Towards Dual-Tracer SPECT for Prostate Cancer Imaging Using [^99mTc]Tc-PSMA-I&S and [¹¹¹In]In-RM2 by Carolina Giammei, Theresa Balber, Veronika Felber, Thomas Dillinger, Jens Cardinale, Marie R. Brandt, Anna Stingeder, Markus Mitterhauser, Gerda Egger, Thomas L. Mindt

“…To mimic heterogeneous tumor lesions in the same individual, we aimed to establish a dual xenograft mouse model for preclinical evaluation. <b>Methods</b>: CHO-K1 cells underwent lentiviral transduction for human GRPR or human PSMA overexpression. …”
Get full text

Impact of Population-Based Screening for Diabetes and Prediabetes Among 67-Year-Olds Using Point-of-Care HbA1c on Healthcare Ultilisation, Results from the VISP Cohort by Andersen JW, Høgh A, Lindholt JS, Søgaard R, Støvring H, Yderstræde KB, Sandbæk A, Dahl M

“…These findings highlight the potential for screening to enhance disease management and underscore the need for strategies to optimize healthcare resource use following screening, especially for individuals without DM.Trial Registration: NCT03395509.Keywords: epidemiology, medication, general practice, Denmark, diabetes…”
Get full text

How repeatable is PAPE effect: the impact of in-season isometric squat activation on countermovement jump performance enhancement in national level soccer players by Jakub Jarosz, Dawid Gawel, Pawel Grycmann, Piotr Aschenbrenner, Michal Spieszny, Michal Wilk, Michal Krzysztofik

“…Given this variability, individually monitoring PAPE responsiveness may be beneficial for optimizing its application.…”
Get full text

Cardiovascular Events and Preoperative Beta-Blocker Use in Non-Cardiac Surgery: A Prospective Holter-Based Analysis by Alexandru Cosmin Palcău, Liviu Ionuț Șerbanoiu, Livia Florentina Păduraru, Alexandra Bolocan, Florentina Mușat, Daniel Ion, Dan Nicolae Păduraru, Bogdan Socea, Adriana Mihaela Ilieșiu

“…Continuous Holter monitoring proved effective in detecting transient arrhythmic events, emphasizing the need for careful perioperative surveillance of these patients, especially the elderly, in order to prevent cardiovascular complications These findings emphasize the necessity of tailored perioperative beta-blocker strategies and support further large-scale investigations to optimize risk stratification and management protocols.…”
Get full text

Effect of triple therapy on mortality and cardiovascular risk in patients with moderate to severe COPD: a meta-analysis of randomized controlled trials by Yubing Li, Jun Li, Hongxia Yang, Yong Zhang

“…However, its long-term effects on mortality and cardiovascular safety remain controversial, highlighting the critical need for systematic evidence to inform clinical decision-making. Methods A systematic search of PubMed, Embase, and the Cochrane Library (up to July 2024) identified 13 randomized controlled trials (RCTs) comparing triple therapy with dual therapies (LAMA/LABA or ICS/LABA) in patients with moderate-to-severe COPD. …”
Get full text

Two-Dimensional Mammography Imaging Techniques for Screening Women with Silicone Breast Implants: A Pilot Phantom Study by Isabelle Fitton, Virginia Tsapaki, Jonathan Zerbib, Antoine Decoux, Amit Kumar, Aude Stembert, Françoise Malchair, Claire Van Ngoc Ty, Laure Fournier

“…The mammography of the left breast of a single clinical case was included. Three methods of image acquisition were identified. They were based on misused, recommended, and reference settings. …”
Get full text

Comparative effectiveness and safety of tenofovir alafenamide versus tenofovir disoproxil fumarate in patients with HBV-associated decompensated cirrhosis: insights from a retrospe... by Lu Chen, Hui-Fang Zhang, Yi-Jing Cai, Lei Zhang, Chao Cai, Ming-Qin Lu, Yue-Ying Zhu

