Transient Interdomain Interactions Modulate the Monomeric Structural Ensemble and Self‐Assembly of Huntingtin Exon 1 by Priyesh Mohanty, Tien Minh Phan, Jeetain Mittal

“…Further, interdomain interactions modulated the stability of N17‐mediated polyQ dimers and promoted a heterogeneous dimerization landscape. …”
Get full text

DPSCs modulate synovial macrophage polarization and efferocytosis via PINK1/Parkin-dependent mitophagy by Jinjin Ma, Xinyu Wang, Dalei Sun, Jiali Chen, Linyi Zhou, Kaiao Zou, Xinxin Ni, Hongting Jin, Jun Lin

“…Results In the rat model, compared with the OA group, the DPSCs group exhibited reduced cell infiltration and collagen deposition, along with elevated levels of anti-inflammatory CD206 and decreased levels of inflammatory CD86, and enhanced the ability of macrophages to phagocytize apoptotic cells in vivo and in vitro. Notably, DPSCs exhibited enhanced efficacy in upregulating autophagosome expression, promoting co-localization with mitochondria and lysosomes, and modulating the expression of mitochondrial mitophagy proteins. …”
Get full text

Modulation of Adult Mesenchymal Stem Cells Activity by Toll-Like Receptors: Implications on Therapeutic Potential by Olga DelaRosa, Eleuterio Lombardo

“…However inconsistent results among authors have been reported suggesting that the source of MSCs, TLR stimuli employed or culture conditions play a role. Notably, activation by TLR ligands has not been reported to modulate the “immunoprivileged” phenotype of MSCs which is of special relevance regarding the use of allogeneic MSC-based therapies. …”
Get full text

RBM24 regulates apoptosis rates by modulating global transcriptome profile in CAL27 cells by Jingjing Sun, Shuyuan Wang, Shumin Peng, Tingting Gao, Zhenjie Gao

Get full text

PSMA2 promotes chemo- and radioresistance of oral squamous cell carcinoma by modulating mitophagy pathway by Chun-I Wang, Cheng-Yi Chen, Ting-Wen Chen, Chun-Chia Cheng, Shu-Wen Hong, Tsung-You Tsai, Kai-Ping Chang

Get full text

Multi-platform omics analysis of Nipah virus infection reveals viral glycoprotein modulation of mitochondria by Gunner P. Johnston, Fikret Aydemir, Haewon Byun, Emmie de Wit, Kristie L. Oxford, Jennifer E. Kyle, Jason E. McDermott, Brooke L. Deatherage Kaiser, Cameron P. Casey, Karl K. Weitz, Heather M. Olson, Kelly G. Stratton, Natalie C. Heller, Viraj Upadhye, I. Abrrey Monreal, J. Lizbeth Reyes Zamora, Lei Wu, D.H. Goodall, David W. Buchholz, Joeva J. Barrow, Katrina M. Waters, Ruth N. Collins, Heinz Feldmann, Joshua N. Adkins, Hector C. Aguilar

Get full text

Temporal ordering of input modulates connectivity formation in a developmental neuronal network model of the cortex. by Caroline Hartley, Simon Farmer, Luc Berthouze

“…We investigated, in a computational model of leaky integrate-and-fire neurones, whether the temporal ordering of burst activity within an external driving input could modulate connectivity formation in the network. Connectivity evolved across the course of simulations using an approach analogous to STDP, from networks with initial random connectivity. …”
Get full text

Modulation of Human Colon Cell Activity by Synthetic Coumarin Derivatives Bearing a Phosphonate Group by Katarzyna Szwaczko, Roman Paduch, Kamil Dziuba, Krzysztof Szafrański, Adrian Wiater

Get full text

Propagation Properties of Laguerre–Gaussian Beams with Three Variable Coefficient Modulations in the Fractional Schrödinger Equation by Xinru Hao, Yong Liang, Min Zou, Bin Zhong, Chao Tan

“…This article investigates the transmission characteristics of Laguerre–Gaussian (LG) beams under cosine modulation, power function modulation and linear modulation based on the variable coefficient fractional Schrödinger equation (FSE), respectively. …”
Get full text

The insulator EACBE regulates V(D)J recombination of Tcrd gene by modulating chromatin organization by Yongchang Zhu, Yongchang Zhu, Ranran Dai, Ranran Dai, Hao Zhao, Junwei Luo, Keyi Li, Wei Xue, Litao Qin, Hongyuan Pan, Shixiu Liao, Bingtao Hao, Bingtao Hao

“…These findings reveal a novel regulatory axis involving special chromatin configuration and highlight distinct roles for specific CTCF binding sites in modulating antigen receptor gene assembly.…”
Get full text

NR1I3 modulates Wnt signaling to promote anterior–posterior axis patterning by Yujia Sun, Ning Ding, Shuqi Li, Yuan Zhang, Yunfei Qin, Zhitai Hao, Shoutao Zhang, Qingnan Tian

Get full text

GluA2 palmitoylation by SELENOK modulates AMPAR assembly and synaptic plasticity in Alzheimer's disease by Jiaying Peng, Zhiyu Cai, Pei Ouyang, Shujing Lin, Shurui Zhang, Danchan Liang, Ziqi Feng, Changbin Chen, Xilin Ye, Guoli Song, Zhonghao Zhang

