Non-Invasive Myocardial Work Identifies Patients with Obstructive Coronary Lesions After Orthotopic Heart Transplantation by Rebeca Manrique Antón, Marina Pascual Izco, Gorka Bastarrika, Agnés Díaz Dorronsoro, Ana Ezponda, Fátima de la Torre Carazo, Nahikari Salteráin, Leticia Jimeno-San Martín, Nerea Martín-Calvo, María Josefa Iribarren, Gregorio Rábago

“…This study explores whether myocardial work (MW) can non-invasively identify OHT patients with obstructive coronary lesions (OCL). <b>Methods</b>: During regular follow-ups, 55 OHT recipients underwent paired, prospective coronary computed tomography angiography (CCTA) and transthoracic echocardiography (TTE) examinations. …”
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Evaluation of the Geomorphon Approach for Extracting Troughs in Polygonal Patterned Ground Across Different Permafrost Environments by Amin Wen, Tonghua Wu, Xiaofan Zhu, Jie Chen, Jianzong Shi, Peiqing Lou, Dong Wang, Xin Ma, Xiaodong Wu

“…As the climate continues to warm, the thawing of ice-rich permafrost leads to changes in the polygonal patterned ground (PPG) landscape, exhibiting an array of spatial heterogeneity in trough patterns, governing permafrost stability and hydrological and ecosystem dynamics. Developing accurate methods for detecting trough areas will allow us to better understand where the degradation of PPG occurs. …”
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Evaluation of serum ESPL1 as a biomarker for early diagnosis of HBV-related hepatocellular carcinoma by Lu-Huai Feng, Lu Wei, Bobin Hu, Hengkai Liang, Qingmei Li, Qianbing Yin, Tumei Su, Long Huang, Hongqian Liang, Jianning Jiang, Jianning Jiang, Minghua Su, Minghua Su

“…ObjectiveTo evaluate the reliability of serum human phosphorylated exospindle polar-like proteinase 1 (ESPL1) as a serum biomarker for early diagnosis of hepatitis B virus (HBV)-related hepatocellular carcinoma (HBV-HCC).MethodsThis retrospective study was conducted on 266 patients with chronic hepatitis B (CHB), liver cirrhosis (LC), and HBV-related HCC. …”
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Enhancing the reverse transcriptase function in Taq polymerase via AI-driven multiparametric rational design by Yulia E. Tomilova, Nikolay E. Russkikh, Igor M. Yi, Elizaveta V. Shaburova, Viktor N. Tomilov, Galina B. Pyrinova, Svetlana O. Brezhneva, Olga S. Tikhonyuk, Nadezhda S. Gololobova, Dmitriy V. Popichenko, Maxim O. Arkhipov, Leonid O. Bryzgalov, Evgeniy V. Brenner, Anastasia A. Artyukh, Dmitry N. Shtokalo, Dmitry N. Shtokalo, Dmitry N. Shtokalo, Denis V. Antonets, Mikhail K. Ivanov, Mikhail K. Ivanov

“…Our objective was to use AI-driven rational design combined with multiparametric wet-lab analysis to identify and validate Taq polymerase mutants with an optimal combination of these properties.MethodsThe experimental procedure was conducted in several stages: 1) On the basis of a foundational paper, we selected 18 candidate mutations known to affect RTase activity across six sites. …”
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SSL5-AnxA5 Fusion Protein Constructed Based on Human Atherosclerotic Plaque scRNA-Seq Data Preventing the Binding of Apoptotic Endothelial Cells, Platelets, and Inflammatory Cells by Yifei Zhao, Xingyu He, Teng Hu, Tianli Xia, Fangyang Huang, Changming Li, Yiming Li, Fei Chen, Mao Chen, Jun Ma, Yong Peng

“…Staphylococcal superantigen-like 5 (SSL5) is an optimal antagonist P-selectin glycoprotein ligand 1 (PSGL1), while annexin V (AnxA5) can precisely detect dead cells in vivo. …”
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UMI-77 targets MCL-1 to activate mitophagy and ameliorate periodontitis in mice by Dalei Sun, Shu Ouyang, Xiaoxuan Xu, Jingjing Yan, Heqian Wang, Chenkai Lan, Wubin Ouyang, Liangjun Zhong, Jun Lin

