Orienteering and hiking programs for older adults as a model of healthy aging: a randomized clinical trial by Clarissa Biehl Printes, Tatiana Quarti Irigaray, José Otávio Franco Dornelles, Rafael Reimann Baptista

“…Objectives: To compare the effects of orienteering vs hiking on the physical fitness and quality of life of older adults. …”
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Analysis and assessment of biomedical scientists’ needs for clinical laboratory: activity-based management as an evaluation methodology by Claudia Bizzoni, Gavino Napolitano, Gavino Napolitano, Simonetta Cesa, Luca Sacella, Caterina Bianciardi, Cosimo Ottomano, Rita Mancini, Giorgio Da Rin

“…IntroductionHealthcare systems have to protect citizens’ health by developing models combining concepts of efficiency, effectiveness and quality of care. The post-Covid-19 pandemic context has highlighted the relevance of efficiently managing and allocating human resources. …”
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Hospitalization costs and out-of-pocket (OOP) payment in lung cancer patients in Iran: Health Sector Evolution Plan (HSEP) has reduced OOP payments and improved financial protectio... by Habib Jalilian, Somayeh Heydari, Elnaz Javanshir, Khosro Jamebozorgi, Nazanin Mir, Abbas Eshraghi, Saeedeh Fehresti

“…<h4>Background and objective</h4>In Iran, Health Sector Evolution Plan, the most significant reform in the healthcare system in recent decades, has been launched since 2014 with the objective of achieving universal health coverage, decreasing out-of-pocket health expenditures and improving access to health services in hospitals and clinics affiliated to the Ministry of Health and Medical Education (MOHME). …”
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Survey on self-reported psychotropic drug prescribing practices of eating disorder psychiatrists for the treatment of young people with anorexia nervosa by Ian C K Wong, Maedeh Y Beykloo, Dasha Nicholls, Mima Simic, Ruth Brauer, Elizabeth Mills

“…Most (40%) respondents estimated that &lt;10% of patients with AN were prescribed psychotropic medications. …”
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Urodynamics tests for the diagnosis and management of male bladder outlet obstruction: long-term follow-up of the UPSTREAM non-inferiority RCT by Madeleine Clout, Amanda L Lewis, Madeleine Cochrane, Grace J Young, Paul Abrams, Peter S Blair, Christopher Chapple, Gordon T Taylor, Sian Noble, Tom Steuart-Feilding, Jodi Taylor, J Athene Lane, Marcus J Drake

“…The objectives were to assess at 5 years post randomisation: What are the symptomatic outcomes for LUTS, measured by the IPSS? …”
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Urodynamics tests for the diagnosis and management of male bladder outlet obstruction: long-term follow-up of the UPSTREAM non-inferiority RCT by Madeleine Clout, Amanda L Lewis, Madeleine Cochrane, Grace J Young, Paul Abrams, Peter S Blair, Christopher Chapple, Gordon T Taylor, Sian Noble, Tom Steuart-Feilding, Jodi Taylor, J Athene Lane, Marcus J Drake

“…The objectives were to assess at 5 years post randomisation: What are the symptomatic outcomes for LUTS, measured by the IPSS? …”
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Impact of personality traits on activities of daily living in patient-reported outcomes one and six months after total knee arthroplasty: a cohort study by Keigo Nanjo, Takashi Ikeda, Ryutaku Kaneyama, Tomoko Sakai, Tetsuya Jinno

“…This study aimed to explore the effect of personality traits measured using the TIPI on ADL in PROMs at one and six months post-TKA. Methods A cohort of 140 individuals undergoing bilateral or unilateral TKA was enrolled. …”
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Endoscopic management of hemorrhagic pancreatic fluid collections: A propensity‐matched analysis by Rishi Pawa, Robert Dorrell, Greg Russell, Madison Nguyen, Clancy Clark, Girish Mishra, Swati Pawa

