Effects of Vernonia amygdalina Extract on the Modulation of Liver Antioxidant Enzymes, Cytokines, Adipokines, DNA Biomarkers, and Growth in Aflatoxin B1-Exposed Broiler Chickens by Olugbenga Oloruntola, Samuel Adeyeye, Fehintoluwa Oluwaniyi, Olumuyiwa Olarotimi, Deborah Oloruntola, Emmanuel Asaniyan, Ojurereoluwa Ayodele, Olufemi Adeniji

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Zhili decoction ameliorates ulcerative colitis by modulating gut microbiota and related metabolite, and inhibiting the TLR4/NF-κB/NLRP3 pathway by Tianying Tan, Qin Chen, Ping Chen, Shuangshuang Li, Shuangshuang Li, Wenting Hu, Wenting Hu, Tao Yang, Yingtian Jia

“…In addition, correlation analysis demonstrated a close relationship between gut microbes, fecal metabolites, and inflammatory factors.ConclusionZLD alleviated UC by regulating gut flora, modulating related metabolite levels, and inhibiting TLR4/NF-κB/NLRP3 pathway.…”
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Ornithine enantiomers modulate essential oil yield and constituents and gene expression of monoterpenes synthase in Salvia officinalis under well-watered and drought stress conditi... by Maryam Mohammadi-Cheraghabadi, Faezeh Ghanati, Naser Karimi, Mansour Ghorbanpour, Saeid Hazrati

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Microglia TRPC1 SUMOylation drives neuroinflammation after stroke by modulating NLRP3 activity via increasing TRPC1 interaction with ARRB2 by Huinan Zhang, Xinzhe Du, Tian Gao, Xing Wang, Huifeng Zhang, Manyang Yu, Jing Huang

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LncRNA HOTTIP modulated by Hedgehog signaling drives colorectal cancer progression by promoting HUWE1-mediated ubiquitin‒proteasome degradation of p53 by Hui Wang, Weiwei Jiao, Defu Li, Zhengping Yu, Huqiao Luo, Jie Zhang, Yuanbing Zhang, Hai Rao, Quqin Lu, Bing Zhao, Shiwen Luo

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DNA‐Nanocrystal Assemblies for Environmentally Responsive and Highly Efficient Energy Harvesting and Storage by Mallikarjuna Reddy Kesama, Sunghwan Kim

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Persistent symptoms in euthyroid Hashimoto’s thyroiditis: current hypotheses and emerging management strategies by Hui Zhang, Hui Zhang, Wenting Tong, Weiyong Zeng, Hongyan Luo, Licai Zhang, Jiasheng Feng, Yang Xiao, Gankun Wang

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“Unraveling EMILIN-1: A Multifunctional ECM Protein with Tumor-Suppressive Roles” Mechanistic Insights into Cancer Protection Through Signaling Modulation and Lymphangiogenesis Con... by Samanta Muzzin, Enrica Timis, Roberto Doliana, Maurizio Mongiat, Paola Spessotto

“…In the tumor microenvironment, it contributes to tissue homeostasis by restraining aberrant lymphatic vessel formation, a process closely linked to tumor dissemination and immune modulation. Notably, EMILIN-1 expression is frequently reduced or its structure altered by proteolytic degradation in advanced cancers, correlating with disease progression and poor prognosis. …”
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mTOR Inhibitor Everolimus Modulates Tumor Growth in Small-Cell Carcinoma of the Ovary, Hypercalcemic Type and Augments the Drug Sensitivity of Cancer Cells to Cisplatin by Kewei Zheng, Yi Gao, Jing Xu, Mingyi Kang, Ranran Chai, Guanqin Jin, Yu Kang

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Polylactic acid electrospun membranes coated with chiral hierarchical-structured hydroxyapatite nanoplates promote tendon healing based on a macrophage-homeostatic modulation strat... by Gang Luo, Juehong Li, Shuai Chen, Zhengqiang Yuan, Ziyang Sun, Tengfei Lou, Zhenyu Chen, Hang Liu, Chao Zhou, Cunyi Fan, Hongjiang Ruan

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Mannan-oligosaccharide modulates gut microbiota and enhances immune-metabolic functions in Chinese mitten crab (Eriocheir sinensis): Insights from an in vitro fermentation model by Wei Li, Shubin Liu, Kaiqi Huang, Xiaoling Zhang, Xiaodan Wang, Jian G. Qin, Liqiao Chen, Erchao Li

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The type of diet consumed during prepuberty modulates plasma cholesterol, hepatic LXRα expression, and DNA methylation and hydroxymethylation during adulthood in male rats. by Ana Aguilar-Lozano, Berenice Palacios-González, Martha Guevara-Cruz, Armando R Tovar, Alam Palma-Guzman, Lilia G Noriega

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Ubiquitin-specific protease 38 modulates atrial fibrillation susceptibility in chronic kidney disease via STRAP stabilization and activation of TGF-β/SMAD signaling by Hong Meng, Zongze Qu, Zheng Xiao, Bin Kong, Hongjie Yang, Wei Shuai, He Huang

