SARS-CoV-2 N protein and anti-spike serologies: insights into COVID-19 disease severity and mortality—a secondary analysis of the ACTIV-1 trial by Alfredo J. Mena Lora, Kimi Enders, Huimin Wu, Luis Parra-Rodriguez, Christopher Palma, Katy Saliba, Sylvain Laverdurre, P Brian Smith, Kevin J. Anstrom, Samuel A. Bozzette, William G. Powderly

“…Design: A secondary analysis of serologic data from participants in the ACTIV-1 randomized clinical trial, which evaluated immunomodulators for the treatment of hospitalized patients with COVID-19. Methods: A subanalysis of the ACTIV-1 immune modulator trial was conducted. …”
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An Informer-based multi-scale model that fuses memory factors and wavelet denoising for tidal prediction by Peng Lu, Yuchen He, Wenhui Li, Yuze Chen, Ru Kong, Teng Wang

“…By employing Fourier-based methods and iterative recursive decomposition strategies, we effectively separated periodic and trend components. …”
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Thrombotic adverse events associated with TNF-alpha blockers: a real-world pharmacovigilance analysis of the FAERS database by Lijuan Song, Nan Yang, Xinglong Xing, Yicong Zhao, Jingkai Di

“…ObjectiveThis research is designed to explore the connection between tumor necrosis factor-α (TNF-α) blocker drugs and thrombotic adverse events.MethodsThe study included data from the FDA Adverse Event Reporting System (FAERS) spanning from the first quarter of 2004 to the first quarter of 2024. …”
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Transcriptomic features of immune inflammation and neural plasticity associated with early neurological improvement in acute ischemic stroke patients with large vessel occlusion by Dong Zhang, Xinying Jing, Ruinan Ma, Zhizhang Li, Xiaoguang Zhang, Ying Ding, Yunhua Yue

“…This study aims to investigate the peripheral blood mRNA molecular characteristics and underlying mechanisms associated with ENI after EVT in AIS-LVO patients, to inform individualized treatment and optimize prognosis.MethodsThis retrospective study included AIS-LVO patients who underwent EVT between January 2022 and December 2023. …”
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Microplastics in Museums: Pollution and Paleoecology by Christine C. Gaylarde, Estefan M. da Fonseca

“…Such research studies, and potential similar investigations on historical stored tissue samples, require optimization before the information stored in these sources can be fully mined. …”
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Post-endoscopic retrograde cholangiopancreatography cholangitis after endoscopic treatment of post-transplant biliary strictures: a retrospective study by Chengcheng Christine Zhang, Ronald Koschny, Christian Rupp, Patrick Michl, Arianeb Mehrabi, Cyrill Wehling, Marcus Kantowski, Peter Sauer

“…We aimed to evaluate the incidence of post-ERCP cholangitis in patients with post-transplant biliary strictures, their impact on survival, and identify potential risk factors. Methods This retrospective study evaluated liver transplant recipients with biliary strictures treated with balloon dilatation at defined intervals. …”
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Elderly patients undergoing laparoscopic radical cystectomy benefit from dynamic D-dimer measurement in combination with vascular ultrasonography: reduction of VTE risk and improve... by Wenbo Gao, Haihong Ye, Yangkai Xu

“…We compared the results of two VTE prophylaxis protocols: dynamic D-dimer measurement in combination with ultrasonography screening in Experimental Group (EG), and conventional VTE prophylaxis in historical control group (HCG).MethodsBetween January 2022 and January 2024, the elderly patients undergoing such surgeries in EG received dynamic measurement of plasma D-dimer at admission and at 1, 3, 7, and 14 days after surgery in combination with ultrasonography screening, and commensurate VTE mechanical prophylaxis measures. …”
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Distribution of Minimum Inhibitory Concentrations and Resistance-associated Gene Mutations in Multidrug-resistant Mycobacterium tuberculosis Strains from Southern Türkiye: Insights... by Huda Ahmed, Hamdi Gokahmetoglu, Gulfer Yakici, Fatih Koksal

“…METHODS: MICs and gene mutations were evaluated for BDQ, DEL, and LZD. …”
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Quantitation of Cannabidiol (CBD) in brain regions and plasma following intranasal administration of a CBD nanoformulation by Gunjan Upadhyay, Oksana Fihurka, Pranav Patel, Juan Sanchez-Ramos

“…Intranasal (IN) nanoparticle delivery may enhance the bioavailability of lipophilic cannabidiol (CBD), addressing limitations associated with systemic administration. Methods Further optimization of nanoparticle properties is necessary to enhance brain uptake and therapeutic potential for neurological disorders. …”
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Explainable artificial intelligence with UNet based segmentation and Bayesian machine learning for classification of brain tumors using MRI images by K. Lakshmi, Sibi Amaran, G. Subbulakshmi, S. Padmini, Gyanenedra Prasad Joshi, Woong Cho

