Synthesis and properties of some S-derivatives of 4-phenyl-5-((5-phenylamino-1,3,4-thiadiazole-2-ylthio)methyl)-1,2,4-triazole-3-thione by A. S. Hotsulia, S. O. Fedotov

“…The combination of these heterocycles in one molecule makes it possible to increase the probability of detecting substances with a certain type of biological activity among the synthesized compounds.The aim of the work was to optimize the synthesis and study of the properties of S-alkyl derivatives of 5-R-4-phenyl-1,2,4-triazole-3-thione, containing a thiadiazole fragment in their structure, as well as the prediction of possible biological activity to rating the prospects of further studies in vivo and in vitro.Materials and methods. …”
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Paper-based molecularly imprinted film designs for sensing human serum albumin by Tzu-Chieh Lin, Chung-Yin Lin, Yi-Ting Hwang, Dar-Fu Tai

“…A general, simple, and inexpensive method for fast and high throughput that monitors target model proteins and the sequential incorporation of functional monomers were presented for the preparation of molecularly imprinted films (MIFs) on cellulose filter papers (MIFPs). …”
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Prussian‐Blue Catalysis and NFC Synergy: a Battery‐Free Laser‐Induced Graphene‐Based Platform for Urine Glucose Monitoring at Point‐of‐Care by Sinan Uzunçar, Gabriel Maroli, Massimo Urban, Arben Merkoçi

“…This study introduces a simplified, polymer‐based synthesis method, enhancing their stability in a single step. …”
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Modified Zuo Gui Wan Ameliorates Ovariectomy-Induced Osteoporosis in Rats by Regulating the SCFA-GPR41-p38MAPK Signaling Pathway by Song C, Yan Q, Ma Y, Li P, Yang Y, Wang Y, Li W, Wan X, Li Y, Zhu R, Liu H, Zhang Z

“…We aimed to validate the anti-OP effect of MZGW and explore its underlying mechanism.Methods: An ovariectomy (OVX) rat model in vivo and a RANKL-induced osteoclasts (OCs) model in vitro were established. …”
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Classification of Bitter gourd leaf disease using deep learning architecture ResNet50 by Artika Artika, Wikky Fawwaz Al Maki

“…This research contributes to the development of methods for detecting bitter melon leaf disease using computer vision and machine learning, achieving high accuracy and supporting automatic disease diagnosis. …”
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Smart indoor monitoring for disabled individuals using an ensemble of deep learning models in an IoT environment by Faisal S. Alsubaei, Abdulrahman A. Alshdadi, Mohammed Rizwanullah

“…Abstract Indoor activity monitoring methods assurance the well-being and security of disabled and aging individuals living in their homes. …”
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AI-driven multi-agent reinforcement learning framework for real-time monitoring of physiological signals in stress and depression contexts by Thanveer Shaik, Xiaohui Tao, Lin Li, Haoran Xie, Hong-Ning Dai, Feng Zhao, Jianming Yong

“…Results Experimental results demonstrate that the proposed multi-agent DRL framework outperforms baseline models in accurately monitoring patients’ vital signs under stress and varying conditions. The optimized agents adapt effectively to dynamic environments, ensuring timely detection of critical health deviations. …”
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A Spatial–Frequency Combined Transformer for Cloud Removal of Optical Remote Sensing Images by Fulian Zhao, Chenlong Ding, Xin Li, Runliang Xia, Caifeng Wu, Xin Lyu

“…FreSA leverages fast Fourier transform to convert features into the frequency domain, using frequency differences between object and cloud regions to achieve precise cloud detection and fine-grained removal. In order to further enhance the features extracted by DBSA and FreSA, we design the dual-domain feed-forward network (DDFFN), which effectively improves the detail fidelity of the restored image by multi-scale convolution for local refinement and frequency transformation for global structural optimization. …”
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The Anti-Nucleocapsid IgG Antibody as a Marker of SARS-CoV-2 Infection for Hemodialysis Patients by Akemi Hara, Shun Watanabe, Toyoaki Sawano, Yuki Sonoda, Hiroaki Saito, Akihiko Ozaki, Masatoshi Wakui, Tianchen Zhao, Chika Yamamoto, Yurie Kobashi, Toshiki Abe, Takeshi Kawamura, Akira Sugiyama, Aya Nakayama, Yudai Kaneko, Hiroaki Shimmura, Masaharu Tsubokura

“…Anti-nucleocapsid IgG (anti-IgG N) antibodies are a commonly used marker to assess prior infection in the general population; however, their efficacy for hemodialysis patients remains unclear. <i><b>Methods:</b></i> A retrospective study of 361 hemodialysis patients evaluated anti-IgG N antibodies for detecting prior SARS-CoV-2 infection. …”
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Point-SPV: end-to-end enhancement of object recognition in simulated prosthetic vision using synthetic viewing points by Ashkan Nejad, Ashkan Nejad, Ashkan Nejad, Burcu Küçükoǧlu, Jaap de Ruyter van Steveninck, Sandra Bedrossian, Joost Heutink, Joost Heutink, Gera A. de Haan, Gera A. de Haan, Frans W. Cornelissen, Marcel van Gerven

“…A behavioral gaze-contingent object discrimination experiment demonstrated that Point-SPV outperformed a conventional edge detection method, by facilitating observers to gain a higher recognition accuracy, faster reaction times, and a more efficient visual exploration. …”
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Morphometric and Molecular Identification of Eimeria Bovis and Eimeria Zuernii on Beef Cattle in Lamongan, East Java, Indonesia by Muhammad 'Ahdi Kurniawan, Lucia Tri Suwanti, Mufasirin Mufasirin, Endang Suprihati, Poedji Hastutiek, Kusnoto Kusnoto, Arif Nur Muhammad Ansori, Yulianna Puspitasari, Aswin Rafif Khairullah, Ikechukwu Benjamin Moses, Bima Putra Pratama, Katty Hendriana Priscilia Riwu

