Synergistical amelioration of muscle atrophy by modulating gut microbiota through the bioconversion of grape seed extract and whey using kefir lactic acid bacteria by Kun-Ho Seo, Eseul Kim, Hyunsook Kim

“…Supplementation with WDG synergistically ameliorated immobilization-induced sarcopenia by restoring grip strength, muscle weight, and the expression of genes related to muscle growth markers. Notably, WDG significantly modulated the abundance of butyrate-producing and intestinal barrier function-related gut bacteria, which were significantly and positively correlated with holding impulse and muscle growth markers. …”
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Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions. by Rocio Sancho, Sophia M Blake, Christian Tendeng, Bruce E Clurman, Julian Lewis, Axel Behrens

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Development of A Chemistry Teaching Module on Acids and Bases Based on Subulussalam Local Wisdom : Exploration of Batik, Bauh Buluh Fish, and Nakan Lancing by Desi Ely Fitri, Ibnu Khaldun, M. Hasan, Zulfadli Zulfadli, M. Nazar, Mentari Mentari

“…This study aims to develop a chemistry teaching module that integrates the local wisdom of Subulussalam, incorporating cultural elements such as Subulussalam batik, ikan bauh buluh, and nakan lancing, and to evaluate the responses of students and teachers to the module. …”
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Transcriptomic Insights into Salt Stress Tolerance Mechanisms in <i>Melia azedarach</i>: 24-Epibrassinolide-Mediated Modulation of Auxin and ABA Signaling Pathways by Xiaoxian Li, Zin Myo Htet, Hong Chen, Jianbing Liu, Fangyuan Yu

“…This study investigates the molecular basis of salt stress responses in <i>Melia azedarach</i> L. and the modulating role of 24-epibrassinolide (EBR) through transcriptomic analysis. …”
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ShenQiGan Extract Repairs Intestinal Barrier in Weaning-Stressed Piglets by Modulating Inflammatory Factors, Immunoglobulins, and Short-Chain Fatty Acids by Rongxia Guo, Chenghui Jiang, Yanlong Niu, Chun Niu, Baoxia Chen, Ziwen Yuan, Yongli Hua, Yanming Wei

“…It significantly lowered serum inflammatory cytokine levels while elevating immunoglobulin levels. The supplement notably enhanced concentrations of acetic acid, propionic acid, butyric acid, and isobutyric acid. …”
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Humanized CXCL12 antibody delays onset and modulates immune response in alopecia areata mice: insights from single-cell RNA sequencing by Seungchan An, Mei Zheng, In Guk Park, Sang Gyu Park, Minsoo Noh, Jong-Hyuk Sung

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Postharvest Shading Modulates Saccharide Metabolic Flux and Enhances Soluble Sugar Accumulation in Tobacco Leaves During Curing: A Targeted Glycomics Perspective by Kesu Wei, Yan Wang, Dong Xiang, Lei Yang, Yijun Yang, Heng Wang, Jiyue Wang, Shengjiang Wu, Yonggao Tu, Chenggang Liang

“…Targeted glycomics analysis identified 21 saccharides, with glucose, D-fructose, and sucrose being dominant. Notably, PS ultimately increased glucose, D-fructose, and sucrose levels by 74.09%, 66.49%, and 17.36%, respectively. …”
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Low-intensity laser exposure enhances rice (Oryza sativa L.) growth through physio-biochemical regulation, transcriptional modulation, and microbiome alteration by Yetong Qi, Yumeng Lei, Temoor Ahmed, Feng Cheng, Kangqi Lei, Han Yang, Hayssam M. Ali, Zhitao Li, Xingjiang Qi

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Identification of host genetic factors modulating β-lactam resistance in Escherichia coli harbouring plasmid-borne β-lactamase through transposon-sequencing by Hyunhee Kim, Travis Bell, Kihyun Lee, Jeongyun Jeong, James C. A. Bardwell, Changhan Lee

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In Silico Identification and Characterization of Spiro[1,2,4]triazolo[1,5-<i>c</i>]quinazolines as Diacylglycerol Kinase α Modulators by Lyudmyla Antypenko, Kostiantyn Shabelnyk, Oleksii Antypenko, Mieko Arisawa, Oleksandr Kamyshnyi, Valentyn Oksenych, Serhii Kovalenko

“…A new class of spiro[1,2,4]triazolo[1,5-<i>c</i>]quinazoline derivatives is presented as promising modulators of diacylglycerol kinase α (DGK-α), a target implicated in cancer, neurological disorders, and immune dysfunction. …”
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Valproic acid improves the efficacy of oxaliplatin/fluoropyrimidine-based chemotherapy by targeting cancer stem cell via β-Catenin modulation in colorectal cancer by Maria Serena Roca, Rita Lombardi, Cristina Testa, Federica Iannelli, Laura Grumetti, Tania Moccia, Veronica Barile, Laura Addi, Domenico Memoli, Alessandra Leone, Simone Di Franco, Giorgio Stassi, Antonio Avallone, Francesca Bruzzese, Biagio Pucci, Alfredo Budillon, Elena Di Gennaro