“…We hypothesised that TAF is non-inferior to TDF for virologic response and superior for renal safety, with corresponding statistical tests to assess non-inferiority and superiority. Methods Patients receiving TAF or TDF were categorized into respective groups based on their treatment regimen. …”
Get full text

CD66b⁺ Tumor-Infiltrating Neutrophil-like Monocytes as Potential Biomarkers for Clinical Decision-Making in Thyroid Cancer by Hamdullah Yanik, Ilgin Demir, Ertugrul Celik, Ece Tavukcuoglu, Ibrahim Burak Bahcecioglu, Adile Begum Bahcecioglu, Mehmet Mert Hidiroglu, Sumeyra Guler, Nese Ersoz Gulcelik, Mehmet Ali Gulcelik, Kerim Bora Yilmaz, Gunes Esendagli

“…CD66b⁺ neutrophil-like monocytes constitute a novel subset of myeloid cells that are implicated in the modulation of anti-tumor immune responses, but their role in thyroid cancer remains unclear. <i>Materials and Methods:</i> Peripheral blood and thyroid nodule tissue samples were obtained from 24 patients with papillary thyroid carcinoma, and from 10 patients who underwent surgery for symptoms of tracheal compression due to benign thyroid nodules. …”
Get full text

Mediating role of psychological resilience between depression and humoral immunological biomarkers in medical staff by Yunyun MA, Yanshuan WEI, Lili QIAN, Xiufeng ZUO, Dechao WANG, Shanfa YU

“…ObjectiveTo explore the mediating effect of psychological resilience on the association between depression and humoral immunological biomarkers in medical staff. MethodsA total of 108 medical staff from a tertiary hospital in Henan Province were selected using stratified cluster sampling from September 2022 to December 2022. …”
Get full text

Characterizing Patient-Reported Fatigue Using Electronic Diaries in Neurodegenerative and Immune-Mediated Inflammatory Diseases: Observational Study by Adrien Bennetot, Rana Zia Ur Rehman, Robbin Romijnders, Zhi Li, Victoria Macrae, Kristen Davies, Wan-Fai Ng, Walter Maetzler, Jennifer Kudelka, Hanna Hildesheim, Kirsten Emmert, Emma Paulides, C Janneke van der Woude, Ralf Reilmann, Svenja Aufenberg, Meenakshi Chatterjee, Nikolay V Manyakov, Clémence Pinaud, Stefan Avey

“…Future research should explore optimized eDiary protocols to balance participant burden with data granularity.…”
Get full text

Psychopathological Comorbidities in Children and Adolescents with Feeding and Eating Disorders: An Italian Clinical Study by Maria Califano, Jacopo Pruccoli, Oliviero Cavallino, Alessandra Lenzi, Antonia Parmeggiani

“…This study explores the psychiatric comorbidities associated with FED, focusing on common etiopathogenetic factors and their clinical implications. Methods: Data were retrospectively collected from the Italian Regional Center for FED in the Emilia-Romagna Region between June 2023 and April 2024. …”
Get full text

10-YEARS ANALYSIS OF CRYOBAG FRACTURE IN A LARGE INVENTORY OF CELLULAR THERAPY PRODUCTS: RATES AND RISK FACTORS by AR Belisário, LT Mendonça, RK Andrade, MC Martins, LA Costa, KL Prata

“…This study aimed to investigate the incidence and determinants of cryobag fractures within a large inventory of cellular therapy products in Brazil. Methods: This retrospective cohort study included cryobags from individuals referred for hematopoietic stem cell transplantation or immunotherapy. …”
Get full text