“…Abstract Objectives Hemorrhagic pancreatic fluid collections (hPFC) are a complication of pancreatitis with an unknown influence on prognosis. …”
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Digital augmentation of aftercare for patients with anorexia nervosa: the TRIANGLE RCT and economic evaluation by Janet Treasure, Katie Rowlands, Valentina Cardi, Suman Ambwani, David McDaid, Jodie Lord, Danielle Clark Bryan, Pamela Macdonald, Eva Bonin, Ulrike Schmidt, Jon Arcelus, Amy Harrison, Sabine Landau

“…Background High-risk patients with complex anorexia nervosa are managed in inpatient/day patient care, but re-admission rates are high, and new treatments are needed. Objective(s) To examine the effectiveness of a digital augmentation of aftercare (ECHOMANTRA). …”
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A phase II trial of mTORC1/2 inhibition in STK11 deficient non small cell lung cancer by Gary Middleton, Helen L. Robbins, Peter Fletcher, Joshua Savage, Manita Mehmi, Yvonne Summers, Alastair Greystoke, Nicola Steele, Sanjay Popat, Pooja Jain, James Spicer, Judith Cave, Paul Shaw, David Gilligan, Danielle Power, Dean Fennell, Maya Bajracharya, David J. McBride, Uma Maheswari, Alexander M. Frankell, Charles Swanton, Andrew D. Beggs, Lucinda Billingham

“…In arm B2 of the National Lung Matrix Trial 54 patients with NSCLC received vistusertib, of which 49 were STK11-deficient (30 with KRAS mutation (B2D), 19 without (B2S)). Objective response (OR) and durable clinical benefit (DCB) rates with 95% credible intervals (CrI) were estimated from posterior probability distributions generated using Bayesian beta-binomial conjugate analysis. …”
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Early detection to improve outcome in people with undiagnosed psoriatic arthritis: the PROMPT research programme including RCT by Neil McHugh, Laura Bojke, Mel Brooke Turfrey, Rachel Charlton, Myka Ransom, Laura C Coates, Howard Collier, Claire Davies, Emma Dures, Philip Helliwell, Jana James, Anya Lissina, Vishnu B Madhok, Alison L Nightingale, Jonathan Packham, Catherine Smith, Eldon Spackman, Cerys Tassinari, William Tillett, Sarah T Brown

“…Secondary objectives were to compare disease and impact of disease between people diagnosed with PsA in the ES and SC arms at 24 months post registration. …”
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Lesson learned in pediatric haploidentical transplantation in a low-resource environment: delivering melphalan IV and using low dose radiation reduce graft failure by Valentine Jiménez-Antolinez, Julia Colunga-Pedraza, Andrés Gómez-De León, Elias González-Lopez, David Gómez-Almaguer, Oscar González-Llano

“…The median follow-up for G1 was 15.9 months, and for G2 was 24.8 months, with an estimated overall survival at 12 months of 63% (95% CI 47–76) versus 85% (95% CI 73–93), and at 24 months of 47% (95% CI 31–64) versus 70% (95% CI 54–82) respectively (p = .007).Conclusion: After September 2018 conditioning regimen modifications were implemented with the objective of reducing primary failure, consisting mainly of switching from busulfan to melphalan as the alkylating agent of choice, and adding, when clinically possible TBI. …”
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Is virtual simulation as effective as clinical simulation: a mixed methods study comparing knowledge acquisition, self-confidence, anxiety, and cost effectiveness by Gdiom Gebreheat, Anu Koju, Jane Whitehorn, Jamie Lee Fairholm, Craig Shepherd, Ruth Paterson

“…Methods: A two-stage sequential mixed methods approach was conducted to meet the objectives. In Stage 1, a two-armed randomized controlled trial was conducted with 67 nursing students. …”
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Reactive Pancreatitis Following Endoscopic Retrograde Cholangiopancreatography: Diagnosis, Prevention and Treatment by Ye. V. Moroz, V. N. Ardashev, M. P. Mantserov, K. V. Dzyuba, V. A. Tsyrik

