Differential patterns of the relationship between exercise dose and mortality risk across severities of airflow limitation: a prospective cohort study with a 5-year follow-up perio... by Yide Wang, Hongxia Duan, Yingqi Wang, Yidie Bao, Linhong Jiang, Xiaoyu Han, Fengsen Li, Peijun Li, Weibing Wu, Xiaodan Liu

“…Subjects/Patients: A total of 2,975 individuals from a cohort categorized by airflow limitation severity (normal, GOLD 1–4). Methods: PA levels were quantified in metabolic equivalent hours per week (MET·h/week). …”
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Effect of enamel pretreatment on the fluoride remineralization of artificial white spot lesions by Diana Ferreira Gadelha Araújo, Fernanda Sandes de Lucena, Maria Cristina Carvalho de Almendra Freitas, Larissa Vasconcellos Nunes, Marília Mattar de Amoedo Campos Velo, Ana Carolina Magalhães, Linda Wang

“…Material and Methods: Twenty-four enamel bovine blocks were obtained and selected by means of initial surface microhardness (SMH) measurements. …”
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Multicenter study on long-term growth in patients with phenylketonuria by S. Stanescu, A. Belanger-Quintana, J. C. Rocha, M. F. Almeida, K. Ahring, K. Dokoupil, A. M. Lammardo, E. van Dam, A. Muriel, A. MacDonald, on behalf of the ENEP group

“…The aim of this study is to determine whether the patients with PKU have a normal growth, the incidence of obesity and the relationship of these parameters with diet and nutritional intake. Material and methods This is a retrospective, multicenter, multinational study including patients with PKU from 8 centers from different countries. …”
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Viral etiology of severe acute respiratory infections in hospitalized patients, Shandong, China. by Chunwang Li, Yujie He, Xiao Pan, Huimin Yin, Yaowen Pei, Shaoxia Song, Lin Sun, Shu Zhang, Julong Wu, Zhong Li, Xianjun Wang, Zengqiang Kou, Lei Zhao, Weijia Xing, Ti Liu

“…This study systematically characterizes the epidemiological and clinical phenotypes of SARI patients in Shouguang county, Shandong Province, China.<h4>Methods</h4>A prospective observational study was conducted at Shouguang People's Hospital between August 28, 2023 and April 30, 2024, enrolling 1,730 hospitalized patients with SARI from the Departments of Infectious Diseases and Respiratory and Critical Care Medicine. …”
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Research progress on treatment of pleural effusion related to immune checkpoint inhibitors by AN Tianqi, TIAN Jianhui, ZHOU Yiyang, LUO Bin, QUE Zujun, LIU Yao, YU Pan, ZHAO Ruihua, YANG Yun

“…Preventing the occurrence of ICIs treatment-related pleural effusion is equally crucial, necessitating comprehensive patient assessment before ICIs administration and continuous monitoring during treatment to promptly detect and manage potential adverse reactions. Through this comprehensive management approach, the impact of ICIs treatment-related pleural effusion on patient quality of life and treatment outcomes can be minimized, optimizing overall treatment results. …”
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Qualitative changes in clinical records after implementation of pharmacist-led antimicrobial stewardship program: a text mining analysis by Keisuke Sawada, Shuji Kono, Ryo Inose, Yuichi Muraki

“…Abstract Background Antimicrobial stewardship programs (ASPs) are essential for optimizing antimicrobial use, but many medium-sized hospitals lack infectious disease (ID) specialists. …”
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B cell-extrinsic and intrinsic factors linked to early immune repletion after anti-CD20 therapy in patients with multiple sclerosis of African ancestry by Gregg J. Silverman, Abhimanyu N. Amarnani, Arnaldo A. Arbini, Angie Kim, Hannah Kopinsky, David Fenyo, Ilya Kister

“…In this study, we explored the immunologic and genetic factors, with serum drug monitoring, that may contribute to a faster rate of B-cell repletion that follows during recovery from treatment with anti-CD20 antibody.MethodsIn AA MS patients treated with an anti-CD20 antibody that had early repopulation of peripheral blood B cells, we assessed for extrinsic factors, including the presence of anti-drug antibodies against ocrelizumab, which may contribute to early repletion. …”
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Machine learning applications in the analysis of sedentary behavior and associated health risks by Ayat S Hammad, Ayat S Hammad, Ali Tajammul, Ismail Dergaa, Ismail Dergaa, Ismail Dergaa, Maha Al-Asmakh, Maha Al-Asmakh

“…ML offers powerful tools for analyzing large datasets and identifying trends in physical activity and inactivity, generating insights that can support effective interventions.ObjectivesThis review aims to: (i) examine the role of ML in analyzing sedentary patterns, (ii) explore how different ML techniques can be optimized to improve the accuracy of predicting sedentary behavior, and (iii) assess strategies to enhance the effectiveness of ML algorithms.MethodsA comprehensive search was conducted in PubMed and Scopus, targeting peer-reviewed articles published between 2004 and 2024. …”
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Juvenile dermatomyositis in Oman: clinical patterns and disease trajectory from a National cohort by Reem Abdwani, Mahadev J. Mal, Eman Al Masroori, Ruqaiya Al Jashmi, Safiya Al Abrawi, Ibrahim Al-Zakwani

“…This study aims to characterize JDM from an Omani national cohort, evaluating clinical manifestations, laboratory features, disease course, and treatment outcomes. Methods A retrospective review of all JDM patients diagnosed and managed by pediatric rheumatologist in tertiary centers in Oman was conducted. …”
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FIVE-YEAR DYNAMICS OF SECONDARY PREVENTION IN PATIENTS WITH STABLE ANGINA AT SPECIALIZED OUT-PATIENT LEVEL IN MOSCOW (PHARMACOEPIDEMIOLOGY STUDY) by S. В. Fitilev, I. I. Shkrebneva, A. V. Vozzhaev, K. O. Tsukanova

