A cytidine deaminase-like protein modulates pyrimidine nucleotide homeostasis in Trypanosoma brucei by Ana Moro-Bulnes, Cristina Bosch-Navarrete, Pablo Antequera-Parrilla, Santiago Castanys, Antonio E. Vidal, Luis Miguel Ruiz-Pérez, Guiomar Pérez-Moreno, Dolores González-Pacanowska

“…Using RNA interference (RNAi) and overexpression approaches, we demonstrate that TbCDA-like modulates pyrimidine nucleotide pools, influencing both ribonucleotide and deoxyribonucleotide profiles. …”
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Slope Position Modulates Soil Chemical Properties and Microbial Dynamics in Tea Plantation Ecosystems by Limei Li, Lijiao Chen, Hongxu Li, Yuxin Xia, Houqiao Wang, Qiaomei Wang, Wenxia Yuan, Miao Zhou, Juan Tian, Baijuan Wang

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Sprayable hydrogel sponge for neurovascular microenvironment reconstruction and inflammation modulation in diabetic wound healing by Xiaozhen Zhou, Pengchao Ma, Yihao Liu, Zhaojian Wang, Shida Chen, Zekun Cheng, Songlu Tseng, Hui Wu, Mengdi Zhang, Fengzhou Du, Nanze Yu, Xiao Long, Jiuzuo Huang, Xiumei Wang

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Reticulospinal modulation of muscle activation and electromechanical coupling: evidence from the StartReact paradigm by Antonia Maria Eilfort, Antonia Maria Eilfort, Antonia Maria Eilfort, Linard Filli, Linard Filli, Linard Filli

“…EMD was defined as the time interval between EMG onset and movement initiation.ResultsOur results revealed faster and more pronounced muscle activation and movement performance in response to LAS compared to MAS. Notably, EMD was significantly reduced in LAS trials, suggesting that enhanced RS drive facilitates more rapid electromechanical coupling.DiscussionThese findings suggest that RS drive not only shortens muscular reaction times – characteristic of the StartReact effect - but also modulates muscle activation and movement dynamics in a way that accelerates the transition from muscle activation to movement. …”
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Vagus nerve modulates acute-on-chronic liver failure progression via CXCL9 by Li Wu, Jie Li, Ju Zou, Daolin Tang, Ruochan Chen, Yanjie Yin

“…Blocking CXCL9 and CXCR3 ameliorated liver inflammation and increased ACLF-associated mortality in ACLF mice with vagotomy. scRNA-seq revealed that hepatic macrophages served as the major source of CXCL9 in ACLF and were validated by immunofluorescence staining and flow cytometry analysis. Notably, the expression of CXCL9 in macrophages was modulated by vagus nerve-mediated cholinergic signaling. …”
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FLNA, a disulfidptosis-related gene, modulates tumor immunity and progression in colorectal cancer by Qiong Li, Renhong Huang, Lingling Lv, Haifeng Ying, Yuan Wu, YuQing Huang, Yuxi Li, Wen Ma, Xiaoshuang Liu, Qinghui Meng, Fengying Xing, Yan Shen, Lan Zheng

“…These findings suggest that modulating disulfidptosis in conjunction with immunotherapy may offer a novel treatment paradigm for CRC.…”
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PUF60‐Regulated Isoform Switching of MAZ Modulates Gastric Cancer Cell Migration by Dong Xing, Ting Zhao, Chenchen Mao, Zheng Han, Wanxia Cai, Teming Zhang, Dianfeng Mei, Wangkai Xie, Jiaye Yu, Zhonghan Wu, Zhiyuan Chen, Shiyu Feng, Xian Shen, Xiangyang Xue, Dan Xiang

“…Targeting MAZ alternative splicing, particularly via PUF60 modulation, represents a novel therapeutic strategy.…”
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BPM Proteins Modulate Heat Stress Response in <i>Arabidopsis thaliana</i> Seedlings by Sandra Vitko, Dunja Leljak-Levanić, Nataša Bauer, Željka Vidaković-Cifrek

“…Heat stress induced HSP70 and HSP90 in all seedlings but expression remained notably higher in <i>amiR-bpm</i> after recovery. …”
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CDK12 antagonizes a viral suppressor of RNAi to modulate antiviral RNAi in Drosophila by Liqin Zhang, Yu Liang, Jiayu Qin, Chen Liu, Mengwei Shang, Xiaoming Sun

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Fucoidan Modulates Osteoarthritis Progression Through miR-22/HO-1 Pathway by Tsung-Hsun Hsieh, Jar-Yi Ho, Chih-Chien Wang, Feng-Cheng Liu, Chian-Her Lee, Herng-Sheng Lee, Yi-Jen Peng

