The role of HSPB1 in modulating ferroptosis in pancreatic cancer via the TP53/SLC7A11/GPX4 axis by Zeyu Tian, Qi Liu, Jihui Luo, Ning Ning, Jing Qu

“…Specifically, HSPB1 suppresses TP53, which in turn modulates the expression of SLC7A11 and GPX4. These changes in the expression of SLC7A11 and GPX4 inhibit ferroptosis, a form of regulated cell death. …”
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Pregnant Women Chronically Infected by <i>Toxoplasma gondii</i> with Depressive Disorder: Differential Modulation of Pro-Inflammatory and Anti-Inflammatory Cytokines by Carolina Salomão Lopes, Ricardo José Victal Carvalho, Tamires Lopes da Silva, Heber Leão Silva Barros, Lucas Vasconcelos Soares Costa, Danielly Christine Adriani Maia Mota, Bellisa Freitas Barbosa, Luan Souza Vieira, Talyene Marques de Araújo, Alírio Resende Costa, Ruth Opeyemi Awoyinka, Tiago Wilson Patriarca Mineo, Angélica Lemos Debs Diniz, José Roberto Mineo

“…Beyond neurotransmitter disturbances, increasing evidence suggests that infectious agents may play a role in the pathophysiology of depression through immune system modulation. <i>Toxoplasma gondii</i> infection has been linked to various mental disorders in the general population, including depression and anxiety. …”
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Indole-3-propionic acid enhances growth performance and reduces diarrhea via modulating redox status and intestinal inflammation in weaned piglets by Dongxu Ming, Xincong Xu, Xianren Jiang, Yanpin Li, Wenjuan Sun, Jiangbo Xiang, Mingyuan Huang, Yu Pi, Xilong Li

“…Piglets fed the diets with 50, 100, and 200 mg/kg of IPA exhibited reduced feed conversion ratios (F:G) compared to the control piglets (P = 0.035). Notably, 50 and 100 mg/kg IPA treatments significantly reduced diarrhea incidence and serum interleukin (IL)-6 content (P < 0.05). …”
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Novel insights into the circadian modulation of lipid metabolism in chicken livers revealed by RNA sequencing and weighted gene co-expression network analysis by Panlin Wang, Fang Li, Yanyan Sun, Yunlei Li, Xiuyu Xie, Xue Du, Lu Liu, Yongshu Wu, Dan Song, Hui Xiong, Jilan Chen, Xiangchen Li

“…Weighted gene co-expression network analysis (WGCNA) revealed 3 modules—green, blue, and red—that significantly correlate with FFA, FAS, and TG, respectively. …”
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Berberine alleviates enterotoxigenic Escherichia coli-induced intestinal mucosal barrier function damage in a piglet model by modulation of the intestinal microbiome by Min Du, Xinran Liu, Xu Ji, Yue Wang, Xiaodan Liu, Chunfang Zhao, Chunfang Zhao, Erhui Jin, Erhui Jin, Youfang Gu, Youfang Gu, Hongyu Wang, Feng Zhang, Feng Zhang

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Translational medicine research on the role of key gene network modulation mediated by procyanidin B2 in the precise diagnosis and treatment of multiple sclerosis by Jian Liu, Meng Pu, Di Guo, Ying Xiao, Jin-zhu Yin, Dong Ma, Cun-gen Ma, Qing Wang

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Circular RNA-encoded oncogenic PIAS1 variant blocks immunogenic ferroptosis by modulating the balance between SUMOylation and phosphorylation of STAT1 by Xin Zang, Xiao-Yu He, Cheng-Mei Xiao, Qing Lin, Meng-Yue Wang, Cheng-Yan Liu, Ling-Yi Kong, Zhong Chen, Yuan-Zheng Xia

“…CircPIAS1, primarily localized in the nucleus, was notably upregulated in tumor tissues compared to adjacent tissues, where it plays a crucial role in promoting cancer cell proliferation. …”
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Dietary mixtures of Bacillus spp. modulates intestinal morphology, resistance to Vibrio parahaemolyticus, response of immune-antioxidant genes, and growth of Dicentrarchus labrax by El-Sayed Hemdan Eissa, Afaf N. Abdel Rahman, Ragaa A. Ahmed, Basma M. Hendam, Yasmin M. Abd El-Aziz, Hagar Sedeek Dighiesh, Moaheda E.H. Eissa, Ekemini Moses Okon, Norhan H. Ahmed

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Unveiling the microbial orchestra: exploring the role of microbiota in cancer development and treatment by Esther Ugo Alum, Daniel Ejim Uti, Okechukwu Paul-Chima Ugwu, Benedict Nnachi Alum, Friday Ogbu Edeh, Christine Ainebyoona

“…Given these associations, there is growing interest in leveraging the microbiota as a biomarker for cancer detection and outcome prediction. Notably, distinct microbial signatures have been identified across various cancer types, suggesting their potential as diagnostic markers. …”
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Alleviating Effects of Citrus Polymethoxyflavones on Autoimmune Thyroiditis via IL‐17 Signaling Pathway by Manxi Wu, Han Yang, Yuhao Wu, Yuanxiao Yin, Junhao Li, Yongfu Ge, Cui Sun, Jinping Cao, Dengliang Wang, Yixiong Zheng, Yue Wang, Chongde Sun