“…Western blot confirmed downregulation of MCL-1 expression to near-normal levels in Group Ba, while TEM detected autolysosomes in both Group Ba and Group Ca, indicating mitophagy activation. …”
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Clinical and histopathological features of lupus nephritis and the risk of long-term kidney outcomes in Indonesia by Ni Made Hustrini, Ni Made Hustrini, Endang Susalit, Monik Ediana Miranda, Meilania Saraswati, Y. K. Onno Teng, Merel van Diepen, Joris I. Rotmans

“…This study highlights the importance of timely detection on kidney involvement in SLE patients, routine use of renin–angiotensin–aldosterone system inhibitors, optimal prescription of immunosuppressive medications, and aggressive screening and prophylactic measures of infectious diseases should be encouraged to improve kidney outcomes in lupus nephritis patients in Indonesia.…”
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Early Outcomes from Proton Craniospinal Irradiation for Leptomeningeal Metastasis From Solid Tumors by Keng Lam, MD, Lewis F. Nasr, MD, Clark R. Andersen, MS, Kathryn E. Marqueen, MD, Jing Li, MD, PhD, Chenyang Wang, MD, Thomas H. Beckham, MD, PhD, Nazanin K. Majd, MD, PhD, Ashley E. Aaroe, MD, Monica Loghin, MD, Barbara J. O'Brien, MD, Susan L. McGovern, MD, PhD

“…We report our experience with pCSI for solid-tumor LM. Methods and Materials: This is a retrospective review of patients treated with pCSI for solid-tumor LM from December 2020 to January 2024 at our center. …”
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Diagnosis of Sarcopenia Using Convolutional Neural Network Models Based on Muscle Ultrasound Images: Prospective Multicenter Study by Zi-Tong Chen, Xiao-Long Li, Feng-Shan Jin, Yi-Lei Shi, Lei Zhang, Hao-Hao Yin, Yu-Li Zhu, Xin-Yi Tang, Xi-Yuan Lin, Bei-Lei Lu, Qun Wang, Li-Ping Sun, Xiao-Xiang Zhu, Li Qiu, Hui-Xiong Xu, Le-Hang Guo

“…By comprehensive comparison, we finally identified the optimal model (SARCO model) as the convenient solution. …”
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Circulating tumor DNA dynamics and recurrence risk in patients undergoing curative intent resection of colorectal cancer liver metastases: A prospective cohort study. by Jeanne Tie, Yuxuan Wang, Joshua Cohen, Lu Li, Wei Hong, Michael Christie, Hui Li Wong, Suzanne Kosmider, Rachel Wong, Benjamin Thomson, Julian Choi, Adrian Fox, Kathryn Field, Matthew Burge, Jenny Shannon, Dusan Kotasek, Niall C Tebbutt, Christos Karapetis, Craig Underhill, Andrew Haydon, Joy Schaeffer, Janine Ptak, Cristian Tomasetti, Nicholas Papadopoulos, Kenneth W Kinzler, Bert Vogelstein, Peter Gibbs

“…<h4>Methods and findings</h4>We prospectively collected plasma samples from patients with resectable CRLM, including presurgical and postsurgical samples, serial samples during any pre- or postoperative chemotherapy, and serial samples in follow-up. …”
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The proportion of endometrial tumours associated with Lynch syndrome (PETALS): A prospective cross-sectional study. by Neil A J Ryan, Raymond McMahon, Simon Tobi, Tristan Snowsill, Shona Esquibel, Andrew J Wallace, Sancha Bunstone, Naomi Bowers, Ioana E Mosneag, Sarah J Kitson, Helena O'Flynn, Neal C Ramchander, Vanitha N Sivalingam, Ian M Frayling, James Bolton, Rhona J McVey, D Gareth Evans, Emma J Crosbie