Get full text

Exploring the combined roles of GALNT1 and GALNT2 in hepatocellular carcinoma malignancy and EGFR modulation by Tagwa E. Osman, Yanru Guo, Shijun Li

“…Conversely, co-transfection of GALNT1 overexpression with GALNT2 knockdown enhanced these malignant characteristics compared to the modified single gene. Notably, we observed that GALNT1 and GALNT2 modulated EGFR protein expression. …”
Get full text

Branched-chain amino acids modulate the proteomic profile of Trypanosoma cruzi metacyclogenesis induced by proline. by Janaina de Freitas Nascimento, Flávia Silva Damasceno, Sabrina Marsiccobetre, Francisca Natália de Luna Vitorino, Renan Weege Achjian, Julia Pinheiro Chagas da Cunha, Ariel Mariano Silber

Get full text

Distinct structural mechanisms of LGR4 modulation by Norrin and RSPOs in Wnt/β-catenin signaling by Huarui Qiao, Fangzheng Hu, Yiang Wang, Lu Wang, Siyu Zhou, Shaojue Guo, Yiwen Xu, Jianfeng Xu, Qianqian Cui, Qilun Yang, H. Eric Xu, Jianwei Zhu, Yong Geng

“…Notably, Norrin binding to LGR4 sterically hinders simultaneous interaction with the Frizzled4 receptor, establishing a regulatory checkpoint in Wnt signaling. …”
Get full text

Retinoic acid modulates peritoneal macrophage function and distribution to enhance antibacterial defense during inflammation by Yujuan Qin, Yujuan Qin, Xi Wang, Xi Wang, Xiamin Zhang, Xiamin Zhang, Lianting Nong, Lianting Nong, Qiyan Hou, Yuhong Chen, Yuhong Chen, Yuting Li, Yuting Li, Wenxian Lin, Xiuli Mao, Kezhao Wu, Wenqian Nong, Tonghua Wang, Lingzhang Meng, Lingzhang Meng, Jian Song, Jian Song, Jian Song

“…RA treatment also induced distinct gene expression profiles in macrophage subpopulations, reflecting its role in immune modulation. Notably, RA-loaded ZIF-8 nanoparticles prolonged RA retention within macrophages, sustaining its effects.ConclusionRA enhances antibacterial defense by modulating macrophage activity, providing new insights into immune regulation. …”
Get full text

The AraC Negative Regulator family modulates the activity of histone-like proteins in pathogenic bacteria. by Araceli E Santiago, Michael B Yan, Tracy H Hazen, Brooke Sauder, Mario Meza-Segura, Mario Meza-Segura, David A Rasko, Melissa M Kendall, Fernando Ruiz-Perez, James P Nataro

“…By employing a bacterial two-hybrid system, LacZ reporter assays, pull-down and electrophoretic mobility shift assay (EMSA) analysis, we demonstrated that Aar binds directly to H-NS and modulates H-NS-induced gene silencing. Importantly, Aar was highly expressed in the mouse intestinal tract and was found to be necessary for maximal H-NS expression. …”
Get full text

Structure-Activity Relationships in Alkoxylated Resorcinarenes: Synthesis, Structural Features, and Bacterial Biofilm-Modulating Properties by Mariusz Urbaniak, Łukasz Lechowicz, Barbara Gawdzik, Maciej Hodorowicz, Ewelina Wielgus

“…This work highlights the dual relevance of alkoxylated resorcinarenes as both supramolecular building blocks and modulators of microbial behavior.…”
Get full text

Computational analysis of Annona muricata phytochemicals for targeted modulation of endocrine networks in polycystic ovary syndrome by Babatunji Emmanuel Oyinloye, Oluwaseun Emmanuel Agboola, Aderonke Moyosola Ayeni, Oluwatoyin Mary Oyinloye, Samuel Sunday Agboola, Olajumoke Tolulope Idowu, Makhosazana Siduduzile Mathenjwa-Goqo, Olutunmise Victoria Owolabi, Bolajoko Idiat Ogunyinka, Foluso Oluwagbemiga Osunsanmi, Basiru Olaitan Ajiboye, Olaposi Idowu Omotuyi

“…The results demonstrated various ligands with remarkable binding affinities for progesterone, androgen, and abiraterone receptor architectures matching or exceeding native standards, implying possible efficacy for coordinately modulating these interconnected hormonal sites. Detailed structural mapping of emodin and coclaurin uncovered conserved non-covalent interaction patterns, notably hydrogen bonding networks, facilitating the ligands’ competitive receptivity and deep projection into dysfunctionally upregulated pockets. …”
Get full text

Silicon-mediated modulation of maize growth, metabolic responses, and antioxidant mechanisms under saline conditions by Muhammad Saad Ullah, Athar Mahmood, Hussam F. Najeeb Alawadi, Mahmoud F. Seleiman, Bilal Ahmad Khan, Muhammad Mansoor Javaid, Abdul Wahid, Fnu Abdullah, Daniel O. Wasonga

Get full text