“…The patients’ status, the presence and pattern of subjective and objective symptoms and laboratory parameters (blood amylase, urinary diastase, leukocytosis) were dynamically estimated after ERCP.Results: 58 (28.0%) patients developed post-ERCP RP, the severe course of pancreatitis being observed in 4.3%. …”
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ASSAS project, Artificial intelligence for Simulation of Severe AccidentS; Simulator development and Isotopic Source Term proposals by Caro Rafael J., Parrado Isabel

“…Then, the paper focuses on the discussion on the proposals made to define the potential isotopic composition for the source term estimates, fitting to the main objectives of the project, as they are the education, the training, or the training for the surrogate models defined by the IA methodology, and how these targets impose restrictions to the isotopic characteristics of the ST used but keeping the major simulator features. …”
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Pre-prescription review system improves prescription safety, efficiency, and cost-effectiveness in pediatric outpatients: a western China study by Bin Yang, Junyan He, Qianbo Li, Xiuling Wang, Lin Song

“…ObjectiveThe study’s objective is to investigate the prescription rationality rate, time efficiency, and estimated economic benefits of a pre-prescription review system (PPRS) in pediatric outpatients in a 5-year retrospective study in western China.MethodThis retrospective before-after study compared data from two phases: pre-intervention phase (2019: PPRS not yet implemented), and post-intervention phase (2020–2023: PPRS fully operational). …”
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Estudio longitudinal de los comportamientos y el nivel de actividad físico-deportiva en el tiempo libre en estudiantes de Costa Rica, México y España (Longitudinal study on leisure... by Maureen Meneses Montero, Francisco Ruiz Juan

“…Existe un predominio de niveles de práctica físico-deportiva que no genera beneficios para la salud, siendo estable con el paso del tiempo.  Abstract. The objective was to estimate the number of active and inactive individuals (those who have abandoned or have never carried out leisure-time physical activity); and to determine if their physical and sport activity, in terms of duration, frequency, intensity, and participation in competitions (physical and sport activity level), is sufficient to achieve health benefits and therefore, if it meets the established recommendations. …”
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Smoking cessation improves health status of patients with chronic diseases: evidence from a longitudinal study of older adults in China by Haoyu Zhu, Peng Xu, Yumeng Wei, Chuchen Zhao, Danni Zhao, Yaxin Li, Xiaobin Ma, Meng Wang, Huafeng Kang

“…Regression analysis unveiled a positive correlation between smoking cessation and enhanced self-assessed health (β estimate = 0.198), while a notable adverse effect was observed in EQ-5D-3L scores (β estimate = -0.179) and grip strength (β estimate = -2.530). …”
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Real-World Prevalence and Outcomes of Patients with Paroxysmal Nocturnal Hemoglobinuria Treated with C5 Inhibitors in the US: A Retrospective Claims Database Analysis by Srinivas K Tantravahi, Dominick Latremouille-Viau, Raj Desai, Soyon Lee, Jincy Paulose, Anumaxine Geevarghese, Annie Guérin, Shravanthi Seshasayee, Mohin Chanpura, Glorian Yen

“…# Background Paroxysmal nocturnal hemoglobinuria (PNH) is a rare blood disorder with C5 inhibitors (C5i), eculizumab and ravulizumab, being part of current treatment options. # Objectives To estimate the 5-year prevalence of PNH and describe the healthcare resource utilization and direct healthcare costs associated with C5i among commercially insured patients with PNH treated with C5i in the US…”
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Healthcare utilization and related costs among older people seeking primary care due to back pain: findings from the BACE-N cohort study by Danielle van der Windt, Milada Cvancarova Småstuen, Kjersti Storheim, Margreth Grotle, Zinajda Zolic-Karlsson, Ørjan Nesse Vigdal, Rikke Munk Killingmo, Lise Kretz

“…Objectives To describe healthcare utilization and estimate associated costs during 1 year of follow-up among older people seeking primary care due to a new episode back pain and to describe healthcare utilization across patients with different risk profiles stratified using the StarT Back Screening Tool (SBST).Design Prospective cohort study.Participants and setting A total of 452 people aged ≥55 years seeking Norwegian primary care with a new episode of back pain were included.Outcome measures The primary outcome of this study was total cost of healthcare utilization aggregated for 1 year of follow-up. …”
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