Potentilla discolor Bunge Ameliorates Streptozotocin-Induced Diabetic Nephropathy in Mice by Modulating GAS5 and miR-21 Expression by Yan Yang, Wen Qiu, Jiyuan Xiao, Xuejian Hu, Jiang Han, Luxia Jiang

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7,8-DHF Modulates Aggressive Behavior in <i>Sebastes schlegelii</i>: Phenotype-Dependent Responses in Aggression-Dimorphic Individuals by Shufei Xu, Xinna Ma, Yang Xiao, Tao Zhang, Chao Ma, Zhen Ma

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Gut Microbiome-Host Genetics Co-Evolution Shapes Adiposity by Modulating Energy and Lipid Metabolism in Selectively Bred Broiler Chickens by Guangqi Gao, Yangbo Jiao, Lai-Yu Kwok, Zhi Zhong

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Hippocampus-sparing volume-modulated arc therapy in patients with World Health Organization grade II glioma: a feasibility study by Renxian Xie, Renxian Xie, Hongxin Huang, Hongxin Huang, Qingxin Cai, Jiayang Lu, Tong Chen, Tong Chen, Keyan Xie, Jianzhou Chen, Chuangzhen Chen

“…This study aimed to assess the feasibility of hippocampus-sparing volumetric-modulated arc therapy (HS VMAT) in patients with World Health Organization (WHO) grade II glioma.MethodsHS VMAT plans and non-hippocampus-sparing volumetric-modulated arc therapy (NHS VMAT) plans were generated using a computed tomography (CT) dataset of 10 patients who underwent postoperative radiotherapy. …”
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Alleviatory Role of Panax Notoginseng Saponins in Modulating Inflammation and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease: mechanisms and Implications by Yanan Hu, Qiuyang Fan, Bo Qiao, Ou Xu, Bijun Lv, Niping Han, Xiaomei Zhang

“…Taken together, the study underscores the potential of PNS in reducing lung inflammation and vascular remodeling in COPD rats, primarily via modulation of the TLR4/NF-κB/HIF-1α/VEGF pathway. This research offers valuable insights for developing new therapeutic strategies for managing and preventing COPD.…”
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Music therapy as a preventive intervention for postpartum depression: modulation of synaptic plasticity, oxidative stress, and inflammation in a mouse model by Qiang Fu, Rui Qiu, Tongtong Yao, Liming Liu, Yaobo Li, Xiaodong Li, Wen Qi, Yuewen Chen, Yong Cheng

“…These findings suggest that music therapy prevents PPD by modulating oxidative stress, inflammation, and synaptic integrity, providing robust preclinical evidence for its potential as a natural preventive intervention for PPD. …”
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Anthraquinones and Aloe Vera Extracts as Potential Modulators of Inflammaging Mechanisms: A Translational Approach from Autoimmune to Onco-Hematological Diseases by Raffaele Cordiano, Santino Caserta, Paola Lucia Minciullo, Alessandro Allegra, Sebastiano Gangemi

“…Additionally, AV enhances antioxidant defenses and restores immune balance by reducing Th1/Th17 subsets while promoting Th2-mediated regulation. Notably, AV also modulates inflammasome-mediated mechanisms and counteracts immunosenescence, which is driven by autophagy-related processes. …”
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Antibiotic growth promoters and waxy corn enhance broiler growth performance through starch digestibility and microbiota modulation in the crop and ileum by Yanwei Xu, Yong Xiao, Chunxiao Ai, Yihong Huang, Huajin Zhou, Jianhui Li, Jianmin Yuan

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In vitro evaluation of antimicrobial and biofilm-modulating effects of commercial cranberry (Vaccinium macrocarpon) extracts against Escherichia coli and Staphylococcus aureus by Veledar-Hamalukić Anisa, Avdić Monia, Demirović Amra

“…This study aimed to authenticate commercially available cranberry extracts, quantify their proanthocyanidin (PAC) content and evaluate their antimicrobial and biofilm-modulating effects against Escherichia coli and Staphylococcus aureus. …”
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Natural compounds target the M23B zinc metallopeptidase Mpg to modulate Neisseria gonorrhoeae Type IV pilus expression by Kathleen R. Nicholson, Shaohui Yin, Jennifer L. Edwards, Chi-Hao Luan, H Steven Seifert

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Dimethyl fumarate attenuates liver injury in a mouse model of cecal ligation and puncture by modulating inflammatory, angiogenic and pyroptotic pathways by Heider Qassam, Ali M. Janabi, Karrar Kareem Gaen, Najah Rayish Hadi

