Brain region-specific gain modulation of place cells by VIP neurons by Nora Lenkey, Anna Christina Garvert, Máté Neubrandt, Birgit Kriener, Koen Vervaeke

“…In contrast, VIP neurons in the hippocampus have minimal impact on place field gain. Notably, simulations indicate that the benefit of gain modulation for RSC place cells is large compared to hippocampal place cells due to their much higher out-of-field activity and, therefore, lower signal-to-noise ratio. …”
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Development of Active External Network Topology Module for Floodlight SDN Controller by A. A. Noskov, M. A. Nikitinskiy, I. V. Alekseev

“…Notably, firewall and routing modules are examples of such modules. …”
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Computational discovery of novel aryl hydrocarbon receptor modulators for psoriasis therapy by Gianluca Santini, Laura Bonati, Stefano Motta

“…The stability of the binding geometries of the most promising compounds of each family was then verified through molecular dynamics simulations and pharmacokinetic characteristics were predicted using ADMETlab 2.0 and SwissADME. Notably, several identified compounds suggest a possible interplay between AhR signaling and sirtuin modulation, highlighting a previously unexplored avenue in psoriasis therapy. …”
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The TIP60-CD44 Axis Modulates Colorectal Cancer Stemness by Asad Mohammad, Sudhakar Jha

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Perivascular interactions and tissue properties modulate directional glymphatic transport in the brain by Chenji Li, Sadegh Dabiri, Arezoo M. Ardekani

“…Our results demonstrate that net glymphatic flow sweeps from periarterial space across parenchyma and is modulated by the periarterial-perivenous interactions, leading to higher pressure in periarterial space that drives unidirectional bulk transport from periarterial space to perivenous space. …”
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The Role of Probiotics in Modulating the Gut Microbiome in Alzheimer’s Disease: A Review by Yushi Dong, Xilin Wu, Yumeng Zhang, Adi Hu, Qian Zhou, Xiqing Yue, Zhenmin Liu, Mohan Li

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Selective Modulation of Fear Memory in Non‐Rapid Eye Movement Sleep by Qiyu Zheng, Yuhua Huang, Changrui Mu, Xiaoqing Hu, Cora Sau Wan Lai

“…Optogenetic inhibition of pyramidal neurons in the frontal association cortex (FrA) during TMR abolishes the behavioral effects of NS‐TMR and SWS‐TMR by modulating SO‐spindle coupling. Notably, calcium imaging of the L2/3 pyramidal neurons in the FrA shows that CS during SWS selectively enhances the activity of neurons previously activated during fear conditioning (FC+ neurons), which significantly correlates with CS‐elicited spindle power spectrum density. …”
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Cold environment regulates ischemic stroke through modulation of gut microbiota by Xiao Zhou, Chanjuan Wei, Jiaming Liu, Xiaoshuang Xia, Lin Wang, Xin Li

“…Our findings identify the significant role of abnormal gut microbiota-derived metabolites in cold exposure-related IS and highlight the potential opportunity to prevent or treat cold-related IS through the modulation of the gut microbiota.…”
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Ketone body, as an emerging modulator of metabolic reprogramming and epigenetics in breast cancer by Fatemeh Mehdikhani, Sadegh Rajabi, Maryam Mohammadlou, Marc Maresca, Rasoul Baharlou

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SGLT2 inhibition mitigates intracerebral hemorrhage risk by modulating inflammation by Mingsheng Huang, Yiheng Liu, Cheng Chen

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STTMC: A Few-Shot Spatial Temporal Transductive Modulation Classifier by Yunhao Shi, Hua Xu, Zisen Qi, Yue Zhang, Dan Wang, Lei Jiang

“…In this paper, we present a novel few-shot AMC model named the Spatial Temporal Transductive Modulation Classifier (STTMC), which comprises two modules: a feature extraction module and a graph network module. …”
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Therapeutic potential of natural arginase modulators: mechanisms, challenges, and future directions by Ting Li, Ting Li, Ting Li, Jieying Wang, Huan Wang, Bowei Zhang, Lijuan Duan, Lijuan Duan

