Melatonin Modulates the Phytochelatin Synthase and Glutathione Synthase Gene Expression and the Antioxidant Performance of Soybean Plants Under Cadmium Stress by Hakimeh Oloumi, Mahmood Maleki

“…MT reduced H2O2 levels by modulating APX, GPX, and CAT activities. This study is the first to reveal that MT mitigates cadmium-induced stress by regulating GS and PCS gene expression in soybean. …”
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Trigonelline exerts its neuroprotective effects in experimental spinal cord injury through modulation of inflammation, apoptosis, and neurotrophic factors by Zhi-Lan Ye, Yuan Cao

“…Conclusions: Trigonelline shows neuroprotective properties in SCI rats by reducing allodynia, hyperalgesia, and inflammation, stabilizing mitochondrial enzyme complexes, and modulating apoptotic and neurotrophic factors. Thus, trigonelline holds promise as a potential neuroprotective agent.…”
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Zuojinwan ameliorates depressive-like behavior and gastrointestinal dysfunction in mice by modulating the FXR-bile acid-gut microbiota pathway by Dan Qiao, Dan Qiao, Bo Chen, Yuzhen Huang, Yuzhen Huang, Kunhan Su, Kunhan Su, Hao Wu, Hao Wu, Weiwei Tao, Weiwei Tao, Wanli Liu, Wanli Liu

“…These findings suggest that ZJW exerts its therapeutic benefits by activating FXR, modulating bile acid metabolism, and reshaping the gut microbiota.…”
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Modulation of TNF‐α mRNA stability by human antigen R and miR181s in sepsis‐induced immunoparalysis by Cao Dan, Bian Jinjun, Hua Zi‐Chun, Ma Lin, Chen Wei, Zhang Xu, Zhou Ri, Cheng Shun, Sun Wen‐Zhu, Jiao Qing‐Cai, Yin Wu

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Social network structure modulates neural activities underlying group norm processing: evidence from event-related potentials by Mengfei Han, Ruoxuan Han, Xin Liu, Duo Xie, Rong Lin, Yaokun Hao, Hanxiao Ge, Yiwen Hu, Yuyang Zhu, Liu Yang

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WOX11-OsPRX130 module confers rice drought tolerance by maintaining ROS homeostasis in rice root by Mingfang Tan, Yijie Wang, Yu Zhao

“…However, it remains unknown whether WOX11 modulates ROS homeostasis in roots to facilitate adaptation to drought stress. …”
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FABP5 is a key player in metabolic modulation and NF-κB dependent inflammation driving pleural mesothelioma by Eleonora Vecchio, Raffaella Gallo, Selena Mimmi, Debora Gentile, Caterina Giordano, Emilio Straface, Rossana Marino, Carmen Caiazza, Arianna Pastore, Maria Rosaria Ruocco, Alessandro Arcucci, Marco Schiavone, Camillo Palmieri, Enrico Iaccino, Mariano Stornaiuolo, Ileana Quinto, Massimo Mallardo, Fernanda Martini, Mauro Tognon, Giuseppe Fiume

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Hydrogen Peroxide Modulates the Timely Activation of Jun and Erk in Schwann Cells at the Injury Site and Is Required for Motor Axon Regeneration by Samuele Negro, Chiara Baggio, Marika Tonellato, Marco Stazi, Giorgia D’Este, Aram Megighian, Cesare Montecucco, Michela Rigoni

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Evaluation of NTCP and Second Cancer Induction from Modulated Arc Therapy for High-Risk Prostate Carcinoma by COUPÔLE Software by Assya Boughalia, Mohamed Fellah, Mohamed Zineddine El Ghribi, Kenza Benacer

“…Using the Schneider model, whole-body risk reached 5.40% for V50Gy. The risk was notably higher for the rectum than for the bladder, highlighting the need for further optimization. …”
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Modulation of TLR4 and upregulation of HO-1 & PPAR-γ by Pioglitazone ameliorates methotrexate-induced liver damage in rats by Rasha Abdelhady, Rana M. Abdelnaby, Mohamed Elsayed Mohamed Amer, Nancy S. Younis, Ebtehal Mohammad Fikry

“…Additionally, current findings revealed modulation of Toll-like receptor 4 following Pioglitazone treatment that was further confirmed by our in silico study. …”
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In Situ Modulation of NiFeOOH Coordination Environment for Enhanced Electrocatalytic‐Conversion of Glucose and Energy‐Efficient Hydrogen Production by Ning Wei, Sufeng Zhang, Xue Yao, Qinglu Li, Nan Li, Jinrui Li, Dingjie Pan, Qiming Liu, Shaowei Chen, Scott Renneckar

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Dosimetric Comparison of Dynamic Conformal Arc Therapy and Volumetric Modulated Arc Therapy using Stereotactic Radiotherapy for Carcinoma Brain by Suhani Pinto, Shreekripa Rao, RECHAL DSOUZA, Srinidhi Chandraguthi, Umesh Velu

