African swine fever virus modulates the endoplasmic reticulum stress-ATF6-calcium axis to facilitate viral replication by Yanjin Wang, Jiaqi Li, Hongwei Cao, Lian-Feng Li, Jingwen Dai, Mengxiang Cao, Hao Deng, Dailang Zhong, Yuzi Luo, Yongfeng Li, Meilin Li, Dingkun Peng, Zitao Sun, Xiaowei Gao, Assad Moon, Lijie Tang, Yuan Sun, Su Li, Hua-Ji Qiu

“…Taken together, our findings reveal for the first time that ASFV modulates the ER stress-ATF6-Ca2+ axis to facilitate viral replication, which provides novel insights into the development of antiviral strategies for ASFV.…”
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Therapeutic Implications of Traditional Chinese Medicine in Clinically Relevant Diseases: Perspectives From microRNA-Modulated Apoptotic Signaling by Xu Q, Wu D, Tan J, Khan FA, Pandupuspitasari NS, Huang C

“…MicroRNAs (miRNAs) are endogenous, non-coding RNA (ncRNA) molecules that regulate genetic expression via post-transcriptional mechanisms. By modulating miRNA expression, TCMs have been proven to confer protective benefits, notably by facilitating apoptosis induction. …”
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Nutrient Solution Selection Modulates Growth Patterns and Leaf Elemental Accumulation in Alfalfa (<i>Medicago sativa</i>) Grown by Jiaqing Li, Yingjian Zhu, Zhenwu Wei, Haowen Chen, Chuanjie Wang, Kai Cao, Xian Zhang

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Exploring the role of gut microbiota modulation in the long-term therapeutic benefits of early MSC transplantation in MRL/lpr mice by Quanren Pan, Fengbiao Guo, Jiaxuan Chen, Haimin Huang, Yanyan Huang, Shuzhen Liao, Zengzhi Xiao, Xi Wang, Liuyong You, Lawei Yang, Xuemei Huang, Haiyan Xiao, Hua-Feng Liu, Qingjun Pan

“…These metabolites activate the aryl hydrocarbon receptor (AHR), upregulate the Cyp1a1 and Cyp1b1 gene, enhance the zonula occludens 1 (ZO-1) protein, promote intestinal repair, and mitigate SLE progression. Notably, FMT from lupus mice significantly reversed hUC-MSC benefits, suggesting that the modulation of the gut microbiota plays a crucial role in the therapeutic response observed in MRL/lpr mice. …”
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Long-Term Conservation Tillage Increases Soil Organic Carbon Stability by Modulating Microbial Nutrient Limitations and Aggregate Protection by Zixuan Han, Xueping Wu, Huizhou Gao, Angyuan Jia, Qiqi Gao

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CircRFWD3 promotes HNSCC metastasis by modulating miR-27a/b/PPARγ signaling by Zihao Wei, Ying Wang, Jiakuan Peng, Honglin Li, Junjie Gu, Ning Ji, Taiwei Li, Xikun Zhou, Xin Zeng, Jing Li, Qianming Chen

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Dietary Galacto-Oligosaccharides Enhance Growth Performance and Modulate Gut Microbiota in Weaned Piglets: A Sustainable Alternative to Antibiotics by Yongchao Wang, Zhong Li, Guowu Chen, Yiyuan Xing, Jingjing Wang, Yujie Zhao, Meng Kang, Ke Huang, Enkai Li, Xiaokang Ma

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Targeting glial fibrillary acidic protein in glaucoma: a monoclonal antibody approach to modulate glial reactivity and neuroinflammation for neuroprotection by Chaoqiang Guan, Linglin Zhang, Kristian Nzogang Fomo, Jie Yang, Norbert Pfeiffer, Franz H. Grus