“…To assess five-year trend in terms of specialists’ adherence to guidelines on secondary prevention of cardiovascular diseases in patients with stable angina on the level of out-patient specialized healthcare institution in Moscow.Material and methods. Two-stage retrospective pharmacoepidemiological study was conducted. …”
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Process standardization and characterization of Mies: Ethiopian honey wine by Weleba Muesho Gebremichael, Kiros Hagos Abay, Desta Berhe Sbhatu, Goitom Gebreyohannes Berhe, Gebreselema Gebreyohannes

“…The filtrate (Mies) was seasoned and fermented for an additional two days, after which its physicochemical, nutritional, sensory, and microbial properties were analyzed using standard methods. As fermentation time increased, the pH values of the three Mies formulations decreased from the first to the twenty-first day. …”
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Decoding chemical interactions among pomegranate, Aphis punicae, and associated insects in Taif fields through open-loop stripping by Nour Houda M’sakni, Taghreed Alsufyani, Noura J. Alotaibi

“…These VOCs are hypothesized to function as early biochemical markers of pest stress and semiochemical cues guiding insect behavior, offering potential integration into decision-support tools within integrated pest management (IPM) frameworks. MethodsVOCs were non-destructively collected using open-loop stripping and analyzed via gas chromatography–mass spectrometry under a metabolomics approach. …”
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The Effects of the Biceps Brachii and Brachioradialis on Elbow Flexor Muscle Strength and Spasticity in Stroke Patients by Binbin Yu, Xintong Zhang, Yihui Cheng, Lingling Liu, null YanJiang, Jiayue Wang, Xiao Lu

“…We aimed to analyze the surface electromyography (sEMG) signal features of elbow flexor muscle (biceps brachii and brachioradialis) spasticity in maximum voluntary isometric contraction (MVIC) and fast passive extension (FPE) in stroke patients and to explore the main muscle groups that affect the active movement and spasticity of the elbow flexor muscles to provide an objective reference for optimizing stroke rehabilitation. Methods. Fifteen patients with elbow flexor spasticity after stroke were enrolled in this study. sEMG signals of the paretic and nonparetic elbow flexor muscles (biceps and brachioradialis) were detected during MVIC and FPE, and root mean square (RMS) values were calculated. …”
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Potential and limitations of secondary prevention of noncommunicable diseases: data from a survey of Russian outpatient physicians by M. N. Mamedov, V. A. Kutsenko, О. M. Drapkina

“…To identify potential and limitations of secondary prevention of noncommunicable diseases in outpatient clinics of various Russian cities.Material and methods. Outpatient physicians from 16 Russian cities took part in the cross-sectional study. …”
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A novel dual embedding few-shot learning approach for classifying bone loss using orthopantomogram radiographic notes by Pradeep Kumar Yadalam, Amit Rajabhau Pawar, Prabhu Manickam Natarajan, Carlos M. Ardila

“…This study will classify bone loss severity (normal, mild, or severe) from OPG notes using a novel dual-embedding few-shot learning framework. Methods This study used a dataset of radiographic notes from OPGs gathered at Saveetha Dental College and Hospital in Chennai. …”
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Moss-derived human complement factor H modulates retinal immune response and attenuates retinal degeneration by Mandy Hector, Verena Behnke, Paulina Dabrowska-Schlepp, Andreas Busch, Andreas Schaaf, Thomas Langmann, Anne Wolf

“…In addition, glycans of the CPV-104 variant are sialylated, an optimization that makes CPV-104 an analog of human CFH. …”
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Measuring protective efficacy and quantifying the impact of drug resistance: A novel malaria chemoprevention trial design and methodology. by Andria Mousa, Gina Cuomo-Dannenburg, Hayley A Thompson, R Matthew Chico, Khalid B Beshir, Colin J Sutherland, David Schellenberg, Roly Gosling, Michael Alifrangis, Emma Filtenborg Hocke, Helle Hansson, Ana Chopo-Pizarro, Wilfred F Mbacham, Innocent M Ali, Mike Chaponda, Cally Roper, Lucy C Okell

“…Here, we apply a novel modelling approach to aid the design and analysis of chemoprevention trials and generate measures of protection that can be applied across a range of transmission settings.<h4>Methods and findings</h4>We developed a model of genotype-specific drug protection, which accounts for underlying risk of infection and circulating genotypes. …”
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Anorexia-cachexia syndrome in cancer patients: pathogenetic aspects and treatment options by A. V. Snegovoy, V. B. Larionova, I. V. Kononenko

“…First, it will allow optimizing monitoring of cancer patients predisposed to CACS development during anticancer treatment. …”
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Plea for routine endoscopic tracheostomy tube adjustment by Bettina Otto, Regina Lindemann, Holger Kirsch, Matthias Schmid, Hartmut Vatter, Christiane Braun

“…Our data further suggest that the supply with tracheostomy tubes needs to be optimized.…”
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Clinical safety and pharmacokinetics of a novel oral niclosamide formulation compared with marketed niclosamide chewing tablets in healthy volunteers: A three-part randomized, doub... by Niklas Walther, Robert Schultz-Heienbrok, Heino Staß, Victor M Corman, Nils C Gassen, Marcel A Müller, Christian Drosten, Martin Witzenrath, Hweeling Lee, Maximilian G Posch

“…(ClinicalTrials.gov: NCT04644705).<h4>Methods</h4>The study consisted of three parts: Part A was a double-blind placebo-controlled single ascending dose trial in three dose groups (200, 600, and 1600 mg) with four participants receiving either the investigational niclosamide formulation or placebo (3:1) under fasted and/or fed conditions. …”
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