Risk of Major Bleeding, Stroke/Systemic Embolism, and Death Associated With Different Oral Anticoagulants in Patients With Atrial Fibrillation and Severe Chronic Kidney Disease by Yunwen Xu, Shoshana H. Ballew, Alexander R. Chang, Lesley A. Inker, Morgan E. Grams, Jung‐Im Shin

“…Methods and Results Using deidentified electronic health records from the Optum Labs Data Warehouse, adults with atrial fibrillation and severe chronic kidney disease (estimated glomerular filtration rate <30 mL/min per 1.73 m2) initiating warfarin, apixaban, or rivaroxaban between 2011 and 2021 were included. …”
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Machine learning-based integration develops relapse related signature for predicting prognosis and indicating immune microenvironment infiltration in breast cancer by Junyi Li, Shixin Li, Dongpo Zhang, Yibing Zhu, Yue Wang, Xiaoxiao Xing, Juefei Mo, Yong Zhang, Daixiang Liao, Jun Li

“…Abstract Breast cancer is the most common type of cancer in women, and while current treatments can cure the majority of early-stage primary BC cases, recurrence remains a significant challenge. Traditional methods of assessing patient prognosis, such as AJCC, TNM staging, and biochemical markers, are no longer sufficient in the era of precision medicine. …”
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Multi-Objective Optimization Algorithm Based Bidirectional Long Short Term Memory Network Model for Optimum Sizing of Distributed Generators and Shunt Capacitors for Distribution S... by Amarendra Alluri, Srinivasa Rao Gampa, Balaji Gutta, Mahesh Babu Basam, Kiran Jasthi, Nibir Baran Roy, Debapriya Das

“…An adaptive moment estimation (adam) optimization approach is employed to train the BiLSTM ML model for identifying the ideal values of distributed generations and shunt capacitors at different load factors. …”
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Numerical optimization of drying of white button mushroom (Agaricus bisporus) employing microwave and fluidized bed drying for preparing value added product by Shahid Ahmad Teli, Adnan Yousuf Sheikh, Rakesh Mohan Shukla, Rishi Richa, Shahzad Faisal, Sanjay Kumar, Ankita Dobhal, Ajay Singh, Avvaru Praveen Kumar

“…The microwave-assisted fluidized bed two-stage novel, energy-efficient drying method was used for Agaricus bisporus drying which can be further utilised for mushroom protein powder, and soup. …”
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The therapeutic efficacy comparison of MSCs derived different tissues unveilings anti-apoptosis more crucial than angiogenesis in treating acute myocardial infarction by Mingjie Pan, Yueyue Xu, Yaping Wang, Yue Jiang, Yuanyuan Xie, Chenxu Tai, Wenqing Wang, Bin Wang

“…In this study, we compared the cardioprotective effect of UCMSCs and ADMSCs targeting the angiogenesis in a mouse MI model and screened out optimum MSCs candidate for precise clinical application. Methods The gene expression profiles of UCMSCs and ADMSCs were investigated through RNA sequencing analysis. …”
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Fat-free noncontrast whole-heart cardiovascular magnetic resonance imaging with fast and power-optimized off-resonant water-excitation pulses by Adèle L.C. Mackowiak, Davide Piccini, Ruud B. van Heeswijk, Roger Hullin, Christoph Gräni, Jessica A.M. Bastiaansen

“…Effective fat suppression is crucial, especially when using whole-heart CMR techniques. Conventional methods often fall short due to rapid fat signal recovery, leading to residual fat content hindering visualization. …”
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Sustainability Assessment and Spatial Optimization of Minority Characteristic Villages Based on the Minimum Cumulative Resistance Model: A Case Study of Qiandongnan, China by Min Wang, An Huang, Qianxi Zhang, Zhe Cheng

“…Finally, this study proposed a targeted spatial optimization pathway. The results reveal there are significant spatial differences in MCVs; villages in the central, southern, and central-western Qiandongnan exhibit stronger sustainability, whereas the southwest and eastern regions are weak. …”
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Optimizing post-thoracotomy pain management: comparing erector spinae vs. paravertebral block in thoracotomy patients: a prospective randomized study by Kerem Baser, Ozal Adiyeke, Ergun Mendes, Funda Gumus Ozcan

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Optimizing Total Ankle Arthroplasty Analysis: A Comprehensive Assessment of Alignment and Patient-Reported Outcome Measures via Weight-Bearing CT by Carlos Felipe Albarrán MD, MSc, Mario Ignacio Escudero MD, Carlos Felipe Muñoz MD, Eddie Birman MD, Hugo Letelier MD, Felipe Chaparro MD, Giovanni Carcuro MD, Manuel Jose Pellegrini MD

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A Martingale-Free Introduction to Conditional Gaussian Nonlinear Systems by Marios Andreou, Nan Chen

“…Moreover, the approach improves the understanding of different sampling methods in characterizing uncertainty. …”
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Extraperitoneal vs transperitoneal laparoscopic cystectomy: optimized surgical techniques and long-term outcomes in a single-center retrospective cohort study by Guanqun Zhu, Yuxuan He, Shicheng Wang, Jiao Huang, Rui Zhang, Zongliang Zhang, Kai Zhao, Xinbao Yin, Xiaokun Yang, Zaiqing Jiang, Guoyi Jiang, Woong Jin Bae, Ke Wang

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Artificial Intelligence Enabled Fully Automated CMR Function Quantification for Optimized Risk Stratification in Patients Undergoing Transcatheter Aortic Valve Replacement by Ruben Evertz, Torben Lange, Sören J. Backhaus, Alexander Schulz, Bo Eric Beuthner, Rodi Topci, Karl Toischer, Miriam Puls, Johannes T. Kowallick, Gerd Hasenfuß, Andreas Schuster