“…Retinal astrocyte reactivity was inhibited by GFAPmAb in a dose-dependent manner by suppressing GFAP protein overexpression. Notably, 25 µg GFAP mAb effectively regulated both astrocyte and microglial reactivity, leading to a substantial attenuation of neuroinflammation. …”
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Gut microbiota modulates depressive-like behaviors induced by chronic ethanol exposure through short-chain fatty acids by Hui Shen, Chaoxu Zhang, Qian Zhang, Qing Lv, Hao Liu, Huiya Yuan, Changliang Wang, Fanyue Meng, Yufu Guo, Jiaxin Pei, Chenyang Yu, Jinming Tie, Xiaohuan Chen, Hao Yu, Guohua Zhang, Xiaolong Wang

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KAT6A chimeras form a self-reinforcing epigenetic module with NURF and MLL/COMPASS to sustain AML by Junhui Lv, Zhinang Yin, Conghui Li, Honglin Wen, Jian Ni, Peiyuan Yang, Zemin Song, Ying Xiang, Honghong Wang, Rui Lu, Li Huang, Ying Zhou, Hai-Bing Zhou, Ruijing Xiao, Pingping Fang, Kaiwei Liang

“…Notably, CBP/P300 inhibition reduces histone acetylation and chromatin accessibility, further impairing the recruitment of this epigenetic module. …”
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Transplanted human striatal progenitors exhibit functional integration and modulate host circuitry in a Huntington’s disease animal model by Linda Scaramuzza, Marta Ribodino, Christian Cassarino, Marta Morrocchi, Gabriela B Gomez Gonzalez, Roberta Parolisi, Edoardo Sozzi, Giacomo Turrini, Valentina Cerrato, Paola Conforti, Eriola Hoxha, Riccardo Tognato, Greta Galeotti, Chiara Cordiglieri, Maria Cristina Crosti, Stefano Zucca, Martina Lorenzati, Serena Bovetti, Paolo Spaiardi, Claudio de’Sperati, Gerardo Biella, Linda Ottoboni, Malin Parmar, Simone Maestri, Dario Besusso, Elena Cattaneo, Annalisa Buffo

“…Multiple complementary techniques including virus-based tracing and electrophysiology assays demonstrated anatomical and functional integration of the grafts. Notably, chemogenetic modulation of graft activity regulated striatal-dependent behaviors, further supporting effective graft integration into host basal ganglia circuits. …”
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ZBTB6 promotes breast cancer progression by inhibiting ARHGAP6 transcription and modulating the STAT3 signaling pathway by Xiaojiang Tang, Chaowei Deng, Yang Liu, Shengyu Pu, Qi Zheng, Yudong Zhou, Na Hao

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WISP1 drives esophageal squamous cell carcinoma progression via modulation of cancer-associated fibroblasts and immune microenvironment by Zhiqiang Yi, Qiqi Zhang, Ting Tao, Xiaojia Liu, Hui Li, Xiujuan Li, Zhiqiang Zhang

“…WISP1 can modulate the activities of CAFs and cancer cells in ESCC, as well as the process of ECM remodeling, thereby influencing the pathological progression of this malignancy. …”
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BAM8-22 targets spinal MrgC receptors to modulate UPRmt activity in the mechanism of bone cancer pain by Mingming Xie, Dan Li, Haohao Zeng, Yulin Huang, Rui Xu, Zhen Wang, Jiacheng Yu, Yu’e Sun, Yu’e Sun

“…Cellular energy metabolism homeostasis is critically dependent on mitochondrial integrity, and emerging evidence suggests that mitochondrial dysfunction in chronic BCP exacerbates pain progression by disrupting nociceptive signaling pathways. Notably, G protein-coupled receptors (GPCRs), a major class of membrane receptors, modulate mitochondrial function through diverse molecular mechanisms. …”
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Engineering a Radiohybrid PSMA Ligand with an Albumin-Binding Moiety and Pharmacokinetic Modulation via an Albumin-Binding Competitor for Radiotheranostics by Saki Hirata, Hiroaki Echigo, Masayuki Munekane, Kenji Mishiro, Kohshin Washiyama, Takeshi Fuchigami, Hiroshi Wakabayashi, Kazuhiro Takahashi, Seigo Kinuya, Kazuma Ogawa