“…Introduction: Stereotactic radiosurgery (SRS) conventionally relies upon dynamic conformal arc therapy (DCAT), yet the untapped potential of volumetric modulated arc therapy (VMAT) has not undergone comprehensive scrutiny. …”
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Host-Mediated Antimicrobial Effects and NLRP3 Inflammasome Modulation by Caulerpin and Its Derivatives in Macrophage Models of Mycobacterial Infections by Maria Gabriella S. Sidrônio, Maria Eugênia G. Freitas, Daniel W. A. Magalhães, Deyse C. M. Carvalho, Vinícius A. B. Gonçalves, Ana Caroline M. de Queiroz Oliveira, Gisela C. Paulino, Gabriela C. Borges, Rafaelle L. Ribeiro, Natália Ferreira de Sousa, Marcus T. Scotti, Demétrius A. M. de Araújo, Francisco Jaime B. Mendonça-Junior, Kristerson R. de Luna Freire, Sandra Rodrigues-Mascarenhas, Bárbara Viviana de O. Santos, Valnês S. Rodrigues-Junior

“…In addition, caulerpin and its diethyl derivative were notably found to modulate IL-1β and TNF-α production in the <i>M. smegmatis</i> infection model after quantifying pro-inflammatory cytokines and NLRP3. …”
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PLNC8 αβ Potently Inhibits the Flavivirus Kunjin and Modulates Inflammatory and Intracellular Signaling Responses of Alveolar Epithelial Cells by Abubakr A. M. Omer, Sanjiv Kumar, Bo Söderquist, Wessam Melik, Torbjörn Bengtsson, Hazem Khalaf

“…The peptide also mitigated virus-induced cytotoxicity and inflammation. Notably, PLNC8 αβ modulated the virus-induced dysregulation of key signaling and inflammatory genes, such as <i>TLR9</i>, <i>TLR3</i>, <i>NOD2</i>, <i>FOS</i>, <i>JUN</i>, <i>IL6</i>, and <i>CXCL8</i>. …”
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Mechanistic studies on the effect of berberine on methicillin-resistant Staphylococcus aureus drug resistance through modulation of wall teichoteic acid by Fangfang Zhou, Xuemei Gu, Ming Lin, Yue Dai, Wei Wang, Zhongbo Xiong, Yanan Li, Mingming Jiang, Lei Wang

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Shikonin-induced secondary metabolite modulation in grape berries (Vitis vinifera L. cv. ‘Öküzgözü’) under salinity stress by Adem Yağcı

“…Under severe salinity, total anthocyanin accumulation increased by up to 60% with shikonin treatment, suggesting its potential role as a modulator of secondary metabolism and antioxidant defense. …”
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Long-Term Aerobic Exercise Enhances Hepatoprotection in MAFLD by Modulating Exosomal miR-324 via ROCK1 by Yang Zhang, Qiangman Wei, Xue Geng, Guoliang Fang

“…Result: Aerobic exercise significantly reduced liver fat and improved insulin sensitivity in both MAFLD patients and HFD mice. Notably, exosomal miR-324 levels were lower in athletes than sedentary controls, indicating an inverse association with insulin sensitivity. …”
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Yogurt in Combination with Inactivated <i>Pediococcus lactis</i> Modulated Feline Lipid Metabolism, Anti-Inflammation and Fecal Microbiota by Jintao Sun, Xinshu Gu, Jiaxue Wang, Xiumin Wang, Zhenlong Wang, Hui Tao, Jinquan Wang, Bing Han

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Modulation of RAAS receptors and miRNAs in COVID-19: implications for disease severity, immune response, and potential therapeutic targets by Thais Freitas Barreto Fernandes, Jose Henrique Pilotto, Priscila Alves Cezar, Fernanda Heloise Côrtes, Mariza G. Morgado, Carmem Beatriz W. Giacoia-Gripp, Nathalia Beatriz Ramos De Sá, Andressa Da Silva Cazote, Agatha Freixinho Neves, Marcel De Souza Borges Quintana, Maria Pia Diniz Ribeiro, Sandra Wagner Cardoso, Valdiléa G. Veloso, Beatriz Grinsztejn, Dalziza Victalina De Almeida

“…Our study provides valuable insights into the molecular mechanisms of COVID-19 pathogenesis and identifies the modulation of RAAS receptors and miRNAs as promising biomarkers for disease severity and potential therapeutic interventions. …”
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Alternative splicing of ZmHsf23 modulates maize heat tolerance by regulating sHSPs and TIL1 expression by Jing Wang, Nannan Song, Qianqian Qin, Anqi Su, Weina Si, Beijiu Cheng, Leiming Wu, Xiaojian Peng, Haiyang Jiang

“…In this study, we demonstrate that the alternative splicing of ZmHsf23 modulates heat stress tolerance in maize. Hsf23 produced two functional transcripts, Hsf23L and Hsf23S, which differ by the presence of a cryptic mini-exon in Hsf23L that is spliced out in Hsf23S. …”
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