Synergistic treatment of sodium propionate and Sishen Pill for diarrhea mice with kidney-yang deficiency syndrome by Meifang Guo, Jiaxin Di, Zhijun Lei

“…ObjectiveThis study aimed to investigate the therapeutic effects of sodium propionate in combination with Sishen Pill in the treatment of diarrhea with kidney-yang deficiency syndrome in mice, with a focus on its influence on intestinal microbiota, enzyme activity, and associated therapeutic outcomes.MethodsA model of diarrhea with kidney-yang deficiency syndrome was established via adenine combined with Folium sennae administration. …”
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Comprehensive geriatric assessment for oral care in older adults: a focus group study by Nattariya Wongiam, Kearkiat Praditpornsilpa, Anjalee Vacharaksa

“…This study aimed to identify the components of CGA essential for proper oral care in older adults based on the perspective of multidisciplinary experts. Methods A scoping review was conducted to provide insights into CGAs that are mentioned in treatment plan models for oral healthcare (Protocol registration number 10.17605/OSF.IO/EZRDV). …”
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Effect analysis of trihalomethane reduction in the raw water from Qingcaosha reservoir using various water treatment processes by WU Jingyu, WANG Weiguo, REN Hui, ZHENG Weiwei

“…ObjectiveTo investigate the content of trihalomethanes (THMs) in treated water after different water treatment processes and their correlations with premanganate index, so as to provide data support for the renovation of water production process and optimization of water quality improvement.MethodsFrom 2022 to 2023, seven centralized water supply units using raw water from Qingcaosha reservoir were selected as the testing sites, among which three units with the conventional treatment process, two units with the advanced treatment process, and two units with the advanced treatment process combined CO2 treatment. …”
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Two-phase linear relationship of Vitamin D and Vitamin A among children aged 0–14 years: a cross-sectional study by Wenyuan Liu, Qiao Wang, Bibo Mao, Fei Xu, Yefang Ke, Shengying Zhang, Chenbo Zhou, Chunyan Liu, Wenbo Lu, Jishan Zheng

“…BackgroundVitamin D and Vitamin A are crucial for children’s immune function, bone health, and cellular growth, but their interrelationship and the impact of various factors remain poorly understood.ObjectiveTo explore the relationship between Vitamin D and Vitamin A levels in children and identify any critical thresholds.MethodsA cross-sectional study was conducted from 2018 to 2021 in Ningbo, Zhejiang, China. …”
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Calibrating multiplex serology for Helicobacter pylori by Emmanuelle A. Dankwa, Martyn Plummer, Daniel Chapman, Rima Jeske, Julia Butt, Michael Hill, Tim Waterboer, Iona Y. Millwood, Ling Yang, Christiana Kartsonaki

“…When mapping such multidimensional continuous measurements onto a binary classification, statistical challenges arise in defining classification cut-offs and accounting for the differences in infection evidence provided by different antigens. …”
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Mining, validating, and quantifying circular RNA transcriptome from total RNA as a biomarker or target by Tan Ze Wang, Raj Kumar Thapa, Frank Yu, Ayesha Warsi, Kassie Rong, Pious Jose, Tahereh Kashkoulinejad-Kouhi, Phyo Wei Win, Christina A. Castellani, Tina Mele, Xiufen Zheng

“…We sought to characterize the circRNA transcriptome from RNA-seq with total RNA from septic peripheral blood mononuclear cells (PBMCs), assess/compare commonly used aligners, and optimize validation methods, considering sepsis is the leading cause of death in intensive care units (ICU) and there is no effective treatment. …”
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Helicopter hoist operations in German mid-range mountains retrospective analysis of incidence, medical characteristics, and mission tactics by Sebastian Heinrich, Christoph Wielant, Frank Lerch, Mirko Friedrich, Jörg Braun, Florian Reifferscheid, Hans-Jörg Busch, for the Scientific Working Group of German Air Rescue

