Efficacy and safety of epaminurad, a potent hURAT1 inhibitor, in patients with gout: a randomized, placebo-controlled, dose-finding study by Jae-Bum Jun, Hye-Soon Lee, Sang-Hyon Kim, Seung-Geun Lee, Doo-Ho Lim, Jinhyun Kim, Yong-Beom Park, Mie Jin Lim, Seung-Jae Hong, Hyo-Jin Choi, Shin-Seok Lee, Hyun Ah Kim, Jiwon Hwang, Chang-Hee Suh, Seungwoo Han, Jung-Yoon Choe, Wan-Hee Yoo, Jung Soo Song

“…The aims of the current study were to evaluate the urate-lowering efficacy and safety of epaminurad compared with placebo in patients with gout, and to determine the optimal dose. Methods This multicenter, randomized, double-blind, placebo-controlled, dose-finding phase 2b clinical trial, which incorporated a standard-treatment reference arm, enrolled patients aged 19–70 years with gout and sUA level ≥ 0.42 mmol/L. …”
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Entrenamiento físico/técnico/táctico vs entrenamiento físico: efectos en la resistencia/velocidad de futbolistas prejuveniles (Physical/technical/tactical training vs physical trai... by Darley Jhosue Burgos Angulo, Kevin Andrés Sánchez Jiménez, Ronald Alberto Feraud Cañizares, Alex Arturo Perlaza Estupiñán, María Antonieta Coello Castro, Boris René Morales Fischer

“…Objective: To analyze the effects of physical/technical/tactical training and physical training in enhancing resistance/speed capacity in pre-youth soccer players. Methods: Quasi-experimental research, which compares the results in two homogeneous independent samples (Experimental Group 1: n=12; Experimental Group 2: n=13) in a 6-month intervention process, where speed resistance is measured with two performance assessment tests, additionally evaluated at the process end the effectiveness of the shot on goal. …”
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Effects of taurine on growth performance, body composition and physiological responses of western white shrimp, Litopenaeus vannamei broodstock by Vahid Morshedi, Mahmoud Nafisi Bahabadi, Mansour Torfi Mozanzadeh, Amin Oujifard, Naser Agh, Khalegh Maneii, Ahmad Qasemi, Nehzat Bakhshi, Hadi Ebrahimi, Rezvan Tamadoni, Shirin Hamedi, Reza Bagherpour, Fatemeh Solimani

“…Tau has been also implicated in osmoregulation, modulation of neurotransmitters, hormone release, and antioxidation. Materials and Methods: A 30-day feeding study was conducted to determine the effects of supplementing the Tau in the diet of broodstock western white shrimp. …”
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Evaluation of the Prebiotic Effect of Spirulina platensis Algal Extract on Lactobacillus acidophilus Survival and Physicochemical Properties of Feta Cheese by Ahmad Yazdani, Hamidreza Kazemeini, Ahmad Nazaktabar

“…It is also known that the optimal balance in the number of microbes in the digestive system depends on nutrition and health. …”
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First-line treatment options for PD-L1-negative lung adenocarcinoma: a real-world analysis by Lijuan Chen, Lijuan Chen, Jie Liu, Jie Liu, Junfeng Lu, Junfeng Lu, Xiufeng Hu, Xiufeng Hu, Erjing An, Erjing An, Yanqiu Zhao, Yanqiu Zhao

“…ObjectiveTo evaluate the optimal first-line treatment options for programmed death-ligand 1 (PD-L1) negative lung adenocarcinoma (LUAD) patients without common gene-alterations.MethodsA total of 159 PD-L1-negative LUAD patients without common gene-alterations were included. …”
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The influence of intraoperative hemodynamic parameters on the results of combined kidney and pancreas transplantation by M. Sh. Khubutiya, M. V. Lebedev, N. K. Kuznetsova, A. M. Talyzin, A. G. Balkarov, S. V. Zhuravel

“…The remaining hemodynamic parameters had no statistically significant differences between the groups (p>0.05). There were no statistically significant differences between the groups in the incidence of postoperative complications, either (p>0.05). …”
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Mechanism of Modified Tongyou Decoction and Its Separated Formulas Inhibiting Vasculogenic Mimicry in Esophageal Cancer TE-1 Cells via NF-κB/HIF-1α Axis by Qian Wang MS, Yingying Tian MS, Lingyu Kong MD, Zeyi Chen MS, Xin Yan PhD, Chenxi Wu PhD, Huijuan Cao PhD, Fanwu Wu PhD, Yongsen Jia PhD, Prof.