“…USP38-CKO attenuated atrial fibrosis and reduced collagen I/III and α-SMA expression, whereas USP38-TG exacerbated these effects. Notably, USP38 modulation did not significantly alter atrial effective refractory period, suggesting its primary involvement in structural rather than direct electrical remodeling. …”
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NOD2 (Nucleotide-Binding Oligomerization Domain-Containing Protein 2)-Mediated Modulation of the Immune Response Induced by BCG (Bacillus Calmette-Guérin) Bacilli by Magdalena Jurczak, Joanna Kaczmarek, Magdalena Kowalewska-Pietrzak, Paulina Stelmach, Magdalena Druszczynska

“…Co-stimulation with BCG + RSV elicited the strongest transcriptional response, notably a 2–4-fold upregulation of NOD2, IL-1β, and IL-6 versus RSV alone. …”
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Edgeworthia gardneri (Wall.) Meisn Mitigates CCL4-induced liver injury in mice by modulating gut microbiota, boosting antioxidant defense, and reducing inflammation by Jiashu Hu, Jitao Sun, Qiu Zhong, Shouhai Chen, Wen Yin, Xi Wei, Linzhen Li, Kun Li, Munwar Ali, Wenjing Sun, Shahid Ali Rajput, Muhammad Abdullah, Hongbin Si, Yi Wu

“…Conclusively, EGM polysaccharide protects against CCl4-induced oxidative stress and inflammation in the liver and alleviates hepatic injury through beneficial gut microbiota modulations. The current study suggests that EGM polysaccharide is an effective agent in counteracting CCl4-induced hepatic damage.…”
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Comparative effect of atorvastatin and risperidone on modulation of TLR4/NF-κB/NOX-2 in a rat model of valproic acid-induced autism by Eman A. E. Farrag, Mona H. Askar, Zienab Abdallah, Safinaz M. Mahmoud, Eman A. Abdulhai, Eman Abdelrazik, Eman Mohamad El Nashar, Faten Mohammed Alasiri, Asma Nasser Saeed Alqahtani, Mamdouh Eldesoqui, Ali M. Eldib, Alshimaa Magdy

“…Conclusions The research results unequivocally demonstrated that atorvastatin can modulate VPA-induced autism by suppressing inflammation, oxidative stress, and apoptosis through TLR4/NF-κB/NOX-2 signaling pathway. …”
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Resveratrol Alleviates the Prenatally Intermittent Hypoxia‐Induced Cognitive Impairment in Male Offspring Mice Through Modulating the SIRT1/HIF‐1α Pathway by Xun He, Ziwei Cao, Xinyi Chen, Jie Hu, Jiaxuan Li, Xinhui Jia, Juncang Wu, Xuechun Liu

“…Administration of resveratrol notably ameliorated the cognitive deficits observed in these offspring and mitigated the heightened levels of pro‐inflammatory cytokines. …”
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Heme Oxygenase-1 Modulates Macrophage Polarization Through Endothelial Exosomal miR-184-3p and Reduces Sepsis-Induce Lung Injury by Chen W, Zhang Y, Chen J, Dong S, Wu X, Wu Y, Du Z, Yang Y, Gong L, Yu J

“…Overexpression of HO-1 downregulates miR-184-3p, which negatively regulates Semaphorin 7A (Sema7a), which attenuated M1 type macrophages (M1) polarization and augmented M2 type macrophages (M2) polarization, thereby partially mitigating lung injury and inflammation.Conclusion: Collectively, we elucidated a novel potential therapeutic mechanism that HO-1 alleviate inflammation by modulating the M1/M2 ratio in sepsis-induced ALI by regulating miR-184-3p/Sema7a expression. …”
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Hydrogel loaded with cerium-manganese nanoparticles and nerve growth factor enhances spinal cord injury repair by modulating immune microenvironment and promoting neuronal regenera... by Zhaoyang Gong, Zhenhao Chen, Dachuan Li, Xiao Lu, Jianwei Wu, Hanqiu Sun, Ximeng Wang, Siyang Liu, Xinlei Xia, Feizhou Lu, Jianyuan Jiang, Chi Sun, Hongli Wang, Feng Zeng, Xiaosheng Ma

“…This study aims to develop a novel composite material combining enzymatic nanoparticles and nerve growth factor (NGF) to modulate the immune microenvironment and enhance SCI repair. …”
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PINK1 modulates Prdx2 to reduce lipotoxicity‐induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction by Hao Zhang, Tianyu Xu, Xiyuan Mei, Qiming Zhao, Qiling Yang, Xianghui Zeng, Zhuang Ma, Haobin Zhou, Qingchun Zeng, Dingli Xu, Hao Ren

“…Key points Our investigation discloses a pivotal relationship between PINK1 and Prdx2 in the context of HFpEF. Notably, PINK1, in addition to its role in mitochondrial autophagy, can increase Prdx2 expression, effectively remove ROS and attenuate cardiomyocyte apoptosis by modulating the JNK and p38 pathways, thereby alleviating myocardial lipotoxicity and improving HFpEF cardiac function. …”
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