Diagnostic Utility of Endocan and Interleukins for Late-Onset Neonatal Sepsis by Preslava Gatseva, Alexander Blazhev, Zarko Yordanov, Victoria Atanasova

“…Patients with suspected nosocomial infection and healthy controls were tested. A sandwich ELISA method was used to measure the serum concentrations. …”
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Survival Outcomes with Regorafenib and/or Trifluridine/Tipiracil Sequencing to Rechallenge with Third-Line Regimens in Metastatic Colorectal Cancer: A Multicenter Retrospective Rea... by Carlo Signorelli, Maria Alessandra Calegari, Annunziato Anghelone, Alessandro Passardi, Giovanni Luca Frassineti, Alessandro Bittoni, Jessica Lucchetti, Lorenzo Angotti, Emanuela Di Giacomo, Ina Valeria Zurlo, Cristina Morelli, Emanuela Dell’Aquila, Adele Artemi, Donatello Gemma, Domenico Cristiano Corsi, Alessandra Emiliani, Marta Ribelli, Federica Mazzuca, Giulia Arrivi, Federica Zoratto, Mario Giovanni Chilelli, Marta Schirripa, Maria Grazia Morandi, Fiorenza Santamaria, Manuela Dettori, Antonella Cosimati, Rosa Saltarelli, Alessandro Minelli, Emanuela Lucci-Cordisco, Michele Basso

“…Background: There is ongoing discussion around the optimal course of treatment for metastatic colorectal cancer (mCRC) following the second line. …”
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Mini-GRID therapy delivers optimised spatially fractionated radiation therapy using a flattening free filter accelerator by M. Isabel Acuña, Charlotte Lamirault, Thibaut Larcher, Elise Brisebard, Tim Schneider, Marjorie Juchaux, Ramon Iglesias-Rey, Sabela Fernández-Rodicio, Pablo Aguiar, Noemi Gómez-Lado, Immaculada Martínez-Rovira, Roberto González-Vegas, Ibraheem Yousef, Antonio Gomez-Caamano, Miguel Pombar, Victor Luna, Manuel Sanchez, Yolanda Prezado

“…Methods The increase in normal tissue tolerances provided by mini-GRID compared to conventional RT and GRID therapy was validated in a rat model of brain irradiation in a longitudinal imaging study, behavioural tests and by histopathological evaluation. …”
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Learning Multi-Attribute Differential Graphs With Non-Convex Penalties by Jitendra K. Tugnait

“…Two proximal gradient descent methods are presented to optimize the objective function. …”
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Developing Site-Specific Prescription Maps for Sugarcane Weed Control Using High-Spatial-Resolution Images and Light Detection and Ranging (LiDAR) by Kerin F. Romero, Muditha K. Heenkenda

“…This efficient and precise alternative to traditional methods could optimize weed control, reduce herbicide usage and provide more profitable yield.…”
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COMPARATIVE ANALYSIS OF FOREIGN EXPERIENCE IN TRAINING OF SOCIAL WORK SPECIALISTS by Hanna Yu. Voshkolup, Natalya O. Shura

“…The main approaches to the acquisition of educational specialization by social work specialists in different countries of the world have been formed, namely: branch, methodical and complex ones. …”
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Causal inference study of PRRSV-MLV vaccine dosing effects on wean-to-finish performance during outbreaks by Swaminathan Jayaraman, Tyler Bauman, Amy Maschhoff, Caleb Shull, Peng Li, Edison Magalhaes, Giovani Trevisan, Daniel C. L. Linhares, Chunlin Li, Gustavo S. Silva

“…This study demonstrates the value of causal inference methods in analyzing real-world vaccination outcomes and provides evidence-based guidance for optimizing PRRSV vaccination protocols in commercial swine production.…”
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Comparison of the effects of IMRT and IMPT on MRI features of normal brain tissue: a retrospective study by Jian Xu, Lili Zhang, Tingting Liu, Qingzeng Liu, Jian Zhu

