano, Gaetano Cardinale, Serena Voccola, Tiziana Zotti, Mariano Intrieri, Giovanni Scapagnini, Sergio Davinelli

“…Baseline omega-3 percentages did not differ significantly between FADS1 and ELOVL2 genotypes. …”
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Identification of Natural Killer Cell‐Associated Clusters in Skin Melanoma and the Impact on Prognosis and Drug Sensitivity by Jun Zhou, Renhui Cai, Danqun Zhang, Caifeng Chen

“…This study aimed to investigate natural killer (NK) cell clusters in skin melanoma, their impact on patient prognosis, and their value as biomarkers for tailoring treatment. Methods We used data from TCGA, GSE19234, GSE65904, GSE244982, and GSE78220. …”
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Clinical application of “purse-string suture” under endoscope in the treatment of refractory postoperative intestinal anastomotic fistula by Guangxu Zhu, Shengjie Zhou, Hongqiao Gao, Shunyao Song, Baoqiang Shan, Youchao Xu, Ningning Sun, Yuanyuan Xu, Shumin Wang, Jianjun Qu, Honglei Gao

“…This study evaluates the safety and efficacy of endoscopic purse-string suturing (EPS) in managing refractory PIAF and identifies prognostic predictors. Methods A retrospective analysis of 55 patients with refractory PIAF treated via EPS (2015–2024) was conducted. …”
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Is selective hospitalist–orthopedic surgeon co-management based on the Charlson comorbidity index useful in peri-operative care of total hip arthroplasty? by Kazuhiko Sonoda, Yusuke Kubo, Sanshiro Inoue, Toshihiko Hara

“…This prospective, single-center study evaluated the utility of selective HOC based on the Charlson comorbidity index (CCI) in THA peri-operative management. Methods: This study included 90 consecutive cases with primary THA by a single orthopedic surgeon. …”
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Clinical efficacy of oxidized regenerated cellulose powder in perioperative blood management in direct anterior total hip arthroplasty by Kaneko Taizo, Hayakawa Kentaro, Miyazaki Tsuyoshi

“…This study aimed to evaluate the effects of ORC powder on perioperative blood loss, hematological parameters, and clinical outcomes in direct anterior THA. Methods: A total of 133 patients who underwent primary THA via the DAA were enrolled in the study. …”
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Effects of Knee and Ankle Braces on Lower Limb Kinematics During Jump-Heading-Landing in Professional Soccer Players Following ACL Reconstruction by Naser Farokhroo, Nader Farahpour, Gabriel Moisan, Began Heydari, Mahdi Majlesi

“…Objective This study investigated the effects of knee and ankle braces on lower limb kinematics during a jump-landing task incorporating heading in elite soccer players with a history of anterior cruciate ligament reconstruction (ACLR). Methods Twelve male soccer players with ACLR and 12 healthy controls performed the task under three experimental conditions: without braces (WS), with a knee brace (KS), and with both knee and ankle braces (KAS). …”
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Impact of changes in conventional risk factors induced by once-weekly GLP-1 receptor agonist exenatide on cardiovascular outcomes: an EXSCEL post hoc analysis by Ruth L. Coleman, Amanda I. Adler, Robert J. Mentz, Marat Fudim, Naveed Sattar, Rury R. Holman

“…Methods We entered participant-level risk factor values over time into a validated type 2 diabetes–specific clinical outcomes model to estimate event rates, and compared simulated with observed relative risk changes in EXSCEL. …”
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NT-proBNP changes predict outcomes in elderly type 2 myocardial infarction patients by Jinling Ma, Ang Li, Suyan Bian

“…This study aimed to determine the association of change in NT-proBNP level with adverse outcomes among elderly individuals with type 2 myocardial infarction (MI). Methods A retrospective analysis was conducted among elderly individuals with type 2 MI between December 2010 and December 2022. …”
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Sex-related disparities in incidence and in-hospital outcomes of Atrial fibrillation complicated by non-ST-elevation myocardial infarction from the national in-sample database (201... by Farah Yasmin, Afsana Ansari Shaik, Muhammad Sohaib Asghar, Afia Salman, Abdul Moeed, Maryam Shaharyar, Rohan Ochani, M.Chadi Alraies

