Nuclear receptor-SINE B1 network modulates expanded pluripotency in blastoids and blastocysts by Ka Wai Wong, Yingying Zeng, Edison Tay, Jia Hao Jackie Teo, Nadia Omega Cipta, Kiyofumi Hamashima, Yao Yi, Haijun Liu, Tushar Warrier, Minh T. N. Le, Soon Chye Ng, Qi-Jing Li, Hu Li, Yuin-Han Loh

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Reprogramming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation by Israel Ríos, Cristina Herrero, Mónica Torres-Torresano, Baltasar López-Navarro, María Teresa Schiaffino, Francisco Díaz Crespo, Alicia Nieto-Valle, Rafael Samaniego, Yolanda Sierra-Palomares, Eduardo Oliver, Fernando Revuelta-Salgado, Ricardo García-Luján, Paloma Sánchez-Mateos, Rafael Delgado, Amaya Puig-Kröger, Angel L Corbí

“…These reprogramming effects were also observed upon GSK3α/β knockdown and through GSK3 inhibition in ex vivo isolated human alveolar macrophages (AMØ). Notably, GSK3 downmodulation potentiated the transcriptional signature of interstitial macrophages (IMØ) while suppressing the AMØ-specific gene profile. …”
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An Agrin–YAP/TAZ Rigidity Sensing Module Drives EGFR‐Addicted Lung Tumorigenesis by Reza Bayat Mokhtari, Divyaleka Sampath, Paige Eversole, Melissa Ong Yu Lin, Dmitriy A. Bosykh, Gandhi T.K. Boopathy, Aravind Sivakumar, Cheng‐Chun Wang, Ramesh Kumar, Joe Yeong Poh Sheng, Ellen Karasik, Barbara A. Foster, Han Yu, Xiang Ling, Wenjie Wu, Fengzhi Li, Zoë Weaver Ohler, Christine F. Brainson, David W. Goodrich, Wanjin Hong, Sayan Chakraborty

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Single-cell RNA sequencing reveals the heterogeneity and regulatory modules of cell-specific RNA-binding proteins in patients with systemic lupus erythematosus by Sheng-Yan Lin, Yikai Yu, Daan Nie, Lili Yang, Yuxue Chen, Yu Chen, Cheng Wen, Zhipeng Zeng

“…Results: Single-cell resolution revealed marked heterogeneity in RBPs expression across keratinocyte, endothelial cell, and T cell in SLE compared to HC. Notably, disease-specific RBPs were enriched in pathways governing interferon response, cytokine signaling, and leukocyte activation. …”
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PUF60‐Regulated Isoform Switching of MAZ Modulates Gastric Cancer Cell Migration by Dong Xing, Ting Zhao, Chenchen Mao, Zheng Han, Wanxia Cai, Teming Zhang, Dianfeng Mei, Wangkai Xie, Jiaye Yu, Zhonghan Wu, Zhiyuan Chen, Shiyu Feng, Xian Shen, Xiangyang Xue, Dan Xiang

“…Targeting MAZ alternative splicing, particularly via PUF60 modulation, represents a novel therapeutic strategy.…”
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Sprayable hydrogel sponge for neurovascular microenvironment reconstruction and inflammation modulation in diabetic wound healing by Xiaozhen Zhou, Pengchao Ma, Yihao Liu, Zhaojian Wang, Shida Chen, Zekun Cheng, Songlu Tseng, Hui Wu, Mengdi Zhang, Fengzhou Du, Nanze Yu, Xiao Long, Jiuzuo Huang, Xiumei Wang

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Extreme temperatures modulate gene expression in the airway epithelium of the lungs in mice and asthma patients by Firdian Makrufardi, Firdian Makrufardi, Syue-Wei Peng, Kian Fan Chung, Marc Chadeau-Hyam, Marc Chadeau-Hyam, Kang-Yun Lee, Kang-Yun Lee, Ta-Chih Hsiao, Kin-Fai Ho, Desy Rusmawatiningtyas, Indah Kartika Murni, Eggi Arguni, Yuan-Hung Wang, Yuan-Hung Wang, Shu-Chuan Ho, Shu-Chuan Ho, Feng-Ming Yang, Kai-Jen Chuang, Kai-Jen Chuang, Sheng-Chieh Lin, Sheng-Chieh Lin, Hsiao-Chi Chuang, Hsiao-Chi Chuang, Hsiao-Chi Chuang, Hsiao-Chi Chuang

“…These findings suggest that extreme temperatures modulate gene expression in the airway epithelium, potentially serving as clinical indicators or biomarkers in response to climate change.…”
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Oral microbiome dysbiosis in women with a history of pregnancy loss: a metagenomic cross-sectional study by Ling Liu, Li Wei, Fang Xiang Mou, Wei Zhang, Rui Fang Wang, Qi Wang, Fang Wang

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Optometry-led psychotherapy module to overcome anxiety and stress occurring during amblyopia therapy by Jyoti Gangta, Renu Thakur, Pinaz Nasim

