Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial. by John A Todd, Marina Evangelou, Antony J Cutler, Marcin L Pekalski, Neil M Walker, Helen E Stevens, Linsey Porter, Deborah J Smyth, Daniel B Rainbow, Ricardo C Ferreira, Laura Esposito, Kara M D Hunter, Kevin Loudon, Kathryn Irons, Jennie H Yang, Charles J M Bell, Helen Schuilenburg, James Heywood, Ben Challis, Sankalpa Neupane, Pamela Clarke, Gillian Coleman, Sarah Dawson, Donna Goymer, Katerina Anselmiova, Jane Kennet, Judy Brown, Sarah L Caddy, Jia Lu, Jane Greatorex, Ian Goodfellow, Chris Wallace, Tim I Tree, Mark Evans, Adrian P Mander, Simon Bond, Linda S Wicker, Frank Waldron-Lynch

“…Furthermore, there was a dose-dependent down modulation of one of the two signalling subunits of the IL-2 receptor, the β chain (CD122) (mean decrease = 58.0%, SE = 2.8%, range 9.8%-85.5%, n = 33), on Tregs and a reduction in their sensitivity to aldesleukin at 90 min and day 1 and 2 post-treatment. …”
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Differential expression of cytokines and vitamin D in benign and malignant thyroid diseases by Huimin Li, Xin Jin, Meng Zhang, Xin Wang, Hai Wang

“…Abstract Given the critical role of cytokines in tumor microenvironment modulation1 and the anti-inflammatory and anti-tumor effects of vitamin D2,3, this study aimed to assess serum levels of IL-4, IL-6, IL-10, IL-17, TNF-α, IFN-γ, and vitamin D in patients with benign thyroid nodules, PTC, and healthy controls, to further elucidate their involvement in thyroid disease progression. …”
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From background diabetic retinopathy to its proliferative stage. What is the role of gut microbiota in the trajectory of DR? a Mendelian randomization study with mediation analysis by Yifan Zhou, Jialong Dong, Zhenyu Wang, Chen Huang, Xiaotong Yu, Xinjun Wang, Bo Yang, Yuechen Wu, Qing Peng

“…The identified GM-metabolite-DR axis establishes an actionable roadmap for targeted microbiome modulation and metabolite-based therapeutic strategies, bridging observational associations to mechanistic intervention opportunities.…”
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Effect of Potassium–Magnesium Sulfate on Intestinal Dissociation and Absorption Rate, Immune Function, and Expression of NLRP3 Inflammasome, Aquaporins and Ion Channels in Weaned P... by Cui Zhu, Kaiyong Huang, Xiaolu Wen, Kaiguo Gao, Xuefen Yang, Zongyong Jiang, Shuting Cao, Li Wang

“…In conclusion, dietary PMS supplementation improved immune function, inhibited the activation of intestinal NLRP3, and modulated the expression of water and ion channels in weaned piglets, thereby contributing to the maintenance of intestinal water and ion homeostasis, which could potentially alleviate post-weaning diarrhea in piglets. …”
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Increased CO₂ Concentration Mitigates the Impact of Nitrite on Zebrafish (<i>Danio rerio</i>) Liver and Gills by Xinyu Wang, Yao Tang, Hui Yang, Ya He, Kang Ou-Yang, Liangmou Wang, Qian Zhang, Dapeng Li, Li Li

“…Increased CO₂ levels also led to a decrease in the expression of gill <i>ae1</i>, whereas the transcriptional levels of <i>nhe1</i> and <i>nhe3b</i>, <i>nkcc</i> and <i>nbc1</i> were notably upregulated. Moreover, there was a decrease in Cl⁻ and Na⁺ concentrations, along with an increase in K⁺ concentrations. …”
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Jawbone mesenchymal stromal cells attenuate acute inflammation via hematopoietic niche reinforcement by Xinyu Wang, Qianye Chen, Jiping Sun, Zihan Huang, Zijian Zhang, Tingwei Lu, Xiangru Huang, Siyuan Sun, Yuanqi Liu, Houwen Pan, Li Mei, Paul R. Cooper, Qinggang Dai, Lei Shen, Lingyong Jiang

