Selective Modulation of Fear Memory in Non‐Rapid Eye Movement Sleep by Qiyu Zheng, Yuhua Huang, Changrui Mu, Xiaoqing Hu, Cora Sau Wan Lai

“…Optogenetic inhibition of pyramidal neurons in the frontal association cortex (FrA) during TMR abolishes the behavioral effects of NS‐TMR and SWS‐TMR by modulating SO‐spindle coupling. Notably, calcium imaging of the L2/3 pyramidal neurons in the FrA shows that CS during SWS selectively enhances the activity of neurons previously activated during fear conditioning (FC+ neurons), which significantly correlates with CS‐elicited spindle power spectrum density. …”
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Astrocytic glucocorticoid receptors in the ventral hippocampus modulate anxiety-like behaviors by Cheng-Lin Lu, Jing Ren, Wei Wang, Liang-Yu Chen, Xiao-Ying Lian, Xiong Cao

“…Targeted deletion of GRs in astrocytes resulted in the development of anxiety-like behaviors in mice. Notably, selective ablation of astrocytic GRs specifically within the vHPC region produced similar behavioral phenotypes. …”
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Cold environment regulates ischemic stroke through modulation of gut microbiota by Xiao Zhou, Chanjuan Wei, Jiaming Liu, Xiaoshuang Xia, Lin Wang, Xin Li

“…Our findings identify the significant role of abnormal gut microbiota-derived metabolites in cold exposure-related IS and highlight the potential opportunity to prevent or treat cold-related IS through the modulation of the gut microbiota.…”
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TP63 as a modulator of ferroptosis in TP53 mutations glioblastoma by Haiping Cai, Jiahao Yang, Feifei Luo, Wu Gan, Yanwen Li, Liang Zhang, Xueying Ke, Alafate Wahafu, Danian Dai, Peng Wang, Dong Zhou

“…Notably, TP63 (mainly ΔNp63 isoform) expression was markedly upregulated in TP53-mutant GBM. …”
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Therapeutic potential of natural arginase modulators: mechanisms, challenges, and future directions by Ting Li, Ting Li, Ting Li, Jieying Wang, Huan Wang, Bowei Zhang, Lijuan Duan, Lijuan Duan

“…These bioactive compounds exert their modulatory effects on Arg activity through multiple mechanisms, including direct enzyme interaction, regulation of signaling pathways, and modulation of cellular metabolism. The therapeutic potential of these metabolites spans across various medical domains, notably in cardiovascular diseases, oncology, neurological disorders, and inflammatory conditions. …”
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SGLT2 inhibition mitigates intracerebral hemorrhage risk by modulating inflammation by Mingsheng Huang, Yiheng Liu, Cheng Chen

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Massively parallel interrogation of human functional variants modulating cancer immunosurveillance by Ying Liu, Yongshuo Liu, Xuran Niu, Ang Chen, Yizhou Li, Ying Yu, Binrui Mo, Zhiheng Liu, Tao Xu, Jie Cheng, Zeguang Wu, Wensheng Wei

“…Beyond residues associated with phosphorylation events, our screens also identified functional mutations that affect mRNA or protein stability, DNA binding capacity, protein-protein interactions, and enzymatic catalytic activity, leading to either gene inactivation or activation. Notably, we uncovered certain mutations that concurrently modulate PD-L1 and HLA-I expression, represented by the clinically relevant mutation SETD2_Y1666. …”
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Dust Content Modulation and Spring Heat Waves in Senegal (2003–2022) by Semou Diouf, Marie-Jeanne G. Sambou, Abdoulaye Deme, Papa Fall, Dame Gueye, Juliette Mignot, Serge Janicot

“…The influence of dust is notably stronger for HWs linked to Tn and Ta than for those related to Tx. …”
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Unique pharmacological properties of etrasimod among S1P receptor modulators by Ibragim Gaidarov, H. Kiyomi Komori, Dariusz T. Stepniak, Karin Bruinsma, Huong Dang, Xiaohua Chen, Todd Anthony, Joel Gatlin, Lisa Karimi‐Naser, Anh‐Tuan Ton, Tim Indersmitten, Paul E. Miller, Andre Ghetti, Najah Abi‐Gerges, David Unett, Hussien Al‐Shamma, Christopher J. Rabbat, Catherine Crosby, John W. Adams

“…However, etrasimod was notably less potent than other S1PR modulators in assays measuring S1P1‐mediated G protein activation (GTPγS binding and cAMP inhibition). …”
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Targeting stemness pathways modulates macrophage polarization and reprograms the tumor microenvironment by Austeja Butkute, Austeja Butkute, Marius Baltramonaitis, Marius Baltramonaitis, Simona Malmige, Adas Darinskas, Vita Pasukoniene, Agata Mlynska, Agata Mlynska