“…The SAPA 16 scores revealed a notable decrease in stress levels following the intervention. …”
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Impact of Penetrating Kelvin Waves on MJO Rainfall Propagation Through Deep Convection Modulation by Xingchao Chen, L. Ruby Leung, Zhe Feng

“…Through a series of sensitivity experiments, we demonstrate that these penetrating Kelvin waves can modulate the eastward propagation speed of MJO rainfall. …”
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Intensity-modulated Radiation Therapy in the Management of Diffuse Choroidal Hemangioma in Sturge-Weber Syndrome by Saeed Karimi, Sadra Ashrafi, Zahra Siavashpour, Mona Malekzadeh Moghani

“… Purpose: This study aimed to report the efficiency and safety of using intensity-modulated radiation therapy (IMRT) in treating diffuse choroidal hemangioma (DCH) in patients with Sturge- Weber syndrome (SWS). …”
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Fecal microbiota transplantation alleviates radiation enteritis by modulating gut microbiota and metabolite profiles by Qin Ding, Jing Xue, Nan Li, Zhihui Hu, Jianbo Song

“…Metabolomics analysis revealed that FMT influenced niacin, nicotinamide, and starch metabolism, with notable changes in pantothenic acid and fatty acid levels. …”
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Integrated Analyses Reveal the Physiological and Molecular Mechanisms of Brassinolide in Modulating Salt Tolerance in Rice by Jia-Shuang Wu, De-Wei Mu, Nai-Jie Feng, Dian-Feng Zheng, Zhi-Yuan Sun, Aaqil Khan, Hang Zhou, Yi-Wen Song, Jia-Xin Liu, Jia-Qi Luo

“…While brassinolide (BR) has been shown to alleviate its adverse effects and modulate plant development, the precise mechanism underlying BR-induced salt tolerance in rice remains unclear. …”
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Modulation of insulin secretion and lipid profiles through glutamate dehydrogenase activators in diabetic rabbits by Abdreshov Serik Nauryzbaevish, Galiya Tatarinova, Oxikbayev Berikzhan, Amantai Kunakbayev4, Gulnara Tashenova, Atanbaeva Gulshat Kapalbaevna, Kulbayeva Marzhan Susarovnalbayeva, Shynybekova Sholpan

“…The study reveals significant modulations in insulin and lipid profiles due to these treatments. …”
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Transient Interdomain Interactions Modulate the Monomeric Structural Ensemble and Self‐Assembly of Huntingtin Exon 1 by Priyesh Mohanty, Tien Minh Phan, Jeetain Mittal

“…Further, interdomain interactions modulated the stability of N17‐mediated polyQ dimers and promoted a heterogeneous dimerization landscape. …”
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Integrated analysis of microRNAs and lncRNAs expression profiles reveals regulatory modules during adventitious shoot induction in Moringa oleifera Lam by Endian Yang, Mengxia Zheng, Limei Zhang, Xiaoyang Chen, Junjie Zhang

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DPSCs modulate synovial macrophage polarization and efferocytosis via PINK1/Parkin-dependent mitophagy by Jinjin Ma, Xinyu Wang, Dalei Sun, Jiali Chen, Linyi Zhou, Kaiao Zou, Xinxin Ni, Hongting Jin, Jun Lin

“…Results In the rat model, compared with the OA group, the DPSCs group exhibited reduced cell infiltration and collagen deposition, along with elevated levels of anti-inflammatory CD206 and decreased levels of inflammatory CD86, and enhanced the ability of macrophages to phagocytize apoptotic cells in vivo and in vitro. Notably, DPSCs exhibited enhanced efficacy in upregulating autophagosome expression, promoting co-localization with mitochondria and lysosomes, and modulating the expression of mitochondrial mitophagy proteins. …”
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Modulation of Adult Mesenchymal Stem Cells Activity by Toll-Like Receptors: Implications on Therapeutic Potential by Olga DelaRosa, Eleuterio Lombardo

“…However inconsistent results among authors have been reported suggesting that the source of MSCs, TLR stimuli employed or culture conditions play a role. Notably, activation by TLR ligands has not been reported to modulate the “immunoprivileged” phenotype of MSCs which is of special relevance regarding the use of allogeneic MSC-based therapies. …”
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RBM24 regulates apoptosis rates by modulating global transcriptome profile in CAL27 cells by Jingjing Sun, Shuyuan Wang, Shumin Peng, Tingting Gao, Zhenjie Gao

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Temporal ordering of input modulates connectivity formation in a developmental neuronal network model of the cortex. by Caroline Hartley, Simon Farmer, Luc Berthouze

“…We investigated, in a computational model of leaky integrate-and-fire neurones, whether the temporal ordering of burst activity within an external driving input could modulate connectivity formation in the network. Connectivity evolved across the course of simulations using an approach analogous to STDP, from networks with initial random connectivity. …”
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