Supervised Machine Learning Thyroid Carcinoma Diagnosis Using Wide-Field SHG Microscopy by Yaraslau Padrez, Radu Hristu, Igor Timoshchenko, Lucian G. Eftimie, Danielis Rutkauskas, Lena Golubewa

“…Papillary (PTC) and follicular (FTC) thyroid carcinomas require different treatment strategies, but their accurate differentiation remains a challenge in conventional histopathology. …”
Get full text

Effect of acid washing and torrefaction combined pretreatment on the properties of waste tobacco stem biomass and the quality of pyrolysis bio-oil by Anni Wang, Jianhang Hu, Jianhang Hu, Jianhang Hu, Long Zhang, Hua Wang, Hua Wang, Hua Wang

“…Aiming at the issues of low yield and poor quality of bio-oil obtained from direct pyrolysis of biomass, in this study, waste tobacco stems (TS) were used as raw materials, and the pretreatment methods of torrefaction and acid washing were adopted to study the effects of different torrefaction temperatures and pretreatment sequences on the quality of TS biomass and bio-oil. …”
Get full text

Application of transcutaneous electrical nerve stimulation in monitored anesthesia care during foraminoscopy: a randomized double-blind controlled trial by Shuhui Sun, Shuhui Sun, Lei Zhang, Dongdong Yu, Li Jiang, Ge Yang, Long Zhang, Yu Tian, Yu Tian, Chunxiao Xu, Chunxiao Xu, Dong Zhang

“…Additionally, by comparing different waveform stimulations, the electrical stimulation parameters can be further optimized.…”
Get full text

Reshaping life after stroke: a grounded theory by Dagmar J.J. van Nimwegen, Sigrid C.J.M. Vervoort, Johanna M.A. Visser-Meily, Lisette Schoonhoven, Janneke M. de Man-van Ginkel

“…Background: Stroke patients often experience different consequences, negatively impacting their psychosocial well-being. …”
Get full text

Dimensional accuracy and resolution assessment of the formlabs form 3B 3D printer for medical applications by Vera Lagerburg, Anne Vrancken, Sietske Bergsma, Janita Dekker, Wouter Diemer, Judith Waldner-Troost, Maaike Koenrades

“…Methods: A custom phantom was designed comprising features to assess accuracy and resolution of the Form 3B printer (Formlabs, Somerville, MA, USA). …”
Get full text

Tomographic Assessment of Bone Regeneration in Osteochondral Lesion Treated with Various Biomaterials in a Sheep Model Study by Taulant Goga, Bledar Goxha, Alberto Maria Crovace, Mario Cinone, Luca Lacitignola, Marta Guadalupi, Erinda Lika

“…This study aims to demonstrate the effectiveness of a tomographic assessment method for optimizing the evaluation of osteochondral regeneration, particularly using Hounsfield units, to enable the evaluation of scaffold integration and tissue regeneration. …”
Get full text

Selective Enrichment of Hypermethylated DNA by a Multivalent Binding Platform by Ruben W. Kolkman, Loes I. Segerink, Jurriaan Huskens

“…In the here proposed method, a methyl binding domain (MBD) protein immobilized at a surface is used as a receptor for (hyper)methylated DNA. …”
Get full text

Effect of music intervention on dental anxiety and fear: A bibliometric analysis of RCTs from 2004 to 2024 by Yena Gan, Jinwei Huang, Sheng Han, He Xu, He Zhu, Duoduo Li, Zening Wei, Feng Sun, Zhigang Cai

“…Notable sex distribution differences were observed across HDI groups. Future research trends should include more extensive trials, personalized interventions, standardized guidelines, and enhanced collaboration to optimize patient engagement and emotional regulation.…”
Get full text

Shorter versus longer-duration antibiotic treatments for immunocompetent patients with bloodstream infections: a systematic review and meta-analysisResearch in context by Ming Liu, Ya Gao, Li Zheng, Zhifan Li, Liang Yao, Jianguo Xu, Qingyong Zheng, Ping Zeng, Jinhui Tian

“…This study aimed to compare the efficacy and safety of shorter versus longer duration antibiotic treatment for immunocompetent patients with bloodstream infections. Methods: We searched Medline, Embase, and Cochrane Central Register of Controlled Trials without language restrictions for randomized controlled trials (RCTs) published between database inception and 25 November 2024, comparing shorter-duration antibiotic treatments with longer-duration antibiotic treatments in patients with bloodstream infections with a minimum difference of 3 days in duration of therapy. …”
Get full text

Comparison of ADMIRE, SAFIRE, and Filtered Back Projection in Standard and Low-Dose Non-Enhanced Head CT by Georg Gohla, Anja Örgel, Uwe Klose, Andreas Brendlin, Malte Niklas Bongers, Benjamin Bender, Deborah Staber, Ulrike Ernemann, Till-Karsten Hauser, Christer Ruff

“…<b>Methods</b>: In this retrospective single-center study, 21 consecutive patients underwent standard NECT on a 128-slice CT scanner. …”
Get full text

Production, Validation, and Exposure Dose Measurement of [¹³N]Ammonia Under Academic Good Manufacturing Practice Environments by Katsumi Tomiyoshi, Yuta Namiki, David J. Yang, Tomio Inoue