“…Although most investigations have centered on mesenchymal stem cells (MSCs) from long bones, the distinct properties and immunoregulatory functions of craniofacial bone marrow derived MSCs remain largely unexplored. Notably, jawbone MSCs not only exhibit a robust capacity for promoting hematopoietic regeneration but also offer therapeutic potential in infectious diseases.MethodsUsing an optimized enzymatic digestion protocol, we obtained a highly viable single‐cell suspension from mouse jawbone in vitro. …”
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Pan-cancer profiling of FZD2 as a prognostic biomarker: integrative multi-omics analysis with experimental validation and functional characterization in gastric cancer by Sijiang Zhou, Sijiang Zhou, Sijiang Zhou, Sijiang Zhou, Da Li, Da Li, Da Li, Da Li, Chao Quan, Chao Quan, Zhu Yu, Zhu Yu, Zhu Yu, Yue Feng, Yue Feng, Yue Feng, Yue Feng, Shengyu Wang, Shengyu Wang, Shengyu Wang, Shengyu Wang, Yong Li, Yong Li, Yong Li, Yong Li, Tongtong Qi, Tongtong Qi, Tongtong Qi, Tongtong Qi, Junqiang Chen, Junqiang Chen, Junqiang Chen, Junqiang Chen

“…FZD2 expression was correlated with various cancer characteristics, including stemness score, matrix score, immune score, tumor mutational burden (TMB), microsatellite instability (MSI), RNA modification genes, and drug sensitivity. Notably, FZD2 was associated with altered sensitivity to several anticancer agents, suggesting its role in modulating treatment responses. …”
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The levels of inflammatory, angiogenic, and stress biomarkers in plasma of donors depending on anti-SARS-CoV-2 IgG titers by D.I. Krenytska, V.L. Karbovskyy, Ludovico Abenavoli, T.M. Falalyeyeva, Giuseppe Guido Maria Scarlata, N.G. Raksha, T.B. Vovk, L.I. Kot, O.M. Savchuk, Maria Luisa Gambardella, O.I. Kovalchuk, V.I. Pankiv, L.I. Ostapchenko

“…PDGF and FGF-2 levels were notably higher in groups of donors with titers of 95 ± 5 and 175 ± 10 Index (S/C). …”
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Non-lethal sonodynamic therapy mitigates hypertensive renal fibrosis through the PI3K/AKT/mTORC1-autophagy pathway by DanDan Liu, Hui Wang, Jialong Li, Siqi Sheng, Shu Wang, Ye Tian

“…Current clinical interventions aimed at halting or reversing renal fibrosis in hypertensive patients are notably limited in their efficacy. Here, we present Non-lethal Sonodynamic Therapy (NL-SDT), in which ultrasound is used to activate locally sonosensitizers, thereby stimulating the production of reactive oxygen species for the purpose of modulating cell function or fate, as a novel methodology to inhibit progression of hypertensive renal fibrosis. …”
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Effect of different light qualities on photosynthetic characteristics and fruit quality of Shine Muscat grapevines grown under rain-sheltered cultivation by GONG Xiaomin, YU Guanghui, LI Xiujie, WANG Rong, CHEN Guangxia, WU Yusen, WU Xinying, ZHANG Zhichang, LI Bo, MA Yujiao

“…To address this limitation, spectral-modulated supplementary lighting emerges as a promising agronomic intervention. …”
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Effect of the Foliar Application of Copper Nanoparticles on the Growth and Yield of Persian Leek (Allium ampeloprasum subsp. Persicum) under Salinity Stress by F. Shakarami, S. Mousavi-Fard, A. Rezaei Nejad, F. Beiranvand

“…Copper \nanoparticles improve plant growth under stress conditions by influencing the content of cellular antioxidants and modulating the hormonal balance of plant tissues.   …”
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Advance of DAM-like genes in bud dormancy of deciduous fruit trees in Rosaceae family by ZHAO Yalin, WANG Lirong

“…Dormancy is highly dependent on external environment, and seasonal variations in bud break and flowering time have been reported in the context of global warming. Notably, advances in bud break and blooming dates in spring have been observed for tree species, like Malus domestica and Prunus mume. …”
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