Modulation of endogenous plasmalogens by genetic ablation of lysoplasmalogenase (Tmem86b) in mice by Sudip Paul, Pooranee Morgan, Gerard Pernes, Yvette Schooneveldt, Thy Duong, Natalie A. Mellett, Kevin Huynh, Andrew J. Murphy, Graeme I. Lancaster, Peter J. Meikle

Get full text

Urban underlying surface modulates summertime thunderstorm processes and associated lightning activities by T. Shi, T. Shi, Y. Yang, G. Lu, Z. Zheng, Y. Zi, Y. Tian, L. Liu, S. Lolli

Get full text

hsa-mir-483-3p modulates delayed breast cancer recurrence by Ok-Hyeon Kim, Tae Jin Jeon, Hana Kang, Eun Seo Chang, Soon Auck Hong, Min Kyoon Kim, Hyun Jung Lee

Get full text

Modulating the serine metabolism in human differentiated astrocytes: an integrated multi omics approach by Farida Tripodi, Elisa Maffioli, Silvia Sacchi, Valentina Rabattoni, Zoraide Motta, Claudia Bearzi, Gabriella Tedeschi, Gabriella Tedeschi, Loredano Pollegioni, Paola Coccetti

Get full text

Nitrogen deposition modulates invasibility and stability of plant communities in microplastic-contaminated wetlands by Ziyi Wang, Mengxuan He, Zirui Meng, Jingqi Lang, Xueqiang Lu, Qing Xue, Limin Liang, Xunqiang Mo

Get full text

Therapeutic potential of Litsea cubeba essential oil in modulating inflammation and the gut microbiome by Liqiong Xia, Ran Li, Ran Li, Ting Tao, Ruimin Zhong, Haifang Du, Ziling Liao, Zhanghua Sun, Changqiong Xu, Changqiong Xu

“…However, unfettered and excessive inflammation can be instrumental in engendering a plethora of chronic ailments and detrimental health repercussions, notably within the gastrointestinal tract. Lipopolysaccharides (LPS) from bacteria are potent endotoxins capable of instigating intestinal inflammation through the disruption of the intestinal epithelial barrier and the stimulation of a pro-inflammatory immune response. …”
Get full text

Modulation of flowering by an alternatively spliced AGL18-1 transcript in Brassica juncea by Qinlin Deng, Huanhuan Lu, Dakun Liu, Yifang Huang, Junjie Feng, Dayong Wei, Zhimin Wang, Qinglin Tang

Get full text

Allosteric modulation of serotonin and dopamine transporters: New insights from computations and experiments by Hoang Nguyen, Mary Hongying Cheng, Ji Young Lee, Shaili Aggarwal, Ole Valente Mortensen, Ivet Bahar

“…They also provide a basis for designing allosteric modulators that may provide better control of specific interactions and cellular pathways, rather than indiscriminately inhibiting the transporter by targeting its orthosteric site.…”
Get full text

OSBPL3 modulates the immunosuppressive microenvironment and predicts therapeutic outcomes in pancreatic cancer by Qihui Sun, Xiaoqi Zhu, Qi Zou, Yang Chen, Tingting Wen, Tingting Jiang, Xiaojia Li, Fang Wei, Keping Xie, Jia Liu

“…Results Our risk prediction model, developed using machine learning algorithms, demonstrated high predictive accuracy across multiple datasets. Notably, the “rf” algorithm model showed an AUC of 1 in the training set and AUCs of 0.887 and 0.977 in two validation datasets. …”
Get full text

Exploring the Therapeutic and Gut Microbiota-Modulating Effects of Qingreliangxuefang on IMQ-Induced Psoriasis by Yu Z, Wang Y, Guo Y, Zhu R, Fang Y, Yao Q, Fu H, Zhou A, Ma L, Shou Q

“…Changes in the gut microbiota were analyzed via 16SrDNA sequencing, and T cell subsets were assessed using flow cytometry.Results: Network pharmacology analysis suggested that QRLXF ameliorated psoriasis by modulating Th17 cell differentiation. Further experiments confirmed the anti-inflammatory effects and relief of psoriatic lesions in IMQ-induced mice. 16SrDNA sequencing revealed significant shifts in the gut microbiota, notably increases in Ligilactobacillus and Lactobacillus genera and decreases in Anaerotruncus, Negativibacillus, Bilophila, and Mucispirillum, suggesting a potential relationship between specific microbiota changes and Th17 cell differentiation.Conclusion: QRLXF alleviated psoriatic dermatitis by regulating Th17 cell responses and modifying gut microbiota profiles, highlighting its therapeutic potential for psoriasis treatment.Plain Language Summary: Psoriasis affects millions globally. …”
Get full text

