Optimized in-solution enrichment of over a million ancient human SNPs by Roberta Davidson, Xavier Roca-Rada, Shyamsundar Ravishankar, Leonard Taufik, Christian Haarkötter, Evelyn Collen, Matthew P. Williams, Peter Webb, M. Irfan Mahmud, Erlin Novita Idje Djami, Gludhug A. Purnomo, Cristina Santos, Assumpció Malgosa, Linda R. Manzanilla, Ana Maria Silva, Sofia Tereso, Vítor Matos, Pedro C. Carvalho, Teresa Fernandes, Anne-France Maurer, João C. Teixeira, Raymond Tobler, Lars Fehren-Schmitz, Bastien Llamas

“…Conclusions In conclusion, we provide researchers in the field of human paleogenomics with a comprehensive understanding of the strengths and limitations of different sequencing and enrichment strategies, and our results offer practical guidance for optimizing experimental protocols.…”
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Heuristic Global Optimization for Thermal Model Reduction and Correlation in Aerospace Applications by João P. Castanheira, Beltran N. Arribas, Rui Melicio, Paulo Gordo, André R. R. Silva

“…Results indicate that these heuristic methods can achieve high-accuracy correlations, with transient simulations exhibiting temperature differences below 3 °C, thereby validating the hypothesis that heuristic methods can effectively navigate complex parameter optimizations. …”
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Optimizing Microneutralization and IFN-γ ELISPOT Assays to Evaluate Mpox Immunity by Yinyi Yu, Krystal Meza, Chase Colbert, Daniel F. Hoft, Anna Jaunarajs, Azra Blazevic, Sharon E. Frey, Getahun Abate

“…The mpox-specific IFN-γ ELISPOT assay was optimized using different mpox antigen preparations. …”
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Optimization of the Lens Nucleus Fragmentation during Phacoemulsification in Patients with Pseudoexfoliation Syndrome by V. M. Malov, A. V. Zolotarev, E. B. Eroshevskaya, I. V. Malov, A. E. Gorbunov

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Influence of surgical timing post-neoadjuvant chemotherapy on survival outcomes in breast cancer patients: A comprehensive systematic review and meta-analysis by Dandan Wang, Xiaowei Sun, Wen Sun, Ruoxi Wang, Hong Pan, Wenbin Zhou

“…Methods: PubMed, Web of Science and Cochrane Library databases in English were systematically searched for this systematic review. …”
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Optimization Design of Charge and Discharge Circuit Control forAuxiliary Converters by LIU Yi, CHEN Xiang, LIU Changqing

“…Through the simplification of the charge circuit and the model construction of the supporting capacitor, the specific reasons for the difference of charging time were spotted, and the method of judging the optimal charging completion and the action logic of the discharge contactor were proposed. …”
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Optimization of the MVB Period Polling Table Based on Chaos-genetic Algorithm by SHEN Qiang, LIN Zhiming, YUE Guo

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Optimal oral antithrombotic regimes for patients with acute coronary syndrome: a network meta-analysis. by Yicong Ye, Hongzhi Xie, Yong Zeng, Xiliang Zhao, Zhuang Tian, Shuyang Zhang

“…<h4>Methods</h4>A systematic search of MEDLINE, EMBASE, and the Cochrane databases was performed to identify all phase 3 randomized controlled trials (RCTs) involving novel oral anticoagulants or oral P2Y12 inhibitors in patients with ACS. …”
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Sex- and Age-Specific Optimal Anthropometric Indices as Screening Tools for Metabolic Syndrome in Chinese Adults by Jia Zhang, Wenhua Zhu, Lifeng Qiu, Lijuan Huang, Lizheng Fang

“…To compare the predictive ability of six anthropometric indices for identification of metabolic syndrome (MetS) and to determine their optimal cut-off points among Chinese adults. Methods. …”
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Determining the Optimal Length of Root Canal Obturations Using GuttaFlow®2 and Thermafill Systems. by Lindihana Emini, Jetmire Alimani-Jakupi, Nexhmije Ajeti, Amela Cana, Zana Jusufi-Osmani, Sahmedin Saliu

“…This study aims to compare the obturation length achieved using the GuttaFlow®2 and Thermafill systems, evaluating their effectiveness through micro-computed tomography (micro-CT). Materials and Methods: Eighty extracted human anterior teeth were decoronated 1 mm below the cementoenamel junction and randomly assigned to two groups. …”
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Optimizing temperature, light intensity, and salinity for carpospore culture of Gracilaria fisheri by Wencheng Yang, Kun Lin, Zhaojun Zeng, Youyou Guo, Chunli Chen, Huihui Wang, Rong Xin, Jiawei Liao, Haiping He, Enyi Xie, Jianjun Cui, Jinhui Wu