“…Conclusion: These findings underscore the importance of addressing gender-specific differences in the management of AF patients with NSTEMI to optimize patient resource allocation.…”
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Efficacy of Virtual Reality–Based Interventions on Cognitive Function in Patients With Neuropsychiatric Disorders: Systematic Review and Meta-Analysis of Randomized Controlled Tria... by Qiujing Du, Yuhan Wei, Yuexuan Ma, Changqing Liu, Shanshan Du, Qi Zhang, Xiaotong Gong, Jiaju Yang, Qijie Li, Ka Li

“…ObjectiveThis meta-analysis aims to evaluate the efficacy of VR-based interventions on cognitive function in patients with neuropsychiatric disorders by synthesizing data from randomized controlled trials (RCTs). MethodsFollowing PRISMA guidelines, we conducted a comprehensive search across PubMed, Web of Science, MEDLINE, EMBASE, and Cochrane Library for RCTs from January 2010 to December 2024. …”
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Prevalence and Risk Factors of Cardiovascular Disease in Rheumatoid Arthritis Patients: A Comparative Analysis of Real-World Data by Tekeoglu S

“…This study evaluates CVD and related risk factors in RA patients compared to age and gender-matched controls without inflammatory diseases, and differences within RA patients with and without CVD.Patients and Methods: This retrospective case-control study reviewed medical records of 405 RA patients (cases) and 950 control patients who attended rheumatology clinics in two branches of a private hospital between January 2021 and January 2024 to assess cardiovascular disease prevalence and associated risk factors.Results: RA patients, with a mean age of 59 (± 23) years, disease duration of 89.5 months, and a female-to-male ratio of 4:1, exhibited a higher prevalence of CVD compared to controls (p = 0.01), despite similar classical risk factors. …”
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Artificial Intelligence-Based Prediction of Bloodstream Infections Using Standard Hematological and Biochemical Markers by Ferhat DEMİRCİ, Murat AKŞİT, Aylin DEMİRCİ

“…This study aimed to develop an interpretable machine learning (ML) model using routine laboratory parameters to predict blood culture positivity. Methods: A total of 1,972 adult patients who underwent complete blood count, C-reactive protein, procalcitonin (PCT), and blood culture testing at a tertiary hospital were retrospectively included. …”
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Manganese‐enhanced MRI during remotely induced myocardial ischemia reperfusion injury in male mice by Matic Pusovnik, Michiel Algoet, Willy Gsell, Stefan Janssens, Wouter Oosterlinck, Uwe Himmelreich

“…Abstract Early assessment of myocardial viability post‐ischemia is crucial to mitigate adverse remodeling and optimize therapy. Current noninvasive methods like late gadolinium enhancement (LGE) MRI may overestimate infarct size. …”
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The influence of tactical positioning on performance in world-championship freestyle swimming by Craig Staunton, Jesús J. Ruiz-Navarro, Peter Edholm, Dennis-Peter Born, Dennis-Peter Born

“…PurposeThis study examined tactical positioning and pacing in short-distance (100 m), middle-distance (200 m, 400 m) and long-distance (800 m, 1,500 m) freestyle events, focusing on the influence of race distance, competition round (HEAT vs. FINAL), and sex.MethodsRace data from multiple World Championships (2013–2023) were analyzed. …”
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Application of the brown macroalga Saccharina latissima (Laminariales, Phaeophyceae) as a feed ingredient for livestock: A review by Sachin Dhakal, Alexander Oliver Jüterbock, Xingen Lei, Prabhat Khanal

“…In conclusion, S. latissima can be a novel feed ingredient for livestock, but year-round biomass availability and identifying cost-effective and energy-efficient post-harvest biomass processing methods that optimize both nutritional values and digestibility of S. latissima are critical for improving animal production, performance, and health.…”
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