“…The goals of cGMP and a-GMP are different: cGMP focuses on process optimization, certification, and commercialization, while a-GMP facilitates the small-scale, in-house production of PET drugs for clinical trials and patient-specific standard of care. …”
Get full text

Spatial and temporal evaluation of iodine uptake and radiodensity in meniscus tissue using contrast-enhanced micro-CT by Federica Orellana, Alberto Grassi, Katja M. Nuss, Peter Wahl, Antonia Neels, Stefano Zaffagnini, Annapaola Parrilli

“…Specific objectives included evaluating the diffusion of CAs within meniscal samples over time, assessing volume changes due to staining, and identifying the iodine ions absorbed by the tissue. Materials and methods: Water-based and PBS-based Lugol solutions (KI3) were used to stain sheep and pig menisci for 24 days. …”
Get full text

Non-Targeted Metabolomics Reveals Tobacco Metabolites Associated with Roasted Tobacco Quality Under Organic Substitution by Feng Tian, Li Zhang, Lina Niu, Xinglong Fan, Yongliang Han, Yuanshang Liu, Jiancai Qian, Shihang Huang, Xixian Ou, Qiang Li

“…This study revealed the significant differences in the metabolite composition under different fertilization conditions, with a strong correlation between metabolites and tobacco quality indices. …”
Get full text

The human gut microbiota is associated with host lifestyle: a comprehensive narrative review by Qin Zeng, Qin Zeng, Xianqiong Feng, Xianqiong Feng, Yanling Hu, Yanling Hu, Shaoyu Su, Shaoyu Su

“…This knowledge gap limits our ability to develop targeted microbiome-based interventions for metabolic and immune-related disorders.MethodsTo address this gap, we conducted a comprehensive evaluation of peer-reviewed literature from 2000 to present, identified through systematic searches of PubMed, Web of Science, and Scopus using key terms related to gut microbiota and lifestyle interventions. …”
Get full text

Towards the Development of the Clinical Decision Support System for the Identification of Respiration Diseases via Lung Sound Classification Using 1D-CNN by Syed Waqad Ali, Muhammad Munaf Rashid, Muhammad Uzair Yousuf, Sarmad Shams, Muhammad Asif, Muhammad Rehan, Ikram Din Ujjan

“…The model achieved an overall accuracy of 0.95, outperforming state-of-the-art methods. Particularly, the normal and crackles categories attained the highest F1-scores of 0.97 and 0.95, respectively. …”
Get full text

Fusion of Multimodal Audio Data for Enhanced Speaker Identification Using Kolmogorov-Arnold Networks by Aryaman Tamotia, Dhruv Shantu Karmokar, Rethi Komal, K. Khadar Nawas, A. Shahina, A. Nayeemulla Khan

“…Although the classical deep learning methods are effective, they have rather high computational cost, which leads to usually cumbersome parameter tuning processes and hence reduce their applicability to real-world deployments. …”
Get full text

A novel monoclonal antibody against human thymic stromal lymphopoietin for the treatment of TSLP-mediated diseases by Lihua Shi, Mingcan Yu, Ying Jin, Peng Chen, Guangmao Mu, Susan H. Tam, Minseon Cho, Mark Tornetta, Chao Han, Man-Cheong Fung, Mark L. Chiu, Di Zhang

“…We further conducted Fc engineering to optimize TAVO101 antibody with reduced affinity to Fcγ receptors and C1q protein but with increased affinity to FcRn receptor for half-life extension.DiscussionBy recognizing a different epitope, similarly potent neutralization of TSLP activities, and longer circulating half-life than tezepelumab, novel anti-TSLP antibody TAVO101 offers a potential best-in class therapeutics for various TSLP-mediated diseases.…”
Get full text

Identification of matrix stiffness-related molecular subtypes in HCC via integrating multi-omics analysis and machine learning algorithms by Hanqi Li, Jiayi Zhang, Yu Shi, Huanhuan Wang, Ruida Yang, Shaobo Wu, Yue Li, Xue Yang, Qingguang Liu, Liankang Sun

“…Investigating matrix stiffness-related signatures provides crucial insights into HCC prognosis and therapeutic response. Methods Multi-omics data from liver hepatocellular carcinoma (LIHC) were integrated using 10 clustering algorithms, identifying three subgroups with distinct survival outcomes and treatment responses. …”
Get full text

Mamba-YOLO-ML: A State-Space Model-Based Approach for Mulberry Leaf Disease Detection by Chang Yuan, Shicheng Li, Ke Wang, Qinghua Liu, Wentao Li, Weiguo Zhao, Guangyou Guo, Lai Wei

“…Traditional detection methods relying on chemical pesticides and manual observation prove inefficient and unsustainable. …”
Get full text

Lightweight Attention-Based CNN Architecture for CSI Feedback of RIS-Assisted MISO Systems by Anming Dong, Yupeng Xue, Sufang Li, Wendong Xu, Jiguo Yu

“…In RIS-assisted communication systems, existing deep learning-based channel state information (CSI) feedback methods often suffer from excessive parameter requirements and high computational complexity. …”
Get full text