Analysis of MMP-8, MMP-20, and TGF-β1 in molar-incisor hypomineralization and assessment of periodontal health by Başak Senian Bilgir, Sema Aydınoğlu, İpek Arslan, Mehtap Atak, Oğuz Köse, Dilara Nil Günaçar

“…In this context, the present study aims to investigate the effect of molar incisor hypomineralization (MIH) on periodontal health and to evaluate the relationship between MIH and GCF volume, as well as GCF biomarkers such as MMP-8, MMP-20, and TGF-β1. Methods The study was conducted on a total of 40 pediatric patients diagnosed with MIH (Study Group/SG), and 40 pediatric patients healthy for MIH (Control Group/CG). …”
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Comparative evaluation of immunomodulatory cytokines for oncolytic therapy based on a high-efficient platform for oHSV1 reconstruction by Yingzheng Gao, Yufang Zou, Changjing Wu, Juan Tao, Zuqing Nie, Jinyuan Yan, Pengfei Wang, Xinwei Huang

“…Methods We developed a CRISPR/Cas9-mediated platform for high-efficiency oHSV1 engineering, replacing the ICP47 locus with murine IFN-γ, GM-CSF, or IL-15Rα/IL-15 fusion protein (IL15Fu). …”
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Histological response and blood glucose level in a diabetic animal model after the oral administration of Mucuna pruriens: A systematic review and meta-analysis by Tri Wahyu Pangestiningsih, Dian Meididewi Nuraini, Morsid Andityas, Ariana Ariana

“…Potential publication bias was detected but was addressed through trim-and-fill analysis. …”
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Comparative Analysis of Irrigation Mist and CO₂ vs. Direct CO₂ Blower in On-Pump Coronary Artery Bypass Grafting Anastomosis: Efficacy, Efficiency, and Fibril... by Ignazio Condello, Giuseppe Speziale, Flavio Fiore, Giuseppe Nasso

“…<i>Background and Objectives:</i> In coronary artery bypass grafting (CABG) on pump, achieving optimal visualization is critical for surgical precision and safety. …”
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Association between male (in)fertility and telomeric dysfunction: a systematic review and meta-analysis by Sunny Kumar Jignesh Kumar Patel, Amit Roy Chowdhury, Sujata Kar, Purna Chandra Mohapatra, Birendranath Banerjee

“…Objective The aim of this meta-analysis was to evaluate the clinical significance and sperm cell reliability for TL assessment (sperm/leukocytes) as a novel predictive biomarker in male (in)fertility, with an overview of general trends. Methods A comprehensive systematic search was carried out for relevant research. …”
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Unprotected left main revascularization: Percutaneous coronary intervention versus coronary artery bypass. An updated systematic review and meta-analysis of randomised controlled t... by Luca Testa, Azeem Latib, Mario Bollati, Rocco Antonio Montone, Antonio Colombo, Filippo Crea, Francesco Bedogni

“…<h4>Background</h4>The optimal treatment of unprotected left main (UPLM) with either PCI or CABG remains uncertain.…”
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Effects of acute weight loss on serum mineral homeostasis in elite male judoka by Burcu Yenturk, Mihrac Koroglu, Nuri Muhammet Celik, Cuneyt Sensoy, Fıkret Soyer

“…This study aimed to examine the effect of acute weight loss on serum mineral concentrations in elite male judoka. Methods: The study included 32 elite-level male judoka who were participating in the Turkish Judo Championship and were selected through convenience sampling. …”
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Reevaluating Backup Monitor Chamber Tolerances for Stereotactic Body Radiotherapy Treatments using Volumetric-modulated Arc Therapy by Yong Sang, Jun Dang, Jianan Wu, Enzhuo Quan

“…This study evaluates the backup monitor chamber constancy in SBRT treatments using volumetric-modulated arc therapy (VMAT) on the Elekta Infinity accelerator to determine if the current tolerances ensure treatment efficacy and safety. Methods: Five SBRT patients treated with VMAT on the Elekta Infinity accelerator between January 2024 and June 2024 were retrospectively selected for this study. …”
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Effectiveness of human albumin for clinical outcome in aneurysmal subarachnoid hemorrhages: a protocol for randomized controlled (HASH) trial by Arshad Ali, Mohsin Khan, Nissar Shaikh, Amr El Mohamad, Mazyona Al-Maadhadi, Noman Shah, Yousef Al-Najjar, Abdul Salam, Ghaya Al-Rumaihi, Ali Ayyad, Sirajeddin Belkhair, Ghanem Al-Sulaiti

“…In view of the scarcity of published data and lack of robust evidence, our group has designed the first-ever RCT to compare the use of human albumin-enhanced fluid management versus standard fluid therapy with crystalloids in patients with aSAH. Methods This single-center open-label, prospective, parallel group randomized control trial will be conducted at Hamad General Hospital, Doha, Qatar, from August 2024 to July 2027. …”
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Whole exome sequencing: the search for mutations associated with hereditary breast cancer in ethnic groups of Siberia by P. A. Gervas, A. Yu. Molokov, N. N. Babyshkina, F. G. Ivanova, T. I. Nikolaeva, D. G. Tikhonov, E. L. Choynzonov, N. V. Cherdyntseva

“…The purpose of the study was to search for new genes associated with HBC in the understudied ethnic groups of Siberia by using whole exome sequencing (WES).Material and Methods. WES was performed on a cohort of 16 probands with BC (Tuvan, Yakut, Altai ethnos). …”
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Diabetes: Non-Invasive Blood Glucose Monitoring Using Federated Learning with Biosensor Signals by Narmatha Chellamani, Saleh Ali Albelwi, Manimurugan Shanmuganathan, Palanisamy Amirthalingam, Anand Paul