“…Novel fully automated analyses may facilitate data analyses but have not yet been compared against conventional manual data acquisition in patients with severe aortic stenosis (AS). Methods. Fully automated and manual biventricular assessments were performed in 139 AS patients scheduled for TAVR using commercially available software (suiteHEART®, Neosoft; QMass®, Medis Medical Imaging Systems). …”
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Analysis of results to optimize anticoagulant therapy in patients who underwent mechanical heart valve replacement: a pilot singlecenter controlled study by S. A. Uranova-Tkachenko, A. V. Bogachev-Prokophiev, R. M. Sharifulin, Y. M. Smirnov, A. N. Pivkin, A. S. Zalesov, D. A. Astapov

“…The analysis will focus on two groups: those maintained at therapeutic INR values (3 ± 0.5) and those maintained at reduced INR values (2 ± 0.5). Material and methods. The analysis of a prospective, randomized, single-center study included 80 patients (56% men and 44% women) who underwent mechanical aortic valve replacement between March 2020 and September 2022. …”
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Final Fusion Strategies in Early-Onset Scoliosis: Does Implant Density Make a Difference After Magnetically Controlled Growing Rod Treatment? by Paolo Brigato, Leonardo Oggiano, Sergio De Salvatore, Davide Palombi, Sergio Sessa, Umile Giuseppe Longo, Andrea Vescio, Pier Francesco Costici

“…This study aimed to compare the radiographic, surgical, and economic outcomes associated with high-density (HD) versus low-density (LD) screw constructs in EOS patients previously treated with MCGRs undergoing definitive fusion. Methods: This retrospective study included 27 EOS patients who underwent definitive posterior spinal fusion between January 2017 and September 2022. …”
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Optimizing laying hen diets: effect of partial maize meal replacement with wheat bran or biscuits crumbs and Bacillus amyloliquefaciens CECT 5940 by Albertina Felizardo Manteiga, Abilio Paulo Changule, Dercia Hilario Magaia, Nilza Jorge Manjate, Florentina Domingos Chilala, Leonel António Joaquim, Leonel António Joaquim, Eunice Justino Chivale, Filomena Dos Anjos, Otilia Henrique Tamele Tomo, Manuel Garcia-Herreros, Manuel Garcia-Herreros, Custodio Bila, Custodio Bila, Custodio Bila, Custodio Bila

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Investigation of flow field characteristics around a novel high-efficiency tandem dual-rotor wind turbine under different rotor spacings by Xinkai Li, Xinkai Li, Xiaojiang Guo, Xiaojiang Guo, Caicai Liao, Caicai Liao, Zhaoliang Ye, Zhaoliang Ye, Xin Shen

“…However, the influence mechanism of rotor spacing on complex flow fields and turbine performance remains unclear.MethodsAiming at this problem, a high-precision computational fluid dynamics (CFD) method was adopted to construct a physical model of dual-rotors with real blade geometry. …”
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Optimizing bone health in people living with HIV: insights from a network meta-analysis of randomized controlled trialsResearch in context by Jui-Chien Wang, Sun-Mei Chung, Po-Ting Wu, Yu-Kang Tu, Pei-Chun Lai, Ta-Wei Tai, Chih-Hsing Wu, Yin-Fan Chang, Fa-Chuan Kuan, Kai-Lan Hsu, Ching-Ju Fang, Chia-Wen Li, Po-Lin Chen, Chien-An Shih

“…Methods: We conducted a network meta-analysis (NMA) with component analysis of randomized controlled trials (RCTs) identified from Medline, EMBASE, Cochrane CENTRAL, Scopus, Web of Science and CINAHL EBSCO databases, from inception to December 1, 2024. …”
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Optimizing early hip maturation strategies in neonatal hip immaturity and dysplasia: a cohort study and network meta-analysisResearch in context by Yu-Cheng Su, Ying-Yu Wang, Pei-Chun Lai, Yu-Kang Tu, Chih-Kai Hong, Ming-Tung Huang, Chii-Jeng Lin, Su-Ying Lee, Che-Wei Lin, Ching-Ju Fang, Po-Ting Wu, Fa-Chuan Kuan, Kai-Lan Hsu, Jou-Hua Wang, Chien-An Shih

“…This study evaluates the clinical effectiveness of various conservative management approaches. Methods: We employed a dual-approach methodology combining original research with systematic evidence synthesis. …”
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Enhancing Histological Techniques for Small Crustaceans: Evaluation of Fixation, Decalcification, and Enzymatic Digestion in <i>Neocaridina</i> Shrimp by Rafał Karol Wild, Dobrochna Adamek-Urbańska, Artur Witold Balicki, Wiktoria Cieśla, Jakub Przybyszewski, Maciej Grzegorz Kamaszewski

“…This study aimed to optimize histological methods for <i>Neocaridina</i> shrimp by evaluating different protocols for fixation, decalcification, and enzymatic digestion. …”
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Discussion and Study of Design on Modification Coefficient and Helix Angle of Gear of Tube Mill by Ben Daochun, Wang Dongsheng, Wang Fuguang, Li Xiaoping, Zha Wenwei

“…The allocation method and precautions of helix angle selection on total modification coefficient for gearare described.Through the analysis calculation and comparison with practice,it concluded that the value of optimizing of distribution on total variation coefficient can be obtained based on the calculation by computer program. …”
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