Novel Epigenetics Control (EpC) Nanocarrier for Cancer Therapy Through Dual-Targeting Approach to DNA Methyltransferase and Ten-Eleven Translocation Enzymes by Risa Mitsuhashi, Kiyoshi Sato, Hiroyoshi Kawakami

“…Herein, we demonstrate the potential of the EpC carrier in HCT116 human colon cancer cells to upregulate tumor suppressor gene expression and rapidly achieve cell cycle arrest. Methods: PLGA core nanoparticles were prepared by the W/O/W double emulsion method. …”
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Prognostic factors in patients with hepatocellular cancer with progression after liver transplantation by I. A. Dzhanyan, M. S. Novruzbekov, O. D. Olisov, V. V. Breder

“…The probability of progression of hepatocellular cancer after orthotopic liver transplantation within the first two years is about 75% and about 10% is detected after the fourth year. Progression of hepatocellular cancer remains the main factor limiting the life expectancy of patients after orthotopic liver transplantation.The aim of the study: to evaluate the results of antitumor treatment of patients with hepatocellular cancer progression after liver transplantation.Materials and methods. …”
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Nonproteinuric Preeclampsia among Women with Hypertensive Disorders of Pregnancy at a Referral Hospital in Southwestern Uganda by Asiphas Owaraganise, Richard Migisha, Wasswa G. M. Ssalongo, Leevan Tibaijuka, Musa Kayondo, Godfrey Twesigomwe, Joseph Ngonzi, Henry Mark Lugobe

“…We recommend increased surveillance for nonproteinuric preeclampsia, especially among first-time pregnant women, who may not be detected by the traditional criteria. Obstetrics care providers should emphasize laboratory testing beyond proteinuria, among all women with hypertensive disorders of pregnancy to optimally diagnose and manage nonproteinuric preeclampsia.…”
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Generation of Cas9 Knock-In <i>Culex quinquefasciatus</i> Mosquito Cells by Elizabeth Walsh, Tran Zen B. Torres, Brian C. Prince, Claudia Rückert

“…To expand the genetic tools used to study <i>Culex</i> mosquitoes, we previously developed an optimized plasmid for transient Cas9 and single-guide RNA (sgRNA) expression in <i>Culex quinquefasciatus</i> cells to generate gene knockouts. …”
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Perioperative Arthroscopic Tourniquet Usage: Practices and Trends of the AANA Membership Are Varied by Brian Day, M.B., M.Sc., F.R.C.P.(Lon), F.R.C.S.(Eng and C)

“…Tourniquet usage in arthroscopy was varied, although some patterns were detected. For example, 91% of responders applied tourniquets for all limb procedures, but many inflated them only as needed, and some preferred not to use a tourniquet. …”
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Phytochemical and morpho-physiological response of Melissa officinalis L. to different NH4 + to NO3̄ ratios under hydroponic cultivation by Farzad Safaei, Abolfazl Alirezalu, Parviz Noruzi, Kazem Alirezalu

“…The highest antioxidant activity by both DPPH (37.39 µg AAE/mL) and FRAP (69.55 mM Fe++/g DW) methods was obtained in 75:25 - NH4 +:NO3̄ treatment. …”
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Recommendations of the Russian League Against Epilepsy (RLAE) on the use of magnetic resonance imaging in the diagnosis of epilepsy by G. N. Avakyan, D. V. Blinov, A. A. Alikhanov, E. M. Perepelova, V. A. Perepelov, S. G. Burd, A. V. Lebedeva, G. G. Avakyan

“…Introduction. The MRI method has revolutionized the diagnosis of epilepsy. …”
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Sustainable Innovation: Harnessing AI and Living Intelligence to Transform Higher Education by Hesham Mohamed Allam, Benjamin Gyamfi, Ban AlOmar

“…AI-driven tools are already enhancing the way students learn by personalizing content, streamlining processes, and introducing innovative teaching methods. Adaptive platforms adjust material based on individual progress, while emotionally intelligent AI systems help support students’ mental well-being by detecting and responding to emotional cues. …”
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Unraveling the microbiome–aroma Nexus: a metagenomic and volatile compound analysis of Yunnan cigars by Jing Pan, Ming-Da Huang, Jin Wang, Jian-Xiong Zhao, Bin Yang, Hong-Hui Yang, Jin-Sheng Huang, Yu-Long Su, Xue-Ru Song, Wei-Guang Wang, Ling-Duo Bu

“…A total of 121 VOCs were detected, with nicotine, ylangene, δ-elemene, (R,S)-anatabine, and phenethyl alcohol identified as key aroma components. …”
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From deformation twinning to α'' martensitic transformation in deforming Ti–12Mo alloy with increasing grain size by Y. Wu, L.Y. Chen, Z. Liu, P. Chen, C.Y. Wang, B. Tang, H.C. Kou, J.S. Li

“…A parallel transition from deformation twins to α'' martensites is detected in the primary products, indicating the variation of the predominant deformation mechanisms. …”
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Predominance of gram-negative multidrug-resistant pathogens causing lower respiratory tract infections among gene X-pert negative presumptive tuberculosis patients in Dar Es Salaam... by Irene Rabiel, Mtebe Majigo, Loveness Urio, Lilian Nkinda, Peter Richard Torokaa, Elieshiupendo M. Niccodem, Mabula Kasubi, Doreen Kamori, Joel Manyahi, Agricola Joachim

