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The Synthetic Cannabinoids ADB-FUBINACA Modulate Mitochondrial Function and Dynamics at Biologically Relevant Concentrations During In Vitro Neurodifferentiation
Published 2024-12-01“…Different mechanisms seem to underlie mitochondrial function-related effects, as only the modulation of energy supply was dependent on CB1R activation. …”
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Natural ligand 3,3’-diindolylmethane functions as an AHR agonist to modulate angiogenesis and organ development in chicken embryos
Published 2025-09-01“…Recent studies have highlighted that interactions between AHR and certain natural ligands can modulate inflammation and immune responses, offering therapeutic potential for a wide range of diseases. …”
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Low-frequency rTMS modulates small-world network properties in an AVH-related brain network in schizophrenia
Published 2025-04-01“…Functional connectivity analyses revealed significant reductions in hyperconnectivity between the right middle temporal gyrus (MTG) and superior putamen, as well as between the left TPJ and left lateral prefrontal cortex (LPFC). Notably, responders showed greater connectivity changes, which were correlated with AVH severity reduction, highlighting the role of network modulation in treatment response.ConclusionThese findings support the network dysregulation model of AVH in schizophrenia and demonstrate that rTMS can modulate AVH-related connectivity, partially restoring network efficiency. …”
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Evolving Dynamics of Fermented Food Microbiota and the Gut Microenvironment: Strategic Pathways to Enhance Human Health
Published 2025-07-01“…These metabolites contribute to improved gut barrier function, modulation of immune responses, and overall metabolic health. …”
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Synbiotic-driven modulation of the gut microbiota and metabolic functions related to obesity: insights from a human gastrointestinal model
Published 2025-04-01“…Abstract Synbiotic interventions have gained increasing attention for modulating gut microbiota and metabolic functions in obesity-related disorders. …”
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Lactiplantibacillus plantarum dfa1 reduces obesity caused by a high carbohydrate diet by modulating inflammation and gut microbiota
Published 2025-07-01“…Microbiome analysis revealed diet-induced dysbiosis, with a notable difference between HGD and HBD impacts, particularly in the Fermicutes/Bacteroides ratio and Akkermansia spp. abundance, which was significantly elevated in the HBD + Lp group. …”
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Aqueous extract of Solanum americanum Mill. relieves functional constipation by modulating the enteric nervous system and gut micro-ecosystems
Published 2025-05-01“…This finding suggests that SAAE may alleviate FC by modulating the enteric nervous system. Notably, SAAE alleviated loperamide-induced gut inflammation, damaged gut barrier, and gut microbiota disruption. …”
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Genetically-stable engineered optogenetic gene switches modulate spatial cell morphogenesis in two- and three-dimensional tissue cultures
Published 2024-12-01“…These advancements demonstrate the capability of precise spatiotemporal modulation in tissue engineering and open up new avenues for developing programmable 3D tissue and organ models, with significant implications for biomedical research and therapeutic applications.…”
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Strategic energy-level modulation in porous heterojunctions: advancing gas sensing through Type-I to Type-II transitions
Published 2025-07-01“…Abstract To significantly enhance reaction efficiency of porous heterojunctions in various applications, precise engineering of customization heterostructures through energy-level modulation is indispensable. Herein, the preparation of a core-shell porous heterojunction, UiO-66@TDCOF, is reported. …”
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The TaNHLP1-TaRACK1A module regulates tillering via abscisic acid signaling in wheat
Published 2025-08-01“…Importantly, both the TaNHLP1 and TaRACK1A mutations promote ABA accumulation in the shoot bases and tiller buds. Notably, the NHLP1-RACK1 module is conserved across monocots and eudicots, and natural variations in the promoter of TaNHLP1-A enhance its transcriptional activity, leading to increased tiller number and yield. …”
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