“…Detailed analysis showed relevant differences in operational tactics between the three bases and potential for optimization. …”
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Dissecting the endothelial cell landscape in meningioma: single-cell insights into PLVAP+ subpopulations and their role in tumor angiogenesis by Liang Zhao, Hongling Jia, Zhikai Xiahou, Li Ren, Yanbing Song, Hao Xu, Zhihan Wang, Jin Xing

“…Therefore, this study utilizes single-cell RNA-sequencing technology to investigate the interaction mechanisms between endothelial cells (ECs) and meningiomas, aiming to identify potential therapeutic targets for the treatment of MEN patients.MethodsTissue origin analysis of different EC subpopulations was performed using Ro/e preference analysis. …”
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Association of triglyceride-glucose index and estimated glucose disposal rate with outcomes in patients with acute myocardial infarction: Cumulative effect and mediation analysis. by Yazhao Sun, Pei Sun, Dongsheng Liu

“…This study aims to investigate whether the combined assessment of the TyG index and METS-IR can improve risk stratification and prognostic prediction in AMI patients.<h4>Methods</h4>This retrospective cohort study included AMI patients admitted to Cangzhou People's Hospital from January to December 2018. …”
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Compliant buffer layer achieves native-like cartilage stress in talar prosthesis: a finite element analysis study by Yaokuan Ruan, Yi Liu, Zhende Jiang, Yifan Zhong, Lu Zheng, Nan Mei, Zhihui Qian, Fei Chang

“…The objective of this study was to identify the most suitable combination of buffering layer material and thickness for talar prosthesis. Methods This study employed dynamic biplane radiography (DBR) integrated with finite element analysis (FEA) to systematically evaluate how prosthetic material selection and buffering layer thickness affect periprosthetic cartilage biomechanics. …”
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Fracture identification and 3D reconstruction of coal-rock combinations based on VRA-UNet network by Dengke WANG, Longhang WANG, Yaguang QIN, Le WEI, Tanggen CAO, Wenrui LI, Lu LI, Xu CHEN, Yuling XIA

“…In the 3D reconstruction of coal-rock combinations fractures, in response to the problem that traditional threshold segmentation methods cannot accurately determine the threshold size between coal and rock, resulting in poor fracture segmentation performance, a new VRA-UNet coal-rock combinations fracture identification model based on deep learning theory is proposed, providing an optimized solution for accurate identification of coal-rock combinations fractures. …”
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Association between caffeine intake and fat free mass index: a retrospective cohort study by Ya-Lan Tian, Xin Liu, Meng-Yao Yang, Yu-Han Wu, Fu-Qiang Yin, Zhen-Tong Zhang, Chao Zhang

“…The aim of this study was to investigate the association between the caffeine intake (from coffee) and fat-free mass index (FFMI).Materials and Methods We carried out a cohort study that included 3,466 women and 3,145 men aged ≥20 years who were intaking caffeine. …”
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Detection of Citrus Huanglongbing in Natural Field Conditions Using an Enhanced YOLO11 Framework by Liang Cao, Wei Xiao, Zeng Hu, Xiangli Li, Zhongzhen Wu

“…To improve detection performance, the DCH-YOLO11 framework incorporates three novel modules: the C3k2 Dynamic Feature Fusion (C3k2_DFF) module, which enhances early and subtle lesion detection through dynamic feature fusion; the C2PSA Context Anchor Attention (C2PSA_CAA) module, which leverages context anchor attention to strengthen feature extraction in complex vein regions; and the High-efficiency Dynamic Feature Pyramid Network (HDFPN) module, which optimizes multi-scale feature interaction to boost detection accuracy across different object sizes. …”
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Blue Light and Green Light Fundus Autofluorescence, Complementary to Optical Coherence Tomography, in Age-Related Macular Degeneration Evaluation by Antonia-Elena Ranetti, Horia Tudor Stanca, Mihnea Munteanu, Raluca Bievel Radulescu, Simona Stanca