“…And evaluate the potential application value of radiomic features in dose optimization and biological dose assessment. Methods A retrospective analysis included 113 patients undergoing brain-target radiotherapy: 44 receiving IMPT (average total dose: 5713.63 ± 774.32 cGy) and 69 receiving IMRT (average total dose: 5489.86 ± 627.05 cGy). …”
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Psycho-emotional conditions in primary care physicians who serve in a direct vicinity to the frontline by Larysa Kupriianova, Daryna Kupriianova

“…Materials and methods. Unsystematic observation, deduction, induction, synthesis, analysis, factor analysis, statistics, survey. …”
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Associating Patient Responses with Drug Sensitivity in Non-Small Cell Lung Carcinoma Using an Immunoassay on Patient-Derived Cell Cultures by Ana Podolski-Renić, Sofija Jovanović Stojanov, Dragana Marić, Jelena Dinić, Miodrag Dragoj, Ana Stepanović, Ema Lupšić, Milica Pajović, Sofija Glumac, Maja Ercegovac, Milica Pešić

“…<b>Methods</b>: We established short-term primary cell cultures from thirteen patients with NSCLC of different subtypes and stages, including both cancer and stromal cells. …”
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Process Development for GMP-Grade Full Extract Cannabis Oil: Towards Standardized Medicinal Use by Maria do Céu Costa, Ana Patrícia Gomes, Iva Vinhas, Joana Rosa, Filipe Pereira, Sara Moniz, Elsa M. Gonçalves, Miguel Pestana, Mafalda Silva, Luís Monteiro Rodrigues, Anthony DeMeo, Logan Marynissen, António Marques da Costa, Patrícia Rijo, Michael Sassano

“…<b>Background/Objectives:</b> The industrial extraction and purification processes of <i>Cannabis sativa</i> L. compounds are critical steps in creating formulations with reliable and reproducible therapeutic and sensorial attributes. <b>Methods:</b> For this study, standardized preparations of chemotype I were chemically analyzed, and the sensory attributes were studied to characterize the extraction and purification processes, ensuring the maximum retention of cannabinoids and minimization of other secondary metabolites. …”
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A Nanostructured Ru‐Mn‐Nb Alloy with Oxygen‐Enriched Boundaries for Ampere‐Level Hydrogen Evolution by Jie Li, Xue Wang, Jun Yu, Kai Xu, Zhe Jia, Hongkun Li, Lei Ren, Yiyuan Yang, Keke Chang, Yangyang Li, Xiangfa Liu, Jian Lu, Sida Liu

“…Thus, alloy catalysts are suitable candidates for future energy applications. Conventional methods for enhancing the performance of alloy catalysts have mainly focused on element composition and thus have often neglected to examine catalyst design. …”
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Electrospun textiles from decellularized bovine pericardium and polyvinyl alcohol (PVA) supporting blood coagulation: innovative approach in biomaterials for research purposes by Luca Di Nunno, Luca Di Nunno, Veronica Pagani, Elena Canciani, Gerardina Ruocco, Gerardina Ruocco, Mattia Spedicati, Mattia Spedicati, Maria Talmon, Luca Fusaro, Dalila Di Francesco, Dalila Di Francesco, Simona Casarella, Manuela Rizzi, Francesca Boccafoschi, Francesca Boccafoschi

“…Among all the patches available on the market, nanofibrous materials offer several advantages, among which the possibility to be properly designed in order to meet specific requirements related to bioactivity and biodegradability. Different patch formulations to support blood clotting are characterized in the present study.MethodsThe approach used is based on electrospun decellularized bovine pericardium (dECM) blended or layered with polyvinyl alcohol (PVA) and crosslinked by (3‐Glycidyloxypropyl)trimethoxysilane (GPTMS). …”
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Explore the Application Value of Metagenomic Next-Generation Sequencing of Bronchoalveolar Lavage Fluid in the Early Diagnosis of Pulmonary Tuberculosis by Lu Y, Zhang C, Wu J, Xu X, Lu A, Huang H, Chen M