“…Fucoidan treatment restored HO-1 expression while reducing inducible nitric oxide synthase and matrix metalloproteinase levels in IL-1β-stimulated cells. Notably, this study revealed that fucoidan modulates the miR-22/HO-1 pathway, a previously uncharacterized mechanism in OA. …”
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Compost Tea Combined with Fungicides Modulates Grapevine Bacteriome and Metabolome to Suppress Downy Mildew by Giuliano Bonanomi, Giuseppina Iacomino, Ayoub Idbella, Giandomenico Amoroso, Alessia Staropoli, Andrea De Sio, Franco Saccocci, Ahmed M. Abd-ElGawad, Mauro Moreno, Mohamed Idbella

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Extreme temperatures modulate gene expression in the airway epithelium of the lungs in mice and asthma patients by Firdian Makrufardi, Firdian Makrufardi, Syue-Wei Peng, Kian Fan Chung, Marc Chadeau-Hyam, Marc Chadeau-Hyam, Kang-Yun Lee, Kang-Yun Lee, Ta-Chih Hsiao, Kin-Fai Ho, Desy Rusmawatiningtyas, Indah Kartika Murni, Eggi Arguni, Yuan-Hung Wang, Yuan-Hung Wang, Shu-Chuan Ho, Shu-Chuan Ho, Feng-Ming Yang, Kai-Jen Chuang, Kai-Jen Chuang, Sheng-Chieh Lin, Sheng-Chieh Lin, Hsiao-Chi Chuang, Hsiao-Chi Chuang, Hsiao-Chi Chuang, Hsiao-Chi Chuang

“…These findings suggest that extreme temperatures modulate gene expression in the airway epithelium, potentially serving as clinical indicators or biomarkers in response to climate change.…”
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Single-cell RNA sequencing reveals the heterogeneity and regulatory modules of cell-specific RNA-binding proteins in patients with systemic lupus erythematosus by Sheng-Yan Lin, Yikai Yu, Daan Nie, Lili Yang, Yuxue Chen, Yu Chen, Cheng Wen, Zhipeng Zeng

“…Results: Single-cell resolution revealed marked heterogeneity in RBPs expression across keratinocyte, endothelial cell, and T cell in SLE compared to HC. Notably, disease-specific RBPs were enriched in pathways governing interferon response, cytokine signaling, and leukocyte activation. …”
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Oral microbiome dysbiosis in women with a history of pregnancy loss: a metagenomic cross-sectional study by Ling Liu, Li Wei, Fang Xiang Mou, Wei Zhang, Rui Fang Wang, Qi Wang, Fang Wang

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Long-term Endurance Training as a Modulator for Preventing Cardiovascular Disease Risk in Obese Individuals by Adi Pranoto, Shidqi Hamdi Pratama Putera, Dewangga Yudhistira, Bayu Ristiawan, Rahmawati Al Adha Nikmah, Aprilyan Putra Bimantoro, Purwo Sri Rejeki

“…This study aimed to evaluate the long-term effects of endurance training as a modulator in the prevention of cardiovascular disease risk in obese individuals. …”
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Lactylation modulation identifies key biomarkers and therapeutic targets in KMT2A-rearranged AML by Dan Liu, Silu Liu, Yujie Ji, Ziyan Jin, Zhewei He, Mengjia Hou, Dongyang Li, Xiao Ma

“…This research examined the influence of lactylation on gene expression within KMT2Ar-AML, initially identifying twelve notable lactylation-dependent differentially expressed genes (DEGs). …”
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GdX inhibits the occurrence and progression of breast cancer by negatively modulating the activity of STAT3 by Zhilin Chen, Lu Xu, Shibin Lin, Hongjun Huang, Qing Long, Jiwei Liu

“…Mechanistically, STAT3 emerged as a downstream target gene of GdX.Conclusions GdX exerts its inhibitory effects on the initiation and progression of BC by negatively modulating the phosphorylation of STAT3.…”
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Skimmianine Modulates Tumor Proliferation and Immune Dynamics in Breast Cancer by Targeting PCNA and TNF-α by Tuğcan Korak, Hayat Ayaz, Fırat Aşır

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Polypropylene microplastic exposure modulates multiple metabolic pathways in tobacco leaves, impacting lignin biosynthesis by Muhammad Arshad, Yaowu Ma, Weichang Gao, Shixiang Zhang, Muhammad Shoaib, Xinru Liu, Yingkai Fan, Gen Li, Huiyu Chuai, Ying Jiang, Jiaguo Jiao, Huijuan Zhang, Jun Wu, Feng Hu, Huixin Li

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Integrated analysis of microRNAs and lncRNAs expression profiles reveals regulatory modules during adventitious shoot induction in Moringa oleifera Lam by Endian Yang, Mengxia Zheng, Limei Zhang, Xiaoyang Chen, Junjie Zhang

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