“…Abstract Detecting brain tumours (BT) early improves treatment possibilities and increases patient survival rates. …”
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The impact of baseline laboratory tests on the management of new-onset hypertension in primary care: A pilot study. by Katia Kteich, Maria R Karam, Marouan Zoghbi, Mabel Aoun

“…This study evaluates the impact of baseline laboratory assessments on blood pressure control and comorbidities in newly diagnosed hypertensive patients.<h4>Methods</h4>This is a multicenter retrospective study that included all patients with new-onset hypertension between January 2015 and January 2020, followed in three primary health care centers until 2022. …”
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The impact of adenomyosis on intrauterine insemination success in unexplained infertile women: a retrospective cross-sectional study by Sefa Arlıer, Sadık Kükrer, Fikriye Işıl Adıgüzel, Ahmet Zeki Nessar, Gülsüm Uysal, Cevdet Adıgüzel, Dilek Kaya Kaplanoğlu

“…This study aimed to assess the independent impact of adenomyosis on intrauterine insemination (IUI) success rates in women with unexplained infertility. Methods This retrospective cross-sectional study included 533 IUI cycles in 374 infertile women treated at the University of Health Science, assisted reproductive technologies center, Adana City Hospital. …”
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Changing snow conditions are challenging moose (Alces alces) surveys in Alaska by Todd J. Brinkman, Kalin A. Kellie, Adele K. Reinking, Glen E. Liston, Natalie T. Boelman

“…Complete snow cover is required to reliably detect and count moose using visual observation from an aircraft. …”
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Comparative Effects of Intermittent vs. Constant Ceftiofur Hydrochloride Exposure on <i>Staphylococcus aureus</i> In Vitro by Junli Wang, Chongyang Li, Fanxi Guo, Zugong Yu

“…This study aims to explore how different concentrations, durations, and dosing frequencies affect susceptibility and bactericidal efficacy of <i>Staphylococcus aureus</i> to optimize CEF dosage regimens. Methods: First, CEF was intermittently administered at 1/2 × minimum inhibitory concentration (MIC), 2 × MIC, 6 × MIC, and 100 × MIC for 30 cycles. …”
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Cardiovascular and Metabolic Adverse Events of Endocrine Therapies in Women with Breast Cancer: A Disproportionality Analysis of Reports in the FDA Adverse Event Reporting System by Shaimaa Elshafie, Lorenzo Villa‐Zapata, Randall L. Tackett, Iman Y. Zaghloul, Henry N. Young

“…This study comprehensively examined adverse reactions of ETs and investigated cardiovascular and metabolic safety signals within the FDA Adverse Event Reporting System (FAERS). Methods Reports in the FAERS through December 2023 were analyzed for documented reactions to tamoxifen, letrozole, anastrozole, and exemestane in female breast cancer patients. …”
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Generation of bovine iPSCs from fetal fibroblasts for in vitro myogenesis and cultured meat by Kaiana Recchia, Methi Wathikthinnakon, Fabiana Fernandes Bressan, Fabiana Fernandes Bressan, Kristine Freude

“…Bovine induced pluripotent stem cells (biPSCs) represent a promising alternative due to their capacity for self-renewal and developmental plasticity.MethodsThis study utilized both lentiviral (integrating) and episomal (non-integrating) reprogramming strategies to generate biPSCs suitable for myogenic differentiation. …”
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Prevalence and Changing Virulence Factors and Biofilm Formation among Non-Albicans Candida Species in Suspected Vulvovaginitis Infections by Rahul Gopichand Walide1*, Ahire Karuna R2, Ravidas Vasave1

“…Methods: Cervicovaginal swabs were prospectively collected from pregnant women presenting with clinical signs and symptoms suggestive of vulvovaginitis. …”
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Prevalence and predictors of thyroid nodules among adults: analyzing the association with metabolic syndrome in a cross-sectional study by Golbarg Abrishami, Maryam Emadzadeh, Aida Bakhshi, Yasamin Moeinipour, Ghazaleh Taghavi, Solmaz Hasani

“…This study explores the prevalence of thyroid nodules and their association with metabolic syndrome, leveraging data from a large cohort. Methods A cross-sectional study was conducted within the Persian Organizational Cohort in Mashhad, comprising 4,121 participants aged 35–70 years. …”
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Afatinib boosts CAR-T cell antitumor therapeutic efficacy via metabolism and fate reprogramming by Xi Zhang, Yue Liu, Yueyu Dai, Lingna An, Fangyuan Zhong, Shifeng Lou

“…In this study, we focused on tyrosine kinase inhibitors (TKIs), which have emerged immunomodulatory potential besides direct tumoricidal effects.Methods Here, we screened 50 approved TKIs drugs and identified that afatinib (AFA) markedly enhanced the expressing of CD62L and inhibited reactive oxygen species level in T cells. …”
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Characterization of spatio-temporal evolution of grain production and identification of its heterogeneity drivers in Sichuan Province based on Geodetector and GWR models by Huae Dang, Yuanjie Deng, Yuanjie Deng, Yuanjie Deng, Yifeng Hai, Hang Chen, Wenjing Wang

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