“…Objective: To explore mechanisms of Modified Tongyou Decoction (MTD) and its separated formulas inhibiting vasculogenic mimicry (VM) in esophageal cancer (EC) TE-1 cells and improving the hypoxic environment via NF-κB/HIF-1α axis on the basis of the hypoxia stimulating the cells’ VM formation. Methods: The extract of MTD was prepared by water extraction and alcohol precipitation-whirl evaporation, and amygdalin, the content of the antitumor active component, was determined by chromatography. …”
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Studying the Beneficial Indicators of Intercropping of Safflower (Carthamus tinctorius L.) with Chickpea (Cicer arietinum L.), Lentil (Lens culinaris Medik), and Bitter Vetch (Lath... by Amin Yari, Farzad Mondani, Alireza Bagheri, Hamid Reza Chaghazardi

“…By selecting crop species with different growth habits and minimal competition, intercropping optimizes resource absorption, resulting in improved yields compared to monoculture. …”
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Frictional Characteristics and Mechanical Model of PTFE Against Stainless Steel Under Low Loads by ZHAO Shoujiang, DAI Junwu

“…This research contributes to enhancing the accuracy of isolation effect predictions and optimizing the design of seismic isolators.MethodsThe specimens of PTFE and 304 stainless steel were prepared to ensure a smooth surface and accurate size, and a test device was designed and constructed. …”
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Cell death pathway regulation by fatty acid metabolism-related genes in neuroblastoma: a multi-omics analysis identifying CHD5 as a novel biomarker by Yankun Chen, Junzhi Liu, Yubin Jia, Jiaxing Yang, Yan Jin, Yun Liu, Benfu Zhong, Qiang Zhao

“…While dysregulated cell death mechanisms and metabolic reprogramming are hallmarks of cancer progression, the interplay between fatty acid metabolism and cell death pathway regulation in neuroblastoma remains incompletely understood. Methods Identifying molecular subtypes influenced by fatty acid metabolism were built by consensus clustering analysis. …”
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Distribution Patterns and Driving Factors of Highly Educated Talent in China from a Heterogeneity Perspective: An Examination Based on Prefectural Administrative Regions by Wu Rongwei, Wang Yuanxin, Zhang Qin, Zhou Liang

“…The number of highly educated individuals continues to grow, and the internal heterogeneity of this group is becoming increasingly evident. Examining these differences in location selection mechanisms from the perspective of heterogeneity is crucial for optimizing talent distribution. …”
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The Effect of Sowing Date on Yield and Quality Characteristics of Autumn Sugar Beet (Beta vulgaris L.) Cultivars in Gonbad Kavous by E Paserakloo, A Biabani, S Yarahamdi, A Saberi, M Naeemi, F Taliei

“…Also, bolting rate between sowing dates is different.Materials and MethodsThe aim of the present study was to investigate the quality and strength changes in the sugar beet in order to assess effect of different sowing dates and cultivars on sugar and root yield. …”
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Accuracy and cost comparison of 3D-printed guides in complex spinal deformity correction: direct vs indirect design by Wei Yang, Wei Yang, Wei Yang, Wei Guo, Wei Guo, Wen-Jun Wu, Rong Ma, Zemin Wang, Honglai Zhang, Wanzhong Yang, Zhaohui Ge, Zhaohui Ge

“…Among these techniques, patient-specific guides, which feature pre-defined and pre-validated trajectories, present an attractive solution for achieving precision in screw placement and osteotomies.MethodsCT scan data (DICOM format) from 10 patients with complex and severe spinal deformities were selected. …”
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Trend analysis of pulmonary tuberculosis incidence among the elderly in Shanghai， 2014‒2023 by HUANG Yu, RAO Lixin, XU Biao, ZHAO Qi, SHEN Xin