“…While specificity and PPV showed no significant differences among methods, BALF mNGS had a higher NPV than sputum-based assays (53.03– 54.17%) but lower than BALF TB-DNA (82.53%, P < 0.0125). …”
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EEG microstate analysis in children with prolonged disorders of consciousness by Yi Zhang, Zhichong Hui, Yuwei Su, Weihang Qi, Guangyu Zhang, Liang Zhou, Jiamei Zhang, Kaili Shi, Yonghui Yang, Lei Yang, Gongxun Chen, Sansong Li, Mingmei Wang, Dengna Zhu

“…Abstract Prolonged disorders of consciousness (pDoC) in children lack objective and effective diagnostic methods to assess consciousness states, hindering targeted treatment selection and delaying recovery. …”
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A Repurposed Drug Selection Pipeline to Identify CNS-Penetrant Drug Candidates for Glioblastoma by Ioannis Ntafoulis, Stijn L. W. Koolen, Olaf van Tellingen, Chelsea W. J. den Hollander, Hendrika Sabel-Goedknegt, Stephanie Dijkhuizen, Joost Haeck, Thom G. A. Reuvers, Peter de Bruijn, Thierry P. P. van den Bosch, Vera van Dis, Zhenyu Gao, Clemens M. F. Dirven, Sieger Leenstra, Martine L. M. Lamfers

“…Therefore, selecting drugs that can reach the tumor region in pharmacologically effective concentrations is of major importance. Methods: In the current study, we utilized a drug selection platform to identify candidate drugs by combining in vitro oncological drug screening data and pharmacokinetic (PK) profiles for central nervous system (CNS) penetration using the multiparameter optimization (MPO) score. …”
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Safety and efficacy evaluation of intracerebroventricular human neural stem cell transplantation in SOD1 mice as a novel approach for ALS by Ivan Lombardi, Clelia Ferrero, Edvige Vulcano, Daniela Maria Rasà, Maurizio Gelati, Diego Pastor, Rose Mary Carletti, Silvia de la Morena, Daniela Celeste Profico, Sabrina Longobardi, Elisa Lazzarino, Elisa Perciballi, Jessica Diana Rosati, Salvador Martinez, Alessandro Vercelli, Angelo Luigi Vescovi, Marina Boido, Daniela Ferrari

“…Here, we assessed the safety and efficacy of intracerebroventricular (ICV) hNSC transplantation as a novel and possibly more effective experimental approach for ALS. Methods We evaluated the safety of administering up to 1 × 106 hNSCs in immunodeficient mice and assessed their potential efficacy in reducing ALS hallmarks employing the SOD1G93A mouse model. …”
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Mechanical Modeling of the Premolar: Numerical Analysis of Stress Distribution Under Masticatory Forces by Marius Turnea, Cezar Mucileanu, Irina Duduca, Mariana Rotariu

“…This study confirms the effectiveness of numerical methods in optimizing the design of dental structures and supports the applicability of these techniques in orthodontics, maxillofacial surgery, and dental prosthetics.…”
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Is 2 h of Hypothermic Machine Perfusion for Pancreas Preservation Effective in Improving Graft Reperfusion? by Benoit Mesnard, MD, Christophe Masset, MD, PhD, Etohan Ogbemudia, MD, PhD, Sarah Bruneau, PhD, Mohamed Elzawahry, MD, Stéphanie Le Bas-Bernardet, PhD, David Minault, Jeremy Hervouet, Diego Cantarovich, MD, PhD, Jérôme Rigaud, MD, PhD, Lionel Badet, MD, PhD, Peter Friend, MD, PhD, Rutger Ploeg, MD, PhD, Gilles Blancho, MD, PhD, James Hunter, MD, PhD, Thomas Prudhomme, MD, Julien Branchereau, MD, PhD

“…Static cold storage (SCS) remains the standard method for organ preservation. The development of parenchymal edema during prolonged hypothermic machine perfusion (HMP) was a major barrier to the introduction of this technique for the preservation of pancreases. …”
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Treatment outcomes and key factors contributing to unfavourable outcomes among isoniazid-resistant pulmonary tuberculosis patients in Shanghai, China by Wenjing Xiao, Jing Chen, Lixin Rao, Xiao Xiao, Xubin Zheng, Zheyuan Wu, Xin Shen

“…There was statistically significant difference in the occurrence of adverse events between the different treatment regimens (P < 0.001). …”
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