“…The aim of this study was to establish the prevalence of LS and the diagnostic accuracy of LS testing strategies in an unselected EC population.<h4>Methods and findings</h4>This was a prospective cross-sectional study carried out at a large United Kingdom gynaecological cancer centre between October 2015 and January 2017. …”
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Sex-specific ultrasound imaging biomarkers of neurodegeneration in a mouse model by Mark B. Russell, Drew P. Locke, Haley M. Adams, Alexander R. Pelley, Rojan Saghian, Rojan Saghian, Alexandre S. Maekawa, Darcie Stapleton, Grace V. Mercer, John G. Sled, John G. Sled, John G. Sled, Lindsay S. Cahill, Lindsay S. Cahill

“…IntroductionEarly detection of neurodegeneration is essential for optimizing interventions. …”
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On-board accelerometers in railway track condition monitoring. A systematic review by Imanol Bravo, Unai Alvarado, Javier Nieto, Pablo Ciáurriz

“…Environmental conditions and the complexity of real-time analysis make it difficult to detect problems early using other methods. The study underlines the need for research into vibration analysis, optimal placement of accelerometers and signal processing techniques to effectively detect track problems, such as loosening of fastenings, at an early stage.…”
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Electronic Sensor-Based Automated Irrigation System for Rice Cultivated Under Alternate Wetting and Drying Technique by Mukesh Kumar, Ramesh Kumar Sahni, Abhishek M. Waghaye, Manoj Kumar, Ravindra D. Randhe

“…In this method, the rice field is initially flooded to a maximum depth of 5 cm. …”
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Considerations on the choice of experimental parameters in residual stress measurements by hole-drilling and ESPI by C. Barile, C. Casavola, G. Pappalettera, C. Pappalettere

“…Over the years, different techniques have been developed to measure residual stresses; nowadays the combination of Hole Drilling method (HD) with Electronic Speckle Pattern Interferometry (ESPI) has encountered great interest. …”
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Global Transcriptome and Correlation Analysis Reveal Cultivar-Specific Molecular Signatures Associated with Fruit Development and Fatty Acid Determination in Camellia oleifera Abel by Shaofeng Peng, Jia Lu, Zhen Zhang, Li Ma, Caixia Liu, Yongzhong Chen

“…We attempt to identify genes related to fatty acid biosynthesis in an oil-tea Camellia seed kernel, generated a comprehensive transcriptome analysis of the seed kernel at different developmental stages, and explore optimal picking time of fruit. Material and Methods. …”
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The Value of Functional Multislice Computed Tomography in the Diagnosis of Instability of the Cervical Spinal Motion Segments by S. К. Ternovoy, N. S. Serova, A. S. Abramov, T. I. Miskaryan

“…Instability of the vertebral motion segments is a very urgent problem of medicine, since it has very serious consequences. Today, search for optimal diagnostic methods continues. The authors propose a new diagnostic technique - functional multislice computed tomography (fMSCT). …”
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Predicting future occlusion or stenosis of lower extremity bypass grafts using artificial intelligence to simultaneously analyze all flow velocities collected in current and previo... by Xiao Luo, PhD, Fattah Muhammad Tahabi, BS, Dave M. Rollins, RVT, Alan P. Sawchuk, MD

“…Current methods evaluating screening duplex ultrasound examinations have a significant failure rate for detecting a bypass graft at risk for failure. …”
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Game Strategies for Data Transfer Infrastructures Against ML-Profile Exploits by Nageswara S. V. Rao, Chris Y. T. Ma, Fei He

“…The infrastructure&#x2019;s throughput profile, estimated as a function of the connection round trip time using Machine Learning (ML) methods, is an indicator of its operational state, and has been utilized for monitoring, diagnosis and optimization purposes. …”
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Features of inpatient treatment of patients with skin diseases and sexually transmitted infections by V. V. Korolenko, T. S. Gruzieva

“…Aim of the study is to analyze the use of inpatient beds for treatment of patients with dermatoses and sexually transmitted infections (STIs). Materials and methods. The indicators of treatment and preventive care for patients with dermatoses and STIs in Ukraine for 2009–2019 were analyzed using statistical, bibliosemantic methods, systematic approach and analysis. …”
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