Application of a high-resolution melt assay for monitoring SARS-CoV-2 variants in Burkina Faso and Kenya by Caitlin Greenland-Bews, Sonal Shah, Morine Achieng, Emilie S. Badoum, Yaya Bah, Hellen C. Barsosio, Helena Brazal-Monzó, Jennifer Canizales, Anna Drabko, Alice J. Fraser, Luke Hannan, Sheikh Jarju, Jean-Moise Kaboré, Mariama A. Kujabi, Cristina Leggio, Maia Lesosky, Jarra Manneh, Tegwen Marlais, Julian Matthewman, Issa Nebié, Eric Onyango, Alphonse Ouedraogo, Kephas Otieno, Samuel S. Serme, Sodiomon Sirima, Ben Soulama, Brian Tangara, Alfred Tiono, William Wu, Emily R. Adams, Abdul Karim Sesay, Chris Drakeley, Feiko O. ter Kuile, Issiaka Soulama, Simon Kariuki, David J. Allen, Thomas Edwards

“…Extracted RNA from SARS-CoV-2-positive samples collected from 205 participants (112 in Burkina Faso, 93 in Kenya) enrolled in the MALCOV study (Malaria as a Risk Factor for COVID-19) between February 2021 and February 2022 were analyzed using our optimized HRM assays. With next-generation sequencing on Oxford Nanopore MinION as a reference, two HRM assays, HRM-VOC-1 and HRM-VOC-2, demonstrated sensitivity/specificity of 100%/99.29% and 92.86%/99.39%, respectively, for detecting Alpha, 90.08%/100% and 92.31%/100% for Delta, and 93.75%/100% and 100%/99.38% for Omicron BA.1. …”
Get full text

Chronic lymphocytic leukemia in combination with COVID-19: clinical features and unfavorable prognosis factors by O. L. Kochneva, E. A. Baryakh, E. N. Misyurina, E. I. Zhelnova, K. V. Yatskov, T. S. Chudnova, Yu. Yu. Polyakov, A. B. Makeshova, M. A. Mingalimov, D. D. Ivanova, L. T. Shimanovskaya, E. N. Zotina, T. N. Tolstykh, E. Yu. Grishina, D. E. Gagloeva, V. N. Yakimets, A. I. Koneva, E. A. Karimova

“…To identify risk factors for hospital mortality and severe course of COVID-19, as well as to optimize therapeutic and preventive measures.Materials and methods. …”
Get full text

Novel perceptions and insights into the rare hematologic malignancy of acute megakaryocytic leukemia: a multicenter clinical retrospective study by Yuan Liu, Yanquan Liu, Xiaojun Chen, Yue Yin, Zhenyuan Xu, Jiachen Xie, Jianzhen Shen, He Huang, Huidong Guo

“…This study endeavors to explore the clinical manifestations, diagnosis, treatment, and prognosis of AMKL, offering novel perspectives for both basic and clinical investigations of rare myeloid tumors in the fields of oncology and hematology.MethodsThe clinical data of 23 patients with AMKL admitted to the Fujian Medical University Union Hospital, the Affiliated Hospital of Putian University, and the First Affiliated Hospital of Gannan Medical University from January 2014 to July 2024 were retrospectively analyzed. …”
Get full text

Hemodynamic effects of adjunct arginine vasopressin to norepinephrine in septic shock: insights from a prospective multicenter registry study by Max Melchers, Vivienne de Smet, Chrissie Rooijakkers, Jonathan Huising, Wander Vermeulen, Beyza Nur Nisa Köktaş, Karlijn Johanna van de Vusse, Kimia Milani Sabzewar, Shakti Bedanta Mishra, Carina Bethlehem, Dirk P. Boer, Nedim Cimic, Mirella van Duijnhoven, Tim Frenzel, Jordi Liesveld, Gianluca Paternoster, Susanne Stads, Jan J. Weenink, Barbara Festen-Spanjer, Peter Pickkers, Arthur Raymond Hubert van Zanten

“…Univariate and multivariable regression analyses were performed to detect associations between characteristics and outcomes. …”
Get full text