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Exploring the value of a well-established conditioned pain modulation paradigm in women: a Translational Research in Pelvic Pain (TRiPP) study by Lysia Demetriou, Danielle Perro, Lydia Coxon, Michal Krassowski, Claire E. Lunde, Claire E. Lunde, Joana Ferreira-Gomes, Ana Charrua, Pedro Abreu-Mendes, Lars Arendt-Nielsen, Lars Arendt-Nielsen, Lars Arendt-Nielsen, Qasim Aziz, Judy Birch, Kurtis Garbutt, Andrew Horne, Anja Hoffman, Lone Hummelshoj, Jane Meijlink, Maik Obendorf, Esther Pogatzki-Zahn, Naoko Sasamoto, Naoko Sasamoto, Kathryn Terry, Kathryn Terry, Kathryn Terry, Rolf-Detlef Treede, Allison Vitonis, Allison Vitonis, Jan Vollert, Nilufer Rahmioglu, Nilufer Rahmioglu, Christian M. Becker, Francisco Cruz, Stacey A. Missmer, Stacey A. Missmer, Stacey A. Missmer, Stacey A. Missmer, Krina Zondervan, Krina Zondervan, Christine B. Sieberg, Christine B. Sieberg, Christine B. Sieberg, Jens Nagel, Jens Nagel, Katy Vincent

“…BackgroundConditioned pain modulation (CPM) is considered a human proxy for descending inhibitory pain pathways. …”
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The stromal vascular fraction mitigates bleomycin-induced skin fibrosis in mice by modulating vascular lesions and secreting antifibrotic factors at different stages of disease by Ziyu Wang, Mengqi Shi, Zonghao Liu, Yahui Chen, Xiangguang Shi, Jiucun Wang

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Allicin mitigates fumonisin B1-induced kidney toxicity in quails: Modulating fibrosis, NF-κB signaling pathway, and mitochondrial damage by Yangwan Zhang, Yihao He, Xueyan Zhu, Yang Liu, Changyu Cao

“…FB1 triggered kidney fibrosis and mitochondrial injury by activating the NF-κB signaling pathway, modulating NXR expression, and regulating corresponding CYP450 subtypes, which culminated in pathological injury to kidney tissues. …”
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Linoleic acid metabolite 13-Hydroxyoctadecadienoic acid as a biphasic ferroptosis modulator in granulosa cells: multi-omics analysis of ovine atretic follicles by Yukun Song, Erhan Hai, Lixia He, Ning Zhang, Nan Zhang, Junlan Wang, Yupeng Sun, Dengke Zeng, Jiaxin Zhang, Jiaxin Zhang

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Corneal sensory nerve loss induced by repeated subconjunctival and topical bupivacaine disrupts tear secretion and enhances bacterial adhesion via neuropeptide modulation. by Ananya Datta, Grace Kelly Orallo, Nahomy Nelson

“…This loss of sensory input led to a marked decrease in SP and CGRP levels in both the cornea and tear fluid, with the most pronounced reduction observed in the combined treatment group. Notably, neuropeptide depletion correlated with increased bacterial adhesion, with a ~ 1.18-fold increase for S. aureus and ~1.20-fold for P. aeruginosa, highlighting the critical role of corneal sensory nerves in modulating ocular surface immunity (P < 0.0001). …”
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Staphylococcus epidermidis uses the SrrAB regulatory system to modulate oxidative stress and intracellular survival in mouse macrophage cell line Ana-1 by Chunjing Zhao, Zongkai Bai, Xiaoting Chen, Shuangjie Shang, Baitong Shen, Li Bai, Di Qu, Yang Wu, Youcong Wu

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Modulation of Quasi‐Biennial Oscillation on Wintertime Variability of Intraseasonal 2‐m Temperature Over Northern Eurasia and Its Potential Impact on Subseasonal Prediction in Chin... by Xinrui Xie, Jiye Wu, Jing‐Jia Luo, Jianxiang Xu, Huiping Yan

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Comparison of novel native probiotics and paraprobiotics in modulating oxidative stress and inflammation in DSS-induced colitis: implications for enhanced therapeutic strategies in... by Niloofar Rezaie, Shadi Aghamohammad, Elham Haj Agha Gholizadeh Khiavi, Mohammad Reza Pourshafie, Malihe Talebi, Mahdi Rohani

“…The objective of this research is to evaluate and compare the potency of probiotics and paraprobiotics to modulate oxidative stress and inflammation. Methods and results In the initial phase, the antioxidant capabilities of 88 strains from Lactobacillus and Bifidobacterium were evaluated. …”
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FAM50A as a novel prognostic marker modulates the proliferation of colorectal cancer cells via CylinA2/CDK2 pathway. by Longhai Li, Zhaoshuai Ji, Guangyun Li, Hao Gu, Yan Sun

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