“…We previously demonstrated that 4-(<i>p</i>-astatophenyl)butyric acid (APBA), an albumin-binding moiety (ABM) labeled with astatine-211 (²¹¹At), enables the modulation of pharmacokinetics and enhancement of therapeutic efficacy when combined with the post-administration of an albumin-binding competitor. …”
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Therapeutic potential of Simvastatin in ALS: Enhanced axonal integrity and motor neuron survival through Apoa4 and Alb modulation by Song Luo, Xiaorui Wang, Bo Ma, Dongliang Liu, Li Li, Lijin Wang, Ning Ding, Liangyu Zou, Jie Wang, Jialin Pan, Daoqian Sang, Huadong Zhou, Hongdang Qu, Yi Lu, Lijuan Yang

“…Our results suggest that simvastatin may have potential therapeutic effects in ALS, likely involving the modulation of Apoa4 and Alb expression. …”
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The integrative genomic and functional immunological analyses of colorectal cancer initiating cells to modulate stemness properties and the susceptibility to immune responses by Issam Tout, Salim Bougarn, Mohammed Toufiq, Neha Gopinath, Ola Hussein, Abbirami Sathappan, Evonne Chin-Smith, Fazulur Rehaman, Rebecca Mathew, Lisa Mathew, Kun Wang, Li Liu, Abdulrahman Salhab, Oleksandr Soloviov, Sara Tomei, Waseem Hasan, Sahar Da’as, Yosra Bejaoui, Nady El Hajj, Karama Makni Maalej, Said Dermime, Kakil Rasul, Paolo Dellabona, Giulia Casorati, Alice Turdo, Matilde Todaro, Giorgio Stassi, Soldano Ferrone, Xinhui Wang, Cristina Maccalli

“…Notably, miRNA-15a and -196a were implicated in regulating tumorigenic pathways, such as epithelial-to-mesenchymal transition (EMT), TGF-β signaling, and immune modulation. …”
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The N6-methyladenosine RNA epigenetic modification modulates the amplification of coxsackievirus B1 in human pancreatic beta cells by Maressa Fernandes Bonfim, Camille Aitchedji, Flore Van Goethem, Lionel Sauvage, Thibault Poinsot, Emilie Calonne, Rachel Deplus, François Fuks, Decio L. Eizirik, Anne Op de Beeck, Anne Op de Beeck

“…Using small interfering RNA (siRNA) targeting m6A writers and erasers, we observed that downregulation of m6A writers increases CVB1 amplification, while the downregulation of m6A erasers decreases it. Notably, the inhibition of Fat Mass and Obesity-associated protein (FTO), a key m6A eraser, reduced by 95% the production of infectious CVB1 in both human insulin-producing EndoC-βH1 cells and in induced pluripotent stem cell (iPSC)-derived islets. …”
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hUC-MSCs and derived exosomes attenuate DEX-induced muscle atrophy through modulation of estrogen signaling pathway by Na Li, Xiaoqin Liu, Qiong Wang, Yushu Chen, Chao Han, Chao Qu, Xin Guan, Wei Zou, Xiaomin Wang, Ang Li, Yin Zhang, Liping Zhu, Ruoyutong Du, Jing Liu, Yanfu Wang

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Gate-all-around tree-shaped NSFET-based biosensor: A high-sensitivity approach for label-free biomolecule detection by U. Gowthami, M. Durga Prakash, B.V.V. Satyanarayana, G. Prasanna Kumar, Asisa Kumar Panigrahy, Amit Krishna Dwivedi

“…This paper proposes and investigates a label-free dielectrically modulated biosensor employing a Gate All Around Tree-Shaped Nanosheet Field Effect Transistor (GAA-TS-NSFET). …”
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