“…This study aimed to investigate how targeting cancer cell stemness with specific inhibitors could modulate macrophage polarization in CRC in vitro and breast cancer in vivo, potentially shifting the immune balance from pro-tumor M2-like to anti-tumor M1-like macrophages. …”
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Probiotics ameliorate atopic dermatitis by modulating the dysbiosis of the gut microbiota in dogs by Hyokeun Song, Seung-Hyun Mun, Dae-Woong Han, Jung-Hun Kang, Jae-Uk An, Cheol-Yong Hwang, Seongbeom Cho

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Micro‐/Nanohierarchical Surfaces for Enhanced Pool Boiling in Large‐Area Silicon Multichips by Youngseob Lee, Kiwan Kim, Yunseo Kim, Daeyoung Kong, Jeonghwan Park, Daehyuk Son, Sungchan Kang, Seogwoo Hong, Hyoungsoon Lee

“…This study examines the enhancement in pool boiling heat transfer on a customized multichip module, designed to mimic artificial intelligence chip layouts for high‐performance computing. …”
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Identification of key modules and hub genes for sepsis-induced myopathy using weighted gene co-expression network analysis by Siming Lin, Siming Lin, Siming Lin, Kexin Cai, Kexin Cai, Kexin Cai, Ai Chen, Weibin Wu, Guili Lian, Shaodan Feng, Shaodan Feng, Zhihong Lin, Zhihong Lin, Liangdi Xie, Liangdi Xie, Liangdi Xie, Liangdi Xie, Liangdi Xie

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Monolithic silicon nitride electro-optic modulator enabled by optically-assisted poling by Christian Lafforgue, Boris Zabelich, Camille-Sophie Brès

“…Abstract Electro-optic (EO) modulation is a key functionality to have on-chip. However, achieving a notable linear EO effect in stoichiometric silicon nitride has been a persistent challenge due to the material’s intrinsic properties. …”
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Application of biological modulator in broiler litter to control Salmonella Heidelberg E2 by Renata Viciniescki, Rafael Levandowski, Nadine Zancanaro Gasperin, Laura Beatriz Rodrigues, Fernando Pilotto

“…Among the proposed strategies for the prevention of this pathogen, the application of biological modulators that act to reduce this pathogen is of particular importance. …”
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OTFS modulation exploration for robust 6G communications in high mobility scenarios by Mohammadi Abderrahim, Dkiouak Aziz, Baghouri Mostafa, Chakkor Saad, El Oualkadi Ahmed, El Mamouni Anass

“…Orthogonal Time-frequency-space (OTFS) modulation represents a pioneering advancement, tailored to the requirements of prospective sixth-generation (6G) wireless networks. …”
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Temperature Modulates Nutrient Metabolism and Antioxidative Fluctuations in <i>Riptortus pedestris</i> by Xiaofeng Li, Yulong Niu, Xin Cui, Yue Cui, Simeng Chen, Shusen Shi, Yu Gao

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Integration of the vegetation phenology module improves ecohydrological simulation by the SWAT-Carbon model by M. Li, S. Chen, F. Hao, N. Wang, Z. Wu, Y. Xu, J. Zhang, Y. Zhang, Y. H. Fu

“…Although the Soil and Water Assessment Tool (SWAT) has been widely used for estimating hydrological cycles, its lack of integration with the phenology module has led to substantial uncertainties. In this study, we developed a process-based vegetation phenology module and coupled it with the SWAT-Carbon model to investigate the effects of vegetation dynamics on runoff in the upper reaches of the Jinsha River watershed in China. …”
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Decellularized Adipose Matrix Rejuvenates Photoaged Skin through Immune Microenvironment Modulation by Jialiang Zhou, Shengjie Jiang, Liyun Wang, Kaili Lin, Jianyong Wu, Haijun Gui, Zhen Gao

“…Conclusion: DAM offers a novel therapeutic approach for skin rejuvenation by modulating the immune microenvironment, demonstrating notable clinical potential.…”
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Emerging therapy targets to modulate microbiome-mediated effects evident in cardiovascular disease by Dorothea Katharina Hoffelner, Tim Hendrikx

“…The human gut microbiota influences host metabolism, immune responses, and inflammation, with microbial dysbiosis linked to metabolic disorders and increased cardiovascular disease risk. Notably, metabolites such as short-chain fatty acids, trimethylamine N-oxide, and bile acids, which are influenced by the microbiome and its functional composition, have been implicated in vascular health, immune modulation, and atherosclerosis. …”
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