Unraveling an Enigmatic Triad: A Case Report of Concurrent Neurosyphilis, Ocular Syphilis, and Otosyphilis in a Patient with HIV by Peter Njouda Shitebongnju, Alexander A. Bobrov

“…Treponema pallidum, the bacterium responsible for syphilis, can lead to neurosyphilis, ocular syphilis, and otosyphilis when left untreated. …”
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Can off-the-shelf visual large language models detect and diagnose ocular diseases from retinal photographs? by Tien Yin Wong, Yih Chung Tham, Ching-Yu Cheng, Wendy Wong, Ya Xing Wang, Hongwei Ji, Zhi Da Soh, Xiaofei Wang, Jocelyn Hui Lin Goh, David Ziyou Chen, Krithi Pushpanathan, Sahana Srinivasan, Weizhi Ma

“…Despite the relatively high detection rates, the quality of diagnostic descriptions was generally suboptimal—with only 21.2% of GPT-4V’s (default) responses, 4.8% of GPT-4V’s (data analyst) responses and 28.6% for Google Gemini’s responses rated as good.Conclusions Although GPT-4V default mode showed generally high sensitivity in abnormality detection, all evaluated VLLMs were inadequate in providing accurate diagnoses for ocular diseases. …”
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Outcomes of Treatment in Ocular Myasthenia Gravis Based on Minimal Manifestation: A Real-World Retrospective Cohort Study by Kemchoknatee P, Santitamrongvtit B, Srisombut T

“…Prednisolones improve symptoms by reducing autoantibody activity, but its optimal use, particularly in ocular myasthenia gravis (OMG), remains unclear due to limited trials and variable responses.Objective: To evaluate the clinical efficacy, optimal dosing, and predictors of first minimal manifestation (MM) with oral prednisolone in myasthenia gravis, based on the Myasthenia Gravis Foundation of America Post-Intervention Status (MGFA-PIS).Methods: Patients with OMG treated with oral prednisolones between 1st January 2015 and 31st December 2022 at Rajavithi Hospital were retrospectively reviewed. …”
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Quality by Design (QbD)-Based Development of a Self-Nanoemulsifying Drug Delivery System for the Ocular Delivery of Flurbiprofen by Ju-Hwan Jeong, Tae-Han Yoon, Si-Won Ryu, Min-Gyeong Kim, Gu-Hae Kim, Ye-Jin Oh, Su-Jeong Lee, Na-Woon Kwak, Kyu-Ho Bang, Kyeong-Soo Kim

“…The optimized FLU-SNE exhibited excellent stability and enhanced permeability, suggesting its potential effectiveness in treating various ocular inflammations, including uveitis and cystoid macular edema.…”
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Impact of fine particulate matter (PM2.5) on ocular health among people living in Chiang Mai, Thailand by Sobia Kausar, Phanika Tongchai, Sumed Yadoung, Shamsa Sabir, Supansa Pata, Woottichai Khamduang, Kriangkrai Chawansuntati, Supachai Yodkeeree, Anurak Wongta, Surat Hongsibsong

“…Logistic regression analysis investigated the relationship between PM2.5 toxicity and ocular symptoms. …”
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Comparison of SPEED and OSDI questionnaires for dry eye symptom in Chinese college students: a cross-sectional study by Xiaohong Meng, Ruojun Geng, Kaili Yang, Jingjing Wei, Zepeng Xu, Menghan Wang, Shengwei Ren

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Dysregulation of Retinal Melatonin Biosynthetic Pathway and Differential Expression of Retina-Specific Genes Following Blast-Induced Ocular Injury in Ferrets by Chetan Pundkar, Rex Jeya Rajkumar Samdavid Thanapaul, Manoj Govindarajulu, Gaurav Phuyal, Joseph B. Long, Peethambaran Arun

“…Ferrets were exposed to tightly coupled blast overpressure waves using an advanced blast simulator, and retinal tissues were collected for quantitative polymerase chain reaction (qPCR) analysis. Results: The results revealed dynamic and multiphasic transcriptional responses. …”
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Targeting glial fibrillary acidic protein in glaucoma: a monoclonal antibody approach to modulate glial reactivity and neuroinflammation for neuroprotection by Chaoqiang Guan, Linglin Zhang, Kristian Nzogang Fomo, Jie Yang, Norbert Pfeiffer, Franz H. Grus

“…A bioinformatics re-analysis of a public glaucomatous retina protein dataset was conducted using GSEA, GO, and Cytoscape with GENEMANIA. …”
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The Results of Transscleral Diode Laser Cyclophotocoagulation in Micropulse Mode Treatment in Patients with Primary Subcompensated Open-Angle Glaucoma and Toxic-Allergic Syndrome o... by I. E. Shvailikova, E. I. Belikova, A. V. Korneeva