“…Conclusion This study suggests that DMF has hepatoprotective effects on septic mice via the modulation of inflammation, adhesion molecules, angiopoietin 2 and pyroptosis.…”
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Selective Modulation of Osteoclast Function by <i>Bothrops moojeni</i> Venom and Its Fractions: Implications for Therapeutic Targeting in Bone Diseases by Fernanda D’Amélio, Hugo Vigerelli, Isabel de Fátima Correia Batista, Rodrigo Pinheiro Araldi, Álvaro R. B. Prieto-da-Silva, Daniel Carvalho Pimenta, Irina Kerkis

“…In contrast, the low-molecular-weight (LMW) fraction selectively modulates OCs without significant cytoskeletal alterations. …”
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Mechanistic insights into the role of FAT10 in modulating NCOA4-mediated ferroptosis in pancreatic acinar cells during acute pancreatitis by Lingpeng Liu, Ben Che, Wenming Zhang, Dongnian Du, Dandan Zhang, Jiajuan Li, Zehao Chen, Xuzhe Yu, Miao Ye, Wei Wang, Zijing Li, Fei Xie, Qing Wang, Leifeng Chen, Jianghua Shao

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Fucoidan Alleviates Porcine Epidemic Diarrhea Virus-Induced Intestinal Damage in Piglets by Enhancing Antioxidant Capacity and Modulating Arginine Metabolism by Qian Zhang, Maojing Wang, Zhonghua Li, Di Zhao, Yongqing Hou, Tao Wu

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Extracellular matrix stiffness in endometrial cancer: driving progression and modulating treatment sensitivity via the ROCK1/YAP1 axis by Rui Sun, Ying Zhao, Yao Liu, Mengyao Zhang, Ziyi Qiu, Xiaohong Ma, Lina Wei, Wei Lu, Zhiming Liu, Jie Jiang

“…In hormone-resistant EC cells, ROCK1 inhibition restored sensitivity to progesterone therapy. Notably, in vivo experiments in a xenograft mouse model confirmed the therapeutic potential of Y-27632, as combination therapy with progesterone showed superior tumor-suppressive effects compared to monotherapy. …”
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Sub-inhibitory concentrations of oxacillin modulate biogenesis and function of extracellular vesicles secreted by oxacillin-sensitive methicillin-resistant Staphylococcus aureus by Zhaoxia Ran, Zhaoxia Ran, Minghui Hao, Binxin Guo, Junrui Wang, Junrui Wang

“…These findings provide new insights into how β-lactam antibiotics influence host–pathogen interactions by modulating the secretion of bacterial vesicles.…”
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Leucine-rich repeat-containing 56 promotes breast cancer progression via modulation of the RhoA/ROCKs signaling axis by Xiqian Zhou, Jiaxin Wang, Meiling Lu, Lin Fang, Junyong Zhao, Dengfeng Li

“…Mechanistically, we found that LRRC56 interacts with IFT88 to regulate yes-associated protein 1 (YAP1) expression via modulating the Ras homolog family member A (RhoA)/ Rho-associated protein kinases (ROCKs) signaling pathway. …”
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Longitudinal immune profiling following autologous hematopoietic stem cell transplantation in multiple sclerosis: insights into immune reconstitution and disease modulation by Malin Müller, Ivan Pavlovic, Anna Wiberg, Joachim Burman

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Cancer cell-intrinsic resistance to BiTE therapy is mediated by loss of CD58 costimulation and modulation of the extrinsic apoptotic pathway by Cong Li, Ye Shen, Patrick Collins, Lingming Liang, Olivier Nolan-Stevaux, Jason S Eng, Flordeliza Fajardo, Donato Tedesco

“…Additionally, loss of CFLAR (Caspase-8 and FADD Like Apoptosis Regulator), BCL2L1, and BID (BH3 Interacting Domain Death Agonist) induced profound changes in sensitivity to TCEs, indicating that key regulators of apoptosis, which are frequently altered in cancer, impact tumor responsiveness to BiTE therapy.Conclusions This study demonstrates that genetic alterations central to carcinogenesis and commonly detected in cancer samples lead to significant modulation of BiTE antitumor activity in vitro and in vivo, findings with relevance for a better understanding of patient responses to BiTE therapy and novel combinations that enhance TCE efficacy.…”
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The protease-activated receptors are expressed in glioblastoma and differentially modulate adherent versus stem-like growth of LN-18 GBM cells by Sandra Bien-Möller, Sandra Bien-Möller, Antonia Grober, Judith Albrecht, Heiko Paland, Heiko Paland, Kerstin Weitmann, Angela Bialke, Sascha Marx, Silke Vogelgesang, Mladen V. Tzvetkov, Wolfgang Hoffmann, Henry W. S. Schroeder, Bernhard H. Rauch, Bernhard H. Rauch

“…Notably, PAR4 protein levels were lower in GBM, while PAR1, 2, and 3 were unchanged. …”
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