“…These bioactive compounds exert their modulatory effects on Arg activity through multiple mechanisms, including direct enzyme interaction, regulation of signaling pathways, and modulation of cellular metabolism. The therapeutic potential of these metabolites spans across various medical domains, notably in cardiovascular diseases, oncology, neurological disorders, and inflammatory conditions. …”
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Targeting stemness pathways modulates macrophage polarization and reprograms the tumor microenvironment by Austeja Butkute, Austeja Butkute, Marius Baltramonaitis, Marius Baltramonaitis, Simona Malmige, Adas Darinskas, Vita Pasukoniene, Agata Mlynska, Agata Mlynska

“…This study aimed to investigate how targeting cancer cell stemness with specific inhibitors could modulate macrophage polarization in CRC in vitro and breast cancer in vivo, potentially shifting the immune balance from pro-tumor M2-like to anti-tumor M1-like macrophages. …”
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TP63 as a modulator of ferroptosis in TP53 mutations glioblastoma by Haiping Cai, Jiahao Yang, Feifei Luo, Wu Gan, Yanwen Li, Liang Zhang, Xueying Ke, Alafate Wahafu, Danian Dai, Peng Wang, Dong Zhou

“…Notably, TP63 (mainly ΔNp63 isoform) expression was markedly upregulated in TP53-mutant GBM. …”
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Probiotics ameliorate atopic dermatitis by modulating the dysbiosis of the gut microbiota in dogs by Hyokeun Song, Seung-Hyun Mun, Dae-Woong Han, Jung-Hun Kang, Jae-Uk An, Cheol-Yong Hwang, Seongbeom Cho

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Numerical Simulation of Oscillatory Magnetic Reconnection Modulated by Solar Convective Motions by Yifu Wang, Lei Ni, Guanchong Cheng, Jialiang Hu, Yuhao Chen, Abdullah Zafar

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Unique pharmacological properties of etrasimod among S1P receptor modulators by Ibragim Gaidarov, H. Kiyomi Komori, Dariusz T. Stepniak, Karin Bruinsma, Huong Dang, Xiaohua Chen, Todd Anthony, Joel Gatlin, Lisa Karimi‐Naser, Anh‐Tuan Ton, Tim Indersmitten, Paul E. Miller, Andre Ghetti, Najah Abi‐Gerges, David Unett, Hussien Al‐Shamma, Christopher J. Rabbat, Catherine Crosby, John W. Adams

“…However, etrasimod was notably less potent than other S1PR modulators in assays measuring S1P1‐mediated G protein activation (GTPγS binding and cAMP inhibition). …”
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Dust Content Modulation and Spring Heat Waves in Senegal (2003–2022) by Semou Diouf, Marie-Jeanne G. Sambou, Abdoulaye Deme, Papa Fall, Dame Gueye, Juliette Mignot, Serge Janicot

“…The influence of dust is notably stronger for HWs linked to Tn and Ta than for those related to Tx. …”
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Modulating the aroma and taste profile of soybean using novel strains for fermentation by Xin Hui Chin, Ryan Soh, Geraldine Chan, Pnelope Ng, Aaron Thong, Hosam Elhalis, Kanagasundaram Yoganathan, Yvonne Chow, Shao Quan Liu

“…A key factor influencing consumer acceptance of soybean products is the aroma and taste profile, which can be modulated through fermentation using unique microbial strains. …”
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Astrocytic glucocorticoid receptors in the ventral hippocampus modulate anxiety-like behaviors by Cheng-Lin Lu, Jing Ren, Wei Wang, Liang-Yu Chen, Xiao-Ying Lian, Xiong Cao

“…Targeted deletion of GRs in astrocytes resulted in the development of anxiety-like behaviors in mice. Notably, selective ablation of astrocytic GRs specifically within the vHPC region produced similar behavioral phenotypes. …”
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