Rapid laboratory confirmation of the 2025 Sudan Virus Disease (Svd) index case in Uganda by Andrew Nsawotebba, Susan Nabadda, Valeria Nakintu, Isaac Ssewanyana, Misaki Wayengera, Jonathan Kabazzi, Stephen Balinandi, Godfrey Pimundu, Tonny Muyigi, Alisen Ayitewala, Samuel Gidudu, Morgan Otita, Ibrahim Mugerwa, Moses Rubangakene, Sulaiman Ikoba, Sam Kalungi, Rhoda Wanyenze, Kevin K. Ariën, Eunice Namboozo, Benedict Kanamwanji, Steven Ssekyondwa, Ronald Kasujja, Derrick Kitwe, Catherine Dambya, Innocent Morunyanga, Reginald Rony Bahatungire, Francis Kakooza, Moses Joloba, Atek Kagirita, Allan Muruta, Pontiano Kaleebu, Henry Kyobe, Charles Olaro, Diana Atwine, Jane Ruth Aceng

“…Comprehensive VHFs panel testing is crucial for detecting pathogens in suspected cases. Sample dilution impacts diagnostic sensitivity, making optimized testing protocols crucial for precise molecular diagnostics. …”
Get full text

Regional patterns of genetic variants in expanded carrier screening: a next-generation sequencing pilot study in Fujian Province, China by Danhua Guo, Danhua Guo, Nani Zhou, Qianqian He, Qianqian He, Na Lin, Na Lin, Shuqiong He, Shuqiong He, Deqin He, Deqin He, Yifang Dai, Yifang Dai, Ying Li, Ying Li, Xuemei Chen, Xuemei Chen, Hailong Huang, Hailong Huang, Jia Jia, Hua Cao, Liangpu Xu, Liangpu Xu

“…BackgroundThis pilot study aimed to characterize the regional distribution of genetic variants associated with autosomal recessive and X-linked recessive (AR/XLR) conditions in Fujian Province, Southeast China, to inform the development of targeted carrier screening programs.MethodsAn expanded carrier screening (ECS) panel utilizing next-generation sequencing (NGS) technology was designed to analyze 332 genes associated with 343 AR/XLR conditions. …”
Get full text

Antibody response after SARS-CoV-2 infection or vaccination in China: A cross-sectional study by Peng Zhu, Yan Chen, Xia Xu, Deyong Tan, Ledong Xiao, Chengling Liao, Huan Xia, Ting Zhang, Jing Zou, Xuan Chen, Man Li, Yang Yang, Jian Zhou, Jia Liu, Wei Zhang, Honghao Zhou, Qing Li

“…Background: It is crucial to understand how antibodies are generated after the individual has been infected or vaccinated to control the COVID-19 pandemic and develop future vaccination strategies. Methods: The level of SARS-CoV-2 IgG/IgM was assessed in 348 plasma samples in the current study. …”
Get full text

Hand hygiene versus additional non-sterile gloves and gowns use to prevent sepsis in preterm infants colonized with multi-resistant drug bacteria: the study protocol of the cluster... by Kirstin Faust, Clara Haug, Julia Pagel, Reinhard Jensen, Anja Stein, Ursula Felderhoff-Müser, David Frommhold, Kirsten Brebach, Christian Wieg, Georg Hillebrand, Barbara Naust, Esther Schmidt, Lutz Koch, Susanne Schmidtke, Arne Simon, Michael Zemlin, Sascha Meyer, Christopher Scholzen, Natascha Köstlin-Gille, Christian Gille, Ann-Carolin Longardt, Manuela Kärlin, Mirjam Lusga, Wolfgang Göpel, Manuel Krone, Stefanie Kampmeier, Franziska Strecker, Dennis Nurjadi, Inke R. König, Egbert Herting, Jan Rupp, Christoph Härtel

“…Therefore, it is an urgent need to optimize and evaluate infection prevention and control (IPC) strategies. …”
Get full text