Optometry-led psychotherapy module to overcome anxiety and stress occurring during amblyopia therapy by Jyoti Gangta, Renu Thakur, Pinaz Nasim

“…The SAPA 16 scores revealed a notable decrease in stress levels following the intervention. …”
Get full text

Impact of Penetrating Kelvin Waves on MJO Rainfall Propagation Through Deep Convection Modulation by Xingchao Chen, L. Ruby Leung, Zhe Feng

“…Through a series of sensitivity experiments, we demonstrate that these penetrating Kelvin waves can modulate the eastward propagation speed of MJO rainfall. …”
Get full text

Intensity-modulated Radiation Therapy in the Management of Diffuse Choroidal Hemangioma in Sturge-Weber Syndrome by Saeed Karimi, Sadra Ashrafi, Zahra Siavashpour, Mona Malekzadeh Moghani

“… Purpose: This study aimed to report the efficiency and safety of using intensity-modulated radiation therapy (IMRT) in treating diffuse choroidal hemangioma (DCH) in patients with Sturge- Weber syndrome (SWS). …”
Get full text

Fecal microbiota transplantation alleviates radiation enteritis by modulating gut microbiota and metabolite profiles by Qin Ding, Jing Xue, Nan Li, Zhihui Hu, Jianbo Song

“…Metabolomics analysis revealed that FMT influenced niacin, nicotinamide, and starch metabolism, with notable changes in pantothenic acid and fatty acid levels. …”
Get full text

Integrated Analyses Reveal the Physiological and Molecular Mechanisms of Brassinolide in Modulating Salt Tolerance in Rice by Jia-Shuang Wu, De-Wei Mu, Nai-Jie Feng, Dian-Feng Zheng, Zhi-Yuan Sun, Aaqil Khan, Hang Zhou, Yi-Wen Song, Jia-Xin Liu, Jia-Qi Luo

“…While brassinolide (BR) has been shown to alleviate its adverse effects and modulate plant development, the precise mechanism underlying BR-induced salt tolerance in rice remains unclear. …”
Get full text

Modulation of insulin secretion and lipid profiles through glutamate dehydrogenase activators in diabetic rabbits by Abdreshov Serik Nauryzbaevish, Galiya Tatarinova, Oxikbayev Berikzhan, Amantai Kunakbayev4, Gulnara Tashenova, Atanbaeva Gulshat Kapalbaevna, Kulbayeva Marzhan Susarovnalbayeva, Shynybekova Sholpan

“…The study reveals significant modulations in insulin and lipid profiles due to these treatments. …”
Get full text

The role of foliar endophytes in modulating southern corn rust severity: implications for biocontrol strategies by Lujia Yang, Lili Li, Yingying Song, Yongsheng Zhang, Jie Yang, Hongying Cui, Wenxiu Guo, Suhong Lv, Xingyuan Men

“…Current SCR management strategies prioritize genetic resistance and chemical control, but how foliar endophytic fungal communities modulate host susceptibility to P. polysora remains poorly understood. …”
Get full text

Chronic Stress Modulates Microglial Activation Dynamics, Shaping Priming Responses to Subsequent Stress by Junyu Chen, Jiacheng Huang, Taolei Han, Nobuhiko Kojima

Get full text

Theoretical study of XUV pulse shaping due to the modulation of an IR pulse in macroscopic systems by Haohan Shi, Yu He, Youda Wang, Zheng Fang, Bitao Hu, Zuoye Liu

“…Here, we examine the evolution of spectral reshaping driven by laser-imposed initial phase modulation during pulse propagation. We present an analytical framework that elucidates the physical mechanism underlying the emergence of these propagation-induced spectral structures, and validate it through numerical simulations. …”
Get full text

Precipitation Patterns and Their Role in Modulating Nitrous Oxide Emissions from Arid Desert Soil by Chunming Xin, Huijun Qin, Yuanshang Guo, Mingzhu He

Get full text