“…Through these experiments, we systematically explored the entire cultivation process to elucidate the variations in carpospore release quantity, attachment rate, and germination rate and in the carposporeling growth rate and pigment content under different combinations of conditions. We found that the optimal conditions for carpospore release were 25°C, 20 μmol·m–2·s–1, and 30 salinity. …”
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Plasma microRNAs to Select Optimal Patients for Antibody Production from Anti-Addiction Vaccines by Thomas R. Kosten, Amrit Koirala, David A. Nielsen, Coreen B. Domingo, Ynhi T. Thomas, Preethi H. Gunaratne, Cristian Coarfa

“…We have plasma stored from 152 cocaine vaccine trial participants following three vaccinations over 9 weeks and examined miRs as potential response biomarkers. <b>Methods</b>: We compared 2517 miRs before anti-cocaine vaccination in participants with the highest (n = 25) to the lowest (n = 23) antibody levels. …”
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Optimized DenseNet Architectures for Precise Classification of Edible and Poisonous Mushrooms by Jay Prakash Singh, Debolina Ghosh, Jagannath Singh, Anurag Bhattacharjee, Mahendra Kumar Gourisaria

“…Traditional methods often result in errors which led to misclassifications and conventional machine learning models often struggle in feature extraction due to subtle differences in mushroom species. …”
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Optimal duration of antimicrobial prophylaxis in patients undergoing distal pancreatectomy: A multicenter cohort study by Kenjiro Okada, Kenichiro Uemura, Sohei Satoi, Tsutomu Fujii, Manabu Kawai, So Yamaki, Toru Watanabe, Hideki Motobayashi, Shinya Takahashi

“…However, there is limited evidence regarding optimal duration of antimicrobial prophylaxis. This study aimed to evaluate the optimal duration of antimicrobial prophylaxis in distal pancreatectomy. …”
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Serum Thyroglobulin: Preoperative Levels and Factors Affecting Postoperative Optimal Timing following Total Thyroidectomy by Anery Patel, Valerie Shostrom, Kelly Treude, William Lydiatt, Russell Smith, Whitney Goldner

“…We evaluated if preoperative TG levels affected postoperative levels and if other factors may influence the optimal time to check postoperative TG. Methods. This is a prospective, observational pilot study. …”
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Development of a Population Pharmacokinetic Model of Levofloxacin in Healthy Adults and Identification of Optimal Dosing Regimens by Yun-Jung Lee, Gaeun Kang, Dae-Young Zang, Dong-Hwan Lee

“…This study aimed to develop a population pharmacokinetic (PK) model of levofloxacin in healthy adults and identify optimal dosing regimens. <b>Methods</b>: In this prospective, open-label study, 12 healthy adults received a single dose of levofloxacin. …”
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Evaluation of Emulsification Techniques to Optimize the Properties of Chalcone Nanoemulsions for Antifungal Applications by Joice Farias do Nascimento, Flavia Oliveira Monteiro da Silva Abreu, Taysse Holanda, Raquel Oliveira dos Santos Fontenelle, Júlio César Sousa Prado, Emmanuel Silva Marinho, Matheus Nunes da Rocha, Jesyka Macêdo Guedes, Bruno Coelho Cavalcanti, Wesley Lyeverton Correia Ribeiro, Márcia Machado Marinho, Helcio Silva dos Santos

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A Randomized Controlled Trial for the Optimal Implementation of Psoriasis Treatment by Integrating Chinese and Western Medicine by Yu Y, Sun X, Hu R, Xia P, Wei Y, Yang W, Huang N, Ding Y, Guo S, Yang C, Weng H, Zhang Y, Ding X, Huang Q, Zhou X, Li X, Li B

“…Currently, the prevalent guideline-recommended regimen is based on psoriasis severity; however, no corresponding studies have been conducted on the hierarchical selection of integrated Chinese and Western medicine treatments.Objective: To explore the optimal implementation of psoriasis treatment by integrating Chinese and Western medicine.Methods: We conducted a 16-week multicenter single-blind randomized controlled trial in China between December 2019 and July 2022. …”
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Subthalamic nucleus deep brain stimulation for cranial-cervical dystonia: optimal stimulation sites and networks by Hutao Xie, Jiansong Huang, Ningfei Li, Houyou Fan, Shihang Yang, Zixiao Yin, Zhaoting Zheng, Zehua Zhao, Yin Jiang, Lin Shi, Anchao Yang, Fangang Meng, Guanyu Zhu, Quan Zhang, Jianguo Zhang

“…Methods: We retrospectively analyzed 51 patients with CCD treated with STN-DBS at a single center. …”
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Explorative Binary Gray Wolf Optimizer with Quadratic Interpolation for Feature Selection by Yijie Zhang, Yuhang Cai

“…Finally, a novel transfer function processes feature information differently at various stages, enabling the algorithm to search and optimize effectively in the binary space, thereby selecting the optimal feature subset. …”
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