“…Sampling was conducted during the rainy season to optimize the detection of Eimeria infections. Using the sugar flotation method, Eimeria oocysts were isolated from 5–10 g of fecal matter per sample. …”
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Comparative Immunogenicity of HIV-1 gp140 Vaccine Delivered by Parenteral, and Mucosal Routes in Female Volunteers; MUCOVAC2, A Randomized Two Centre Study. by Catherine A Cosgrove, Charles J Lacey, Alethea V Cope, Angela Bartolf, Georgina Morris, Celine Yan, Susan Baden, Tom Cole, Darrick Carter, Elizabeth Brodnicki, Xiaoying Shen, Sarah Joseph, Stephen C DeRosa, Lili Peng, Xuesong Yu, Guido Ferrari, Mike Seaman, David C Montefiori, Nicole Frahm, Georgia D Tomaras, Wolfgang Stöhr, Sheena McCormack, Robin J Shattock

“…<h4>Background</h4>Defining optimal routes for induction of mucosal immunity represents an important research priority for the HIV-1 vaccine field. …”
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Advancing personalized diagnosis and treatment using deep learning architecture by Rahat Ullah, Nadeem Sarwar, Mohammed Naif Alatawi, Abeer Abdullah Alsadhan, Hathal Salamah Alwageed, Maqbool Khan, Aitizaz Ali

“…Traditional diagnostic methods, which rely on symptom observation and biomarker detection, often lack specificity and fail to provide personalized treatment options. …”
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Multi-Source Heterogeneous Data-Driven Digital Delivery System for Oil and Gas Surface Engineering by Wei Zhang, Zhixiang Dai, Taiwu Xia, Gangping Chen, Yihua Zhang, Jun Zhou, Cui Liu

“…Utilizing a layered collaborative framework, the system combines optimization algorithms and anomaly detection methods during data processing to enhance the relevance and reliability of high-dimensional data. …”
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Uptake of DU145 and LNCaP prostate cancer cell line derived extracellular vesicles is inversely correlated with blood–brain barrier integrity in vitro by Ana Špilak, Adrián Klepe, Sophia Theresa Kriwanek, Heinz-Peter Friedl, Andreas Brachner, Christa Nöhammer, Winfried Neuhaus

“…This study investigated the interaction and effects of sEVs derived from low (LNCaP) and moderately metastatic (DU145) prostate cancer (PCa) cell lines with the human brain endothelial cell line hCMEC/D3. Methods Systematic optimization of the cell culture membrane insert set-up for sEV transport studies was accomplished with inserts with different pore sizes, varied coating procedures and medium compositions. …”
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De novo establishment of an ex vivo culture for living myocardial slices applying a microphysiological system – MPSlms by Jordan Maria, Schmieder Florian, Waleczek Florian J. G., Polk Christoph, Stucki-Koch Angelika, Philipp Jürgen, Dietzel Leila, Clement Alexander, Behrens Stephan, Thum Thomas, Sonntag Frank, Fiedler Jan

“…Basic cell culture models lack cardiac tissue architecture and intercellular communication, limiting their translational capability. Force measurement methods on ex vivo cultured living myocardial slices (LMS) have been described for contraction analysis studies after compound treatment. …”
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CRISPR/Cas-Based Prenatal Screening for Aneuploidy: Challenges and Opportunities for Early Diagnosis by Irisappan Ganesh, Ilangovan Karthiga, Manoranjani Murugan, Kumar Rangarajalu, Vishnu Bhat Ballambattu, Sambandam Ravikumar

“…The existing prenatal screening techniques for detecting aneuploidy have several limitations. The ability to diagnose aneuploidy early in a non-invasive manner is not feasible with the current screening methods, as they may produce false positive or false negative results. …”
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Clinical Markers of the Heart and Blood Vessels Syntropic Lesions in Patients with Systemic Lupus Erythematosus, Their Diagnostic Value (Second Notice) by L. Kobak, O. Voloshyna, O. Khukhlina, L. Babinets, N. Chmyr, S. Guta, R. Ivanochko

“…In patients with systemic lupus erythematosus the optimal diagnostic value among clinical monomarkers and their constellations for the detecting of A. …”
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Noninvasive genetic testing for type IV collagen nephropathy using oral mucosa DNA sampling in children with haematuria by Jiaojiao Liu, Dayin Zhou, Xiaowen Wang, Tong Shen, Chunyan Wang, Rufeng Dai, Xinli Han, Lin Huang, Wenli Xu, Jing Chen, Yihui Zhai, Jia Rao, Duan Ma, Qian Shen, Hong Xu

“…Hence, we performed noninvasive and convenient genetic testing approaches for type IV collagen-related nephropathy.Methods We used noninvasive oral mucosa sampling as an alternative method for DNA isolation for genetic testing and designed a panel targeting three type IV collagen nephropathy-related genes in children with hematuria. …”
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AFN-Net: Adaptive Fusion Nucleus Segmentation Network Based on Multi-Level U-Net by Ming Zhao, Yimin Yang, Bingxue Zhou, Quan Wang, Fu Li

“…However, due to the challenge of detecting small targets and complex boundaries in datasets, traditional methods often fail to achieve satisfactory results. …”
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