“…Purpose: to analysis the results of microimpulse transscleral diode laser cyclophotocoagulation (DCPC) technique as a method of choice in patients with open-angle subcompensated glaucoma (OAG) with toxic allergic syndrome of the ocular surface (TASOS).Methods. …”
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Fusarium spp. and Aspergillus flavus infection induces pathogen-specific and pathogen-independent host immune response in patients with fungal keratitis by Shreya Dinesh, Shreya Dinesh, Lalitha Prajna, Prajna Namperumalsamy Venkatesh, Kuppamuthu Dharmalingam, Bharanidharan Devarajan

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Vogt-Koyanagi-Harada syndrome potentially associated with COVID-19 vaccination: a case report and literature review by Zhiqiang Cui, Yan Luo, Yanli Yi, Xuli Guo, Yuqi Liu, Xiang Wang, Xiaonan Liu

“…To investigate the potential association between COVID-19 vaccination and Vogt-Koyanagi-Harada (VKH) syndrome, offering novel insights for the diagnosis and management of vaccine-related ocular disorders. A case report combined with a literature review was conducted. …”
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Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic... by P. A. Faccia, F. M. Pardini, J. I. Amalvy

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Impact of Preoperative Prism Adaptation Test and Patch Test Measurements on Surgery in Concomitant Horizontal Strabismus: A Prospective Interventional Study by Rahul Singh, Disha Chaudhary, Charu Sagar, Vandana Kohli

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Stimuli-responsive hydrogels, their mass transfer, intermolecular interactions, and applications in biomedical devices by Parker M. Toews, Ashwin Velraj, Jeffrey S. Bates

“…Abstract Hydrogels are versatile materials that can be used in biomedical applications, where their multifunctional capabilities can be leveraged as sensors, actuators, drug delivery devices, and chemomechanically responsive materials. This review article explores the diverse applications of hydrogels and their chemomechanical response. …”
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Glucose-Sensing Carbohydrate Response Element-Binding Protein in the Pathogenesis of Diabetic Retinopathy by Christopher R. Starr, Assylbek Zhylkibayev, Oleg Gorbatyuk, Alli M. Nuotio-Antar, James Mobley, Maria B. Grant, Marina Gorbatyuk

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Secreted phosphoprotein 1 on ophthalmic diseases by LIU Yuan, SANG Aimin

“…Through diverse molecular mechanisms including modulation of apoptotic pathways, regulation of oxidative stress responses, and mediation of inflammatory processes, SPP1 is intricately involved in the pathogenesis and progression of various ocular disorders such as dry eye syndrome, glaucoma, and diabetic retinopathy. …”
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Experience-dependent plasticity of multiple receptive field properties in lateral geniculate binocular neurons during the critical period by Meng Pan, Jingjing Ye, Yijing Yan, Ailin Chen, Xinyu Li, Xin Jiang, Xin Jiang, Wei Wang, Xin Meng, Shujian Chen, Yu Gu, Xuefeng Shi, Xuefeng Shi

“…The direction and orientation selectivity of ipsilateral eye responses, but not of contralateral eye responses in these neurons, were dramatically reduced. …”
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Immune responses in rodent whole eye transplantation: elucidation and preliminary investigations into rejection diagnosis and monitoring by Bing Li, Yong Wang, Charles R. Owens, Touka Banaee, Charleen T. Chu, Kayvon Jabbari, Anna D. Lee, Neil J. Khatter, Alan G. Palestine, An-Jey A. Su, Christene A. Huang, Kia M. Washington

“…Histopathological examinations of both ocular and surrounding skin tissues provided insights into cellular changes, complemented by ocular RT-qPCR for molecular analysis. …”
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Identification and validation of integrated stress-response-related genes as biomarkers for age-related macular degeneration by Jingyi Niu, Ling Jin, Yijun Hu, Yiting Wang, Xiaoning Hao, Wenwen Geng, Ruirui Ma

“…Therefore, this study aimed to identify potential biomarkers for AMD through bioinformatics analysis based on the transcriptome database and integrated stress response related genes (ISR-RGs).MethodsTranscriptomic data GSE76237, GSE247168, and ISR-RGs were sourced from public databases and related literature. …”
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IL-10 and IL-6/IL-10 as predictive biomarkers for treatment response in non-infectious uveitis by Rodrigo A. Valenzuela, Rodrigo A. Valenzuela, Fabian Vega-Tapia, Nathaly Elizalde, Ivan Flores, Felipe M. Rojas, Felipe M. Rojas, Felipe M. Rojas, Felipe M. Rojas, Annelise Goecke, Loreto Cuitino, Loreto Cuitino, Cristhian A. Urzua, Cristhian A. Urzua, Cristhian A. Urzua

“…Uveitis, a group of heterogeneous diseases causing ocular inflammation, is a major contributor to vision loss globally. …”
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