“…A high proportion of isolates, 71/138(51.4%) were multidrug resistant (MDR).Conclusion This study revealed a high prevalence of LRTIs caused by non-TB pathogens, particularly MDR strains in presumptive TB. MTB was detected only in high‑quality sputum samples. The high resistance rate to commonly prescribed antibiotics for LRTIs called for further large-scale studies to guide and/or refine treatment guidelines and optimize patient care.…”
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Validation of the EVendo score for assessing high-risk varices in Western European patients with cirrhosis by Julian Müller-Kühnle, Christian Benignus, Severin Schricker, Moritz Schanz, Julia Todoroff, Jörg Latus, Wolfram Zoller, Dominik Marschner

“…While esophagogastroduodenoscopy (EGD) remains the gold standard for detecting GEV, it is an invasive procedure. The EVendo score, a non-invasive predictive tool, has demonstrated promise in identifying GEV and varices needing treatment (VNT). …”
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Combination of immune checkpoint inhibitors and anthracyclines as a potential first-line regimen for dedifferentiated liposarcoma: systematic review and meta-analysis by Zhuang Aobo, Zhou Xiao, Xu Chengfei, Xi Zhe, Chen Yingxue, Zhang Chenhe, Xie Fuan, Yang Fan, Xiao Mengmeng, Ye Feng, Li Wengang

“…These results provide a foundation for future prospective studies aimed at optimizing immunotherapy approaches for this rare and challenging malignancy.…”
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A real-world pharmacovigilance study of Sorafenib based on the FDA Adverse Event Reporting System by Dongdong Zhang, Dongdong Zhang, Dongdong Zhang, Ying Cai, Ying Cai, Ying Cai, Yixin Sun, Peiji Zeng, Wei Wang, Wenhui Wang, Xiaohua Jiang, Yifan Lian, Yifan Lian, Yifan Lian

“…The ultimate goal was to optimize patient safety and provide evidence-based guidance for the appropriate use of this drug.MethodsReports from the FDA Adverse Event Reporting System (FAERS) database were comprehensively collected and analyzed, covering the first quarter of 2004 to the first quarter of 2024. …”
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Study of the immunological efficacy and safety of a candidate vaccine against Lassa hemorrhagic fever by O. Popova, O. V. Zubkova, T. A. Ozharovskaia, D. I. Zrelkin, D. V. Voronina, P. P. Goldovskaya, V. Yu. Kan, I. V. Dolzhikova, A. V. Kovyrshina, D. M. Grousova, I. A. Ermolova, D. V. Shcheblyakov, D. Yu. Logunov, A. L. Gintsburg

“…Standard genetic engineering techniques, molecular biology techniques, virological methods, and animal testing procedures were used in the course of the study. …”
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Clinical and epidemiologic characteristics of dengue and other etiologic agents among patients with acute febrile illness, Puerto Rico, 2012-2015. by Kay M Tomashek, Olga D Lorenzi, Doris A Andújar-Pérez, Brenda C Torres-Velásquez, Elizabeth A Hunsperger, Jorge Luis Munoz-Jordan, Janice Perez-Padilla, Aidsa Rivera, Gladys E Gonzalez-Zeno, Tyler M Sharp, Renee L Galloway, Mindy Glass Elrod, Demetrius L Mathis, M Steven Oberste, W Allan Nix, Elizabeth Henderson, Jennifer McQuiston, Joseph Singleton, Cecilia Kato, Carlos García Gubern, William Santiago-Rivera, Jesús Cruz-Correa, Robert Muns-Sosa, Juan D Ortiz-Rivera, Gerson Jiménez, Ivonne E Galarza, Kalanthe Horiuchi, Harold S Margolis, Luisa I Alvarado

“…Of 8,996 participants enrolled from May 7, 2012 through May 6, 2015, more than half (54.8%, 4,930) had a pathogen detected. Pathogens most frequently detected were CHIKV (1,635, 18.2%), FLU A/B (1,074, 11.9%), DENV 1-4 (970, 10.8%), and ORV (904, 10.3%). …”
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Connection between the effectiveness of ankylosing spondylitis treatment and the state of bone tissue metabolism by O. V. Syniachenko, Ye. D. Yehudina, M. V. Yermolaeva, O. O. Khaniukov, H. S. Taktashov, Yu. О. Potapov, K. Yu. Gashinova

“…There was no effect of the treatment in 4% of the patients, the mild improvement was detected in 21% of the examined patients, the improvement – in 70 %, significant improvement – in 4 %. …”
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Blue Light and Green Light Fundus Autofluorescence, Complementary to Optical Coherence Tomography, in Age-Related Macular Degeneration Evaluation by Antonia-Elena Ranetti, Horia Tudor Stanca, Mihnea Munteanu, Raluca Bievel Radulescu, Simona Stanca

“…<b>Methods:</b> A comprehensive literature search was performed using the PubMed database for studies published prior to February 2025. …”
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Viral etiology of severe acute respiratory infections in hospitalized patients, Shandong, China. by Chunwang Li, Yujie He, Xiao Pan, Huimin Yin, Yaowen Pei, Shaoxia Song, Lin Sun, Shu Zhang, Julong Wu, Zhong Li, Xianjun Wang, Zengqiang Kou, Lei Zhao, Weijia Xing, Ti Liu

“…In patients aged ≥70 years, COVID-19 was the most frequently detected virus, with a infection rate of 10.69% (65/608). …”
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Research progress on treatment of pleural effusion related to immune checkpoint inhibitors by AN Tianqi, TIAN Jianhui, ZHOU Yiyang, LUO Bin, QUE Zujun, LIU Yao, YU Pan, ZHAO Ruihua, YANG Yun

“…Preventing the occurrence of ICIs treatment-related pleural effusion is equally crucial, necessitating comprehensive patient assessment before ICIs administration and continuous monitoring during treatment to promptly detect and manage potential adverse reactions. Through this comprehensive management approach, the impact of ICIs treatment-related pleural effusion on patient quality of life and treatment outcomes can be minimized, optimizing overall treatment results. …”
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