“…<b>Objectives:</b> This narrative review critically compares green and blue FAF in terms of their diagnostic utility relative to OCT, with a focus on lesion detectability, macular pigment interference, and clinical decision-making in retinal disorders. <b>Methods:</b> A comprehensive literature search was performed using the PubMed database for studies published prior to February 2025. …”
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Conversational AI agent for precision oncology: AI-HOPE-WNT integrates clinical and genomic data to investigate WNT pathway dysregulation in colorectal cancer by Ei-Wen Yang, Brigette Waldrup, Enrique Velazquez-Villarreal, Enrique Velazquez-Villarreal

“…To address this gap, we developed AI-HOPE-WNT, the first conversational artificial intelligence (AI) agent purpose-built to investigate WNT signaling in CRC using natural language–driven, integrative bioinformatics.MethodsAI-HOPE-WNT employs a modular architecture combining large language models (LLMs), a natural language-to-code engine, and a backend statistical workflow interfaced with harmonized data from cBioPortal. …”
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Factors Influencing Telemedicine Adoption Among Health Care Professionals: Qualitative Interview Study by Fiona Schürmann, Daniel Westmattelmann, Gerhard Schewe

“…Specifically, it investigated the nuanced roles of perceived risks, benefits, and trust referents (eg, technology, treatment, technology provider, and patient) in shaping behavioral intentions, while integrating contextual factors. MethodsWe used a qualitative research design involving semistructured interviews with 14 HCPs experienced in offering video consultations. …”
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Global, regional, and national burden of chronic kidney disease and its underlying etiologies from 1990 to 2021: a systematic analysis for the Global Burden of Disease Study 2021 by Ling Deng, Shujin Guo, Yuping Liu, Yaojia Zhou, Youren Liu, Xiaoxia Zheng, Xijie Yu, Ping Shuai

“…Abstract Background We aimed to investigate global, regional, and national burden of chronic kidney disease (CKD) and its underlying etiologies from 1990 to 2021. Methods We summarized the results of the Global Burden of Disease (GBD) 2021 to derive the disease burden of CKD by considering four distinct types of epidemiological data, namely incidence, prevalence, mortality, and disability-adjusted life years (DALYs). …”
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The impact of parental absence on the mental health of middle school students in rural areas of Western China by Xiaohong Ren, Cen Lin, Lu Pan, Qiuyue Fan, Dapeng Wu, JinLong He, Ping He, Jiaming Luo

“…However, studies specifically examining the dual impact of parental separation and migration on psychological outcomes among adolescents in Western China remain relatively limited.AimThis study aims to systematically examine the association between various parental absence situations and mental health outcomes in early adolescence, with the objective of informing targeted interventions and policy formulations to optimize psychosocial support systems for vulnerable youth population.MethodsThe Wilcoxon rank-sum test was employed to analyze continuous and ordinal variables that exhibited non-normal distributions. …”
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Multi‐microRNA diagnostic panel for heart failure with preserved ejection fraction in preclinical and clinical settings by Reza Parvan, Natale Rolim, Andreas B. Gevaert, Alessandro Cataliotti, Emeline M. vanCraenenbroeck, Volker Adams, Ulrik Wisløff, Gustavo Jose Justo Silva, the OptimEx Study Group

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Current status of nurses’ public health emergency response capacity for emerging infectious disease: a cross-sectional study by Qin Qiu, Qin Qiu, Yuntong Liu, Fanping Meng, Fanping Meng, Xinhua Wang, Chunxiang Su

“…ObjectivesThis study aimed to assess the current status of nurses’ public health emergency response capacity for emerging infectious diseases (EIDs) in tertiary hospitals in Beijing, explore the deficiencies of nurses’ emergency response capacity, and analyze the influencing factors in the post-epidemic era.MethodsA convenience sampling method was utilized to recruit registered nurses in 3 tertiary hospitals in Beijing from 27 August and 2 September 2024. …”
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