“…ObjectiveTo describe the epidemiological characteristics and trend of pulmonary tuberculosis among the elderly in Shanghai from 2014 to 2023, to estimate the incidence between 2024‒2025, so as to provide references for optimizing the prevention and control strategies of pulmonary tuberculosis for elderly in Shanghai.MethodsData of pulmonary tuberculosis patients aged ≥60 years in Shanghai registered in the Tuberculosis Registration and Management System of Chinese Center for Disease Control and Prevention from 2014 to 2023 was derived to describe the demographic characteristics of the elderly patients with pulmonary tuberculosis, and to calculate the reported incidence rate and annual percentage change (APC) of pulmonary tuberculosis. …”
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Treatment Regimens with Ranibizumab in Neovascular Age-Related Macular Degeneration: Real-World Results from the PACIFIC Study Author List by Lorenz K, Haritoglou C, Barthelmes D, Sefat AMM, Berk H, Beeke E, Scheffler M, Iwersen M, Müller B, Ziemssen F

“…This study investigates the utilization and effectiveness of ranibizumab in nAMD, focusing on different treatment regimens in real-world settings.Materials and Methods: The PACIFIC study, a non-interventional, prospective, multicenter study, included nAMD patients treated with ranibizumab at 185 sites across Germany, the Netherlands and Switzerland. …”
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In-vitro immune-modulation of triple-negative breast cancer through targeting miR-30a-5p/MALAT1 axis using nano-PDT combinational approach by Asmaa Ramzy, Mohammad Abdel-Halim, Tamer Manie, Noha M. Elemam, Samar Mansour, Rana A. Youness, Aya Sebak

“…Special focus is directed towards evaluation of the role of the selected treatment agents on the non-coding RNAs (ncRNAs) involved in tuning the immuno-oncogenic profile of TNBC, for instance, the miR-30a-5p/MALAT1 network. Methods: This study enrolled 30 BC patients. CLNPs and ce-6-loaded CLNPs with different physicochemical features were synthesized and optimized using ionotropic gelation. …”
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Effect of Spatial Variations in Floodplain Vegetation on Bed Shear Stress Distribution by REN Chun-ping, YANG Fan, ZHANG Yuan-yuan, WANG Hong-fei

“…[Methods] A two-dimensional hydrodynamic model was established using Delft3D-FM and validated with measured water levels and discharges. …”
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Reducing time and computing costs in EC-Earth: an automatic load-balancing approach for coupled Earth system models by S. Palomas, M. C. Acosta, G. Utrera, E. Tourigny

“…Likewise, when compared to the EC-Earth high-resolution EUCP runs, the method presented showed an improvement of 34 % in the speed, with a 6.7 % reduction in the core hours consumed.…”
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A qualitative study of father involvement with their young children in mainland China by Yang Liu, Yang Liu, Mingchun Guo, Cassandra K. Dittman, Cassandra K. Dittman, Ying Zheng, Ying Zheng, Divna M. Haslam, Divna M. Haslam

“…Thus, it is critical to explore subjective experiences of and possible influences on Chinese fathers’ involvement with children from their point of view.MethodsThis study conducted semi-structured interviews with 35 Chinese fathers of preschoolers. …”
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THE EFFECTIVENESS OF THE DEVELOPMENT OF TERRITORIES IN THE STATE REGIONAL SYSTEM POLITICIANS by Natallia Gavkalova, Ludmila Avedyan, Oleksandr Akimov, Liudmyla Akimova, Victoria Belyavtseva

“…A set of measures was proposed to optimize the processes of managing the development of territories, in particular, the creation of mechanisms for combating post-pandemic consequences, stimulating purchasing consumer demand at the local level, improvement of tax policy, creation of favourable conditions for improving the qualification level of employees, rationalization of the financial redistribution mechanism resources between different territories, as well as between regional and state budgets, dissemination of effective anti-corruption practices at the local level. …”
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