“…Photoplethysmography (PPG), a photosensitive method that detects blood volume variations, has shown promise for non-invasive glucose monitoring. …”
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Multiclass skin lesion classification and localziation from dermoscopic images using a novel network-level fused deep architecture and explainable artificial intelligence by Mehak Arshad, Muhammad Attique Khan, Nouf Abdullah Almujally, Areej Alasiry, Mehrez Marzougui, Yunyoung Nam

“…Abstract Background and objective Early detection and classification of skin cancer are critical for improving patient outcomes. …”
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Hypersensitive pneumonitis and cardiovascular comorbidity by A. V. Medvedev, N. G. Demyanenko, G. E. Alichubanova, S. A. Kasimtseva, M. N. Kovalevskaya, R. V. Tarasov

“…The combination of hypersensitivity pneumonitis with cardiovascular diseases significantly aggravates the course of both pathologies. Early detection of risk factors and assessment of concomitant conditions using the Charlson index allows optimizing the diagnosis and treatment of this category of patients. …”
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A Deep Learning Framework for Healthy Lifestyle Monitoring and Outdoor Localization by Mehrab Rafiq, Naif S. Alshammari, Haifa F. Alhasson, Dina Abdulaziz Alhammadi, Mohammed Alshehri, Ahmad Jalal, Hui Liu

“…The proposed system achieved an overall classification accuracy of 88.4% on the Extrasensory dataset and 86.4% on the Domino dataset, outperforming several existing state-of-the-art methods. These results highlight the effectiveness of the preprocessing pipeline and feature optimization techniques in enhancing recognition and localization performance. …”
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Development of a two-component recombinant vaccine for COVID-19 by Yi-Sheng Sun, Fang Xu, Han-Ping Zhu, Yong Xia, Qiao-Min Li, Yuan-Yuan Luo, Hang-Jing Lu, Bei-Bei Wu, Zhen Wang, Ping-Ping Yao, Zhan Zhou, Zhan Zhou

“…Vaccination remains one of the most effective methods for preventing COVID-19. While most of the antigenic regions are found in the receptor binding domain (RBD), the N-terminal domain (NTD) of the S protein is another crucial region for inducing neutralizing antibodies (nAbs) against COVID-19.MethodsIn the two-dose immunization experiment, female BALB/c mice were intramuscularly immunized with different ratios of RBD-Fc and NTD-Fc proteins, with a total protein dose of 8 μg per mouse. …”
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Study on the correlation between mineral bone metabolism and CRP in patients with SHPT during perioperative period by Lei Yan, Qiuyue Xiong, Qin Xu, Pengru Ren, Tiantian Li, Huixia Cao, Fengmin Shao

“…Abstract Objective This study mainly observes changes in perioperative mineral bone metabolism‐related indicators and inflammatory factors in patients with secondary hyperparathyroidism (SHPT), and analyzed the correlation between mineral bone metabolism‐related indicators and inflammatory factors. Methods Clinical data were collected. The study detects mineral bone metabolism‐related indicators and inflammatory factor of perioperative patients with SHPT before and 4 days after operation. …”
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Use of Large Language Models to Classify Epidemiological Characteristics in Synthetic and Real-World Social Media Posts About Conjunctivitis Outbreaks: Infodemiology Study by Michael S Deiner, Russell Y Deiner, Cherie Fathy, Natalie A Deiner, Vagelis Hristidis, Stephen D McLeod, Thomas J Bukowski, Thuy Doan, Gerami D Seitzman, Thomas M Lietman, Travis C Porco

“…Future studies should further explore LLMs’ potential to support public health monitoring through the automated assessment and classification of potential infectious eye disease or other outbreaks. Their optimal role may be to act as a first line of documentation, alerting public health organizations for the follow-up of LLM-detected and -classified small, early outbreaks, with a focus on the most severe ones.…”
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Results of complex treatment of patients with locally advanced squamous cell carcinoma of the paranasal sinuses and nasal cavity using induction chemotherapy by T.   I. Dеshkina, L.  V. Bolotina, A.  R. Gevorkov, A.  V. Boyko, A.  L. Kornietskaya, A. P. Polyakov, P.   V. Golubev, R.  S. Sydykova, A. A. Fedenko

“…About 600 new cases of malignant neoplasms of the paranasal sinuses and nasal cavity are detected annually in Russia. To date, there are no randomized trials to determine the optimal treatment algorithm for this group of patients. …”
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Determination of seven non-regulated disinfection byproducts in Tehran drinking water by Zahra Jafari, Amir Salemi

“…A central composite design was used to optimize the extraction parameters. Results and discussion: The method was sensitive enough to detect traces of the target compounds, with LOD values of 0.4-20 ng L-1. …”
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MRD4U: A path to development for personalized liquid biopsy for children with central nervous system tumors by Anthony R. Miller, Tithi Shah, Corinne N. Strawser, Adithe Rivaldi, Sarah A. Wilson, Huachun Zhong, Jocelyn M. Lucyshyn, Elizabeth AR Garfinkle, Makenna McCoy, Seth Cummins, Alejandro Otero Bravo, Peter Chang, Gregory L. Wheeler, David M. Gordon, Benjamin J. Kelly, Caitlyn Evanovich, Samara L. Potter, Elizabeth A. Varga, Diana P. Rodriguez, Richard K. Wilson, Catherine E. Cottrell, Ralph Salloum, Sara Khan, Maryam Fouladi, Elaine R. Mardis, Margot A. Lazow, Katherine E. Miller

“…Methods Our research focused on the optimization of next-generation sequencing library preparation from cell-free DNA (cfDNA), evaluating four commercial kits to address the low nucleic acid yield in CSF-derived cfDNA. …”
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