“…Mechanistically, PMFs, specifically tangeretin and nobiletin, alleviated AITDs by modulating the IL‐17 signaling pathway, regulating key regulators such as TNF receptor‐associated factor 3 (TRAF3), TRAF3‐interacting protein 2 (Act1), nuclear factor kappa B subunit 1 (NFKB1), interleukin 1 beta (IL‐1β), interleukin 6 (IL6), and tumor necrosis factor‐α (TNF‐α). …”
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Dietary and environmental modulation for the gut environment: yogurt promotes microbial diversity while chloride hot springs improve defecation status in healthy adults by Jungmi Choi, Midori Takeda, Shunsuke Managi

“…While yogurt has been widely studied for its ability to modulate the gut microbiota as a dietary factor, the effects of chloride hot spring bathing as an environmental factor remain largely unexplored. …”
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<i>Eisenia bicyclis</i> Extract Ameliorates Colitis in In Vitro and In Vivo Models Through Modulation of mTOR Axis and Gut Microbiota Composition by Qunzhe Wang, Yuri Im, Jumin Park, Hye Lim Lee, Dae Gon Ryu, Hyemee Kim

“…<i>Eisenia bicyclis</i>, a marine alga, is known for its anti-inflammatory, antioxidant, and gut microbiota-modulating properties. This study explored the mechanisms by which a 70% ethanol extract of <i>E. bicyclis</i> may alleviate UC, through both in vitro and in vivo experiments. …”
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Ketamine Induces Lasting Antidepressant Effects by Modulating the NMDAR/CaMKII-Mediated Synaptic Plasticity of the Hippocampal Dentate Gyrus in Depressive Stroke Model by Idriss Ali Abdoulaye, Shan-shan Wu, Enkhmurun Chibaatar, Da-fan Yu, Kai Le, Xue-jin Cao, Yi-jing Guo

“…Furthermore, the colocalization analysis indicated a significant and selectively increased conjunction of β-CaMKII and postsynaptic density protein 95 (PSD95) coupled with a notable decrease in NMDAR2-β association with PSD95 after ketamine treatment. …”
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The lncRNA LOC100257036 and vvimiR156 modulate gibberellin signaling through AGAMOUS during cluster formation in Sistan Yaghooti grape by Shahla Sahraei, Nafiseh Mahdinezhad, Abbasali Emamjomeh, Kaveh Kavousi, Mahmood Solouki, Massimo Delledonne

“…However, the compact clusters and small berries are notable features that negatively impact its marketability. …”
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High-dose multi-strain Bacillus probiotics enhance treatment and reduce antibiotic usage in children with persistent diarrhea through immune and microbiota modulation by Ha Thuy Dang, Thuy Thi Bich Phung, Dien Minh Tran, Anh Thi Phuong Bui, Yen Hai Vu, Minh Thi Luong, Hang Minh Nguyen, Huong Thi Trinh, Hao Thi Ngoc Vo, Trang Thi Thu Nguyen, Anh Hoa Nguyen, Pham Dinh Tung, Linh Huyen Tran, Anh Thi Van Nguyen

“…This is archived by improving the native gut microbiota and modulating immunological responses. Trial registration: ClinicalTrials.gov, Identifier No: NCT05812820, 14/4/2023.…”
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Anticancer Effect of <i>Cycas media</i>: Molecular Basis Through Modulation of PI3K/AKT/mTOR Signaling Pathway by Jawaher Alqahtani, Esraa M. Mosalam, Hend E. Abo Mansour, Aya Ibrahim Elberri, Hanaa A. Ibrahim, Sebaey Mahgoub, Ismail A. Hussein, Mohammed F. Hawwal, Maryam Al Hmoudi, Ehssan Moglad, Rehab Ahmed, Fatma Alzahraa Mokhtar, Engy Elekhnawy, Walaa A. Negm

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An innovative method for improving the performance of unmanned aerial vehicle-based generalized spatial modulation and non-orthogonal multiple access in 6G networks by Mounika Neelam, Anuradha Sundru

“…We propose a nonorthogonal multiple access (NOMA)-based multiuser generalized spatial modulation (GSM) system that allows various transmitting antennas. …”
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Senecio scandens Buch.-Ham. polysaccharides exert anti-atopic dermatitis effects by modulating gut microbiota and the MAPK/NF-κB pathway by Zhi-Qin Hu, Shu-Shu Xie, Ming-Yuan Zhou, Yu-Chi Chen, Fang-Mei Zhou, Zhi-Shan Ding, Xiao-Qing Ye

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Discovery of 1,3-disubstituted prop-2-en-1-one derivatives as inhibitors of neutrophilic inflammation via modulation of MAPK and Akt pathways by Mohammad Abdel-Halim, Dalia S. El-Gamil, Mennatallah A. Hammam, Mohamed El-Shazly, Yi-Hsuan Wang, Po-Hsiung Kung, Yu-Cheng Chen, Michal Korinek, Ashraf H. Abadi, Matthias Engel, Tsong-Long Hwang

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Structural Characterization of Morchella esculenta Polysaccharides and Its Ability to Modulate Intestinal Barrier and Intestinal Microbiota in Dextran Sulfate Sodium‐Induced Coliti... by Shutong Chen, Bo Teng, Wancong Zhang, Jude Juventus Aweya, Kit‐Leong Cheong

“…Besides, MEPs modulated gut microbiota, enhancing microbial diversity and promoting homeostasis compared to untreated. …”
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